GenomeNet

Database: Pfam
Entry: Tme5_EGF_like
LinkDB: Tme5_EGF_like
Original site: Tme5_EGF_like 
#=GF ID   Tme5_EGF_like
#=GF AC   PF09064.12
#=GF DE   Thrombomodulin like fifth domain, EGF-like
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1dx5
#=GF GA   21.40 21.40;
#=GF TC   21.40 21.40;
#=GF NC   21.30 21.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0001
#=GF RN   [1]
#=GF RM   10761923
#=GF RT   Structural basis for the anticoagulant activity of the
#=GF RT   thrombin-thrombomodulin complex. 
#=GF RA   Fuentes-Prior P, Iwanaga Y, Huber R, Pagila R, Rumennik G, Seto
#=GF RA   M, Morser J, Light DR, Bode W; 
#=GF RL   Nature. 2000;404:518-525.
#=GF DR   INTERPRO; IPR015149;
#=GF DR   SCOP; 1dx5; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family adopt a fold similar to other EGF
#=GF CC   domains, with a flat major and a twisted minor beta sheet.
#=GF CC   Disulphide pairing, however, is not of the usual 1-3, 2-4, 5-6
#=GF CC   type; rather 1-2, 3-4, 5-6 pairing is found. Its extended major
#=GF CC   sheet (strands beta-2 and beta-3 and the connecting loop)
#=GF CC   projects into thrombin's active site groove. This domain is
#=GF CC   required for interaction of thrombomodulin with  thrombin, and
#=GF CC   subsequent activation of protein-C [1].
#=GF SQ   191
#=GS D2HSG5_AILME/406-439        AC D2HSG5.1
#=GS A0A3N0YA18_ANAGA/313-346    AC A0A3N0YA18.1
#=GS A0A4W5QVP8_9TELE/209-245    AC A0A4W5QVP8.1
#=GS A0A665WGE2_ECHNA/211-247    AC A0A665WGE2.1
#=GS G3UIR2_LOXAF/407-440        AC G3UIR2.1
#=GS A0A384AY23_BALAS/380-413    AC A0A384AY23.1
#=GS A0A4W6D0H8_LATCA/185-228    AC A0A4W6D0H8.1
#=GS A0A670K883_PODMU/317-354    AC A0A670K883.1
#=GS A0A6I8PPQ6_XENTR/379-416    AC A0A6I8PPQ6.1
#=GS A0A3Q3G5C4_9LABR/196-232    AC A0A3Q3G5C4.1
#=GS A0A6Q2XQU9_ESOLU/235-271    AC A0A6Q2XQU9.1
#=GS S7MCK3_MYOBR/101-134        AC S7MCK3.1
#=GS A0A6G0I6E1_LARCR/341-381    AC A0A6G0I6E1.1
#=GS A0A3M0K4B6_HIRRU/342-373    AC A0A3M0K4B6.1
#=GS F8W3I7_DANRE/315-350        AC F8W3I7.1
#=GS A0A452QDE4_URSAM/406-439    AC A0A452QDE4.1
#=GS A0A3B3I0X5_ORYLA/111-146    AC A0A3B3I0X5.1
#=GS A0A673BYB8_9TELE/227-259    AC A0A673BYB8.1
#=GS A0A1S3G126_DIPOR/405-438    AC A0A1S3G126.1
#=GS A0A315VXC5_GAMAF/339-372    AC A0A315VXC5.1
#=GS A0A2Y9I2E6_NEOSC/497-530    AC A0A2Y9I2E6.1
#=GS A0A4D9ERF4_9SAUR/378-415    AC A0A4D9ERF4.1
#=GS A0A2Y9IPG6_ENHLU/406-439    AC A0A2Y9IPG6.1
#=GS A0A5C6P102_9TELE/215-248    AC A0A5C6P102.1
#=GS A0A340XFE9_LIPVE/407-440    AC A0A340XFE9.1
#=GS A0A4Z2J4P0_9TELE/301-332    AC A0A4Z2J4P0.1
#=GS A0A2U3W9Z9_ODORO/497-530    AC A0A2U3W9Z9.1
#=GS H0XR13_OTOGA/403-436        AC H0XR13.1
#=GS K7FQE6_PELSI/296-333        AC K7FQE6.1
#=GS A0A087YRK2_POEFO/382-418    AC A0A087YRK2.2
#=GS F1PB37_CANLF/407-440        AC F1PB37.1
#=GS U3KAV4_FICAL/336-361        AC U3KAV4.1
#=GS A0A3Q1F9N5_9TELE/257-294    AC A0A3Q1F9N5.1
#=GS K7FCA6_PELSI/380-413        AC K7FCA6.1
#=GS A0A402FYC5_9SAUR/407-443    AC A0A402FYC5.1
#=GS A0A674A1L2_SALTR/279-313    AC A0A674A1L2.1
#=GS K1PR82_CRAGI/1029-1062      AC K1PR82.1
#=GS A0A3Q0GEC4_ALLSI/378-415    AC A0A3Q0GEC4.1
#=GS L5JX78_PTEAL/347-381        AC L5JX78.1
#=GS A0A3Q1MBI9_BOVIN/402-435    AC A0A3Q1MBI9.1
#=GS A0A3Q0E4T7_CARSF/218-251    AC A0A3Q0E4T7.1
#=GS A0A3P9Q4Z4_POERE/316-358    AC A0A3P9Q4Z4.1
#=GS A0A5G2QPN5_PIG/406-439      AC A0A5G2QPN5.1
#=GS F7C9T2_MACMU/438-471        AC F7C9T2.2
#=GS A0A5F4VUE5_CALJA/405-438    AC A0A5F4VUE5.1
#=GS A0A3P8ZGW0_ESOLU/340-377    AC A0A3P8ZGW0.2
#=GS A0A4W5KMV6_9TELE/90-126     AC A0A4W5KMV6.1
#=GS I3KYM9_ORENI/356-392        AC I3KYM9.2
#=GS A0A218UJ57_9PASE/950-981    AC A0A218UJ57.1
#=GS A0A2U9CYV4_SCOMX/361-402    AC A0A2U9CYV4.1
#=GS A0A3B5QFN2_XIPMA/225-257    AC A0A3B5QFN2.1
#=GS A0A2U9CU49_SCOMX/379-415    AC A0A2U9CU49.1
#=GS A0A452E649_CAPHI/402-435    AC A0A452E649.1
#=GS A0A1L8G1F7_XENLA/379-416    AC A0A1L8G1F7.1
#=GS A0A3P9Q4Z4_POERE/476-509    AC A0A3P9Q4Z4.1
#=GS A0A3Q7VK44_URSAR/497-530    AC A0A3Q7VK44.1
#=GS A0A0D9SBG0_CHLSB/457-490    AC A0A0D9SBG0.1
#=GS A0A384DEU9_URSMA/332-365    AC A0A384DEU9.1
#=GS A0A3P4QBX1_GULGU/406-439    AC A0A3P4QBX1.1
#=GS W5NN90_LEPOC/374-409        AC W5NN90.1
#=GS A0A341BUZ8_NEOAA/407-440    AC A0A341BUZ8.1
#=GS A0A671EYY1_RHIFE/406-440    AC A0A671EYY1.1
#=GS A0A2R8ZHT7_PANPA/462-495    AC A0A2R8ZHT7.1
#=GS A0A667Y5H9_9TELE/347-383    AC A0A667Y5H9.1
#=GS A0A315VW77_GAMAF/321-363    AC A0A315VW77.1
#=GS A0A1A6GJJ6_NEOLE/436-469    AC A0A1A6GJJ6.1
#=GS A0A1S2ZW58_ERIEU/406-440    AC A0A1S2ZW58.1
#=GS A0A5C6NM76_9TELE/302-340    AC A0A5C6NM76.1
#=GS A0A553RQ68_9TELE/189-221    AC A0A553RQ68.1
#=GS A0A1S3S903_SALSA/373-408    AC A0A1S3S903.1
#=GS A0A670K0E5_PODMU/325-362    AC A0A670K0E5.1
#=GS A0A1S3MAL9_SALSA/377-413    AC A0A1S3MAL9.1
#=GS G9KT75_MUSPF/406-439        AC G9KT75.1
#=GS A0A498NTY2_LABRO/338-371    AC A0A498NTY2.1
#=GS A0A3Q2CY78_CYPVA/228-264    AC A0A3Q2CY78.1
#=GS A0A3B3I0I9_ORYLA/215-248    AC A0A3B3I0I9.1
#=GS M7BGJ8_CHEMY/378-415        AC M7BGJ8.1
#=GS A0A2U3V8H9_TURTR/407-440    AC A0A2U3V8H9.2
#=GS A0A3Q1D023_AMPOC/321-357    AC A0A3Q1D023.1
#=GS A0A0N8K0I4_SCLFO/320-356    AC A0A0N8K0I4.1
#=GS A0A3Q2E4H8_CYPVA/325-367    AC A0A3Q2E4H8.1
#=GS H2P167_PONAB/252-285        AC H2P167.1
#=GS TRBM_MOUSE/405-438          AC P15306.1
#=GS G3WH56_SARHA/402-435        AC G3WH56.1
#=GS A0A091CTT8_FUKDA/98-131     AC A0A091CTT8.1
#=GS A0A3Q1G5L7_9TELE/218-254    AC A0A3Q1G5L7.1
#=GS A0A5J5CNC1_9PERO/378-414    AC A0A5J5CNC1.1
#=GS A0A4W6CLT8_LATCA/151-194    AC A0A4W6CLT8.1
#=GS A0A3P9D7N9_9CICH/219-255    AC A0A3P9D7N9.1
#=GS A0A4W6CLT3_LATCA/249-285    AC A0A4W6CLT3.1
#=GS A0A2K5PQF9_CEBCA/461-494    AC A0A2K5PQF9.1
#=GS A0A674N0B9_TAKRU/207-240    AC A0A674N0B9.1
#=GS F6PNE7_HORSE/389-422        AC F6PNE7.2
#=GS A0A3P9Q5U9_POERE/224-260    AC A0A3P9Q5U9.1
#=GS A0A4U5U8M0_COLLU/378-414    AC A0A4U5U8M0.1
#=GS A0A5C6NL74_9TELE/378-414    AC A0A5C6NL74.1
#=GS Q4SWS1_TETNG/339-377        AC Q4SWS1.1
#=GS A0A1V4IG90_PATFA/380-415    AC A0A1V4IG90.1
#=GS G3I3T4_CRIGR/640-673        AC G3I3T4.1
#=GS A0A485NFL2_LYNPA/498-531    AC A0A485NFL2.1
#=GS A0A672HQE6_SALFA/345-381    AC A0A672HQE6.1
#=GS A0A151ND44_ALLMI/373-410    AC A0A151ND44.1
#=GS A0A671XIK6_SPAAU/190-232    AC A0A671XIK6.1
#=GS A0A493THK3_ANAPP/383-418    AC A0A493THK3.1
#=GS L8Y9T9_TUPCH/368-401        AC L8Y9T9.1
#=GS A0A4W5KMV6_9TELE/233-269    AC A0A4W5KMV6.1
#=GS A0A671WM82_SPAAU/224-257    AC A0A671WM82.1
#=GS A0A3Q4GBX6_NEOBR/214-250    AC A0A3Q4GBX6.1
#=GS A0A2Y9EEC5_PHYMC/407-440    AC A0A2Y9EEC5.1
#=GS F6V4R1_ORNAN/397-436        AC F6V4R1.3
#=GS G3UPU6_MELGA/126-159        AC G3UPU6.1
#=GS A0A674P196_TAKRU/217-250    AC A0A674P196.1
#=GS A0A672TRD6_STRHB/383-418    AC A0A672TRD6.1
#=GS A0A6G1ABG6_CROCR/407-440    AC A0A6G1ABG6.1
#=GS A0A2U9CJK6_SCOMX/224-255    AC A0A2U9CJK6.1
#=GS A0A3B5KVC5_TAKRU/240-273    AC A0A3B5KVC5.2
#=GS A0A3Q1GM27_9TELE/257-294    AC A0A3Q1GM27.1
#=GS A0A553N4S0_9TELE/322-356    AC A0A553N4S0.1
#=GS H2SGM2_TAKRU/358-394        AC H2SGM2.3
#=GS H2QK24_PANTR/462-495        AC H2QK24.2
#=GS A0A3B1K3B4_ASTMX/372-409    AC A0A3B1K3B4.1
#=GS A0A2I0M9A6_COLLI/32-66      AC A0A2I0M9A6.1
#=GS A0A151ND61_ALLMI/315-352    AC A0A151ND61.1
#=GS A0A2Y9DKT9_TRIMA/413-446    AC A0A2Y9DKT9.1
#=GS A0A674C4Y6_SALTR/343-379    AC A0A674C4Y6.1
#=GS A0A091PYW9_LEPDC/312-347    AC A0A091PYW9.1
#=GS A0A673X1V6_SALTR/220-255    AC A0A673X1V6.1
#=GS A0A3Q1GJQ2_9TELE/292-329    AC A0A3Q1GJQ2.1
#=GS A0A663EA47_AQUCH/375-411    AC A0A663EA47.1
#=GS A0A315V003_GAMAF/389-421    AC A0A315V003.1
#=GS A0A1U7QHW5_MESAU/410-443    AC A0A1U7QHW5.1
#=GS G3NQ94_GASAC/371-401        AC G3NQ94.1
#=GS H3CU14_TETNG/400-433        AC H3CU14.1
#=GS A0A4Z2J473_9TELE/323-358    AC A0A4Z2J473.1
#=GS A0A4W6CLT3_LATCA/89-132     AC A0A4W6CLT3.1
#=GS A0A5A9NG97_9TELE/369-402    AC A0A5A9NG97.1
#=GS A0A0Q3M0F9_AMAAE/378-413    AC A0A0Q3M0F9.1
#=GS A0A5C6NNS1_9TELE/144-180    AC A0A5C6NNS1.1
#=GS F7D9A3_MONDO/385-418        AC F7D9A3.2
#=GS A0A498NS86_LABRO/322-355    AC A0A498NS86.1
#=GS G1Q0S6_MYOLU/408-441        AC G1Q0S6.1
#=GS A0A4V5PAV1_MONMO/407-440    AC A0A4V5PAV1.1
#=GS A0A2I3GMT7_NOMLE/399-432    AC A0A2I3GMT7.1
#=GS A0A3Q1ISZ5_ANATE/178-220    AC A0A3Q1ISZ5.1
#=GS A0A3P8VSE0_CYNSE/416-452    AC A0A3P8VSE0.1
#=GS A0A4W2EKU6_BOBOX/402-435    AC A0A4W2EKU6.1
#=GS W5P4Y3_SHEEP/379-412        AC W5P4Y3.1
#=GS A0A3P8UHL7_CYNSE/433-466    AC A0A3P8UHL7.1
#=GS A0A2I0T778_LIMLA/379-415    AC A0A2I0T778.1
#=GS A0A3Q2CJY8_CYPVA/325-367    AC A0A3Q2CJY8.1
#=GS G3NKB6_GASAC/356-392        AC G3NKB6.1
#=GS L5LFZ0_MYODS/101-134        AC L5LFZ0.1
#=GS A0A4W5QPS6_9TELE/218-252    AC A0A4W5QPS6.1
#=GS G5CBC6_HETGA/393-427        AC G5CBC6.1
#=GS A0A3Q3BAF9_KRYMA/445-480    AC A0A3Q3BAF9.1
#=GS A0A4W5KSH1_9TELE/213-249    AC A0A4W5KSH1.1
#=GS A0A3P8YMK0_ESOLU/224-255    AC A0A3P8YMK0.2
#=GS O35370_RAT/405-438          AC O35370.1
#=GS A0A3B3IJ01_ORYLA/204-246    AC A0A3B3IJ01.1
#=GS A0A3Q3AC43_KRYMA/209-240    AC A0A3Q3AC43.1
#=GS A0A3Q7SND7_VULVU/422-455    AC A0A3Q7SND7.1
#=GS A0A3P9Q4U2_POERE/179-221    AC A0A3P9Q4U2.1
#=GS A0A3Q1BVH6_AMPOC/341-383    AC A0A3Q1BVH6.1
#=GS W5NN91_LEPOC/370-406        AC W5NN91.1
#=GS A0A667YKV0_9TELE/1-41       AC A0A667YKV0.1
#=GS A0A2I4CAN5_9TELE/381-417    AC A0A2I4CAN5.1
#=GS A0A4U5U9K1_COLLU/341-381    AC A0A4U5U9K1.1
#=GS A0A3Q3N3C5_9LABR/194-231    AC A0A3Q3N3C5.1
#=GS A0A3Q2WTP3_HAPBU/234-270    AC A0A3Q2WTP3.1
#=GS A0A5J5MSX0_MUNRE/402-435    AC A0A5J5MSX0.1
#=GS A0A674P2Z3_TAKRU/302-340    AC A0A674P2Z3.1
#=GS A0A4W6D0M9_LATCA/170-213    AC A0A4W6D0M9.1
#=GS A0A673TK14_SURSU/407-440    AC A0A673TK14.1
#=GS A0A2Y9Q3F5_DELLE/407-440    AC A0A2Y9Q3F5.1
#=GS M4B059_XIPMA/383-418        AC M4B059.2
#=GS A0A3P8T501_AMPPE/393-429    AC A0A3P8T501.1
#=GS A0A672J903_SALFA/231-264    AC A0A672J903.1
#=GS A0A674C428_SALTR/349-385    AC A0A674C428.1
#=GS A0A1X7TVZ2_AMPQE/1331-1364  AC A0A1X7TVZ2.1
#=GS A0A672HQ40_SALFA/361-397    AC A0A672HQ40.1
#=GS A0A2U3YBW2_LEPWE/406-439    AC A0A2U3YBW2.1
#=GS A0A1S3SRP8_SALSA/221-255    AC A0A1S3SRP8.1
#=GS TRBM_CANLF/407-440          AC Q5W7P8.1
#=GS A0A665WGD7_ECHNA/378-414    AC A0A665WGD7.1
#=GS A0A3B3ILB6_ORYLA/223-259    AC A0A3B3ILB6.1
#=GS A0A4X2KAA1_VOMUR/402-435    AC A0A4X2KAA1.1
#=GS M3WF86_FELCA/498-531        AC M3WF86.3
#=GS A0A6G0I6J1_LARCR/378-414    AC A0A6G0I6J1.1
#=GS A0A5E4CF10_MARMO/406-439    AC A0A5E4CF10.1
#=GS H0W956_CAVPO/390-423        AC H0W956.2
#=GS L8J0V7_9CETA/142-175        AC L8J0V7.1
D2HSG5_AILME/406-439                   ......MFCNQTACPA.D.C..DPNSPT.......SCQCPEGYILDDGF....MC........
A0A3N0YA18_ANAGA/313-346               ......MHCTQPQCPA.E.C..DFNNED.......QCNCPDGFVLDEGK....IC........
A0A4W5QVP8_9TELE/209-245               qfvcla------ECSP.K.C..DPSNAH.......QCYCPNGYFLENKNd.esIC........
A0A665WGE2_ECHNA/211-247               ......LYCGKPECPA.L.C..DPNNAF.......QCYCPDGYVIEERVd.gqVC........
G3UIR2_LOXAF/407-440                   ......MFCNETACPA.D.C..DPNSLD.......SCQCPDGYILDEGS....MC........
A0A384AY23_BALAS/380-413               ......MFCNQTSCPA.D.C..DPNNLA.......ICRCPEGYILDEGS....VC........
A0A4W6D0H8_LATCA/185-228               .....v-HCAERDCPA.D.CvyDPDVERid...lqKCYCPDGYIRHNGN....--dtalct..
A0A670K883_PODMU/317-354               ......MFCNETSCPA.E.C..DPHTGD.......TCYCADGFILQDD-....--pdgtkvc.
A0A6I8PPQ6_XENTR/379-416               .....q-FCNTTTCPA.F.C..NDNFVD.......QCNCPDGYVLDTDE....--elkfvc..
A0A3Q3G5C4_9LABR/196-232               ......RHCGKEECVA.E.C..DPNNKF.......QCFCPEGYITDER-....--gavrmc..
A0A6Q2XQU9_ESOLU/235-271               ....ia--CLKAECNP.K.C..DNNLNQ.......HCTCPNGFILDERN....--nskmc...
S7MCK3_MYOBR/101-134                   ......MFCNQTECPA.D.C..DPNYPD.......TCRCPEGYILDEGS....VC........
A0A6G0I6E1_LARCR/341-381               ......MHCTERECPA.K.C..ILNKGLsnnitslDCFCPDGYIRDG--....--adsa....
A0A3M0K4B6_HIRRU/342-373               ......LYCNATECPA.V.C..D--AGG.......ACDCPEGFLLDGDE....LC........
F8W3I7_DANRE/315-350                   ......MHCPDMRCKA.E.C..DPNNDY.......QCDCPDGFLFDED-....--drycv...
A0A452QDE4_URSAM/406-439               ......MFCNQTACPA.D.C..DPNSPT.......FCQCPEGYILDDGF....MC........
A0A3B3I0X5_ORYLA/111-146               .....r--CSTLSCEF.L.C..HPSPQG......gTCYCPDGFIVAND-....--srsct...
A0A673BYB8_9TELE/227-259               ......MHCGQMKCPA.V.C..EGNFE-.......SCDCPDGYIISEGF....C-e.......
A0A1S3G126_DIPOR/405-438               ......MICNQTACPA.D.C..DPHNPE.......YCECPEGFILDEGS....MC........
A0A315VXC5_GAMAF/339-372               ......RHCGKQECPA.E.C..DPNDNF.......QCFCPDGYVSEER-....--gvs.....
A0A2Y9I2E6_NEOSC/497-530               ......MFCNQTACPA.D.C..DPNSPT.......SCQCPEGYILDEGF....MC........
A0A4D9ERF4_9SAUR/378-415               ......LFCNQIECPA.D.C..DPHTQD.......TCYCPDGFVLDHHN....--dsakmc..
A0A2Y9IPG6_ENHLU/406-439               ......MFCNQTACPA.D.C..DPNSPT.......SCQCPEGYILDDGF....MC........
A0A5C6P102_9TELE/215-248               ......LHCAQEKCPA.S.C..EGSAGE.......SCQCPDGFIASDRF....CH........
A0A340XFE9_LIPVE/407-440               ......MFCNQTSCPA.D.C..DPNNLA.......ICRCPEGYILDEGS....VC........
A0A4Z2J4P0_9TELE/301-332               .....l-ICAEKDCPA.T.C..DGNNQD.......SCFCPVGYIKD---....--ire.....
A0A2U3W9Z9_ODORO/497-530               ......MFCNQTACPA.D.C..DPNSPT.......SCQCPEGYILDDGF....IC........
H0XR13_OTOGA/403-436                   ......MFCNQTSCPA.D.C..DPNTPA.......DCKCPEGYILDEGS....VC........
K7FQE6_PELSI/296-333                   ......RFCNQTECPA.D.C..DPHTLD.......SCYCPDGFILNEG-....--drgekmc.
A0A087YRK2_POEFO/382-418               ......LHCGEQMCPA.E.C..DPNNNF.......QCFCPDGYLLEE--....--rggssfc.
F1PB37_CANLF/407-440                   ......MFCNQTACPA.D.C..DPNSPT.......SCQCPEGYILDDGF....MC........
U3KAV4_FICAL/336-361                   .psrpp----------.-.-..-PKGGG.......DCFCPEGFLLDGDN....VC........
A0A3Q1F9N5_9TELE/257-294               ...lhr--CSTLSCEY.V.C..HPSPQG......gTCYCPDGFIVANDS....--rscv....
K7FCA6_PELSI/380-413                   ......RFCNQTECPA.D.C..DPHTLD.......SCYCPDGFILNEGD....R-c.......
A0A402FYC5_9SAUR/407-443               .....g--CNRTECPA.Q.C..DPHTGD.......SCYCPDGYILQE--....--fedgtkvc
A0A674A1L2_SALTR/279-313               ......MHCPLAKCPV.I.C..DRNSAG......tQCDCPSGFIKSDDY....CH........
K1PR82_CRAGI/1029-1062                 .ncsyg----------.-.CkqDPNNQTv.....gHCFCPEGFILSE--....--ldmssc..
A0A3Q0GEC4_ALLSI/378-415               ......LFCNESQCPA.E.C..DPHVQS.......NCMCPDGFILDET-....--etgpkmc.
L5JX78_PTEAL/347-381                   ......MFCNTTSCPA.D.C..DPNNPA.......TCQCPEGYILDEGF....KCt.......
A0A3Q1MBI9_BOVIN/402-435               ......MFCNQTSCPA.D.C..DPHYPT.......ICRCPEGYIIDEGS....TC........
A0A3Q0E4T7_CARSF/218-251               .....i-FCNQTSCPA.I.C..DPNTLS.......NCECPEGYILDEGF....MC........
A0A3P9Q4Z4_POERE/316-358               ....qd--CSQRECPA.I.C..NNNLXLekk.dmqQCYCPQGFILD---....--lwegsatc
A0A5G2QPN5_PIG/406-439                 ......MFCNQTSCPA.D.C..DPNKQD.......SCQCPDGYILDEGS....IC........
F7C9T2_MACMU/438-471                   ......MFCNQTACPA.D.C..DPNTRG.......NCECPDGYILDDGF....MC........
A0A5F4VUE5_CALJA/405-438               ......MFCNQTACPA.D.C..DPNTKS.......NCECPEGYILDEGF....MC........
A0A3P8ZGW0_ESOLU/340-377               ......LYCPSEECLA.E.C..DPNDPH.......QCNCPEGYVVDV--....--rnddmfcv
A0A4W5KMV6_9TELE/90-126                ....fl--CLAEECPP.E.C..DRSKTY.......QCNCPMGYLLDDRNg.lsVC........
I3KYM9_ORENI/356-392                   ......LFCGKEECPA.E.C..DPNNKF.......QCYCPDGYVAEER-....--ggsmvc..
A0A218UJ57_9PASE/950-981               ......LHCNATECPA.V.C..DAE--G.......ACECPEGFLLDGDD....LC........
A0A2U9CYV4_SCOMX/361-402               .....q-HCAERHCLA.R.C..DNSVQDkt...mqDCYCPTGYIKDVR-....--nntafct.
A0A3B5QFN2_XIPMA/225-257               .....q-HCAQQSCPA.V.C..AA--GG......aACRCADGFLLEERR....C-e.......
A0A2U9CU49_SCOMX/379-415               ......LHCGKEECPA.E.C..DPNDAY.......QCYCPEGYVSEQ--....--rgdhtfc.
A0A452E649_CAPHI/402-435               ......MFCNQTSCPA.D.C..DPHNPA.......ICWCPEGYILDEGS....VC........
A0A1L8G1F7_XENLA/379-416               .....q-FCNSTICPA.F.C..NDNFVD.......QCNCPEGYVLDT--....--deestylc
A0A3P9Q4Z4_POERE/476-509               ...svq------ECPA.E.C..DPNYNF.......QCFCPDGYLLEE--....--rggssfc.
A0A3Q7VK44_URSAR/497-530               ......MFCNQTACPA.D.C..DPNSPT.......FCQCPEGYILDDGF....MC........
A0A0D9SBG0_CHLSB/457-490               ......MFCNQTACPA.D.C..DPNTRA.......NCECPDGYILDDGF....MC........
A0A384DEU9_URSMA/332-365               ......MFCNQTACPA.D.C..DPNSPT.......FCQCPEGYILDDGF....MC........
A0A3P4QBX1_GULGU/406-439               ......MFCNQTACPA.D.C..DPYSPT.......SCQCPEGYILDDGF....MC........
W5NN90_LEPOC/374-409                   .....l-LCISHECRA.L.C..DPYKPW.......QCTCPEGYIMDDENa..tIC........
A0A341BUZ8_NEOAA/407-440               ......MFCNQTSCPA.D.C..DPNNLA.......ICRCPEGYILDEGS....VC........
A0A671EYY1_RHIFE/406-440               ......MFCNQTACPA.D.C..DPNTST.......LCRCPEGYILEEDS...rMC........
A0A2R8ZHT7_PANPA/462-495               ......MFCNQTACPA.D.C..DPNTQA.......SCECPEGYILDDGF....IC........
A0A667Y5H9_9TELE/347-383               ......LHCGKAECPA.E.C..DPNNPY.......QCDCPDGYILEERQd.emVC........
A0A315VW77_GAMAF/321-363               ....qe--CHQRECPA.I.C..NSNEALekk.dmqQCYCPEGYIVDL--....--ghgsatc.
A0A1A6GJJ6_NEOLE/436-469               ......MFCNASSCPA.D.C..DPNTPE.......FCRCPEGFILDDGA....IC........
A0A1S2ZW58_ERIEU/406-440               ......MFCNQTQCPA.D.C..DPNNPA.......SCRCPEGFILDDDF....KCt.......
A0A5C6NM76_9TELE/302-340               .....r-LCTERQCLA.S.C..DRNAESn.....vQCFCPAGFILDTSNg.snIC........
A0A553RQ68_9TELE/189-221               .....f-YCATTVCAA.L.C..-MRGGS.......VCWCPEGFVRSEQS....C-e.......
A0A1S3S903_SALSA/373-408               .lvcla------ECIA.E.C..DPSTPH.......DCNCPNGYLLDEKNg.esIC........
A0A670K0E5_PODMU/325-362               ......MFCNETSCPA.E.C..DPHTGD.......TCYCADGFILQDD-....--pdgtkvc.
A0A1S3MAL9_SALSA/377-413               .....l-LCLAEECPT.E.C..DRSKTY.......QCYCPIGYLLDDRNg.ssIC........
G9KT75_MUSPF/406-439                   ......MFCNQTACPA.D.C..DPYSPT.......SCQCPEGYILDDGF....MC........
A0A498NTY2_LABRO/338-371               ......MHCEKSICPA.D.C..DPNNNA.......LCNCPDGFLLEDQF....C-v.......
A0A3Q2CY78_CYPVA/228-264               ......LHCGEEECPA.M.C..DPNNQF.......QCFCPDGFLLEER-....--angffc..
A0A3B3I0I9_ORYLA/215-248               .....k-HCAEERCEK.V.C..EGNMDS.......SCSCPEGYIEDENF....C-v.......
M7BGJ8_CHEMY/378-415                   ......LFCNQTECPA.D.C..DPHTQD.......TCYCPDGFVLDHYN....--gsakmc..
A0A2U3V8H9_TURTR/407-440               ......MFCNQTSCPA.D.C..DPNNLA.......VCRCPEGYILDEGS....VC........
A0A3Q1D023_AMPOC/321-357               ......RHCGREECAA.E.C..DPNDRF.......QCFCPEGYISEE--....--rgsdvfc.
A0A0N8K0I4_SCLFO/320-356               .....q-HCPSYECPA.I.C..DPNNPE.......QCRCPLGYIYDVK-....--atqgvc..
A0A3Q2E4H8_CYPVA/325-367               ....qv--CNQKTCPA.I.C..HPNPKQes..kntPCFCPEGFILDHSEgaatC-h.......
H2P167_PONAB/252-285                   ......MFCNQTACPA.V.C..DSNTQA.......NCECPEGYILDEGF....IC........
TRBM_MOUSE/405-438                     ......MFCNETSCPA.D.C..DPNSPT.......VCECPEGFILDEGS....VC........
G3WH56_SARHA/402-435                   ......LFCNTTACRA.K.C..NPYNVD.......DCKCPEGYILDENQ....MC........
A0A091CTT8_FUKDA/98-131                ......MFCNQTECPA.D.C..DPNNLN.......VCYCPEGFILDEGN....VC........
A0A3Q1G5L7_9TELE/218-254               ......RYCGQEECAA.E.C..DPNDRY.......QCFCPEGYISEE--....--rgtdvfc.
A0A5J5CNC1_9PERO/378-414               ......LHCGKEECAA.E.C..DPNDQF.......MCFCPDGYIADERG....--vqmvc...
A0A4W6CLT8_LATCA/151-194               .....v-HCAERDCPA.D.CvyDPDVERid...lqKCYCPDGYIRHNGN....--dtalct..
A0A3P9D7N9_9CICH/219-255               ......LFCGKEECPA.E.C..DPNNNF.......QCYCPDGYVVEERVd.stVC........
A0A4W6CLT3_LATCA/249-285               ......LHCGEEECDA.Q.C..DPNDVF.......QCYCPDGYVKEE--....--rdegafc.
A0A2K5PQF9_CEBCA/461-494               ......MFCNQTACPA.D.C..DPNTKS.......NCECPEGYILDEGF....MC........
A0A674N0B9_TAKRU/207-240               ......LHCGEEECLA.E.C..DPNDRY.......QCFCPEGYIL----....--ggednr..
F6PNE7_HORSE/389-422                   ......MFCNQTACPA.D.C..DPNNPS.......NCQCPEGYILDDGV....IC........
A0A3P9Q5U9_POERE/224-260               ......RHCGEQECPA.E.C..DPNYNF.......QCFCPDGYLLEE--....--rggssfc.
A0A4U5U8M0_COLLU/378-414               ......LHCGKTECVA.E.C..DPNDKY.......QCFCPNGYVSEE--....--rehetfc.
A0A5C6NL74_9TELE/378-414               ......LHCGEEECLA.E.C..DPNDRY.......QCFCPEGYILEERQp.daVC........
Q4SWS1_TETNG/339-377                   ......RHCEESRCEP.Q.C..DPNSQGq.....mQCFCPEGYILDQSNs.sgVC........
A0A1V4IG90_PATFA/380-415               ......LHCNRSQCPA.Q.C..DPHSL-.......SCECPEGFVLDDAE....--sekic...
G3I3T4_CRIGR/640-673                   ......MFCNESSCPA.D.C..DPNTPD.......FCHCPEGFILDEGH....IC........
A0A485NFL2_LYNPA/498-531               ......MFCNQTTCPA.D.C..DPNNPD.......SCQCPDGYILDDGY....IC........
A0A672HQE6_SALFA/345-381               ....rk--CTVRDCPA.T.C..DKNEKH.......QCYCPDGYVADEVN....--gtvfc...
A0A151ND44_ALLMI/373-410               ......LFCNESQCPA.E.C..DPHVQS.......NCVCPDGFILDET-....--etgpkmc.
A0A671XIK6_SPAAU/190-232               ......RYCPERECPA.I.C..DRNTDNena.dmqQCECPDGYILDMVNd.taVC........
A0A493THK3_ANAPP/383-418               ......LHCEHSQCPA.E.C..SSNS--.......-CYCPEGFLLEEAS....--gndtamc.
L8Y9T9_TUPCH/368-401                   ......MFCNQTSCPA.D.C..DPNTPG.......SCQCPEGYILDDGF....MC........
A0A4W5KMV6_9TELE/233-269               ......LHCPFEECLA.E.C..DPNDPH.......QCNCPEGYLVDV--....--rneirfc.
A0A671WM82_SPAAU/224-257               ......MHCAQQKCPA.I.C..DGHTDS.......ACSCPVGFIATDKI....C-e.......
A0A3Q4GBX6_NEOBR/214-250               ......LFCGKEECPA.E.C..DPNNKF.......QCYCPDGYVAEERGd.stVC........
A0A2Y9EEC5_PHYMC/407-440               ......MFCNQTSCPA.D.C..DPNNLA.......ICRCPEGYILDEGS....VC........
F6V4R1_ORNAN/397-436                   ......LFCNQTQCPA.D.C..DPSPEG.......PCSCPAGYILEEEA....--eaeggnvc
G3UPU6_MELGA/126-159                   .....r-QCEDGRCLA.E.C..DF-SNL.......SCFCPEGFVTDQ--....--lpngv...
A0A674P196_TAKRU/217-250               ......LHCAQEKCPA.S.C..EGSAGE.......SCQCPDGFIASDRF....CH........
A0A672TRD6_STRHB/383-418               ......LHCNRSQCPA.K.C..DPYTL-.......SCECPDGFVLDDADn.gqVC........
A0A6G1ABG6_CROCR/407-440               ......MFCNQTTCPA.D.C..DPNNPD.......SCQCPDGYILDDGY....MC........
A0A2U9CJK6_SCOMX/224-255               ......LHCGKQKCP-.-.C..NRQTGS.......ACYCPEGFIRDEDF....C-l.......
A0A3B5KVC5_TAKRU/240-273               ......LHCAQEKCPA.S.C..EGSAGE.......SCQCPDGFIASDRF....CH........
A0A3Q1GM27_9TELE/257-294               ...lhr--CSTLSCEY.V.C..HPSPQG......gTCYCPDGFIVANDS....--rscv....
A0A553N4S0_9TELE/322-356               ......MQCFEFNCTA.E.C..DSNNNA.......QCNCPDGFILENDR....FCv.......
H2SGM2_TAKRU/358-394                   ......LHCGEEECLA.E.C..DPNDRY.......QCFCPEGYILEERQq.daVC........
H2QK24_PANTR/462-495                   ......MFCNQTACPA.D.C..DPNTQA.......SCECPEGYILDDGF....IC........
A0A3B1K3B4_ASTMX/372-409               ......LYCPQWECPAvD.C..DPNNPF.......QCNCPRGFILEER-....--ptglic..
A0A2I0M9A6_COLLI/32-66                 .....c--CNRSQCPA.Q.C..DPHSL-.......SCECPEGFVLDDV-....--eskkic..
A0A151ND61_ALLMI/315-352               ......LFCNESQCPA.E.C..DPHVQS.......NCVCPDGFILDET-....--etgpkmc.
A0A2Y9DKT9_TRIMA/413-446               ......MFCNQTACPA.D.C..DPNNLD.......SCHCPDGYILDDGS....MC........
A0A674C4Y6_SALTR/343-379               ......LHCPFEECLA.E.C..DPNDPH.......QCNCPEGYLIDV--....--rneirfc.
A0A091PYW9_LEPDC/312-347               ......LHCNHSQCPA.Q.C..DTNTL-.......SCECPEGFVLDDANs.gqVC........
A0A673X1V6_SALTR/220-255               .lvcfa------ECIA.E.C..DPSTPH.......HCNCPNGYLLDDKNg.ksIC........
A0A3Q1GJQ2_9TELE/292-329               ...lhr--CSTLSCEY.V.C..HPSPQG......gTCYCPDGFIVANDS....--rscv....
A0A663EA47_AQUCH/375-411               ......LYCNRSQCPA.E.C..DPHTL-.......SCECPDGFLLDSDA....--dsghvc..
A0A315V003_GAMAF/389-421               ......LHCAQQSCPA.E.C..-VAGRA.......ACRCADGFLLEERR....C-v.......
A0A1U7QHW5_MESAU/410-443               ......LFCNESSCPA.D.C..DPYAPD.......FCYCPEGFILDEGH....IC........
G3NQ94_GASAC/371-401                   ......LHCAQQKCPA.V.C..END---.......QCFCPEGFIRSGQ-....--yce.....
H3CU14_TETNG/400-433                   ......LHCAQKKCPA.V.C..DVETGG.......SCYCPEGFIREDNF....CH........
A0A4Z2J473_9TELE/323-358               ......LHCGKEECVA.E.C..DPNNRY.......ECYCPDGYVAS---....--getqvvc.
A0A4W6CLT3_LATCA/89-132                .....v-HCAERDCPA.D.CvyDPDVERid...lqKCYCPDGYIRHNGN....--dtalct..
A0A5A9NG97_9TELE/369-402               ......RYCPTFECPA.D.C..DVNNNA.......QCHCPYGFIVEDDT....C-f.......
A0A0Q3M0F9_AMAAE/378-413               ......LHCNRSQCPA.K.C..DPYTL-.......SCECPEGFVLSNNDn.rqVC........
A0A5C6NNS1_9TELE/144-180               ......LHCGEEECLA.E.C..DPNDRY.......QCFCPEGYILEERQp.daVC........
F7D9A3_MONDO/385-418                   .....s-FCNTSECPA.I.C..NPYNPD.......DCQCPDGYILDEDQ....MC........
A0A498NS86_LABRO/322-355               ......LHCDAAKCRA.D.C..DSNQIE.......QCNCPDGFLLDQDL....YC........
G1Q0S6_MYOLU/408-441                   ......MFCNQTECPA.D.C..DPNYPD.......TCRCPDGYILDEGS....VC........
A0A4V5PAV1_MONMO/407-440               ......MFCNQTSCPA.D.C..DPNNLA.......ICRCPEGYILDEGS....VC........
A0A2I3GMT7_NOMLE/399-432               ......MFCNQTACPA.D.C..DPNTQA.......NCECPEGYILDDGF....IC........
A0A3Q1ISZ5_ANATE/178-220               .....q-HCAERDCPA.R.C..ILNSDVkke.dmqQCFCPEGYIRDT--....--rdgetic.
A0A3P8VSE0_CYNSE/416-452               ......LYCGEVECPA.E.C..DPNDPF.......QCYCADGYISEERGd.stVC........
A0A4W2EKU6_BOBOX/402-435               ......MFCNQTSCPA.D.C..DPHYPT.......ICRCPEGYIIDEGS....TC........
W5P4Y3_SHEEP/379-412                   ......MFCNQTSCPA.D.C..DPHNPA.......VCWCPEGYILDEGS....VC........
A0A3P8UHL7_CYNSE/433-466               .....q-YCGKQKCPA.L.C..DKDNVD.......ICFCPDGYIKNQDV....C-q.......
A0A2I0T778_LIMLA/379-415               ......LHCNRSQCPA.E.C..DAHSL-.......SCECPEGFLLDNDAdggwV-c.......
A0A3Q2CJY8_CYPVA/325-367               ....qv--CNQKTCPA.I.C..HPNPKQes..kntPCFCPEGFILDHSEgaatC-h.......
G3NKB6_GASAC/356-392                   ......LFCGEEECAA.E.C..DPNNRF.......QCFCPDGYVADERG....--gdtvc...
L5LFZ0_MYODS/101-134                   ......MFCNQTECPA.D.C..DPNYPD.......ICRCPDGYILDEGS....VC........
A0A4W5QPS6_9TELE/218-252               ......MHCPLAKCPV.I.C..DRNSAE......aQCNCPSGFIKSDDY....C-q.......
G5CBC6_HETGA/393-427                   ......MFCNQTECPA.D.C..DPNNLN.......ICYCPEGFILDEGN....LCv.......
A0A3Q3BAF9_KRYMA/445-480               ......LFCGAEECPA.V.C..DPNDPL.......LCYCPEGYVVEER-....--dkgic...
A0A4W5KSH1_9TELE/213-249               ......LHCPFEECLA.E.C..DPNDPH.......QCNCPEGYLVDV--....--rneirfc.
A0A3P8YMK0_ESOLU/224-255               ......MHCSSAKCPA.I.C..DG--QN.......QCICPDGFIKHLHF....C-e.......
O35370_RAT/405-438                     ......MFCNETSCPA.D.C..DPNSPS.......FCQCPEGFILDEGS....IC........
A0A3B3IJ01_ORYLA/204-246               .....e-HCNSRDCKA.E.C..LPNTELeak.dmqQCYCPKGYITDNRNg.tvI-c.......
A0A3Q3AC43_KRYMA/209-240               ......LFCGQETCPA.V.C..--ESRD.......QCSCPDGFVLGEQT....C-e.......
A0A3Q7SND7_VULVU/422-455               ......MFCNQTACPA.D.C..DPNSPT.......SCQCPEGYILDDGF....MC........
A0A3P9Q4U2_POERE/179-221               ....qd--CSQRECPA.I.C..NNNLXLekk.dmqQCYCPQGFILD---....--lwegsatc
A0A3Q1BVH6_AMPOC/341-383               .....p-HCSERDCPA.R.C..EKNPEQekk.emqQCFCPEGYIVD---....--irdgtttc
W5NN91_LEPOC/370-406                   ......LYCSSYECPA.V.C..DPNVYW.......MCKCPDGFVLDQR-....--edglyc..
A0A667YKV0_9TELE/1-41                  ......MHCTEQDCPA.R.C..IPNSESgg...epQCYCPNGYIQDRRN....--atyic...
A0A2I4CAN5_9TELE/381-417               ......LFCGAEECPA.T.C..DPNDPR.......QCYCPDGFLSEE--....--rrtgvfc.
A0A4U5U9K1_COLLU/341-381               ......MHCTERECPA.K.C..IPNKDLsnnitslDCFCPDGYIRDS--....--adsa....
A0A3Q3N3C5_9LABR/194-231               .....q-HCTERACLA.K.C..ITNDGK......iQCSCPLGYISDTV-....--ngtayc..
A0A3Q2WTP3_HAPBU/234-270               ......LFCGKEECPA.E.C..DPNNNF.......QCYCPDGYVVEERVd.stVC........
A0A5J5MSX0_MUNRE/402-435               ......MFCNQTSCPA.D.C..DPHNPT.......ICRCPDGYILDEGS....VC........
A0A674P2Z3_TAKRU/302-340               .....r-LCTERQCLA.S.C..DRNAESn.....vQCFCPTGFILDTSNg.snIC........
A0A4W6D0M9_LATCA/170-213               .....v-HCAERDCPA.D.CvyDPDVERid...lqKCYCPDGYIRHNGN....--dtalct..
A0A673TK14_SURSU/407-440               ......MFCNETTCPA.D.C..DPNNPD.......SCQCPDGYILDDGH....IC........
A0A2Y9Q3F5_DELLE/407-440               ......MFCNQTSCPA.D.C..DPNNLA.......ICRCPEGYILDEGS....VC........
M4B059_XIPMA/383-418                   ......RHCGKPECPA.E.C..DPNYNL.......LCFCPDGYVSS---....--erggsvf.
A0A3P8T501_AMPPE/393-429               ......RHCGREECAA.E.C..DPNDRF.......QCFCPEGYISEE--....--rgsdvfc.
A0A672J903_SALFA/231-264               ......LHCAQQSCPA.M.C..ERNTGD.......SCYCPDGFVLS---....--gklcv...
A0A674C428_SALTR/349-385               .....l-LCLAEECPT.E.C..DRSKTY.......QCYCPKGYLLDDRNg.ssIC........
A0A1X7TVZ2_AMPQE/1331-1364             .....h-HCAEKKCEN.I.C..LPKSGG......yQCACPTGI------....--vpvgsyc.
A0A672HQ40_SALFA/361-397               ......LYCGKPECPA.E.C..DPNDRF.......QCYCPGGYISEE--....--rghdvfc.
A0A2U3YBW2_LEPWE/406-439               ......MFCNQTACPA.D.C..DPNSPT.......SCQCPEGYILDEGF....MC........
A0A1S3SRP8_SALSA/221-255               ......MHCPLAKCPV.I.C..DRNSDG......tQCDCPSGFIKSDDY....CH........
TRBM_CANLF/407-440                     ......MFCNQTACPA.D.C..DPNSPT.......SCQCPEGYILDDGF....MC........
A0A665WGD7_ECHNA/378-414               ......LYCGKPECPA.L.C..DPNNAF.......QCYCPDGYVIEERVd.gqVC........
A0A3B3ILB6_ORYLA/223-259               .....i-YCNKEECPA.K.C..DPNNMF.......QCFCPDGFLLEER-....--gtsmic..
A0A4X2KAA1_VOMUR/402-435               ......LFCNTTACPA.K.C..NPYNAD.......DCKCPEGYILDENQ....MC........
M3WF86_FELCA/498-531                   ......MFCNQTTCPA.D.C..DPNNPD.......SCQCPDGYILDDGY....IC........
A0A6G0I6J1_LARCR/378-414               ......LHCGKTECVA.E.C..DPNDRY.......QCFCPDGYVSEEREh.etVC........
A0A5E4CF10_MARMO/406-439               ......MFCNETACPA.D.C..DPNTPD.......SCQCPEGYILDDGF....MC........
H0W956_CAVPO/390-423                   ......LFCNETECPA.D.C..DPNAPQ.......ICYCPEGFILDEGS....MC........
L8J0V7_9CETA/142-175                   ......MFCNQTSCPA.D.C..DPHYPT.......ICRCPEGYIIDEGS....TC........
#=GC seq_cons                          ......haCspppCPA.-.C..DPNs.t.......pChCP-GYILD-t.....h.........
//
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