#=GF ID Tox-REase-3
#=GF AC PF15647.12
#=GF DE Restriction endonuclease fold toxin 3
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 25.00 25.00;
#=GF TC 31.40 30.20;
#=GF NC 23.50 21.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 90746521 -E 1000 --cpu 8 HMM pfamseq
#=GF TP Family
#=GF CL CL0236
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR028905;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted toxin of the restriction endonuclease fold present
#=GF CC in bacterial polymorphic toxin systems. In bacterial polymorphic
#=GF CC toxin systems, the toxin is exported by the type 2, type 6, type
#=GF CC 7 or PrsW-peptidase dependent secretion system [1].
#=GF SQ 28
#=GS Q9K120_NEIMB/359-466 AC Q9K120.1
#=GS A0A098MDE3_9BACL/284-392 AC A0A098MDE3.1
#=GS K9WVQ9_9NOST/737-836 AC K9WVQ9.1
#=GS A0A8A4TJN0_SULCO/3643-3751 AC A0A8A4TJN0.1
#=GS A0A269VMW2_9BACL/78-186 AC A0A269VMW2.1
#=GS V9G5H8_9BACL/1-55 AC V9G5H8.1
#=GS A0A7W9US26_9ACTN/1444-1551 AC A0A7W9US26.1
#=GS A0A8J3CEB3_9PSEU/1214-1320 AC A0A8J3CEB3.1
#=GS A0A1V4SDK6_RUMHU/9-114 AC A0A1V4SDK6.1
#=GS A0A1C4XAP5_9ACTN/455-560 AC A0A1C4XAP5.1
#=GS A0A8J7EC72_9CYAN/116-221 AC A0A8J7EC72.1
#=GS A0A934N4G1_9GAMM/258-366 AC A0A934N4G1.1
#=GS S5UWF0_STRC3/1459-1567 AC S5UWF0.1
#=GS A0A1X7HNX2_9BACL/253-361 AC A0A1X7HNX2.1
#=GS K0ET12_NOCB7/2-84 AC K0ET12.1
#=GS A0A090BVF8_9GAMM/31-107 AC A0A090BVF8.1
#=GS A0A374K410_9FIRM/50-158 AC A0A374K410.1
#=GS A0A1H8YNI6_9PSEU/71-178 AC A0A1H8YNI6.1
#=GS A0A090ZAB0_PAEMA/590-694 AC A0A090ZAB0.1
#=GS A0A9X3YLF1_9GAMM/893-1005 AC A0A9X3YLF1.1
#=GS A0A6G3SGW0_9ACTN/1082-1187 AC A0A6G3SGW0.1
#=GS A0A0M6WZE9_9FIRM/40-147 AC A0A0M6WZE9.1
#=GS A0A7W7RKH5_9ACTN/1-62 AC A0A7W7RKH5.1
#=GS A0A433UZZ3_9CYAN/1-64 AC A0A433UZZ3.1
#=GS A0A069DN78_9BACL/272-379 AC A0A069DN78.1
#=GS A0A7Y0B441_9ACTN/1449-1556 AC A0A7Y0B441.1
#=GS S0FQT2_RUMCE/653-760 AC S0FQT2.1
#=GS W7SIA6_KUTS7/3-107 AC W7SIA6.1
Q9K120_NEIMB/359-466 ............QNAKYREALdiHYEDLIRRKTDGSSKF.....ING...REIDAVTNDALIQA...KRTISAi...dKPKNFLNQKNRKQIKATIEAANQQGKRAEFWFKYG.V.HSQV....KSY.........IESKGGIVKTGlg.............
A0A098MDE3_9BACL/284-392 ..........tl--EKVNKPD..AAADALADRIGGQSRVkfsgdSAG...REFDAISDQYVAQS...KPALQT.....-----VNKSVRDQMKATFEVAQETGRKVYYHFEGQ.P.AQSVidklNEYssrygidvvI----------dtkp...........
K9WVQ9_9NOST/737-836 ............EIGKAGK--..DWEEAVQKKTGGKSAI.....IEG...REIDSVTDEALIQA...KNINTS.....NPKNFLNKKTRTQIKETIRLADERGKRAEFWFKEE.P.HPLI....REY.........IENKRGIVKVG...............
A0A8A4TJN0_SULCO/3643-3751 ......kilptg------DID..PAADALAKRLKGEASVkm.egFGN...REFDAISQEYVAQT...FGGESFa...fKPKSFLSKRRRNQIRETLRAARETGREAFFEFVGNrP.AQEV....VDF.........INR--------nadrinak.......
A0A269VMW2_9BACL/78-186 .........nle---VVNKPD..AAADALAGRIGGQSRVkfsndPAH...REFDAISDQYVAQS...KPALQT.....-----VNKSIRDQMKATFEAAQETGRKVYYHFEGQ.P.AQSVidklNEYssrygieviI----------dtkp...........
V9G5H8_9BACL/1-55 ............---------..----------------.....---...--------------...------.....-----MNKKVRDQMKATFEAAEQTGKKVYYHFEGE.P.AQSVidklHEY.........-----------sqrygidvhidtd..
A0A7W9US26_9ACTN/1444-1551 ..........el--HEVNKPD..PDADKLAEKLGGEPRRrfandPDG...REFDAISDEYVAQA...KPADFT.....-----LNKKFRKQAQATFEAAIQSGRTPYFQFDGP.P.GPGVidklQEY.........-----------grrygvepvidtt..
A0A8J3CEB3_9PSEU/1214-1320 ........llks----ANKYD..PQAEGLAKRIGGETQMhfandPDG...REFDVVSDRFIGEA...KPENFK.....-----LGKDFRSKARAMFNICKETGRAPYFQFQGE.P.HRDViraiQRY.........-----------akeygiepvvdt...
A0A1V4SDK6_RUMHU/9-114 ...........d-LKKVDSPD..PAADKLAERINGESRVrfsndTTG...REFDAISDRYIAQS...KPADFK.....-----LGSSFRNQAKATFEAASQNGKQPYFHFEGS.P.SSSV....LSK.........I----------aeyafrygiepiid.
A0A1C4XAP5_9ACTN/455-560 ........elid----VNVND..PAAIALAARIGGRPSVk..fdPRG...REFDAVSHRYVAQS...KPANYK.....-----MGSDFRNQAKATFEKAIETGRVPYFHFEGP.P.AGGVirklHEY.........-----------gvrygiepvidtr..
A0A8J7EC72_9CYAN/116-221 ..........gl--VTVNKPD..SAADALATKIGGQPRVrfasdADS...REFDAVSDEFIAQA...KPAVGS.....-----VSRKFRNQAKATFEAAQQTGRKVYYEFEGQ.P.TGDVinalKRY.........-----------esrygvevvid....
A0A934N4G1_9GAMM/258-366 .........gli---KVDVED..ADADALANHLGGRSSVrfkndPVG...KEFDAVSDQYIAEA...KPAFKS.....-----FGKDERIQAKRAFEAAKETGRDVYYHFNGE.P.GSSVirqlEEYskrydikvvI----------dtkp...........
S5UWF0_STRC3/1459-1567 ............NLVKVNKPD..PAADALAERLGGESRVkfehdPKG...REIDAISDDYVAQS...KPGGMQ.....-----MGSALRNQAKATFEYAIQSGRTPYFHFDGE.P.GPGViaklQEYgrrygiepvIDTK-------p..............
A0A1X7HNX2_9BACL/253-361 ............ELVKVPKGD..EAADMLSKKLGGQSRVkfsndPNR...REFDTISDQYIAQT...KPPLNS.....-----LDKQFRKQAKATIEAAIETGRKAYFHFEGK.P.DDRVlrqlKEY.........AERY-------gveiiidtkp.....
K0ET12_NOCB7/2-84 .......kfgnd---------..----------------.....PSG...REFDVVSDEFIGQV...KPGGQQ.....-----LGSAFRNQGKESFEAARATGRKVYYHFDGE.P.GPGVi..dKLY.........-----------eysarygvdvvidtt
A0A090BVF8_9GAMM/31-107 qnrkksgkqhgq----AGK--..PYEEVVREKTFVKSEV.....ING...REIDSFTNDALIQA...KDSESAv...nKPHNFLNKKTRTQIKETV-----------------.-.----....---.........-----------vfl............
A0A374K410_9FIRM/50-158 ..........ei--IQCNTKD..AAADELAKRIGGQSRSafaddPIQ...REFDVISDQYIAQA...KPPLKC.....-----VNKTVRTQMKATFEAAKKYERKIYYQFEGI.P.SQEVldklYEY.........-----------serygveviidtep.
A0A1H8YNI6_9PSEU/71-178 ..........al--SQVNKPD..AAADELAAKLGGVSRVkfandPDG...REFDAISDLYVAQT...KSTRVK.....-----MGSKFRNQARMTFEFAKQSGRIPFFHFEVP.P.DPEVlakiAEY.........-----------grrygidpvvkig..
A0A090ZAB0_PAEMA/590-694 ........lkqs-----AKED..AGADLLAEKLGGQSRMifnndPKG...REFDVVSDQYIGQT...KTSMNS.....-----LSSQFREQAKATIEAAIETGRKAYFHFETA.P.VDNVirqlREY.........-----------ekrydveiiid....
A0A9X3YLF1_9GAMM/893-1005 ........ltlt-----NDID..PAAEDFARRFNGQSSV....kIEGfgdREFDMVSDTYVGQTfgpKVVGEKpafelSGKNFMSQKRRLQIRATLEAAHITQRKALFEFRGGaP.ASEV....KDF.........IRRN-------gervgv.........
A0A6G3SGW0_9ACTN/1082-1187 ...........e-LQKVPKPD..PAADKLAEKLGGESRMkfendPSG...REFDAISDDYVAQT...KPEGMQ.....-----MGSAFRNQAKATFERAIESGRTPYFHFEGQ.P.TAEVvsklQD-.........-----------ygrrygldpvid...
A0A0M6WZE9_9FIRM/40-147 ..........ei--IQCNTKD..AAADELAKRIGGQSRSafaddPIQ...REFDVISDQYIAQA...KPPLKC.....-----VNKTVRTQMKATFEAAKKYERKVYYQFEGI.P.SQEVldklYEY.........-----------serygveviidte..
A0A7W7RKH5_9ACTN/1-62 ...........m---------..----------------.....---...-----------AQA...KLSRVQ.....-----VNKTFRNQAKAAFEAASQSGRSVYYHFQGG.PlSPEV....RSR.........LE---------eyanrygvdlv....
A0A433UZZ3_9CYAN/1-64 ...........m---------..----------------.....---...------TSEALIQA...KDSESAi...nKPYNFLNKKTRKQIKETIRLASELGKRAEFWFQNK.P.HPEV....RKY.........IED--------r..............
A0A069DN78_9BACL/272-379 .........glk---QANKED..VNADLLAKKIGGQSRMifnndPKG...REFDVISEQYIGQT...KTSMNS.....-----LSSQFREQAKATIEASIETGGKAYFHFETA.P.ADKVirqlKEY.........-----------ekrynveividis..
A0A7Y0B441_9ACTN/1449-1556 ..........dl--IEVTKPD..ADADKLAEKLGGEPRRrfandPDG...REFDAISDEYVAQA...KPADFT.....-----LNKKFRKQAQATFEAALQSGRTPYFHFDGP.P.GPGVidklQEY.........-----------grrygvepvidtt..
S0FQT2_RUMCE/653-760 ...........k-LVQVNKAD..AAADALASRLGGQSRVkfandSVG...REFDAVSDAYIAQT...KPALQT.....-----VNQSVRNQMKATFEAAQETGRKVYYHFEGQ.P.AQSVinklNEY.........-----------sqrygidviidtn..
W7SIA6_KUTS7/3-107 ............NLVKVNKPD..ADADKLAERIGGESRMkfendPAG...KEYDTITDRYVAET...KPANFT.....-----LNKDWRRQAKAVFDMAVKTGRTPYFHFEGP.P.GPGVlealKRY.........A----------eryaiepvi......
#=GC seq_cons ...............pssc.D..ssADtLAc+lGGpS+htFtsDssG...REFDslSDpYlAQu...KPuhts..........ls+phRsQhKATFEAAppoGRcsYFHF-Gt.P.uspVlptLp-Y....................spchhh.........
//
