GenomeNet

Database: Pfam
Entry: Toxin-deaminase
LinkDB: Toxin-deaminase
Original site: Toxin-deaminase 
#=GF ID   Toxin-deaminase
#=GF AC   PF14424.8
#=GF DE   The  BURPS668_1122 family of deaminases
#=GF PI   DEAM-TOXIN1;
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Zhang D;0000-0001-8535-7620
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF SE   Manual
#=GF GA   29.60 29.60;
#=GF TC   29.90 30.90;
#=GF NC   29.20 28.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0109
#=GF RN   [1]
#=GF RM   21890906
#=GF RT   Evolution of the deaminase fold and multiple origins of
#=GF RT   eukaryotic editing and mutagenic nucleic acid deaminases from
#=GF RT   bacterial toxin systems.
#=GF RA   Iyer LM, Zhang D, Rogozin IB, Aravind L;
#=GF RL   Nucleic Acids Res. 2011; [Epub ahead of print]
#=GF DR   INTERPRO; IPR032721;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A member of the nucleic acid/nucleotide deaminase superfamily 
#=GF CC   prototyped by Burkholderia BURPS668_1122 [1]. Members of this
#=GF CC   family are found as toxins in polymorphic toxin systems in a
#=GF CC   wide range of bacteria and in the eukaryote Perkinsus. Members
#=GF CC   of this family typically possess a DxE catalytic motif in
#=GF CC   Helix-2 of the core fold instead of the more common C[H]xE
#=GF CC   motif.  The Perkinsus versions are predicted to be inactive [1].
#=GF SQ   163
#=GS L1NQP2_9NEIS/213-338        AC L1NQP2.1
#=GS A0A1H0W324_9CLOT/245-373    AC A0A1H0W324.1
#=GS C0Z7L6_BREBN/40-121         AC C0Z7L6.1
#=GS A0A239SK43_9BURK/887-1053   AC A0A239SK43.1
#=GS A0A386PKJ3_CLOSE/244-372    AC A0A386PKJ3.1
#=GS K6TTY1_9CLOT/245-373        AC K6TTY1.1
#=GS A0A4P2VM49_9PROT/260-420    AC A0A4P2VM49.1
#=GS G7M3G9_9CLOT/245-373        AC G7M3G9.1
#=GS A0A1I7JDI1_9CLOT/226-352    AC A0A1I7JDI1.1
#=GS E0I806_9BACL/738-875        AC E0I806.1
#=GS A0A0A3JAG8_9BACI/2-137      AC A0A0A3JAG8.1
#=GS A0A0Q8R221_9BURK/609-727    AC A0A0Q8R221.1
#=GS A0A402AVV4_9CHLR/2232-2303  AC A0A402AVV4.1
#=GS A0A1M6FG10_9VIBR/248-367    AC A0A1M6FG10.1
#=GS C4IFV0_CLOBU/251-379        AC C4IFV0.1
#=GS A0A559IW81_9BACL/387-524    AC A0A559IW81.1
#=GS A0A543NEB0_9ACTN/693-809    AC A0A543NEB0.1
#=GS A0A1G6M343_9BURK/3023-3157  AC A0A1G6M343.1
#=GS A0A090Y5P9_PAEMA/713-863    AC A0A090Y5P9.1
#=GS A0A6I1MMZ1_9CLOT/245-373    AC A0A6I1MMZ1.1
#=GS A0A1H3FWJ7_9FIRM/1-62       AC A0A1H3FWJ7.1
#=GS A0A1Q2L143_9BACL/39-191     AC A0A1Q2L143.1
#=GS A0A077P6W7_XENBV/743-816    AC A0A077P6W7.1
#=GS A0A543N7M0_9ACTN/519-657    AC A0A543N7M0.1
#=GS A0A5B9DDQ4_9ARCH/288-407    AC A0A5B9DDQ4.1
#=GS A0A4U0P5H2_9NEIS/779-913    AC A0A4U0P5H2.1
#=GS A0A143G596_9GAMM/4146-4279  AC A0A143G596.1
#=GS F9YTA3_CAPCC/1-57           AC F9YTA3.1
#=GS A0A1M5BIS2_9BACL/2-105      AC A0A1M5BIS2.1
#=GS F9YTA2_CAPCC/2-56           AC F9YTA2.1
#=GS A0A370H6Y9_9NOCA/55-125     AC A0A370H6Y9.1
#=GS A0A1I5PEZ8_9PSEU/1439-1506  AC A0A1I5PEZ8.1
#=GS A0A0M1V0D1_PAESO/477-608    AC A0A0M1V0D1.1
#=GS A0A504JR31_9FLAO/28-121     AC A0A504JR31.1
#=GS A0A074LM79_9BACL/323-463    AC A0A074LM79.1
#=GS A9C332_DELAS/3613-3686      AC A9C332.1
#=GS A0A2T0BAK0_9CLOT/245-373    AC A0A2T0BAK0.1
#=GS A0A2S6CXG7_9CYAN/89-159     AC A0A2S6CXG7.1
#=GS G8LSH0_HUNCD/253-396        AC G8LSH0.1
#=GS F9YT98_CAPCC/1-57           AC F9YT98.1
#=GS A0A1G4WU60_9FIRM/424-573    AC A0A1G4WU60.1
#=GS A0A1S8TIB5_9CLOT/244-370    AC A0A1S8TIB5.1
#=GS A0A1I1T0F4_9CLOT/126-266    AC A0A1I1T0F4.1
#=GS A0A3E1NJ61_9BACT/468-588    AC A0A3E1NJ61.1
#=GS A0A561P3M9_9BACL/17-153     AC A0A561P3M9.1
#=GS A0A2M9JE33_9ACTN/53-134     AC A0A2M9JE33.1
#=GS A0A2A2M2E2_9BILA/1263-1417  AC A0A2A2M2E2.1
#=GS A0A1I2V7H3_9FIRM/428-577    AC A0A1I2V7H3.1
#=GS A0A1R3KZE9_9ROSI/256-396    AC A0A1R3KZE9.1
#=GS A0A0B3W1L9_9FIRM/368-505    AC A0A0B3W1L9.1
#=GS A0A1I6KMI6_9FIRM/55-212     AC A0A1I6KMI6.1
#=GS A0A3D9H0N8_9PROT/427-561    AC A0A3D9H0N8.1
#=GS A0A3Q8S6U3_9BACL/934-1071   AC A0A3Q8S6U3.1
#=GS U5MQS4_CLOSA/245-373        AC U5MQS4.1
#=GS A0A1M6TAD2_9CLOT/256-384    AC A0A1M6TAD2.1
#=GS A0A077LEW9_9PSED/929-1101   AC A0A077LEW9.1
#=GS A0A4S2DPX6_9CLOT/245-373    AC A0A4S2DPX6.1
#=GS A0A073CX48_PLAAG/3-44       AC A0A073CX48.1
#=GS K7WML4_9NOST/12-140         AC K7WML4.1
#=GS A0A6I3L3R3_9NOCA/356-472    AC A0A6I3L3R3.1
#=GS C0Z7L4_BREBN/289-409        AC C0Z7L4.1
#=GS A0A083ZYP8_9GAMM/1263-1377  AC A0A083ZYP8.1
#=GS A0A5D0CPD1_9BACL/2-36       AC A0A5D0CPD1.1
#=GS A0A4R4PQK5_9ACTN/206-278    AC A0A4R4PQK5.1
#=GS A0A3D9SZT8_9ACTN/67-196     AC A0A3D9SZT8.1
#=GS A0A2S0U799_9BACL/801-942    AC A0A2S0U799.1
#=GS A0A367FRS1_9ACTN/1-38       AC A0A367FRS1.1
#=GS A0A371J690_9FIRM/242-372    AC A0A371J690.1
#=GS N9WHX2_9CLOT/242-369        AC N9WHX2.1
#=GS A0A075JSY7_9BACI/13-160     AC A0A075JSY7.1
#=GS A0A1D7XNK9_9CLOT/264-392    AC A0A1D7XNK9.2
#=GS H6NNJ5_9BACL/212-354        AC H6NNJ5.1
#=GS A0A1H3N0Z1_9FIRM/428-577    AC A0A1H3N0Z1.1
#=GS C7PLG8_CHIPD/1916-2031      AC C7PLG8.1
#=GS W7WSS0_9BURK/329-458        AC W7WSS0.1
#=GS A0A1C5CSU1_9ACTN/14-81      AC A0A1C5CSU1.1
#=GS A0A074LRW7_9BACL/36-187     AC A0A074LRW7.1
#=GS R6EP07_9FIRM/437-569        AC R6EP07.1
#=GS F9YT94_CAPCC/568-707        AC F9YT94.1
#=GS A0A386PHU4_CLOSE/430-566    AC A0A386PHU4.1
#=GS G8M2W1_HUNCD/63-222         AC G8M2W1.1
#=GS K0ET81_9NOCA/349-470        AC K0ET81.1
#=GS A0A1G9S028_9FIRM/245-373    AC A0A1G9S028.1
#=GS A0A4R6UU32_9ACTN/544-690    AC A0A4R6UU32.1
#=GS F9YTA5_CAPCC/2-55           AC F9YTA5.1
#=GS A0A1Z4UIB4_9CYAN/21-154     AC A0A1Z4UIB4.1
#=GS G8LYG7_HUNCD/567-698        AC G8LYG7.1
#=GS A0A1G6ZHV1_9PSEU/1429-1498  AC A0A1G6ZHV1.1
#=GS A0A0A7RVY7_9CAUD/424-552    AC A0A0A7RVY7.1
#=GS L9ZTJ8_9EURY/282-404        AC L9ZTJ8.1
#=GS A0A3D9SMH0_9ACTN/2-111      AC A0A3D9SMH0.1
#=GS A0A0M0L7W3_9BACI/26-159     AC A0A0M0L7W3.1
#=GS A0A368KZV2_9BACT/30-101     AC A0A368KZV2.1
#=GS A0A1Z4J995_LEPBY/1-64       AC A0A1Z4J995.1
#=GS A0A1K1YTK7_9BACL/2192-2341  AC A0A1K1YTK7.1
#=GS A0A139XFH3_9CYAN/87-161     AC A0A139XFH3.1
#=GS A0A0R3Q5B6_9BILA/849-970    AC A0A0R3Q5B6.1
#=GS A0A1H3N144_9FIRM/238-384    AC A0A1H3N144.1
#=GS A0A1V4IW90_9CLOT/245-373    AC A0A1V4IW90.1
#=GS A0A3N7CT33_9BURK/5418-5497  AC A0A3N7CT33.1
#=GS M1MDW4_9CLOT/246-374        AC M1MDW4.1
#=GS A0A0B8NJ57_9NOCA/139-204    AC A0A0B8NJ57.1
#=GS A0A0R2HXK3_CARDV/358-486    AC A0A0R2HXK3.1
#=GS A0A1I0QPB2_9BACT/784-891    AC A0A1I0QPB2.1
#=GS A0A2A7MFB4_9CLOT/243-371    AC A0A2A7MFB4.1
#=GS A0A433UI97_ANAVA/39-158     AC A0A433UI97.1
#=GS A0A5R9GE87_9BACL/45-191     AC A0A5R9GE87.1
#=GS A0A243SBP6_9FLAO/14-92      AC A0A243SBP6.1
#=GS A0A433SEU4_9BURK/2548-2682  AC A0A433SEU4.1
#=GS I8AF84_9BACI/20-73          AC I8AF84.1
#=GS A0A174ARG8_9CLOT/245-373    AC A0A174ARG8.1
#=GS A0A386PGH8_CLOSE/1-140      AC A0A386PGH8.1
#=GS A0A285PGS4_9RHIZ/2171-2240  AC A0A285PGS4.1
#=GS Q81R60_BACAN/333-469        AC Q81R60.1
#=GS A0A345HF63_9FLAO/3-82       AC A0A345HF63.1
#=GS A0A285NUF8_9PSED/1305-1459  AC A0A285NUF8.1
#=GS A0A1T0B4H2_9PAST/1-66       AC A0A1T0B4H2.1
#=GS K2KEA1_9GAMM/1254-1392      AC K2KEA1.1
#=GS A0A0J8D7R8_CLOCY/247-375    AC A0A0J8D7R8.1
#=GS A0A4U9R168_HATHI/7-148      AC A0A4U9R168.1
#=GS A0A1I6KML5_9FIRM/294-450    AC A0A1I6KML5.1
#=GS A0A386PH87_CLOSE/2-109      AC A0A386PH87.1
#=GS A0A4V1QP88_9BURK/1138-1297  AC A0A4V1QP88.1
#=GS A0A364K8V2_9BACL/3-105      AC A0A364K8V2.1
#=GS A0A517TA46_9BACT/279-395    AC A0A517TA46.1
#=GS A0A398BK45_9BACI/532-668    AC A0A398BK45.1
#=GS F9YT96_CAPCC/1-57           AC F9YT96.1
#=GS A0A0J6NRM0_9NEIS/3902-4037  AC A0A0J6NRM0.1
#=GS A0A0G3UFL8_9ACTN/49-134     AC A0A0G3UFL8.1
#=GS A0A1I1T2X4_9CLOT/131-267    AC A0A1I1T2X4.1
#=GS F9YTA0_CAPCC/1-57           AC F9YTA0.1
#=GS A0A3S0PF07_9GAMM/984-1116   AC A0A3S0PF07.1
#=GS A0A504JN54_9FLAO/3-96       AC A0A504JN54.1
#=GS A0A5J6PIL4_9BACI/432-568    AC A0A5J6PIL4.1
#=GS L1QFW1_9CLOT/73-201         AC L1QFW1.1
#=GS A0A2D0HJU1_9NOSO/9-128      AC A0A2D0HJU1.1
#=GS G0AKE7_COLFT/3343-3475      AC G0AKE7.1
#=GS A0A3S1DT80_9BACL/564-689    AC A0A3S1DT80.1
#=GS A0A1I1I5H7_9CLOT/245-373    AC A0A1I1I5H7.1
#=GS A0A0D0EZX2_9FLAO/3-60       AC A0A0D0EZX2.1
#=GS A0A398B0S4_9BACI/19-155     AC A0A398B0S4.1
#=GS A0A495VYX9_9PSEU/1358-1463  AC A0A495VYX9.1
#=GS A0A2Z4LR84_9FLAO/1123-1202  AC A0A2Z4LR84.1
#=GS A0A4V3CIE5_9BACL/722-842    AC A0A4V3CIE5.1
#=GS A0A1H9PXF1_9LACT/1-122      AC A0A1H9PXF1.1
#=GS A0A3P3VVJ0_9FLAO/3-88       AC A0A3P3VVJ0.1
#=GS A0A1I2V1F2_9FIRM/236-384    AC A0A1I2V1F2.1
#=GS A0A494X994_9BURK/3757-3891  AC A0A494X994.1
#=GS B7KL47_GLOC7/64-143         AC B7KL47.1
#=GS A0A0G4JTD0_9GAMM/1650-1777  AC A0A0G4JTD0.1
#=GS A0A2G4F6E1_9CYAN/72-146     AC A0A2G4F6E1.1
#=GS B4W4S3_9CYAN/73-143         AC B4W4S3.1
#=GS A0A268DYP0_9BACI/1-113      AC A0A268DYP0.1
#=GS A0A1X7JN56_9BACL/129-262    AC A0A1X7JN56.1
#=GS A0A543NGI8_9ACTN/540-664    AC A0A543NGI8.1
#=GS Q87U34_PSESM/1382-1545      AC Q87U34.1
#=GS A0A1X7GBR6_TRICW/3126-3260  AC A0A1X7GBR6.1
#=GS A0A1E5KV53_9ENTE/1-111      AC A0A1E5KV53.1
#=GS W1IVK2_9GAMM/45-121         AC W1IVK2.1
#=GS E6KXI0_9PAST/809-937        AC E6KXI0.1
#=GS A0A1Y4HGL2_9FIRM/2-124      AC A0A1Y4HGL2.1
#=GS B8HLN7_CYAP4/71-151         AC B8HLN7.1
#=GS A0A386PG52_CLOSE/26-165     AC A0A386PG52.1
L1NQP2_9NEIS/213-338                   ....................................veyrtkfkirggnlsylegiingrsvnankiwr--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.----------Sssl........drvtNE.PKIF..TATEVK..GK..N.G.N....A-.---WL...RHT...D..SEYRMLNDLAYKLG.......gK.........Pgh....vyH.........Q....V......Y...GHLTIVSEYPYCTSCT.........H.VI.Q.QFQ.TMFPN.LRLTL----ing........
A0A1H0W324_9CLOT/245-373               ....................................................................k-TTFKIDQSKALND.......SINIAVAIY..D.....--.---.EKE.F..RAISGS......N.EIKN.....................---.---.YCTSPPL----...............-E.KAIF..KSSKVN..KL..G.K.L....GI.G--YE...RAF...D..SEKKIFEEIHKQIE.......aK.........I........L.........K....D......E...GNLILYSKWEPCPSCY.........F.VI.S.QFC.IKHPN.IKIQVKYSK...........
C0Z7L6_BREBN/40-121                    ..............................svkehaaksldipnknvlpkvvngdsghsnyspsmnska--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.-----...---...-..--------------........N.........P........S.........K....A......L...GKIKLFTEIDTCASCS.........R.VI.E.QFH.RDYPG.IDIEVIHN-d..........
A0A239SK43_9BURK/887-1053              ..............................................................vdnrmrh-----------VST.......NANIALAEV..T.....LA.DGT.RTI.Y..YCLSGL......Q.RRVLptnaptv.......rfvdagrAYL.ERE.NNVITQQ-GEDplara....qahptePP.ELRF..VVADAN..LP..T.Y.H....AAsGTAKS...RTL...D..TERLILAQIYADHP........A.........G........E.........N....V......V...RSIVMCSRMPFCDSCA.........V.NL.A.MVP.YHYPD.AALRFYY--va.........
A0A386PKJ3_CLOSE/244-372               ....................................................................k-TTFKINQSKALQD.......SINIAVAIF..D.....--.---.NKE.F..KAISGS......N.NISN.....................---.---.YCMAPPL----...............-E.KAVF..KSSKVN..KL..G.K.L....GV.G--YN...RVN...D..SEKKIFEEIHKQIE.......vK.........A........L.........K....N......E...GNLILYSKWEPCPSCY.........S.VI.S.QFC.KKYPD.IKVKVKYSK...........
K6TTY1_9CLOT/245-373                   ..................................................................ksi---FKINQSNALQD.......SINIAVAVY..D.....--.---.NKE.F..KAISGS......N.NIKN.....................---.---.YCTSPPK----...............-D.EAIF..KSSKVN..KL..G.K.L....GI.G--YD...RVN...D..SEKKIFEEIHKQIK.......aK.........V........L.........K....N......E...GNLILYSKWEPCPSCY.........F.VI.S.QFC.EKHPN.IKVQVKYCK...........
A0A4P2VM49_9PROT/260-420               .........................................................vtdkkqnsrdhn-----------AKK.......TISYAKLTL..N.....NA.INN.KIH.L..YSVSGE......NfKFVP.....................DED.EPS.KIFVNLK--KNnhnfpyitpaenpltNM.QRIL..KATQAI..KN..G.G.N....Q-.DLSTT...RYS...D..SEAKILEAIVDNTK.......dT.........A........K.........E....T......Q...GDLEIYTSKPACLSCR.........N.VY.N.YFK.EIRPK.INVKIL---tlt........
G7M3G9_9CLOT/245-373                   ....................................................................k-TTFKIDQSKTLQD.......SINIALAVF..D.....--.---.NKE.F..KAISGS......N.DITN.....................---.---.YCIAPPQ----...............-S.AATF..RSSKVN..KL..G.K.L....GI.G--YD...RVN...D..SEKKILEEIHKQIE.......aK.........V........L.........K....N......E...GKLILYSKWEPCPSCY.........F.VI.S.QFC.KKHPN.IKVQVKYS-r..........
A0A1I7JDI1_9CLOT/226-352               .................................................................kdki----YINQSNTIQD.......SVNIAVARF..N.....--.---.NDI.F..RAVSGQ......N.NIEK.....................---.---.SSLI-------...............PE.KPVF..KSYKVN..RL..G.Q.M....GY.G--YD...RAY...D..SEKKIIEDIHYKIG.......kG.........I........L.........K....D......E...GNLTIITKWEPCPSCY.........S.VI.N.QFM.KLHDK.INVEVKYMK...........
E0I806_9BACL/738-875                   ....................................................................v-KNIRNSLPSDLKR.......SGNVGLAEV..E.....IP.GLK.-KE.F..YAHSGI......D.VLSD.....................---.ARS.AASAVSDISLK...............PT.NPIF..KASTD-..--..-.S.T....ID.GRDLL...RDI...D..TEYKILNDVASQLG........N.........K........F.........D....Q......K...GKLTLFTEKPPCASCS.........N.VI.E.EFM.ARYKN.ITVEVVHNN...........
A0A0A3JAG8_9BACI/2-137                 ......................................................nlsntqrkkidrkin-------------Tl....lnNGNVATADV..N.....IL.GVK.-KE.F..NAHSQI......H.-SSD.....................SLG.AD-.--VMDFS----...............--.---Y..ATAESN..RI..F.K.N....YV.IDEFP...RYN...D..TEVKILEDIASKIK........D.........-........P.........N....I......K...GEINLFSELNTCQSCT.........N.VI.L.EFR.EKYPN.IKLNVFTN-d..........
A0A0Q8R221_9BURK/609-727               .....................kvnqlrqsldigakrniaiaefkingetgemvgisgnatrpgtvgape--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.KRRF..DTI---..T-..-.-.-....--.TGNNT...REL...D..SEVKILENLASRLK........-.........-........P.........D....A......I...GTLHLFSELPLCISCK.........G.VV.P.QFE.QAFPG.IRVIVTH--g..........
A0A402AVV4_9CHLR/2232-2303             ..............................................................arptgnn--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.----Q...RDE...D..SEYKLLNNLAQTLNpt....raK.........V........S.........N....I......I...GRIDLYSERTPCSSCR.........D.VI.W.DFE.KMFPK.IDVYVWY--k..........
A0A1M6FG10_9VIBR/248-367               .................................rakqyrdsgnvgkkrniatsdyeingekgmadavsg--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.---------KN...............TN.DAPF..VKIPDV..DN..R.KfS....TF.EVGHD...RAF...D..SEVKIFEHIASKYP........-.........-........T.........S....A......T...GKIDLYSELECCPSCS.........E.VI.N.QFK.KMYPN.IEVNVI---w..........
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A0A5D0CPD1_9BACL/2-36                  ...................................................................ae--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.-----...---...-..--------------........-.........-........-.........-....-......-...----VNTDREPCASCS.........P.II.E.QFK.AKYPD.IEVFVYF--vk.........
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A0A1T0B4H2_9PAST/1-66                  ................................................................mentk--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.-----...EKT...D..SEYKIFSNLADQLG........S.........N........N.........Q....A......K...GQVTIFTERPACQSCL.........G.VA.E.QFN.KRYPN.IKVNIFDNN...........
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A0A0J8D7R8_CLOCY/247-375               ..................................................................sda---YKIHQSEALQD.......SINIAVAVY..D.....--.---.EKE.F..RAISGS......N.EIIN.....................---.---.YCSAPPL----...............-E.KANF..KSSKVN..KL..G.K.L....GI.G--YD...RVN...D..SEKKIFEEIHRQIE.......eK.........S........L.........K....N......E...GSLILYSKWKPCPSCY.........S.VI.N.QFR.KRHPG.IKVQVRYVK...........
A0A4U9R168_HATHI/7-148                 ..............................................................lnisnky----KNKLPQWAIG.......KGNFGCAQV..T.....IE.DIT.KNE.Y..FAHSAI......Q.AEIE.....................SVK.GT-.------WISIK...............LD.STLL..KAIKVD..GN..N.V.V....GG.AGAWL...RDV...D..TEFKILSEIQNQLG........T.........K........Y.........N....T......V...DKIKFFTELECCPSCL.........D.VI.K.QFF.KLYPN.IDIEIIY--ki.........
A0A1I6KML5_9FIRM/294-450               .....................................................divsgireanrgvnnl--------------.......GGNVSFTEA..L.....ID.GTE.---.-..YSIKGC......S.KPKN.....................-IE.G-F.APVLGDVNAKT...............VP.ERFF..VTEYVD..SQ..G.N.VyaeyIK.GTNWN...RCI...D..TEARTFEELALKLGa......tKgidgaidwgN........I.........N....V......K...GIINLYTELKPCPSCL.........G.VI.E.QFK.EIYKN.ININVLWN-d..........
A0A386PH87_CLOSE/2-109                 ....................................................hkiqslddisdevatrl--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----NGISFK...............PE.NQQF..KTLNIN..KD..N.V.V....DG.INSWN...RNV...D..TEFKIIEDTSGKLG........D.........N........V.........N....A......K...GNITLYTDLYPCPSCQ.........Y.VI.E.QFM.KKYSN.IKVDIIY--kl.........
A0A4V1QP88_9BURK/1138-1297             ..............................................................klvftha---------REILR.......GRNIAYAEV..YalrngVP.SLE.-KT.Y..FSVSGK......Q.QAKNrrngykl......etieadetH--.---.-------IDADrefvlrqkaragkgmPE.EPS-..RSFPDF..DE..N.R.T....R-.---RW...RGD...D..SEYKLLSVLRADLA........-.........G........V.........R....G......P...KTIKMVTRMAPCVMCK.........Q.AL.A.AFS.QDFPD.IPLEVGY--lg.........
A0A364K8V2_9BACL/3-105                 .....................................................hykevtrlseenvvpl--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.---------KP...............PH.QRRF..QTLNID..GL..G.N.I....NT.EEGYN...RAV...E..PIPKLLEQIADQLQ........G.........Q........P.........Q....A......A...GTINLNVKFPLSISCQ.........W.VI.C.QFH.QQFPN.ITLDIVDQ-n..........
A0A517TA46_9BACT/279-395               .............eagtkkapvvavseleldnqtftvrafsgetqldnfapyvpdpnrrlkanidypek--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.-SQFL...RDV...D..AEAKIFERMLDLTN........-.........-........P.........N....T......S...GTLRMYVDKILCLSCK.........D.MA.K.RFK.KLRPN.IKLE-----lsw........
A0A398BK45_9BACI/532-668               .....................................................................VKELRGKLTSRYKK.......SGNFAVAEV..D.....VS.GIS.KSE.F..YAQSSI......N.DFKG.....................NLE.DK-.----VPDISLQ...............PE.NPMF..KATKAV..GK..E.G.E....S-.---YL...RNT...D..TEYKILNDIASRLG........E.........N........I.........Q....A......T...GKIKLFTELDTCDSCS.........K.VI.A.EFA.TKYKN.IELEVIHNN...........
F9YT96_CAPCC/1-57                      ....................................................................m--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.-----...---...-..-----LNDLAKDLG.......aK.........Qgg....vyP.........H....I......T...GEIKIVSEFKYCDSCT.........G.VI.Q.QFN.KMFPN.IKL------ilvdg......
A0A0J6NRM0_9NEIS/3902-4037             .....................................................dqirkqypimnekgmp--------------.......AGNAGVAEI..N.....VY.GKE.SVE.V..KAHSRI......G.NSPE.....................GQR.DG-.-FVSLPP----...............PG.ERIL..TPYAGP..--..-.-.F....K-.--GVP...RES...D..TEFKILEAFAQKYR........N.........D........V.........G....V......R...GNINLFTERPPCESCS.........K.VIrE.QFV.ELFPN.VEVRLYH--gn.........
A0A0G3UFL8_9ACTN/49-134                .......................aewtgalkgiqhrkdaerqvvnlladeiyrhlgcrstaqyrarira--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.-----...---...-..--------------........-.........-........-.........V....R......R...GTVDLYSDMGPCHSCR.........S.VI.K.DFR.VDFPT.LAVQVRYR-n..........
A0A1I1T2X4_9CLOT/131-267               ....................................................................v-KNIRQSLPSRYKT.......SGNLATAEV..S.....ID.GIN.QNK.F..FSHSGI......D.KMQD.....................NLI.GK-.----ADNISVQ...............PD.NPMF..KAIEAA..NK..N.G.E....F-.---YL...RDS...C..TEYKILNDIADRLK........D.........S........V.........N....P......S...GKIKLFTELEPCDSCK.........N.VI.D.SFR.NEFKN.IEIDVIHN-g..........
F9YTA0_CAPCC/1-57                      ...................................................................ml--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.-----...---...-..------NKLAKDLGae....kgK........iY........A.........H....I......T...GELKIVSERAYCASCQ.........G.VI.Q.QFN.KMFPN.IKL------ilidg......
A0A3S0PF07_9GAMM/984-1116              ...................................................................vg--NLRAALTGDART.......SGNVGVAQI..N.....IP.GVS.-PM.M..AASSQI......Q.TPSA.....................-VE.QA-.LGFVGVV----...............PE.--TF..PSTVVP..TA..T.G.F....P-.---LL...RTG...D..SEAVILNNVAAQLG........D.........N........T.........S....I......A...GTIDLLTERPPCDSCS.........N.II.Q.MFQ.SKYPN.IKINILNN-g..........
A0A504JN54_9FLAO/3-96                  .............................................................rsgdefeg--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.NPIF..DTYKVD..KQ..G.N.I....DV.DGAWS...REW...D..TEYVMLSEIAQSKGav...kggV.........Y........P.........K....V......K...GEIIISSELPYCVSCQ.........G.VI.Q.DFS.DMFPN.LDV------ilid.......
A0A5J6PIL4_9BACI/432-568               .....................................................................VKELRGKLSSKYKK.......SGNFALAEV..D.....VN.SLN.KKE.F..YASSKI......D.EFKG.....................DLE.EK-.----VPEISLK...............PN.EPIF..EASLAP..GK..D.G.K....P-.---FM...RDS...D..TEYKILNEIALKLG........D.........D........V.........H....A......T...GKIKLFTELDTCDSCS.........K.VI.A.EFA.NKYKN.IELEVIHNN...........
L1QFW1_9CLOT/73-201                    ...................................................................vg--TISINQSDALQD.......SINIAVAIY..N.....--.---.GKE.F..KAVSGS......D.EVEG.....................---.---.FCMAKPI----...............-G.QVAF..KSSKVN..KL..G.K.L....GI.G--YN...RIN...D..SEKKILEEINKQIE.......sN.........E........L.........E....D......K...GELVLYSKWQPCPSCY.........Y.VI.S.QFC.EKYPR.IKFKVKYRN...........
A0A2D0HJU1_9NOSO/9-128                 ...............eirktcnvpaparnvaiarvwvdetftelfafsgkllregavvvpnqpmfktfe--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..----V-..--..-.-.-....--.-TGHR...RDL...D..SEYKILEALAEKYT........N.........N........R.........E....V......N...GKIELFTEREPCDSCE.........Y.VI.K.QFR.QTFPN.IQLNVHH--gn.........
G0AKE7_COLFT/3343-3475                 ....................................................................l-KDLRLVLPSGPKT.......GGNMGIAQI..D.....IP.GIP.-ST.M..AASSQI......N.--TP.....................TIT.QQA.LGFVGQV----...............PE.--TF..TSSAVP..SA..S.G.V....L-.---IN...RAV...D..SEAKILNNVAARLG........D.........N........T.........S....V......A...GTINLLTERAPCSSCS.........N.II.Q.QFQ.TKYPN.IIINVMDNN...........
A0A3S1DT80_9BACL/564-689               ....tteeslnkinqirqeinvgskkniafaeyeingikgeligisgnaeragtvgvlekrifdtittg--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.--NNP...RTL...D..SEVKILENLASNLS........-.........-........K.........D....A......S...GKVYLFSELPFCISCS.........G.VI.K.QFE.QRFPN.IEIIVD---hg.........
A0A1I1I5H7_9CLOT/245-373               ....................................................................k-TTFKIDQSKALQD.......SINIAVAIY..D.....--.---.NKE.F..KAISGS......N.NITN.....................---.---.YCTAPPL----...............-E.EAIF..KSSKVN..KL..G.K.L....GI.G--YD...RVN...D..SEKKIFEEIHKQIE.......aK.........V........L.........K....N......Q...GNLILYSKLEPCPSCC.........F.VI.S.QFC.KKHPN.IKVQVKYSK...........
A0A0D0EZX2_9FLAO/3-60                  ....................................................nklalslepnakitdqf--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.-----...---...-..--------------........-.........-........L.........H....Y......E...GTLKIISENAYCTSCQ.........G.IV.V.QFN.KMFPK.INIVLI---dat........
A0A398B0S4_9BACI/19-155                .....................................................................VKELRGNLLSKYKK.......AGNFALAEV..D.....VS.GIS.KSE.F..YAQSRI......N.NLKG.....................SLE.DK-.----VPDISLQ...............PE.NPMF..KATKAV..GK..D.G.E....S-.---YL...RDT...D..TEYKILNDIASRLG........E.........N........T.........Q....A......T...GTIKLFTELDTCDSCS.........R.VI.A.DFA.AKYKN.IKLEIIHN-d..........
A0A495VYX9_9PSEU/1358-1463             ........................grrniavaeyeingvsgerigvsgghqypdsapmptspqysrgpa--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.--NIS...RDS...D..SEWKILEELGSRLQ........-.........-........P.........G....A......T...GRIHITSERPVCPSCQ.........V.VI.D.DFR.RAFPG.IDL------tysdl......
A0A2Z4LR84_9FLAO/1123-1202             ..........................................................itepqifdaie--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.VGGWI...RNT...D..SEYKMLNKLADDLGg......vK.........G........Ss......ypN....V......T...GEIKIVSERDYCASCQ.........G.VL.Q.QFS.EMFPN.LKL------ilid.......
A0A4V3CIE5_9BACL/722-842               .......rqkynagkkrnvaaakgkingeeidlesvsgeftaddyfnkgnfkppqpedyhyegpisdyt--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.-----...--S...H..TEQKIVEYLRLKYK........D.........N........P.........K....V......T...GMIEIISERPYCDNCI.........D.LV.D.QFQ.KDFPK.IKV------irvevi.....
A0A1H9PXF1_9LACT/1-122                 ..................................................................mpn---------SKLKN.......QGNMAVADV..K.....IK.DLP.-DE.F..MAHSKI......H.GPNS.....................---.-K-.-----GA----...............-D.LGNF..SPSSEN..RI..F.E.S....YT.IDKFP...RYN...D..TEVKILEDIASKIK........D.........-........P.........N....I......S...GKIDLFTELPACQSCT.........N.VI.L.EFR.KKFPN.IELNIF---tk.........
A0A3P3VVJ0_9FLAO/3-88                  ...............................................................srnnfy--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..---KVD..KK..G.H.I....NS.SGAWS...REF...D..SEYVGLIEIAQKLG.......eK.........K........E.........HkfpnV......K...GKITIASELPYCISYQ.........G.VI.Q.DFA.SMFPN.VEIYL----vdg........
A0A1I2V1F2_9FIRM/236-384               .............evkeseltdmytaftiynsvnakkilekdrfellkedvemmqdkekfseflvlgql--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.----------Kfik........piprEY.EKVF..KTLMVN..SK..N.E.I....NG.KLAYD...RFA...D..PTFVNLNDIALKLG........D.........N........Y.........G....A......S...GNVKIHVELYPCPSCQ.........Y.VI.K.QFQ.ERYKN.IKLEVVYG-k..........
A0A494X994_9BURK/3757-3891             ....................................................................v-ADLRATLTGSAKT.......SGNMGVAQI..N.....IP.GVQ.-QT.M..AASSQI......A.NPTE.....................AQQ.AL-.-GFVGQ-----...............-V.QETF..PSSSVW..TG..G.N.D....PV.L--LN...RSV...D..SEAKILNNVAAQLG........D.........N........T.........S....V......S...GTINLFTERAPCASCS.........N.VI.Q.QFQ.EKYPN.IKINVMDN-g..........
B7KL47_GLOC7/64-143                    .......................................................ksqggqfepivdsh--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.-SGYL...MNT...D..SEYKALCAIADTLDm......fY.........D........S.........S....V......E...GKLYLYTERRPCESCQ.........E.IV.K.QFK.EKFSN.IDVEVF---wd.........
A0A0G4JTD0_9GAMM/1650-1777             ...................................................................vi--DLRAGLPSAPKR.......SGNVAVAQI..D.....IQ.GMP.-KT.L..ASHNHI......D.QAGK.....................G--.---.-FVGEGS----...............--.-QNF..KFDTIP..TA..D.G.R....S-.---LE...RNI...D..SEYKILDNLADKLG........A.........N........T.........S....V......K...GSVTIFTEKPACGSCL.........G.VI.E.QFQ.RKYPS.IKVDVLDNN...........
A0A2G4F6E1_9CYAN/72-146                ............................................................qfepsvdsr--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....-T.GRSMD...--T...D..AEYKVLSAIADRLEl......sY.........D........R.........G....V......K...GNLYLYSELQPCESCN.........N.VL.K.QFK.EKFPN.INIDVF---wd.........
B4W4S3_9CYAN/73-143                    ...........................................................sldsrtrrlm--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.-----...-NT...D..AEYKILSAIAETLEr......sY.........D........L.........E....I......E...GSLYLYTELQPCESCN.........D.VL.R.QFK.DKFPN.INVDVF---wd.........
A0A268DYP0_9BACI/1-113                 ....................................................................m--------------.......---------..D.....IP.IVE.QKE.F..YSSSQV......D.ISSG.....................---.---.NPNLEGF-SLK...............PE.NPTF..RATKAP..DK..K.G.D....N-.---FV...RET...D..TEYKILNDLAEKIG........E.........N........N.........N....V......T...GNVKLFTEKDTCGSCN.........N.II.S.QFK.ERYPN.ITIEVIHN-g..........
A0A1X7JN56_9BACL/129-262               ..................................................................tqa---IRDSLPNKYKN.......YGNVAVADV..N.....IP.GLK.-TE.F..KAHSRI......H.KENA.....................---.-DG.FSSVTGE----...............--.-GQF..PAKSVN..QK..G.E.V....DG.EGAFP...RDN...D..TERKILEDIANQLG........N.........N........K.........Q....T......R...GKIDLFTELPACRSCS.........D.II.M.KFR.QEYPN.IKLNVYS--ge.........
A0A543NGI8_9ACTN/540-664               ............................................................gtknvrekk----------NIGK.......GKNTAIVDY..D.....ID.GMG.EGQ.K..IGVSGK......K.NSPD.....................---.--G.TSPVPND----...............-S.EREF..SARS--..ED..G.G.H....S-.-----...APW...D..SEVKALEDLSQDLS........-.........-........S.........D....A......K...GKLEIYTERPPCSSCR.........S.VI.S.QFE.EKYPN.VDLHVS---wgk........
Q87U34_PSESM/1382-1545                 .................................................................ltle----SIVTPQAPKRimk.qvrGANLSFLQA..Y.....TE.SGE.RIV.Y..YALSGG......N.KAKDlk................lqlDVT.EST.ERVIDGVIYRDarar.......magrQP.DPGF..TSLPVI..RD..V.D.H....LV.VRSFG...RYL...D..SERLIATVLKEDMA........-.........-........S.........T....K......L...THIKVFTVLDTCRSCG.........GfVL.P.RLK.LDFPD.AQFSVTYLK...........
A0A1X7GBR6_TRICW/3126-3260             ....................................................................v-ADLRATLTGSAKT.......SGNVGVAQI..N.....IP.GVQ.-PT.M..AASSQI......A.NPTD.....................AQK.AL-.-GFVGQV----...............PE.--IF..RSSSVW..TG..G.N.D....PV.L--LN...RSV...D..SEAKILNNVAAQLG........D.........N........T.........S....V......S...GTINLLTERAPCASCS.........N.VI.Q.QFQ.SKYPN.ITINVMDN-g..........
A0A1E5KV53_9ENTE/1-111                 ....................................................................m--------------.......----AVADV..K.....IK.DLP.-DE.F..MAHSKI......H.GPNS.....................---.---.---------KG...............AD.LGNF..SPSSEN..RI..F.E.S....YT.IDKFP...RYN...D..TEVKILEDIASKIK........D.........-........P.........N....I......S...GKIDLFTELPACQSCT.........N.VI.L.EFR.KKFPN.IELNIF---tk.........
W1IVK2_9GAMM/45-121                    .......................................................vdvpnpnkrlfttt--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.VVTHP...RAF...D..SEAKIFEHIASKIN........-.........-........P.........N....A......K...GTVNLYSELPICKSCQ.........G.VI.K.QFE.TMHPN.VKVNIIN--k..........
E6KXI0_9PAST/809-937                   ...................................................................ls--EARSTLSPKLQR.......SGNAAVAQI..N.....ID.GLT.TRK.L..VGHSQI......D.KAQG.....................---.---.SFVGQGE----...............--.-TKF..ESLKLP..NK..K.G.D....L-.---ID...RRV...D..SEYKILSNLADQLG........S.........N........R.........Q....A......K...GQVTIFTERPACLSCL.........G.VV.D.QFI.KRYPN.IKVNVFDNN...........
A0A1Y4HGL2_9FIRM/2-124                 ................................................................pnnnl------------GK.......RGNMAMADV..D.....IS.GVK.-DS.F..VAHSKI......N.TETD.....................---.-KG.ADVA-------...............--.--EF..SYLKSA..TE..R.I.Ft..tYV.DEKYP...RYH...D..TEAKILEDIAAQIS........-.........D........R.........N....V......D...GVINLYSELPCCQSCS.........N.II.L.EFR.RMFPN.IMLNIF---ve.........
B8HLN7_CYAP4/71-151                    .................................................pkseggqfepsvdsrtnrmm--------------.......---------..-.....--.---.---.-..------......-.----.....................---.---.-----------...............--.----..------..--..-.-.-....--.-----...-DT...D..AEYKVLSEIAEILE........K.........Sy......dP.........E....V......E...GDLYLYSELQPCQSCQ.........C.VI.E.QFK.AKFPN.IKIHL----fsd........
A0A386PG52_CLOSE/26-165                .................................................sdeyinlsntqrkkidrrid-------------Kl.....eLGNVATADV..N.....IP.GIK.-KE.F..SAHSQI......H.SIDS.....................-LG.AD-.--V--------...............-M.DFSY..TPAESE..RI..F.K.N....YV.VDEFP...RYN...D..TEAKILEDIASKIK........-.........D........K.........N....I......K...GEVNLFTELDTCQSCT.........N.II.L.EFR.ATYPN.IKLNIFTNN...........
#=GC seq_cons                          ....................................................................t...................................................................................................................................a..........t.....t............h....R.h...D..oEhKILpclupplt........p.........t..................p....s......p...GplpLaoEhssCsSCp.........s.VI.p.QFp.ccaPN.Iclplh..............
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