#=GF ID   Toxin_30
#=GF AC   PF08117.17
#=GF DE   Ptu family
#=GF PI   Toxin_30; Toxin_30_;
#=GF AU   Lee SC;0000-0002-0504-0859
#=GF SE   Short protein clustering
#=GF GA   24.50 24.50;
#=GF TC   24.70 25.20;
#=GF NC   24.40 24.20;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Insect_toxin
#=GF CL   CL0083
#=GF RN   [1]
#=GF RM   11669615
#=GF RT   Solution structure of Ptu1, a toxin from the assassin bug
#=GF RT   Peirates turpis that blocks the voltage-sensitive calcium
#=GF RT   channel N-type. 
#=GF RA   Bernard C, Corzo G, Mosbah A, Nakajima T, Darbon H; 
#=GF RL   Biochemistry 2001;40:12795-12800.
#=GF DR   INTERPRO; IPR012325;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of toxic peptides that are  isolated from
#=GF CC   the saliva of assassin bugs. The  saliva contains a complex
#=GF CC   mixture of proteins  that are used by the bug either to
#=GF CC   immobilise  the prey or to digest it. One of the proteins (Ptu1)
#=GF CC    has been purified and shown to block reversibly the  N-type
#=GF CC   calcium channels and to be less specific for  the L- and P/Q-
#=GF CC   type calcium channels expressed in  BHK cells [1].
#=GF SQ   1
#=GS A0A137NUV0_CONC2/27-61  AC A0A137NUV0.1
A0A137NUV0_CONC2/27-61             aqk--QECLPQGSKCLGEALQCCG-KLRCMHYANRCV--q..
#=GC seq_cons                      AQK..QECLPQGSKCLGEALQCCG.KLRCMHYANRCV..Q..
//