#=GF ID Tricorn_2nd
#=GF AC PF26550.2
#=GF DE Tricorn protease second beta propeller domain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Andreeva A;0000-0002-0450-0091
#=GF SE Bateman A
#=GF GA 102.50 102.50;
#=GF TC 102.50 102.50;
#=GF NC 102.40 102.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 90746521 --cpu 8 -E 1000 HMM pfamseq
#=GF TP Repeat
#=GF CL CL0186
#=GF RN [1]
#=GF RM 11719810
#=GF RT Crystal structure of the tricorn protease reveals a protein
#=GF RT disassembly line.
#=GF RA Brandstetter H, Kim JS, Groll M, Huber R;
#=GF RL Nature. 2001;414:466-470.
#=GF RN [2]
#=GF RM 12470958
#=GF RT Navigation inside a protease: substrate selection and product
#=GF RT exit in the tricorn protease from Thermoplasma acidophilum.
#=GF RA Kim JS, Groll M, Musiol HJ, Behrendt R, Kaiser M, Moroder L,
#=GF RA Huber R, Brandstetter H;
#=GF RL J Mol Biol. 2002;324:1041-1050.
#=GF DR SO; 0001068; polypeptide_repeat;
#=GF CC This entry represents the second beta propeller domain of the
#=GF CC tricorn proteases. The Tricorn protease family is involved in
#=GF CC the degradation of oligopeptides, likely derived from the
#=GF CC proteasome. Members of this family function by sequentially
#=GF CC breaking down oligopeptides and channelling the resulting
#=GF CC products to other proteases, such as F1, F2, and F3, which
#=GF CC complete the terminal degradation step to yield free amino
#=GF CC acids. The Tricorn protease family is characterized by its
#=GF CC assembly into complex structures, such as hexameric toroids,
#=GF CC which may further assemble into larger icosahedral
#=GF CC supermolecules. This structural organization facilitates the
#=GF CC efficient processing of substrates through distinct channels
#=GF CC within the protease complex. The family belongs to the peptidase
#=GF CC S41B family, indicating a shared evolutionary origin and
#=GF CC functional characteristics among its members.
#=GF SQ 1790
#=GS A0A088ET91_9SPHI/310-671 AC A0A088ET91.1
#=GS A0A4S3KSA5_9GAMM/312-670 AC A0A4S3KSA5.1
#=GS A0A6I6N589_9ACTN/446-688 AC A0A6I6N589.1
#=GS A0A7Y6M200_9ACTN/292-642 AC A0A7Y6M200.1
#=GS A0A6M2BVY4_9GAMM/337-692 AC A0A6M2BVY4.1
#=GS A0A1H8DU25_9ACTN/584-823 AC A0A1H8DU25.1
#=GS A0A7M2TG94_STRCW/485-728 AC A0A7M2TG94.1
#=GS A0A2T0MDK3_9ACTN/312-661 AC A0A2T0MDK3.1
#=GS B4D285_9BACT/314-723 AC B4D285.1
#=GS A0A2X0JEP1_9ACTN/301-653 AC A0A2X0JEP1.1
#=GS A0A5C7BDK7_9FLAO/303-656 AC A0A5C7BDK7.1
#=GS A0A0S2I5S2_9BACT/318-654 AC A0A0S2I5S2.1
#=GS A0A2H3NWX8_9BACT/296-641 AC A0A2H3NWX8.1
#=GS A0A6I4U158_9SPHN/309-660 AC A0A6I4U158.1
#=GS A0A4S1M622_UNCXX/298-631 AC A0A4S1M622.1
#=GS A0A2U3C215_9ACTN/290-670 AC A0A2U3C215.1
#=GS TRI_SACS2/342-667 AC P95871.1
#=GS L7EZJ4_9ACTN/303-675 AC L7EZJ4.1
#=GS A0A239NV32_9ACTN/277-406 AC A0A239NV32.1
#=GS A0A1G9DCE1_9ACTN/305-664 AC A0A1G9DCE1.1
#=GS A0A1D8G1N3_9ACTN/553-796 AC A0A1D8G1N3.1
#=GS A0A918PA38_9ACTN/369-735 AC A0A918PA38.1
#=GS A0A5P8K453_9ACTN/307-667 AC A0A5P8K453.1
#=GS A0A934S8C9_9BACT/307-662 AC A0A934S8C9.1
#=GS A0A975XM13_9MICC/434-724 AC A0A975XM13.1
#=GS A0AA48H1M0_9BACT/310-665 AC A0AA48H1M0.1
#=GS A0A101RR49_9ACTN/418-664 AC A0A101RR49.1
#=GS A0A1Q4XGR1_9PSEU/285-637 AC A0A1Q4XGR1.1
#=GS A0A918DHU9_9ALTE/308-670 AC A0A918DHU9.1
#=GS A0A1X7CST0_9ACTN/272-629 AC A0A1X7CST0.1
#=GS A0A2U3H210_9ACTN/290-663 AC A0A2U3H210.1
#=GS A0A1K1QNF5_9FLAO/314-667 AC A0A1K1QNF5.1
#=GS A0A429AQR6_9ACTN/300-633 AC A0A429AQR6.1
#=GS A0A916UUN2_9BURK/319-701 AC A0A916UUN2.1
#=GS A0A4Q6V642_9ACTN/438-685 AC A0A4Q6V642.1
#=GS A0A2R4C8T9_9BURK/312-688 AC A0A2R4C8T9.1
#=GS A0A1H9H165_9ACTN/464-705 AC A0A1H9H165.1
#=GS A0A088ESI0_9SPHI/312-677 AC A0A088ESI0.1
#=GS A0AA48H504_9BACT/310-614 AC A0AA48H504.1
#=GS A0A3P0XBY6_9BACT/297-689 AC A0A3P0XBY6.1
#=GS A0A561ENU2_9ACTN/291-654 AC A0A561ENU2.1
#=GS A0A850QRR5_9BURK/325-685 AC A0A850QRR5.1
#=GS A0A1H9S4B3_9ACTN/303-661 AC A0A1H9S4B3.1
#=GS A0A6F8ZIR0_9FIRM/285-635 AC A0A6F8ZIR0.1
#=GS A0A0Q5HIF6_9BURK/309-685 AC A0A0Q5HIF6.1
#=GS A0A918FW11_9ACTN/290-659 AC A0A918FW11.1
#=GS A0A346XYI7_9ACTN/289-714 AC A0A346XYI7.1
#=GS A0A6M4IIR7_9BACT/314-682 AC A0A6M4IIR7.1
#=GS A0A101P5E0_9ACTN/278-635 AC A0A101P5E0.1
#=GS L0FYV4_ECHVK/309-672 AC L0FYV4.1
#=GS A0A7K1TCW7_9BACT/309-692 AC A0A7K1TCW7.1
#=GS A0A1I6S4R1_9SPHI/308-625 AC A0A1I6S4R1.1
#=GS A0A0K8QVN2_9BACT/331-700 AC A0A0K8QVN2.1
#=GS A0A2H5AYC8_9ACTN/282-649 AC A0A2H5AYC8.1
#=GS A0AAE0KPJ1_9CHLO/103-296 AC A0AAE0KPJ1.1
#=GS A0A2W2E492_9ACTN/284-635 AC A0A2W2E492.1
#=GS A0A7X0IEY7_9ACTN/281-659 AC A0A7X0IEY7.1
#=GS A0A6N7GGY6_9ACTN/287-643 AC A0A6N7GGY6.1
#=GS G4CUJ1_9ACTN/301-667 AC G4CUJ1.1
#=GS A0A0B9AJM1_BRELN/314-676 AC A0A0B9AJM1.1
#=GS A0A9E4ZQ80_9CREN/288-617 AC A0A9E4ZQ80.1
#=GS A0A3Q8VF02_9ACTN/293-651 AC A0A3Q8VF02.1
#=GS A0A6G2VZL5_9ACTN/431-674 AC A0A6G2VZL5.1
#=GS A0A1Q2CFQ4_9ACTN/288-649 AC A0A1Q2CFQ4.1
#=GS A0A1M7NFZ0_9BACT/311-667 AC A0A1M7NFZ0.1
#=GS A0A1H2A2P7_9ACTN/297-653 AC A0A1H2A2P7.1
#=GS A0A066Z4M3_9ACTN/289-647 AC A0A066Z4M3.1
#=GS A0A542Q4T6_9ACTN/294-667 AC A0A542Q4T6.1
#=GS A0A1T5EIZ9_9BACT/317-666 AC A0A1T5EIZ9.1
#=GS A0A1G9CWB6_9ACTN/280-614 AC A0A1G9CWB6.1
#=GS A0AAE0KPC2_9CHLO/103-296 AC A0AAE0KPC2.1
#=GS A0A2P2GSD4_STREW/489-736 AC A0A2P2GSD4.1
#=GS A3QCA6_SHELP/327-670 AC A3QCA6.1
#=GS A0A5B7UUV8_9ACTN/291-654 AC A0A5B7UUV8.1
#=GS A0A437LHI6_9BURK/344-704 AC A0A437LHI6.1
#=GS A0A4Y8AX29_9FLAO/307-673 AC A0A4Y8AX29.1
#=GS A0A1V4ABE9_9ACTN/323-685 AC A0A1V4ABE9.1
#=GS A0A6P2BSE1_9ACTN/301-654 AC A0A6P2BSE1.1
#=GS M7XH94_9BACT/308-657 AC M7XH94.1
#=GS W2UKV5_9FLAO/310-657 AC W2UKV5.1
#=GS A0A1H7FMB1_9BURK/330-732 AC A0A1H7FMB1.1
#=GS A4AWP7_MARSH/313-657 AC A4AWP7.1
#=GS A0A3A9V4L1_9FLAO/311-664 AC A0A3A9V4L1.1
#=GS A0A7Y7DMU9_9ALTE/308-660 AC A0A7Y7DMU9.1
#=GS A0A516G7T1_9MICO/294-674 AC A0A516G7T1.1
#=GS A0A7H1BC73_9ACTN/295-652 AC A0A7H1BC73.1
#=GS A0A1H8F4E2_9ACTN/310-687 AC A0A1H8F4E2.1
#=GS G2NHS9_STREK/458-703 AC G2NHS9.1
#=GS A0A1I6SE89_9SPHI/354-716 AC A0A1I6SE89.1
#=GS A0A919M390_9BACT/309-665 AC A0A919M390.1
#=GS A0A7H0HRS2_9ACTN/290-651 AC A0A7H0HRS2.1
#=GS A0A1W6N3L3_9PROT/285-637 AC A0A1W6N3L3.1
#=GS A0A4P7SU67_9MICC/547-746 AC A0A4P7SU67.1
#=GS A0A1H7SNS5_9BURK/365-741 AC A0A1H7SNS5.1
#=GS A0A1M5B1H2_9BACT/311-658 AC A0A1M5B1H2.1
#=GS A0A8J3VYK9_9ACTN/266-638 AC A0A8J3VYK9.1
#=GS A0A2G5J2Q6_9ACTN/322-679 AC A0A2G5J2Q6.1
#=GS A0A3S3SS25_9SPHI/302-668 AC A0A3S3SS25.1
#=GS A0A1W2F0L1_KIBAR/284-637 AC A0A1W2F0L1.1
#=GS A0A062XW34_9BACT/315-679 AC A0A062XW34.1
#=GS A0A0J6XY65_9ACTN/299-676 AC A0A0J6XY65.1
#=GS A0A2L0N7F8_9ACTN/299-667 AC A0A2L0N7F8.1
#=GS A0A285QQY8_9ACTN/301-668 AC A0A285QQY8.1
#=GS A0A918MJM1_9ACTN/474-718 AC A0A918MJM1.1
#=GS A0A081N1Q3_9GAMM/310-663 AC A0A081N1Q3.1
#=GS A0A931E7P6_9BACT/309-677 AC A0A931E7P6.1
#=GS A0A5P2BCZ0_STRVZ/308-666 AC A0A5P2BCZ0.1
#=GS K1KU23_CECL9/306-650 AC K1KU23.1
#=GS A0A4P6TSS9_STRSO/294-652 AC A0A4P6TSS9.1
#=GS A0A514JUU4_9ACTN/310-668 AC A0A514JUU4.1
#=GS A0A2U2Z7J8_9ACTN/296-677 AC A0A2U2Z7J8.1
#=GS A0A5B8J763_9ACTN/484-751 AC A0A5B8J763.1
#=GS A0A2W2FT56_9ACTN/282-656 AC A0A2W2FT56.1
#=GS A0A1E5SYG2_9BACT/309-649 AC A0A1E5SYG2.1
#=GS W0V6V6_9BURK/313-680 AC W0V6V6.1
#=GS A3D1Y7_SHEB5/317-665 AC A3D1Y7.1
#=GS A0A261Q981_9BACT/311-682 AC A0A261Q981.1
#=GS A0AA46TH62_9ACTN/297-657 AC A0AA46TH62.1
#=GS A0A839QW22_9MICO/92-432 AC A0A839QW22.1
#=GS A0A8J3WT04_9ACTN/269-619 AC A0A8J3WT04.1
#=GS A0A8J3GA25_9BACT/309-667 AC A0A8J3GA25.1
#=GS C1N9P1_MICPC/313-696 AC C1N9P1.1
#=GS A0A4Y3RTF7_9ACTN/474-720 AC A0A4Y3RTF7.1
#=GS A0A7U4E6N3_RUNSL/309-678 AC A0A7U4E6N3.1
#=GS A0A2P8QAM7_9ACTN/307-665 AC A0A2P8QAM7.1
#=GS A0A7X8YEW7_9MICC/304-671 AC A0A7X8YEW7.1
#=GS A0A1V6LV43_9FLAO/312-653 AC A0A1V6LV43.1
#=GS A0A7W9DVD7_9ACTN/281-661 AC A0A7W9DVD7.1
#=GS A0A1Z3HRD9_9CYAN/287-659 AC A0A1Z3HRD9.1
#=GS A0A366IPV7_9MICO/310-666 AC A0A366IPV7.1
#=GS A0A7H8NBR9_9ACTN/463-711 AC A0A7H8NBR9.1
#=GS A0A2M9IEP1_9ACTN/492-736 AC A0A2M9IEP1.1
#=GS A0A1H4FT91_ALKAM/309-656 AC A0A1H4FT91.1
#=GS A0A5N8VSK2_9ACTN/294-652 AC A0A5N8VSK2.1
#=GS A0A923KL36_9BURK/314-667 AC A0A923KL36.1
#=GS A0A1E7MYT1_KITAU/289-657 AC A0A1E7MYT1.1
#=GS A0A941EAC8_9ACTN/293-655 AC A0A941EAC8.1
#=GS A0A940YWQ2_9ACTN/285-648 AC A0A940YWQ2.1
#=GS A0A0Q7SLX1_9BURK/308-679 AC A0A0Q7SLX1.1
#=GS A0A561UKI7_9ACTN/284-631 AC A0A561UKI7.1
#=GS A0A7Y0JGN6_9ACTN/290-648 AC A0A7Y0JGN6.1
#=GS A0A1G8IX75_9ACTN/352-673 AC A0A1G8IX75.1
#=GS A0A401UEI5_9BACT/310-648 AC A0A401UEI5.1
#=GS A0A1I4XJH0_9GAMM/320-674 AC A0A1I4XJH0.1
#=GS A0A1G5JBS8_9ACTN/297-658 AC A0A1G5JBS8.1
#=GS A0A1H6EYK8_9ACTN/280-613 AC A0A1H6EYK8.1
#=GS A0A1Z1WCL3_9ACTN/245-623 AC A0A1Z1WCL3.1
#=GS A0A5N8WGA2_9ACTN/307-664 AC A0A5N8WGA2.1
#=GS A0A432MRA2_9BACT/393-759 AC A0A432MRA2.1
#=GS A0A9W6MB92_9ACTN/291-631 AC A0A9W6MB92.1
#=GS A0A918CCC8_9ACTN/291-649 AC A0A918CCC8.1
#=GS A0A7H8K4B0_9ACTN/547-785 AC A0A7H8K4B0.1
#=GS I5C2I4_9BACT/304-650 AC I5C2I4.1
#=GS A0A1E7JMX0_9ACTN/468-710 AC A0A1E7JMX0.1
#=GS A0A086W769_9BURK/309-684 AC A0A086W769.1
#=GS A0A4U3L1E5_9BACT/309-675 AC A0A4U3L1E5.1
#=GS A0A926L5G4_9ACTN/452-696 AC A0A926L5G4.1
#=GS A0A3N4ZQA7_9ACTN/290-652 AC A0A3N4ZQA7.1
#=GS Q085Y2_SHEFN/316-666 AC Q085Y2.1
#=GS A0A0M2WP35_9BURK/341-706 AC A0A0M2WP35.1
#=GS A0A1Y3WB53_9BACT/318-648 AC A0A1Y3WB53.1
#=GS A0A6B3G8S7_9ACTN/439-685 AC A0A6B3G8S7.1
#=GS A0A0G4GDX5_VITBC/620-898 AC A0A0G4GDX5.1
#=GS A9WS36_RENSM/446-738 AC A9WS36.1
#=GS A0A233SJC7_STRDA/424-669 AC A0A233SJC7.1
#=GS A0A3Q9WIT5_9MICC/375-688 AC A0A3Q9WIT5.1
#=GS A0A918NB53_9ACTN/292-650 AC A0A918NB53.1
#=GS A0A5B8XQN1_9DELT/286-648 AC A0A5B8XQN1.1
#=GS A0A919L8I6_9ACTN/334-692 AC A0A919L8I6.1
#=GS A0A7U3UQ62_9ACTN/462-706 AC A0A7U3UQ62.1
#=GS A0A238Z6R7_9ACTN/297-672 AC A0A238Z6R7.1
#=GS A0A2Z5K1P2_9ACTN/285-652 AC A0A2Z5K1P2.1
#=GS A0A1A9IUZ0_9ACTN/296-654 AC A0A1A9IUZ0.1
#=GS A0A6I6JVE0_9BACT/308-654 AC A0A6I6JVE0.1
#=GS A0A505DG34_9ACTN/1-279 AC A0A505DG34.1
#=GS A0A5P8K1W5_9ACTN/298-656 AC A0A5P8K1W5.1
#=GS A0A931BA08_9ACTN/327-700 AC A0A931BA08.1
#=GS A0A0Q8RKI5_9BURK/314-692 AC A0A0Q8RKI5.1
#=GS A0A8J8FBW1_9BACT/310-671 AC A0A8J8FBW1.1
#=GS A0A923PPL6_9BACT/277-624 AC A0A923PPL6.1
#=GS A0A1N6FAJ0_9BACT/317-659 AC A0A1N6FAJ0.1
#=GS A0A2R4T1D3_9ACTN/289-648 AC A0A2R4T1D3.1
#=GS A0A4R6SVL2_9SPHI/317-682 AC A0A4R6SVL2.1
#=GS A0A419VUK3_9BACT/320-660 AC A0A419VUK3.1
#=GS A0A142XL31_9BACT/322-663 AC A0A142XL31.1
#=GS A0A1V0TS54_9ACTN/342-710 AC A0A1V0TS54.1
#=GS A0A364Y888_9BACT/308-670 AC A0A364Y888.1
#=GS A0A5B8VAG3_9BACT/305-666 AC A0A5B8VAG3.1
#=GS A0A2K8VBA4_9FLAO/304-661 AC A0A2K8VBA4.1
#=GS A8H1V5_SHEPA/317-657 AC A8H1V5.1
#=GS U1GK92_9ACTN/301-672 AC U1GK92.1
#=GS A0A7W5DTD2_9PORP/328-680 AC A0A7W5DTD2.1
#=GS A0A2D0NA32_FLAN2/311-682 AC A0A2D0NA32.1
#=GS A0A1Z1WAF4_9ACTN/296-656 AC A0A1Z1WAF4.1
#=GS A0A7K1UNR9_9MICC/297-662 AC A0A7K1UNR9.1
#=GS W2CH90_9BACT/317-660 AC W2CH90.1
#=GS A0A840PME6_9ACTN/270-630 AC A0A840PME6.1
#=GS A0A7W9MG56_9ACTN/284-630 AC A0A7W9MG56.1
#=GS A0A239NV32_9ACTN/487-726 AC A0A239NV32.1
#=GS A0A6F8YUD2_9ACTN/44-416 AC A0A6F8YUD2.1
#=GS A0A841DF84_PLAVE/281-628 AC A0A841DF84.1
#=GS A0A5P0YSB4_9ACTN/465-707 AC A0A5P0YSB4.1
#=GS A0AA36IN05_9DINO/463-711 AC A0AA36IN05.1
#=GS A0A919HEW6_9ACTN/552-815 AC A0A919HEW6.1
#=GS E1ICY4_9CHLR/285-651 AC E1ICY4.1
#=GS A0A8J7WMM8_9ACTN/449-711 AC A0A8J7WMM8.1
#=GS A0A939DG32_9GAMM/314-642 AC A0A939DG32.1
#=GS A0A939HEH4_9MICC/428-725 AC A0A939HEH4.1
#=GS A0A1H6A4X5_9ACTN/285-634 AC A0A1H6A4X5.1
#=GS A0A124HPY8_9ACTN/272-630 AC A0A124HPY8.1
#=GS A0A6N2I228_9ACTN/455-705 AC A0A6N2I228.1
#=GS A0A2K8PHS3_STRLA/301-666 AC A0A2K8PHS3.1
#=GS A0A7H5EYT5_9BACT/277-618 AC A0A7H5EYT5.1
#=GS A0A0C2B0V3_9ACTN/323-701 AC A0A0C2B0V3.1
#=GS A0A4S2TC09_9ACTN/303-668 AC A0A4S2TC09.1
#=GS A0A248JZS9_9PROT/339-710 AC A0A248JZS9.1
#=GS H5UV51_9MICO/337-703 AC H5UV51.1
#=GS A0A0T1SQE9_9ACTN/298-663 AC A0A0T1SQE9.1
#=GS A0A365ZN39_9ACTN/415-762 AC A0A365ZN39.1
#=GS A0A7W3TFK5_9ACTN/410-653 AC A0A7W3TFK5.1
#=GS A0A0C5FPS6_9ACTN/309-668 AC A0A0C5FPS6.1
#=GS A0A1D7QD33_9SPHI/320-682 AC A0A1D7QD33.1
#=GS A0A1I4ZZX1_9GAMM/308-668 AC A0A1I4ZZX1.1
#=GS A0A367EIE6_9ACTN/305-685 AC A0A367EIE6.1
#=GS A0A1I2M498_9ACTN/327-712 AC A0A1I2M498.1
#=GS A0A7H8JPB6_9ACTN/297-653 AC A0A7H8JPB6.1
#=GS A0A9X3YKT8_9GAMM/317-676 AC A0A9X3YKT8.1
#=GS A0A1I5B6T2_9FLAO/313-668 AC A0A1I5B6T2.1
#=GS A0A1M5GUX2_9BACE/319-654 AC A0A1M5GUX2.1
#=GS A0A562UQJ7_9ACTN/286-666 AC A0A562UQJ7.1
#=GS A0A2G3JZC3_9NEIS/316-685 AC A0A2G3JZC3.1
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A0A941IWZ4_9BACT/313-669 ............................id--FAQLSPSG.KRAIMGARGEVFT.VP.V....E.H...G.N.VR....................NI..TN.N.....SH.A....AERK.P.L..W..S.............P............K.G....D...K...IAWF..SD............K........N.G.K.........Y.E.............LM.....L.....T....T............Q..........D....G.....L....G...DVe....................sIGI..G..E................S..K...M..I.......W...E......P.CWS...P.DG.......K..YIAFVDDDVRIRVL................D................I....................S............T.....................K...................S.................I...............K..............TI...D...V...............A.................G.....N..........N.......Fe......rgD.......M.......G.......I......T...WSKDSKYLAY.AKA...........................GAN.H..F.R.RI..HI..W...S..S...........A............D........N................S...............V....K.....P..V...T..NAMA.DAFSPAWDRNGKQLYFL.AS..T.......D...L...G...L....E...S.....S.....Y....V...N.T.....S.V.M......S.P....D...D...A...RysA......YVIN..LNKA..D.K.S.....P..F....E..P....RS......D.........E..E...E.....V.......K......K.....E....E.E..PKEdadkkdskk................................................................kskdkeeetDKGITIDFE.......DIENRIMAM.P..M...P.K.RQYQyT.L.......A.GPE....GS...VFI.S...E.S..T.D...K.G.-----......................----N...TI.H..KF..T.L...K..E..R..E......S..K.E..F.V..............TD..A..R..SVS..ISA.NGKQ..M.LA.K.M.G.TSWKV----mgt......................................................................
A0A917HJ84_9SPHI/317-665 ..............................IYSADLSPDG.KRVTFGARGDVFT.VP.A....K.T...G.V.TR....................NL..TQ.S.....SG.A....HDRN.V.G..W..S.............P............D.G....R...W...VSFI..SD............R........T.G.E.........D.E.............LY.....I.....Q....Q............Q..........D....G.....A....A...PAk....................qLTK..G..G................R..V...Y..K.......F...N......P.IWS...P.DS.......K..YLLYGDRGQDLHIV................D................I....................Q............S.....................G...................T.................A...............T..............VV...A...H...............S.................D.....E..........G.......T.........V.......G.......S.......Y......T...FGPDSKWIAY.TTP..........................gKAR.E..F.T.VI..RL..Y...N..I...........V............T........R................K...............T....I.....T..V...T..DTWY.NSGQPEFSTDGKLLYFV.SQ..R.......D...F...N...P....T...Y.....S.....S....T...E.W.....N.H.A......Y.N....D...M...S...R..P......YFVR..LSAD..A.K.S.....P..F....A..E....ES......D.........E..V...V.....V.......K......R.....D....S.T..DDSkkedkg.....................................................................ekreesaKKEVTVVVDe.....dGLADRIESL.P..V...T.P.GSYS.G.L.......V.ATD...eG-...-VY.Y...S.S..S.S...R.G.-----......................---DR...KF.R..FF..S.L...T..D..K..K......E..T.E..I.-..............GN..F..G..SYS..VTP.DRKK..I.LF.R.T.S.DGFFIENL-g........................................................................
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A0A3G2JLI9_9ACTN/296-653 .....................fgeaspdht---------A.RGSAVCVRGGIHW.VT.H....R.S...G.P.AR....................AL..AA.T.....PG.V....RARM.P.R..AfrA.............A............G.E....E...W...AVWV..TD............A........E.G.D.........D.A.............LE.....F.....A....P............A..........T....G.....T....V...PGap.................prrLAA..G..Q................L..G...R..V.......M...E......L.AVA...P.DG.......S..RAAVAAHDGRLLLV................E................R....................E............T.....................G...................E.................V...............R..............EV...D...R...............S.................D.....D..........G.......E.........V.......S.......G.......L......T...FSPDSAWLAW.AHP...........................GPR.P..L.S.QL..RL..A...H..T...........T............D........L................S...............V....T.....E..A...T..PLRF.QDYAPAFTLDGRHLAFL.SN..R.......A...F...D...P....V...Y.....D.....E....H...V.F.....D.L.A......F.V....V...G...A...R..P......HLIT..LAAT..T.P.S.....P..F....G..P....QR......H.........G..R...S.....F.......E......T.....P....D.K..DETpd.............................................................................segTPATRIDLE.......GLADRIVPF.P..V...E.A.GRYS.T.L.......R.AAK....DG...VLW.L...R.H..P.V...Q.G.VLGAArah................pedPDPHT...EL.E..RY..D.L...A..Q..R..R......L..E.H..L.A..............PD..A..D..HFE..VSG.DGRR..V.LL.W.S.D.GRLRVV---pg.......................................................................
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A0A1S2Q7K9_9ACTN/295-663 ........................ldgisv------GETG.RASAVVVRGSLYW.LT.H....R.D...G.P.AR....................TI..TD.T.....PG.V....RVRL.P.E..M..L.............G............T.G....G...R...LAYI..TD............A........E.G.E.........D.A.............VE.....I.....A....Y............L..........P....R.....A....S...GDre.................prrPAS..G..G................L..G...R..V.......L...E......M.VSD...P.QG.......E..RLAIASNDGRLLLI................T................V....................Seeeaa.agtaepD.....................G...................E.................V...............T..............EL...V...R...............S.................V.....N..........G.......P.........V.......R.......D.......L......A...FSPDGAWLTW.SHP..........................gIGR.S..L.R.QI..KM..A...R..I...........K............D........R................L...............I....V.....D..V...T..NGRF.EDENPVFTSDGRYLAFL.SW..R.......G...F...D...P....V...Y.....D.....V....H...T.G.....D.L.S......F.P....L...G...C...R..P......YLVP..LSSA..T.P.S.....P..F....A..L....NP......E.........G..R...P.....A.......A......G.....G....L.D..PLEee..............................................................................egGGTVTVELE.......GLESRVTPF.P..V...A.A.SKYS.A.L.......R.PVA...gGG...LVW.L...R.W..P.I...S.G.ALGETfan................pddTTGRP...TL.E..HF..T.I...S..K..A..K......K..A.E..L.V..............SH..L..D..WFA..VSG.DGTR..L.VV.V.D.E.GVLRA----vpss.....................................................................
A0A0N1GEW4_9ACTN/360-733 ...........................vdg---VSVDETG.RASAVVVRGSLYW.LT.H....R.D...G.P.AR....................TI..AD.T.....PG.V....RVRL.P.E..M..L.............G............A.S....G...R...VAYV..TD............A........E.G.E.........D.A.............VE.....I.....A....S............L..........P....R.....A....S...GVra.................prrLAS..G..V................V..G...R..V.......Q...E......L.VAD...P.RG.......E..RIAIAAHDGRLLLL................D................V....................Gdad......eegT.....................G...................E.................V...............V..............EL...I...R...............S.................V.....N..........G.......P.........V.......R.......D.......M......A...FSPDGAWLTW.SHP..........................gIGR.S..L.R.QI..KM..A...R..I...........Agagt...gvgggT........G................A...............V....V.....D..V...T..NGRF.EDENPVFTRDGRYLAFL.SW..R.......G...F...D...P....V...Y.....D.....V....H...T.G.....D.L.S......F.P....L...G...C...R..P......YLVP..LSSA..T.P.S.....P..F....A..L....SP......D.........G..R...P.....A.......A......Gg..ldP....V.A..DEEn................................................................................aDGAVTVEIE.......GLESRVTPF.P..V...T.A.SKYS.A.L.......C.PVA...gGG...LVW.L...R.W..P.I...S.G.ALGETfan................pddTSGRP...TL.E..YF..N.I...T..K..A..K......K..S.E..L.V..............GH..L..D..WFA..VSG.DGSR..L.VV.V.D.E.DELRAV---pst......................................................................
D9X836_STRVT/1-173 .............................m----------.-------------.--.-....-.-...-.-.--....................--..--.-.....--.-....----.-.-..-..-.............-............-.-....-...-...----..--............-........-.-.-.........-.-.............--.....-.....-....-............-..........-....-.....-....-...--......................---..-..-................-..-...-..-.......-...-......-.---...-.--.......-..--------------................-................-....................-............-.....................-...................-.................-...............-..............--...-...-...............-.................-.....-..........-.......-.........-.......-.......-.......-......-...----------.---...........................---.-..-.-.--..--..-...-..-...........-............-........-................-...............-....-.....-..-...-..----.---------DGKHLAFL.ST..R.......S...F...D...P....V...Y.....D.....E....H...V.F.....D.L.A......F.V....E...G...A...R..P......HLIT..LAAT..T.P.S.....P..F....G..P....QR......H.........G..R...S.....F.......E......T.....P....D.R..EETpd.............................................................................segTPTTRIDLE.......GLADRIVPF.P..V...E.A.ARYS.N.L.......R.AAK....DG...VLW.L...R.H..P.V...A.G.VLGASrat................pddPDPKS...EL.E..RY..D.L...A..Q..Q..R......V..E.H..L.A..............VD..A..D..HFE..VSG.DGKR..V.LL.W.T.D.GRLKVV---psd......................................................................
A0A1V4CXM2_9ACTN/303-666 .............................i-DSLSVDTTG.RASAVCVRGSLYW.LT.H....R.D...G.P.AR....................TL..AD.T.....PG.V....RVRL.P.V..M..L.............G............S.T....G...R...VAYL..TD............A........E.G.E.........D.A.............IE.....I.....A....H............L..........P....R.....A....A...GPte.................prrLAG..G..Q................L..G...R..V.......H...E......L.EPS...P.DG.......D..LLAVAASDGRLLLV................D................T....................Sp.........dgD.....................G...................G.................V...............T..............EL...I...R...............S.................D.....N..........G.......P.........V.......G.......D.......L......A...FAPDSAWLAW.SHP..........................gIGR.T..L.R.SI..KI..A...R..L...........A............D........R................T...............T....V.....D..V...T..NGRF.EDEEPVFTSDGRYLAFL.SW..R.......G...F...D...P....V...Y.....D.....V....H...T.G.....D.L.S......F.P....L...G...C...R..P......YLVP..LSSA..T.P.S.....P..F....A..L....SP......E.........G..R...P.....A.......A......G.....G....L.D..PDVsgg...........................................................................egdgDGTVTVEVE.......GLASRVTAF.P..V...S.A.SKYS.S.L.......R.PVS...gGG...LVW.L...R.W..P.I...S.G.VLGETfan................pgeTSNRP...TL.E..HF..D.L...T..K..A..K......R..S.E..L.T..............GE..L..D..WFV..VSG.DGTR..L.VA.Y.D.D.DELRAM---pat......................................................................
A0A944HK68_9ACTN/327-688 ............................lg--DAAPDHTG.RGSAVEVRGGIHW.VT.H....R.G...G.P.AR....................AL..AV.E.....PG.V....RARL.P.R.tF..R.............V............D.G....E...E..hVVWV..TD............A........E.G.D.........D.A.............LE.....F.....A....P............A..........T....G.....A....A...AGap.................prrLAA..G..R................L..G...R..V.......L...S......L.AVA...P.DG.......S..RAAVASHDGRVLLV................E................R....................E............S.....................G...................E.................V...............R..............EV...D...R...............S.................E.....H..........G.......D.........A.......Q.......G.......L......V...FSPDSGWLAW.SHP...........................GPS.P..L.R.QI..KL..A...N..T...........G............D........L................T...............V....S.....E..A...T..PLRF.ADFQPAFTLDGRHLAFL.SE..R.......A...F...D...P....V...Y.....D.....T....H...V.F.....D.L.A......F.I....G...G...C...R..P......HLIT..LAAT..T.P.S.....P..F....G..P....QR......H.........G..R...A.....F.......D......S.....D....K.D..GPSdsat..........................................................................degaAPVTRIDLD.......GLADRIVPF.P..V...E.A.ARYS.T.L.......R.AAK....DG...LLW.L...R.H..P.L...R.G.VLGTArat................pddPGPKT...VL.E..RY..D.L...A..Q..Q..H......V..E.E..L.S..............GD..A..A..YFR..VSG.DGRR..V.LL.H.T.D.DKLKVV---psd......................................................................
A0A0S2K814_9GAMM/307-681 ............................ak--NASLSPSG.KRALFESRGEIFT.VP.V....E.H...G.S.TR....................NL..TK.D.....HS.S....ADRA.P.I..W..S.............P............K.G....D...K...IAWF..SD............E........G.E.Q........gY.K.............LV.....L.....Q....N............Q..........D....G.....M....G...ERk....................tISI..G..E................S..K...M..A.......W...E......P.QWS...P.DG.......K..YIAFVDDDVRYRLV................D................L....................E............S.....................E...................T.................I...............K..............TI...DvggN...............N.................L.....E..........R.......G.........R.......T.......G.......L......T...WAPDSKWLAY.AKQ...........................ADN.G..F.K.QI..KV..W...S..L...........E............E........G................Q...............S....R.....A..I...T..NRMA.NSVSPAWDQSGKHLFFL.AS..T.......Dy.gL...D...S....G...W.....A.....N....T...-.S.....S.M.S......A.D....H...E...Y...A..P......YIIN..LAKD..L.D.S.....P..F....A..L....RS......D.........E..E...K.....V.......K......K.....E....A.K..PDEgkadadkkadkaess...................................................dkpkdatkkkegkdkkKDGVVVSIDf.....dSIERRIMPL.P..M...P.E.GRYS.G.V.......I.HGP...kGS...VFF.A...K.R..A.D...K.G.-----......................--WSF...SL.H..KY..S.V...K..K..R..E......A..K.P..Y.V..............SG..I..S..DVN..ISA.DTKK..L.IV.K.K.G.RSWHVVDA-t........................................................................
A0A2U9P1M5_STRAS/288-646 .........................fssas-----PDHTA.RGSAVCVRGSVHW.VT.H....R.A...G.P.AR....................AL..AA.E.....PG.V....RARR.P.R.aF..R.............V............D.G....E...D..wVVWV..TD............A........E.G.D.........D.A.............LE.....F.....A....P............A..........G....G.....L....A...PGat.................prrIAA..G..Q................L..G...R..V.......L...D......L.AVA...P.DG.......S..RAAVASHDGRVLLV................E................R....................E............S.....................G...................E.................V...............R..............EV...D...R...............S.................E.....D..........G.......D.........V.......S.......G.......L......T...FSPDSVWLAW.AHP...........................GPR.P..L.S.QL..KL..A...N..T...........T............D........L................S...............V....T.....E..A...T..PLRF.QDYAPAFTLDGKHLAFL.SS..R.......S...F...D...P....I...Y.....D.....E....H...V.F.....D.L.A......F.L....E...T...S...R..P......YLIT..LAAT..T.P.S.....P..F....G..P....QR......H.........G..R...P.....F.......D......A.....P....E.K..DETpe.............................................................................gesGPATRIDLD.......GLADRIVPF.P..V...E.A.ARYS.N.L.......R.AAK....DG...VLW.L...R.H..P.V...R.G.VLGASrat................pddPDPKT...EL.E..RY..D.L...A..Q..Q..R......L..E.H..L.A..............SD..A..D..HFE..VSG.DGKR..L.LL.W.A.D.DRLRVV---psd......................................................................
A0A316TW36_9BACT/307-662 ............................ia--RMTAAPGG.KRIVFEARGELFN.VP.A....S.D...G.Y.TS....................NL..TR.S.....SG.A....FDHN.P.A..W..S.............P............D.G....T...T...LAYW..SD............K........D.G.E.........Y.E.............IY.....L.....H....N............M.........tD....G.....S....E...PQ.....................kLSD..R..G................E..G...Y..G.......Y...S......L.NWS...P.DS.......E..KLAFIDETNTIYVI................D................A....................E............N.....................G...................R.................V...............R..............EA...G...H...............T.................N.....W..........N.......I.........G.......H.......Ngry.gyvL......S...WSPDSKWLAF.TRG...........................LEN.A..Q.Y.AV..ML..Y...D..T...........E............E........N................E...............L....H.....Q..A...T..TGFY.SDSSPVFSADGNYLFYA.SN..R.......E...F...S...S....V...Y.....S.....D....M...D.N.....T.W.V......Y.P....N...S...T...Q..L......VTVS..LTGD..I.P.S.....L..L....P..P....KN......D.........V..V...E.....V.......T......G.....G....E.E..EAGengn.........................................................................gngddEEEMSVSIDf.....dGFESRITEI.P..V...P.A.GNIG.N.L.......M.AFD....GK...LVY.L...R.Y..P.N...S.G.S----......................GGGSP...SL.M..AF..D.F...E..K..R..E......Q..I.T..I.M..............ES..V..N..RAQ..PTA.DGKA..I.LV.Q.S.N.GRFGVIQ--pq.......................................................................
A0A197SUK6_9ACTN/292-654 ..........................vdal----SVDTTG.RASAVVVRGSLYW.LT.H....R.D...G.P.AR....................TI..TD.T.....AG.V....RVRL.P.E..M..L.............G............T.G....G...Q...VAYV..TD............A........D.G.E.........D.A.............VE.....I.....A....Y............L..........P....R.....A....S...GDre.................prrLAS..G..E................V..G...R..V.......Q...E......L.LSD...P.EG.......E..RLAIASHDGRLLLI................D................A....................Te.........esN.....................G...................E.................V...............T..............EL...I...R...............S.................I.....N..........G.......P.........V.......R.......D.......L......A...FSPDGNWLTW.SHP..........................gIGR.S..L.R.QI..KM..A...R..I...........A............Gp.....gaR................V...............I....V.....D..V...T..NGRF.EDENPVFTRDGRYLAFL.SW..R.......G...F...D...P....V...Y.....D.....V....H...T.G.....D.L.S......F.P....L...G...C...R..P......YLVP..LSSA..T.P.S.....P..F....A..L....LP......D.........G..R...P.....A.......A......G....gL....D.P..LEEs................................................................................gDGTVTVEVE.......GLESRVTPF.P..V...A.A.SKYS.A.L.......H.PVS...gGG...LVW.L...R.W..P.I...S.G.ALGETfan................padTSGRP...TL.E..HF..D.I...T..K..A..R......K..T.E..L.V..............DH..L..D..WFA..VSG.DGSR..L.VV.V.D.E.GDLRAV---pat......................................................................
TRI1_STRCO/292-650 .....................fgsaspdht---------A.RGSAVAVRGGVHW.VT.H....R.S...G.P.AR....................AL..AA.T.....PG.V....RNRL.P.R.tF..R.............V............D.G....E...E..wVVWV..TD............A........E.G.D.........D.A.............LE.....F.....A....P............A..........T....G.....L....A...PGat.................arrLAA..G..Q................L..G...R..V.......L...H......L.AVA...P.DG.......S..RVAVASHDGRVLLV................E................R....................E............S.....................G...................E.................V...............R..............EV...D...R...............S.................E.....D..........G.......D.........A.......S.......G.......L......V...FSPDSSWLAW.SHP...........................GPE.P..L.R.QL..KL..A...N..T...........T............D........L................S...............V....S.....E..A...T..PLRF.KDYSPAFTLDGKHLAFL.ST..R.......S...F...D...P....V...Y.....D.....E....H...V.F.....D.L.A......F.V....E...G...A...R..P......YLIT..LAAT..T.P.S.....P..F....G..P....QR......H.........G..R...P.....F.......E......T.....P....D.R..EETpd.............................................................................segTPTTRIDIE.......GLADRIVPF.P..V...E.A.ARYS.R.L.......R.AAK....DG...VLW.L...R.H..P.L...T.G.VLGASran................pedPDPNT...EL.E..RY..D.L...A..Q..Q..R......V..E.H..L.G..............GD..A..D..HFE..VSG.DGKR..V.LL.W.T.D.GRLKVV---psd......................................................................
A0A5S5BX35_9FLAO/312-673 .............................i-RSAGISPSG.ARAVFDFRGEIIT.VP.A....E.K...G.D.VN....................NL..TN.T.....PG.V....HEKY.P.T..W..S.............P............D.A....K...H...IAYF..SD............A........S.G.E.........Y.A.............LH.....L.....K....S............T.........aN....G.....N....V...IN......................LPL..S..G................T..G...F..Y.......A...Y......L.HWS...P.DS.......K..KLCFVDNGRNLYVT................D................V....................A............S.....................K...................K.................V...............T..............KI...A...T...............Dv..............lyQ.....P..........G.......A.........F.......R.......D.......Lf....gS...WSHDSNWVSY.TIV...........................TET.N..F.E.QA..FA..Y...S..V...........D............Q........N................K...............S....Y.....A..I...S..DGLS.NVSEPVFDPSGKYLYMT.AS..T.......D...A...G...P....V...V.....N.....W....F..dQ.S.....N.Q.D......M.E....L...S...N...A..I......YVVT..LQKD..L.I.S.....P..L....I..K....EN......D.........V..E...E.....V.......K......A.....I....A.E..EEEekdeankkd................................................................kkkdkkkteIKPLRIDWE.......GIQNRIINL.P..I...P.T.GIYS.N.L.......T.SVE...eGK...LMY.L...S.Q..K.A...H.S.SFR--......................--DPQ...SL.M..RF..D.F...E..E..R..K......A..E.E..V.-..............ME..A..D..SFE..ISA.DGKK..M.MF.R.K.G.DAWGITE--vg.......................................................................
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A0A5R9JCC6_9PROT/347-694 .............................i--DYALSPNG.KRALFSARGDLFS.VP.A....E.H...G.A.IR....................NL..TH.S.....SN.A....DEDH.P.A..W..S.............P............D.G....S...Q...VAYS..TD............G........S.G.N.........Q.Q.............IA.....V.....R....P............A..........A....G.....G....P...ER.....................lLTH..F..P................G..G...F..F.......Y...T......P.VWS...P.DG.......R..SLAFPDGEHRLWIV................G................L....................D............G.....................S...................A.................P...............R..............QV...A...S...............D.................P.....V..........S.......E.........I.......H.......D.......A......A...WSPDGKWLAY.SIA...........................RNQ.V..E.R.GI..YL..Y...D..V...........A............G........G................H...............A....T.....K..V...S..SDFE.NDSDPVFSPNGKYLFFV.SA..R.......H...E...N...P....T...L.....S.....E....T...E.F.....N.I.A......T.I....K...Q...S...G..I......YAAT..LARD..T.A.S.....P..F....A..P....RS......E.........E..G...A.....W.......K......Q.....D....K.K..ADDagw...........................................................................hpgaSPPVHIDLD.......GLMARAVPL.P..V...P.A.MDIA.A.L.......D.ARG....DR...VFY.Q...S.T..P.P...Q.M.IEGPL......................PGEKP...AL.H..AY..D.M...E..K..R..H......D..E.T..I.V..............EG..L..D..GYA..LAA.DGAH..V.LV.K.E.G.PGYSI----detk.....................................................................
A0A2V1IVN4_9BACT/309-644 ............................ir--AVSTSPDG.RRMAVTARGEVFD.IP.V....K.E...G.V.TR....................CI..TL.T.....PG.A....NERN.A.T..W..S.............P............D.G....R...S...IAYI..SD............R........T.G.E.........T.E.............IW.....L.....Q....P............A..........E....G.....G....E...PR.....................qLTK..D..N................D..T...Y..I.......R...N......L.QWS...P.DS.......R..HILYTDRKNRIVEV................D................P....................A............G.....................G...................S.................K...............R..............TV...R...Q...............N.................P.....E..........G.......E.........F.......F.......D.......V......A...YSPDSRWITY.TRS...........................GAN.N..M.S.VV..YV..M...N..L...........A............S........G................E...............E....I.....A..V...T..DKWY.DSSSPVFSSDGRYLIFS.SA..R.......D...F...N...P....I...Y.....S.....R....T...E.W.....N.H.A......Y.G....N...M...D...C..L......YIAL..LEAS..T.P.S.....P..L....L..P....SD......P.........A..V...A.....T.......A......E.....Q....P.E..KATgsk............................................................................teaSNAPTVRIDp.....dGISGRIVRL.P..L...P.T.SWYA.N.I.......Y.SDG....HR...VWY.Y...-.-..-.-...S.G.-----......................----G...ST.K..VF..D.L...A..T..Q..K......E..E.T..V.A..............ER..A..-..SME..VSP.DGKT..A.TF.V.R.G.NDIFV----tplt.....................................................................
A0A518D1Z2_9BACT/320-736 ............................va--SASPGPTG.ARVVIEARGELFD.AP.A....D.E...G.F.TR....................AL..TR.S.....SG.V....AERS.P.A..W..S.............P............D.G....A...W...IAYF..SD............R........T.G.E.........Y.E.............LT.....V.....K....R............A..........D....G.....G....D...FEgane.............hgertLSN..L..G................A..G...F..R.......S...N......I.TWA...P.DA.......H..KLVFTDNAGQLWLA................T................C....................Ddw.......gsgD.....................V...................T.................I...............A..............TI...A...V...............D.................P.....A..........G.......N.........P.......L.......G.......A......S...WSPGSDWLTY.SHK..........................hPVT.R..N.G.AV..FL..H...E..L...........A............T........G................T...............T....T.....C..V...T..SGAF.DDSSPAFGANGDFLYYA.SA..R.......H...F...T...G...aL...Y.....A.....D....Q...D.S.....T.W.I......Y.N....G...T...Q...V..L......IAVP..LRAD..V.D.V.....P..L....V..P....TN......D.........E..E...P.....I.......E......T.....D....E.D..ASDdgaaaddepaddasdaaddasddtsddtsddd.................tsddgtsddgtsddgateaddgasevdaddeetDEALVIDVD.......GFEARGIQI.P..I...D.P.GRIS.A.L.......V.GTS....KG...LLF.V...R.T..T.P...R.G.V----......................-SGAP...RL.V..LL..D.T...E..E..W..E......E..A.T..V.I..............ER..L..S..GFD..VCS.RADK..L.LL.M.R.G.NSIAIVD--la.......................................................................
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