#=GF ID   UL141
#=GF AC   PF16758.12
#=GF DE   Herpes-like virus membrane glycoprotein UL141
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_4i9x
#=GF GA   35.00 35.00;
#=GF TC   37.80 57.20;
#=GF NC   34.00 30.60;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF WK   Immunoglobulin_V-set_domain
#=GF CL   CL0159
#=GF RN   [1]
#=GF RM   23555243
#=GF RT   Structure of human cytomegalovirus UL141 binding to TRAIL-R2
#=GF RT   reveals novel, non-canonical death receptor interactions.
#=GF RA   Nemcovicova I, Benedict CA, Zajonc DM;
#=GF RL   PLoS Pathog. 2013;9:e1003224.
#=GF DR   INTERPRO; IPR031918;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   UL141 is a family of glycoproteins from herpesvirus species. At
#=GF CC   it N-terminus it carries an Ig-like beta-sandwich domain, which
#=GF CC   binds to the cysteine-rich region of TRAIL-R2, a family of
#=GF CC   tumour necrosis factor receptor proteins. UL141 is both
#=GF CC   necessary and sufficient to retain TRAIL receptors in the ER,
#=GF CC   thereby preventing their cell surface expression and it is also
#=GF CC   necessary and sufficient to inhibit cell surface expression of
#=GF CC   CD155 [1].
#=GF SQ   14
#=GS G8XTJ5_SCMVC/38-227       AC G8XTJ5.1
#=GS G8XU86_9BETA/44-225       AC G8XU86.1
#=GS I3WF29_RHCM6/102-291      AC I3WF29.1
#=GS Q8QS73_9BETA/52-238       AC Q8QS73.1
#=GS A0A7T7IJT8_9BETA/39-228   AC A0A7T7IJT8.1
#=GS UL14_HCMVA/48-234         AC P16756.2
#=GS A0A7T7IJR2_9BETA/39-232   AC A0A7T7IJR2.1
#=GS Q8QRX2_9BETA/58-274       AC Q8QRX2.1
#=GS UL14_HCMVM/48-234         AC Q6SWB7.1
#=GS G8XT87_SCMVC/38-231       AC G8XT87.1
#=GS A0A0K1GZS0_9BETA/35-227   AC A0A0K1GZS0.1
#=GS A0A0K1GZN8_9BETA/102-291  AC A0A0K1GZN8.1
#=GS UL141_HCMVM/51-241        AC Q6RJQ3.2
#=GS Q7TFU8_RHCM6/35-227       AC Q7TFU8.1
G8XTJ5_SCMVC/38-227                  ..SPAPLIMPLGSRITVPCTFLPHSWPMISIRARFCQSE..YAGYELVVNVTN.GTLDTDGLTSLLH.....NA.SWKFVDMTLGHS.VSLSFNITDNTTGMFDCLLRNETHGYMTTRFTVITQIETLHRPGEIECVPKLGLRPDGDKIWTTEYNEWQRHNCGTFY..GF.....DRLYY..YLAATN..........K.....-SNTKPPC.P.PN.EPDRCWPVVQRY..............
G8XU86_9BETA/44-225                  sv--GPLLAGHGEKISIPCFSHTTGQYMTGLYVVFCARH..--IQNAVLLFRN.GTKFLDTLSKHHA....rHG.TIVYHNSTAGTSfLQFSFTFEEKMAGRYNCLISNLTHTVVTTRFTLLDRVLSHRYRKYDVPNMVLPTHANTTQVWSAYPNKLHHLTCVTSK..HT.....IYDVF..YIYTAM..........S.....--------.-.--.------------tvscqhlskacrhl
I3WF29_RHCM6/102-291                 ..SPAPLIMPIGSQVTVPCAFLPHSWPMVSIRARFCQSE..YGGYELKINATN.GTVVDDDLTYRLI.....NA.SWKFHDLAISHY.VTLTMNISDNTTGMFDCVLRNATHGFLMTRFTIVTQIETLHRLGDPDCAPKLGFHADGKKIWSAEYNEWQRHQCGTFY..GF.....DRLYY..YLAASN..........Q.....-SNTKPPC.P.PS.EPDRCWPVLQQY..............
Q8QS73_9BETA/52-238                  .l-SSPKMLPYGDRLDVSCIFPSHAWPEVSIHVRLCYWP..EIVRSLVVDAHS.GQLLHNDVTCQIS.....SG.RWSFEDGGAAQT.LTLSFRLITQTAGTYHCVLGNETHGVVTESTALVADVHELQKTDR-SCDLAFGSRTQTKYLWTPDPSKLRSRDCGWEG..ER.....HRLVH..YIPGSS..........G.....---EEPSC.E.EN.EHQLCVPFIWK-s.............
A0A7T7IJT8_9BETA/39-228              ..SPAPLIMPLGSQITIPCTFLPHSWPMVSIRARFCQSE..YAGHELIVNVTN.GTLVRDDLTGRLS.....NA.SWDFVNLGLAHY.ITLNLNVTNNATAMFDCVLRNDTHGRVTKRFTVITFVETLQRPGEPDCRPKLGFNSDGDRIWTSEHNEWQRQTCGTFY..GF.....DRVFY..YLAKTN..........H.....SNHNLP-C.P.PS.APDRCWPVVQQY..............
UL14_HCMVA/48-234                    ..PGSPQLLPYGDRLEVACIFPAHDWPEVSIRVHLCYWP..EIVRSLVVDARS.GQVLHNDASCYIA.....GG.RWRFEDGGAAQR.LSLSFRLITETAGTYTCVLGNETHSLATETTALVADVHDLRHSDR-SCDLAFGSRSQTRYLWTPDPSRLRSINCGWEG..ER.....HRVVH..YIPGTS..........G.....---LLPSC.E.ED.ERELCVPFISQS..............
A0A7T7IJR2_9BETA/39-232              .v-SAPTMPPYGDRFNLTCEFPTGGWTEAAVQIRFCNTP..NCRSLLLVNSKQvTGEFQNKSHEQLQ.....EL.QWKLETEGPVQK.LTVSFLVTSNVSGIYQCAIVNKMDMDVLKTMVVIAEVELRRRPHV-YCDLQFGEQSQTQYLWTPDPEKVRLVNCGEVG..GLvkntwHKHLH..YAVGNS..........G.....---MQPPC.DlER.DMSLCHSYVF--qs............
Q8QRX2_9BETA/58-274                  ..SPAPMLVAEGERVTVPCTVMIHQWPLAVIRATFCLSPptERSVELVFNLSR.GGEVVVPLEEKLTesrlrGGvSYNFTDLHVAHL.FSLTFRATASSAGVYECLLRNDSHALVLQRFVVLTHLETLSWADEPCCTPPLGRHSQDRQIWSPTPWRLKHVDCGWSSqmGF.....RRNRF..YIEPASigdgteinidAgegedEECWGPLCqP.EE.QPDRCWPVVRQY..............
UL14_HCMVM/48-234                    ..PGSPQLLPYGDRLEVACIFPAHDWPEVSIRVHLCYWP..EIVRSLVVDARS.GQVLHNDASCYIA.....GG.RWRFEDGGAAQR.LSLSFRLITETAGTYTCVLGNETHSLATETTALVADVHDLRHSDR-SCDLAFGSRSQTRYLWTPDPSRLRSINCGWEG..ER.....HRVVH..YIPGTS..........G.....---LLPSC.E.ED.ERELCVPFISQS..............
G8XT87_SCMVC/38-231                  .v-SAPLMPPYGDRFDLTCEFPTGGWQEAALQIRFCHHP..GCRSLLMVNPRDvTGQFQNKNHEYLP.....EL.QWKMETDGPVQR.LTVSFVVTSSVSGVYQCTVANGLTMEVLKTMVIISEVELRRRPHV-YCDIRFGHRSQIRYLWTPDPEKVRLVNCGEVR..GN.....VRNTWhkHLHYAV..........G.....ESGLQPSC.S.MDrDMSLCHRY----vfes..........
A0A0K1GZS0_9BETA/35-227              .v-SAPLMPPYGDRFNLTCDFPTGDWSEAALQIRFCYHP..SCRSFLMVTPKDiNGEFKNKSDNHLP.....EL.QWKLETVGPVQR.LTVSFLVVSSVSGIYRCTILTGINIEVLKTVIIIADVELRRRPDT-YCDIRFSHLSQLQYLWTPNPDKVRLLNCGEVR..ERns.lwQKHVH..YAVGMS..........G.....---LEPSC.T.VNrDMVLCH------ryvaes........
A0A0K1GZN8_9BETA/102-291             ..SPAPLIMPIGSQVTVPCAFLPHSWPMVSIRARFCQSE..YGGYELKINATN.GTAVDDDLTHRLI.....NA.SWKFHDLAISHY.VTLTMNISDNTTGMFDCVLRNATHGFLTSRFTIVTQIETLHRPGDPDCAPKLGFHADGKKIWSSEYNEWQRHQCGTFY..GF.....DRLYY..YLAANN..........Q.....-SNTKPPC.P.PS.EPDRCWPVLQQY..............
UL141_HCMVM/51-241                   ..SPAPVLVAEGEQVTIPCTVMTHSWPMVSIRARFCRSH..DGSDELILDAVK.GHRLMNGLQYRLP.....YA.TWNFSQLHLGQI.FSLTFNVSTDTAGMYECVLRNYSHGLIMQRFVILTQLETLSRPDEPCCTPALGRYSLGDQIWSPTPWRLRNHDCGMYR..GF.....QRNYF..YIGRAD..........A.....EDCWKPAC.P.DE.EPDRCWTVIQRY..............
Q7TFU8_RHCM6/35-227                  .v-SAPLMPPYGDRFNLTCDFPTGDWSEAALQIRFCYHP..SCRSFLMVTPKDiNGEFKNKSDNHLP.....EL.QWKLETVGPVQR.LTVSFLVVSSVSGIYRCTILTGINIEVLKTVIIIADVELRRRPDT-YCDIRFSHLSQLQYLWTPNPDKVRLLNCGEVR..ERns.lwQKHVH..YAVGMS..........G.....---LEPSC.T.VNrDMVLCH------ryvaes........
#=GC seq_cons                        ...sAPllhPhG-RlslsCtF.sHuWP.suI+sRFChp...tssppLlVssps.GshhpschsppLs.....pu.pW+Fcshusupp.loLSFplssssuGhYcClLtNtoHuhlhpphsllscVEsL+Rscc.sCs.thGp+SpschlWTP-Ps+l+phsCGpht..th.....cRhha..Ylsuss..........u........hpPsC.s..s.-.shCashl.p...............
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