#=GF ID UQ_con
#=GF AC PF00179.30
#=GF DE Ubiquitin-conjugating enzyme
#=GF AU Ponting CP;0000-0003-0202-7816
#=GF AU Schultz J;
#=GF AU Bork P;0000-0002-2627-833X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE Prosite
#=GF GA 27.00 27.00;
#=GF TC 27.00 27.00;
#=GF NC 26.90 26.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF WK Ubiquitin-conjugating_enzyme
#=GF CL CL0208
#=GF RN [1]
#=GF RM 1321826
#=GF RT Three-dimensional structure of a ubiquitin-conjugating enzyme
#=GF RT (E2).
#=GF RA Cook WJ, Jeffrey LC, Sullivan ML, Vierstra RD;
#=GF RL J Biol Chem 1992;267:15116-15121.
#=GF RN [2]
#=GF RM 8268156
#=GF RT Tertiary structures of class I ubiquitin-conjugating enzymes are
#=GF RT highly conserved: crystal structure of yeast Ubc4.
#=GF RA Cook WJ, Jeffrey LC, Xu Y, Chau V;
#=GF RL Biochemistry 1993;32:13809-13817.
#=GF RN [3]
#=GF RM 9048545
#=GF RT Crystal structure of a class I ubiquitin conjugating enzyme
#=GF RT (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms
#=GF RT resolution.
#=GF RA Cook WJ, Martin PD, Edwards BF, Yamazaki RK, Chau V;
#=GF RL Biochemistry 1997;36:1621-1627.
#=GF RN [4]
#=GF RM 9241264
#=GF RT TSG101 may be the prototype of a class of dominant negative
#=GF RT ubiquitin regulators.
#=GF RA Koonin EV, Abagyan RA;
#=GF RL Nat Genet 1997;16:330-331.
#=GF RN [5]
#=GF RM 9253709
#=GF RT The breast cancer gene product TSG101: a regulator of
#=GF RT ubiquitination?
#=GF RA Ponting CP, Cai YD, Bork P
#=GF RL J Mol Med 1997;75:467-469.
#=GF RN [6]
#=GF RM 18276160
#=GF RT Anatomy of the E2 ligase fold: implications for enzymology and
#=GF RT evolution of ubiquitin/Ub-like protein conjugation.
#=GF RA Burroughs AM, Jaffee M, Iyer LM, Aravind L;
#=GF RL J Struct Biol. 2008;162:205-218.
#=GF DR INTERPRO; IPR000608;
#=GF DR PROSITE; PDOC00163;
#=GF DR SCOP; 1aak; fa;
#=GF DR SMART; UBCc;
#=GF DR HOMSTRAD; uce;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Proteins destined for proteasome-mediated degradation may be
#=GF CC ubiquitinated. Ubiquitination follows conjugation of ubiquitin
#=GF CC to a conserved cysteine residue of UBC homologues. TSG101 is one
#=GF CC of several UBC homologues that lacks this active site cysteine
#=GF CC [4, 5].
#=GF SQ 73676
#=GS F4X7Q3_ACREC/20-157 AC F4X7Q3.1
#=GS A0A8I6THZ4_CIMLE/14-151 AC A0A8I6THZ4.1
#=GS A0A0D3CA42_BRAOL/8-145 AC A0A0D3CA42.1
#=GS A0A168IAF5_MUCCL/5-142 AC A0A168IAF5.1
#=GS A0A6J0CXI2_PERMB/2-138 AC A0A6J0CXI2.1
#=GS A0A7K4PQ19_MELMO/3-104 AC A0A7K4PQ19.1
#=GS A0A8B7BW82_PHODC/8-145 AC A0A8B7BW82.1
#=GS A0A0B1TJD7_OESDE/11-100 AC A0A0B1TJD7.1
#=GS A0A7J0FM44_9ERIC/21-66 AC A0A7J0FM44.1
#=GS A0A6P3FBB5_OCTDE/16-144 AC A0A6P3FBB5.1
#=GS F6Q6J4_MONDO/25-139 AC F6Q6J4.2
#=GS A0A7K9JZE5_9PASE/4495-4653 AC A0A7K9JZE5.1
#=GS A0A1U8BC43_NELNU/9-144 AC A0A1U8BC43.1
#=GS W5NAD5_LEPOC/206-360 AC W5NAD5.1
#=GS A0A091J377_EGRGA/815-965 AC A0A091J377.1
#=GS A0A8C8IUF9_ONCTS/311-447 AC A0A8C8IUF9.1
#=GS A0A8H7QP90_9FUNG/9-134 AC A0A8H7QP90.1
#=GS A0A2K6RFK5_RHIRO/36-174 AC A0A2K6RFK5.1
#=GS A0A5J5DNE8_9PERO/23-164 AC A0A5J5DNE8.1
#=GS A7RUX3_NEMVE/36-172 AC A7RUX3.1
#=GS A0A401L8K6_ASPAW/2-144 AC A0A401L8K6.1
#=GS G1N8H6_MELGA/14-147 AC G1N8H6.2
#=GS A0A6P8PFV7_GEOSA/6-147 AC A0A6P8PFV7.1
#=GS A0A3M0JAV6_HIRRU/2-110 AC A0A3M0JAV6.1
#=GS A0A8H4NHB3_9HYPO/11-165 AC A0A8H4NHB3.1
#=GS A0A8C4U4Z6_FALTI/8-145 AC A0A8C4U4Z6.1
#=GS A0A3N4LCP7_9PEZI/869-996 AC A0A3N4LCP7.1
#=GS A0A161WD49_9PEZI/71-208 AC A0A161WD49.1
#=GS A0A834XM05_9HYME/6-144 AC A0A834XM05.1
#=GS A0A6A2ZKM5_HIBSY/9-146 AC A0A6A2ZKM5.1
#=GS Q9LIY1_ORYSJ/51-187 AC Q9LIY1.1
#=GS A0A8H5H4F8_9AGAR/16-131 AC A0A8H5H4F8.1
#=GS A0A2K6E434_MACNE/16-144 AC A0A2K6E434.1
#=GS D3BBH9_POLPP/87-226 AC D3BBH9.1
#=GS A0A8B7TF81_HIPAR/8-51 AC A0A8B7TF81.1
#=GS A0A5N7BGW4_9EURO/835-988 AC A0A5N7BGW4.1
#=GS A0A674K9S0_TERCA/15-114 AC A0A674K9S0.1
#=GS A0A8B7NW88_HYAAZ/52-178 AC A0A8B7NW88.1
#=GS A0A368G1I0_ANCCA/13-140 AC A0A368G1I0.1
#=GS A0A8C2W7G0_CHILA/6-144 AC A0A8C2W7G0.1
#=GS A0A667YN81_9TELE/8-142 AC A0A667YN81.1
#=GS A0A7K6FNZ9_9CORV/4487-4645 AC A0A7K6FNZ9.1
#=GS A0A559M1P6_9HELO/18-119 AC A0A559M1P6.1
#=GS A0A8C8GM29_ONCTS/11-141 AC A0A8C8GM29.1
#=GS C9JFD2_HUMAN/36-141 AC C9JFD2.1
#=GS A0A5N6Q2L3_9ASTR/17-141 AC A0A5N6Q2L3.1
#=GS A0A5N6TQ48_9EURO/36-174 AC A0A5N6TQ48.1
#=GS A0A6A6YH70_9PEZI/1-105 AC A0A6A6YH70.1
#=GS A0A835WKH3_9CHLO/15-152 AC A0A835WKH3.1
#=GS A0A2G8K2I7_STIJA/115-269 AC A0A2G8K2I7.1
#=GS A0A8J5GVI4_ZINOF/8-56 AC A0A8J5GVI4.1
#=GS A0A7M7R6Q2_APIME/32-176 AC A0A7M7R6Q2.1
#=GS A0A1C7NB04_9FUNG/76-220 AC A0A1C7NB04.1
#=GS A0A851KXD0_VIDCH/1-146 AC A0A851KXD0.1
#=GS A0A2K6PI21_RHIRO/1-135 AC A0A2K6PI21.1
#=GS A0A8C9ZYY0_SANLU/5-142 AC A0A8C9ZYY0.1
#=GS Y1A1_ENCCU/36-191 AC Q8SSK3.1
#=GS A0A4S4MDK3_9AGAM/5-142 AC A0A4S4MDK3.1
#=GS A0A165WKM6_DAUCS/8-116 AC A0A165WKM6.1
#=GS A0A372RLD1_9GLOM/9-155 AC A0A372RLD1.1
#=GS A0A7R8D253_LEPSM/16-142 AC A0A7R8D253.1
#=GS A0A091VQG8_NIPNI/1-136 AC A0A091VQG8.1
#=GS A0A852F463_PEUTA/65-202 AC A0A852F463.1
#=GS D8M0Y1_BLAHO/5-143 AC D8M0Y1.1
#=GS A0A7M4FZR8_CROPO/154-253 AC A0A7M4FZR8.1
#=GS A0A0Q3QQQ5_AMAAE/3868-3965 AC A0A0Q3QQQ5.1
#=GS J4D9T7_THEOR/17-162 AC J4D9T7.1
#=GS M2N9T7_BAUPA/10-138 AC M2N9T7.1
#=GS A0A7N8YLX7_9TELE/35-157 AC A0A7N8YLX7.1
#=GS A0A022QD37_ERYGU/4-141 AC A0A022QD37.1
#=GS I3L2Q4_HUMAN/9-50 AC I3L2Q4.1
#=GS A0A3B5PUI0_XIPMA/52-189 AC A0A3B5PUI0.1
#=GS Q5CQL8_CRYPI/9-149 AC Q5CQL8.1
#=GS A0A7K8RG57_9PASS/78-217 AC A0A7K8RG57.1
#=GS R1F706_EMIHU/9-148 AC R1F706.1
#=GS A0A674AC87_SALTR/953-1102 AC A0A674AC87.1
#=GS A0A7M7H832_NASVI/4485-4643 AC A0A7M7H832.1
#=GS A0A671TI12_SPAAU/5-156 AC A0A671TI12.1
#=GS A0A2U4BP05_TURTR/50-100 AC A0A2U4BP05.1
#=GS A0A8D2H6U0_UROPR/105-259 AC A0A8D2H6U0.1
#=GS A0A7K4Y049_REGSA/10-143 AC A0A7K4Y049.1
#=GS A0A834HY33_RHYFE/6-144 AC A0A834HY33.1
#=GS A0A0J7L691_LASNI/8-156 AC A0A0J7L691.1
#=GS A0A077ZTQ3_STYLE/5-143 AC A0A077ZTQ3.1
#=GS A0A166FH68_DAUCS/5-127 AC A0A166FH68.1
#=GS A0A851EW85_PITSO/1-145 AC A0A851EW85.1
#=GS A0A7K1IMI0_9ACTN/5-142 AC A0A7K1IMI0.1
#=GS A0A2U3YIU4_LEPWE/6-144 AC A0A2U3YIU4.1
#=GS A0A4V1XPC3_9PEZI/294-410 AC A0A4V1XPC3.1
#=GS A0A5M3N147_CONPW/6-143 AC A0A5M3N147.1
#=GS A0A3Q3NRC4_9LABR/7-139 AC A0A3Q3NRC4.1
#=GS A0A668AI72_9TELE/3164-3322 AC A0A668AI72.1
#=GS A0A5N7DGD4_9EURO/160-301 AC A0A5N7DGD4.1
#=GS A0A1E1LII0_9HELO/9-165 AC A0A1E1LII0.1
#=GS A0A8D2I7T0_UROPR/1-46 AC A0A8D2I7T0.1
#=GS A0A0D9YXI9_9ORYZ/33-162 AC A0A0D9YXI9.1
#=GS A0A6P3FLX5_OCTDE/5-141 AC A0A6P3FLX5.1
#=GS A0A7K5X818_9CHAR/16-138 AC A0A7K5X818.1
#=GS A0A072NVM9_9EURO/9-160 AC A0A072NVM9.1
#=GS A0A8H5JUA1_9HYPO/8-146 AC A0A8H5JUA1.1
#=GS A0A401GKD9_9APHY/6-143 AC A0A401GKD9.1
#=GS G3U516_LOXAF/267-366 AC G3U516.1
#=GS A0A8H7NPY6_BIOOC/10-166 AC A0A8H7NPY6.1
#=GS A0A804J513_MUSAM/9-153 AC A0A804J513.1
#=GS A0A8D2JHB2_VARKO/4559-4717 AC A0A8D2JHB2.1
#=GS B5Y4Z4_PHATC/51-192 AC B5Y4Z4.1
#=GS A0A7L3J5J8_THACH/1-107 AC A0A7L3J5J8.1
#=GS J9I1E1_9SPIT/9-142 AC J9I1E1.1
#=GS A0A3N4I4Z4_ASCIM/903-1039 AC A0A3N4I4Z4.1
#=GS A0A8H7WH58_9HELO/10-139 AC A0A8H7WH58.1
#=GS A0A4Q4X3Q6_9PEZI/8-159 AC A0A4Q4X3Q6.1
#=GS A0A8H5HF09_9AGAR/41-111 AC A0A8H5HF09.1
#=GS R1DRC8_EMIHU/15-169 AC R1DRC8.1
#=GS A0A7K7DA71_PHEME/1-98 AC A0A7K7DA71.1
#=GS A0A7L0XQB2_TYRSA/66-161 AC A0A7L0XQB2.1
#=GS A0A8H7A783_PLEOS/8-147 AC A0A8H7A783.1
#=GS A0A1S9DH56_ASPOZ/8-144 AC A0A1S9DH56.1
#=GS A0A0M9F0F8_FUSLA/305-433 AC A0A0M9F0F8.1
#=GS E9E2R3_METAQ/7-158 AC E9E2R3.1
#=GS A0A5D2T0S1_GOSMU/9-146 AC A0A5D2T0S1.1
#=GS A0A0D2DRL3_9EURO/5-143 AC A0A0D2DRL3.1
#=GS H3B7T0_LATCH/4536-4694 AC H3B7T0.2
#=GS A0A101ME70_9EURO/34-169 AC A0A101ME70.1
#=GS X6NP93_RETFI/3-144 AC X6NP93.1
#=GS A0A058ZEP1_FONAL/12-163 AC A0A058ZEP1.1
#=GS A0A8D0DFX3_SALMN/7-145 AC A0A8D0DFX3.1
#=GS D5GFJ3_TUBMM/10-162 AC D5GFJ3.1
#=GS A0A7K8P3X7_COCCO/1-132 AC A0A7K8P3X7.1
#=GS A0A7L1J852_SMUAF/166-265 AC A0A7L1J852.1
#=GS A0A8J6ASB4_9EUKA/9-153 AC A0A8J6ASB4.1
#=GS A0A672JHV6_SALFA/82-219 AC A0A672JHV6.1
#=GS A0A5A7SWJ8_CUCME/5-142 AC A0A5A7SWJ8.1
#=GS A0A8D2QRB8_ZOSLA/6-143 AC A0A8D2QRB8.1
#=GS A0A2I1CNH1_ASPN1/1-137 AC A0A2I1CNH1.1
#=GS A0A8C8ZVS7_PROSS/26-170 AC A0A8C8ZVS7.1
#=GS A0A2T6ZYE3_TUBBO/11-160 AC A0A2T6ZYE3.1
#=GS A0A0L7LWZ3_PLAF4/5-84 AC A0A0L7LWZ3.1
#=GS M0ZTH9_SOLTU/1-127 AC M0ZTH9.1
#=GS A0A5J9TZW6_9POAL/7-148 AC A0A5J9TZW6.1
#=GS A0A8C6S773_9GOBI/2-71 AC A0A8C6S773.1
#=GS A0A484CR99_PERFV/59-196 AC A0A484CR99.1
#=GS A0A4W6DI98_LATCA/14-152 AC A0A4W6DI98.1
#=GS A0A8C7L6D2_ONCKI/8-143 AC A0A8C7L6D2.1
#=GS A0A6P5KRX2_PHACI/8-145 AC A0A6P5KRX2.1
#=GS A0A8H3YPJ6_VENIN/7-145 AC A0A8H3YPJ6.1
#=GS A0A7L3J3W6_THACH/166-265 AC A0A7L3J3W6.1
#=GS Q4WYH5_ASPFU/804-958 AC Q4WYH5.1
#=GS A0A3Q0JKS2_DIACI/32-147 AC A0A3Q0JKS2.1
#=GS A0A7K4RKH5_COLPI/78-217 AC A0A7K4RKH5.1
#=GS T0MHR5_9MICR/1-136 AC T0MHR5.1
#=GS A0A5E4AX07_MARMO/175-329 AC A0A5E4AX07.1
#=GS A0A850ZB53_9PASS/1-92 AC A0A850ZB53.1
#=GS A0A7J7F6L8_DICBM/23-162 AC A0A7J7F6L8.1
#=GS Q2H1G0_CHAGB/14-170 AC Q2H1G0.1
#=GS A0A8X8W3Q8_SALSN/1-84 AC A0A8X8W3Q8.1
#=GS A0A2I3SBQ7_PANTR/30-83 AC A0A2I3SBQ7.1
#=GS A0A8D2FMP0_THEGE/9-161 AC A0A8D2FMP0.1
#=GS A0A1J4JJR6_9EUKA/38-176 AC A0A1J4JJR6.1
#=GS A0A2P5YNP2_GOSBA/9-142 AC A0A2P5YNP2.1
#=GS A0A5E4F468_PRUDU/19-112 AC A0A5E4F468.1
#=GS A0A5D2WYS9_GOSMU/5-142 AC A0A5D2WYS9.1
#=GS A0A4U6X0V1_9PEZI/5-142 AC A0A4U6X0V1.1
#=GS A0A1R3GV36_COCAP/93-234 AC A0A1R3GV36.1
#=GS A0A8C5R614_9ANUR/16-109 AC A0A8C5R614.1
#=GS I3L2H7_HUMAN/1-90 AC I3L2H7.1
#=GS A0A8C9EEV6_PHOSS/960-1109 AC A0A8C9EEV6.1
#=GS A0A850TUK8_GRUAM/65-202 AC A0A850TUK8.1
#=GS M4F5K5_BRARP/37-173 AC M4F5K5.1
#=GS A2DJZ7_TRIV3/1-136 AC A2DJZ7.1
#=GS A0A8C8B1M1_9STRI/36-180 AC A0A8C8B1M1.1
#=GS A0A813DAG9_POLGL/234-332 AC A0A813DAG9.1
#=GS A0A1X7VAS3_AMPQE/73-228 AC A0A1X7VAS3.1
#=GS A0A1U8HZS8_GOSHI/10-103 AC A0A1U8HZS8.1
#=GS A0A3B6HQQ9_WHEAT/16-135 AC A0A3B6HQQ9.1
#=GS A0A8I3WK00_CALJA/173-327 AC A0A8I3WK00.1
#=GS A0A671YZP1_SPAAU/5-142 AC A0A671YZP1.1
#=GS A0A2P2SW60_9PEZI/9-144 AC A0A2P2SW60.1
#=GS A0A7J7V567_MYOMY/40-116 AC A0A7J7V567.1
#=GS A0A2K5KNP0_CERAT/16-145 AC A0A2K5KNP0.1
#=GS A0A094CUV6_9PEZI/31-166 AC A0A094CUV6.1
#=GS V4T8X8_CITCL/10-153 AC V4T8X8.1
#=GS A0A8D2GC37_THEGE/6-144 AC A0A8D2GC37.1
#=GS A0A2K0WJC9_GIBNY/9-139 AC A0A2K0WJC9.1
#=GS E3K7M1_PUCGT/12-151 AC E3K7M1.2
#=GS A0A7K9PTV6_9CORV/12-156 AC A0A7K9PTV6.1
#=GS A0A7T8HEP9_CALRO/11-130 AC A0A7T8HEP9.1
#=GS A0A0D2EIM5_9EURO/88-171 AC A0A0D2EIM5.1
#=GS A0A8E2J5X7_9APHY/28-164 AC A0A8E2J5X7.1
#=GS A0A0V1P248_9BILA/73-228 AC A0A0V1P248.1
#=GS A0A8J4VI90_9ROSI/10-155 AC A0A8J4VI90.1
#=GS A0A317T206_9PEZI/5-140 AC A0A317T206.1
#=GS A0A6J1VRQ8_9SAUR/33-148 AC A0A6J1VRQ8.1
#=GS A0A430QE67_SCHBO/16-135 AC A0A430QE67.1
#=GS A0A2V5HIG8_ASPV1/9-137 AC A0A2V5HIG8.1
#=GS G4LZZ9_SCHMA/5-142 AC G4LZZ9.1
#=GS S8B8V6_PENO1/7-151 AC S8B8V6.1
#=GS A0A0G2FP69_9PEZI/12-171 AC A0A0G2FP69.1
#=GS A0A8C7M6T7_ONCKI/15-145 AC A0A8C7M6T7.1
#=GS A0A8H6Z5X4_9AGAR/9-142 AC A0A8H6Z5X4.1
#=GS A0A7J8M7K7_9ROSI/5-142 AC A0A7J8M7K7.1
#=GS A0A509ARI2_PLABA/136-269 AC A0A509ARI2.1
#=GS A0A3Q3GH18_KRYMA/79-218 AC A0A3Q3GH18.1
#=GS A0A851D2V1_TODME/1-103 AC A0A851D2V1.1
#=GS A0A0P7X1D4_SCLFO/62-123 AC A0A0P7X1D4.1
#=GS A0A7K9P1X0_9CORV/1-121 AC A0A7K9P1X0.1
#=GS A0A7L1TQJ9_PHANI/2-142 AC A0A7L1TQJ9.1
#=GS A0A8C0IQ09_CHEAB/788-939 AC A0A8C0IQ09.1
#=GS A0A2G8JZJ1_STIJA/28-92 AC A0A2G8JZJ1.1
#=GS A0A672T4P9_SINGR/10-138 AC A0A672T4P9.1
#=GS A0A1B6P916_SORBI/11-162 AC A0A1B6P916.1
#=GS A0A804IY78_MUSAM/9-146 AC A0A804IY78.1
#=GS A0A7J6YZB0_9COLE/25-142 AC A0A7J6YZB0.1
#=GS A0A5A8C1I3_CAFRO/10-119 AC A0A5A8C1I3.1
#=GS K3XZS6_SETIT/5-142 AC K3XZS6.1
#=GS A0A7L3EW98_9PASS/6-146 AC A0A7L3EW98.1
#=GS A0A8H7AXE9_9EURO/1-84 AC A0A8H7AXE9.1
#=GS A0A8C2VHK4_CHILA/14-144 AC A0A8C2VHK4.1
#=GS A0A7K8P3Q1_COCCO/65-202 AC A0A7K8P3Q1.1
#=GS A0A668TAI8_OREAU/9-145 AC A0A668TAI8.1
#=GS G1N5D7_MELGA/97-238 AC G1N5D7.2
#=GS A0A0D9UWA7_9ORYZ/827-962 AC A0A0D9UWA7.1
#=GS A0A5G2RBL8_PIG/116-181 AC A0A5G2RBL8.2
#=GS A0A7L1YY74_9PASS/36-169 AC A0A7L1YY74.1
#=GS A0A074VLK8_9PEZI/1004-1115 AC A0A074VLK8.1
#=GS A0A8J5WXD3_ZIZPA/60-142 AC A0A8J5WXD3.1
#=GS A0A8C6HCH6_MUSSI/14-144 AC A0A8C6HCH6.1
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