#=GF ID Vac_Fusion
#=GF AC PF02346.23
#=GF DE Chordopoxvirus multifunctional envelope protein A27
#=GF AU Bashton M;0000-0002-6847-1525
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_822 (release 5.2)
#=GF GA 27.60 27.60;
#=GF TC 27.60 34.50;
#=GF NC 27.50 23.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 8 -E 1000 -Z 90746521 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 2389560
#=GF RT Vaccinia virus induces cell fusion at acid pH and this activity
#=GF RT is mediated by the N-terminus of the 14-kDa virus envelope
#=GF RT protein.
#=GF RA Gong SC, Lai CF, Esteban M;
#=GF RL Virology 1990;178:81-91.
#=GF RN [2]
#=GF RM 23990784
#=GF RT Crystal structure of vaccinia viral A27 protein reveals a novel
#=GF RT structure critical for its function and complex formation with
#=GF RT A26 protein.
#=GF RA Chang TH, Chang SJ, Hsieh FL, Ko TP, Lin CT, Ho MR, Wang I, Hsu
#=GF RA ST, Guo RT, Chang W, Wang AH;
#=GF RL PLoS Pathog. 2013;9:e1003563.
#=GF DR INTERPRO; IPR003436;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This is a family of viral fusion proteins from the
#=GF CC chordopoxviruses. Swiss:P26312 a 14-kDa Vaccinia Virus protein
#=GF CC has been demonstrated to function as a viral fusion protein
#=GF CC mediating cell fusion at endosmomal (low) pH [1]. More recently
#=GF CC it has been shown that A27 forms disulfide-linked protein
#=GF CC complexes with A26 protein providing an anchor for A26 protein
#=GF CC packaging into mature virions. A27 regulates virion-membrane
#=GF CC fusion rather than inducing it and is critical for the
#=GF CC successful egress of mature virus particles [2].
#=GF SQ 47
#=GS G3EI23_9POXV/39-94 AC G3EI23.1
#=GS Q98297_MCV1/423-478 AC Q98297.1
#=GS Q08FM6_DPV83/82-130 AC Q08FM6.1
#=GS A0A2U9QHW2_9POXV/48-103 AC A0A2U9QHW2.1
#=GS A0A2U9QHS6_9POXV/419-473 AC A0A2U9QHS6.1
#=GS PG154_VACCW/50-105 AC P11258.3
#=GS A0A1L3IZP0_9POXV/164-232 AC A0A1L3IZP0.1
#=GS PG154_VACCC/50-105 AC P20535.1
#=GS A0A650AJN4_9POXV/626-681 AC A0A650AJN4.1
#=GS Q9Q8I5_MYXVL/138-186 AC Q9Q8I5.1
#=GS Q9J542_FOWPN/412-467 AC Q9J542.1
#=GS A0A514TRC6_9POXV/54-109 AC A0A514TRC6.1
#=GS PG153_VAR67/417-471 AC Q89489.1
#=GS A0A2C9DST1_9POXV/400-451 AC A0A2C9DST1.1
#=GS A0A0M3ZJQ6_9POXV/397-452 AC A0A0M3ZJQ6.1
#=GS PG153_MONPV/428-482 AC A0A7H0DNC4.1
#=GS Q98299_MCV1/478-533 AC Q98299.1
#=GS Q1HTR9_9POXV/10-66 AC Q1HTR9.1
#=GS A0A894ZSX4_9POXV/386-441 AC A0A894ZSX4.1
#=GS PG153_VACCW/417-473 AC P24758.2
#=GS A0A223FMY9_9POXV/433-487 AC A0A223FMY9.1
#=GS A0A1B1MRG5_9POXV/39-94 AC A0A1B1MRG5.1
#=GS Q6TVL6_ORFSA/33-86 AC Q6TVL6.1
#=GS A0A097IVZ7_9POXV/165-233 AC A0A097IVZ7.1
#=GS PG154_MONPV/50-105 AC P0DTN3.1
#=GS Q90188_MONPV/50-105 AC Q90188.1
#=GS A0A3F2YKS2_SHEVT/95-143 AC A0A3F2YKS2.1
#=GS A0A7D0UCN1_9POXV/93-141 AC A0A7D0UCN1.1
#=GS A0A650AJH2_9POXV/472-527 AC A0A650AJH2.1
#=GS A0A9E6RLP0_9POXV/30-85 AC A0A9E6RLP0.1
#=GS G3EI22_9POXV/438-492 AC G3EI22.1
#=GS PG154_VAR67/50-105 AC P33816.1
#=GS Q1HTS0_9POXV/572-625 AC Q1HTS0.1
#=GS Q775Q1_CAMPS/50-105 AC Q775Q1.1
#=GS A0A223FMX7_9POXV/57-112 AC A0A223FMX7.1
#=GS Q6TVL8_ORFSA/411-464 AC Q6TVL8.1
#=GS A0A6B9R4Q9_9POXV/34-89 AC A0A6B9R4Q9.1
#=GS A0A6B9R212_9POXV/387-451 AC A0A6B9R212.1
#=GS A0A2C9DST2_9POXV/476-532 AC A0A2C9DST2.1
#=GS Q6VZ82_CNPV/413-468 AC Q6VZ82.1
#=GS Q8V3I2_SWPV1/92-140 AC Q8V3I2.1
#=GS A0AAE9NWP9_9POXV/412-467 AC A0AAE9NWP9.1
#=GS Q8QQ29_CAMPS/417-471 AC Q8QQ29.1
#=GS A0A1B1MRN8_9POXV/539-594 AC A0A1B1MRN8.1
#=GS Q6TUQ2_YMTV5/94-142 AC Q6TUQ2.1
#=GS A0A514TRC1_9POXV/505-558 AC A0A514TRC1.1
#=GS Q9Q8W3_RFVKA/128-176 AC Q9Q8W3.1
G3EI23_9POXV/39-94 ..............RLTNIEK...KLNNITVKFSNIEK.............CCNKNEEVIYRLENHAETLRLTMLTLAKKIDIQTG..
Q98297_MCV1/423-478 ..............RVQIIQR...QIRWLEHYLRNASK.............CCHENSRIESRLRHHLETMRQYSVLLSRKTDIQSG..
Q08FM6_DPV83/82-130 ..............RLMVMEK...ILKISIERCKVLEN.............-------TVKRLETHTETVRRNMLTLGKKIDVQTG..
A0A2U9QHW2_9POXV/48-103 ..............RISMLEK...TVNDLLDTHTELIR.............CCSEAEDRMRRLETHASTLRSSILNLTTKIDVQTG..
A0A2U9QHS6_9POXV/419-473 ..............RLDLLNA...KISGYIPLIRHLKD.............MCHRENNAAKKLEEHIETMRQYMIMTSQKVDH---ht
PG154_VACCW/50-105 ..............RLTNLEK...KITNVTTKFEQIEK.............CCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTG..
A0A1L3IZP0_9POXV/164-232 ..............RLMILEK...VFKKTYERNTNIDEvikrlneidmdikRLEVIDSDILRLENHFETIRRNMLTMAKKIDVQTG..
PG154_VACCC/50-105 ..............RLTNLEK...KITNVTTKFEQIEK.............CCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTG..
A0A650AJN4_9POXV/626-681 .............m-VKELEK...RVETLVQAHLRVVD.............CCSTVTTGLDRLEKHADTLRATMLSLVNKIDVQT-r.
Q9Q8I5_MYXVL/138-186 ..............RLMVLEK...LVQLTIKRQKRHNK.............-------AIRRIENHLETVRKGMLMLSKKIDAQTG..
Q9J542_FOWPN/412-467 .............a-LRRLER...RLGRIEQDHVEVAK.............SCSIVAEAIDRLERHADTLRHSMVNLAKKIDYQTG..
A0A514TRC6_9POXV/54-109 ..............RLTKLEN...RVTDLINNFSEMEK.............CCKHNNEVLTRLEEHAETLRKAMLALAIKIDLQTG..
PG153_VAR67/417-471 .........rirld-----NH...ILNTLDHNLNSIGH............yCCDT--AAVDRLEHHIETLGQYAVILARKINMQS-l.
A0A2C9DST1_9POXV/400-451 ...........fte-MQRVNR...VIQSLNSE------.............CCKGNRGKVSRLESHIETMRQYSVALSNKTDIQTD..
A0A0M3ZJQ6_9POXV/397-452 ..............QLQALED...KINKVTSDHVEIAK.............SCNIVAETINRLERHADTLRLSMVNLARKIDIQTG..
PG153_MONPV/428-482 .........rirld-----NH...ILNTLDHNLNSIGH............yCCDTV--AVDRLEHHIETLGQYTVILARKINMQT-l.
Q98299_MCV1/478-533 .............l-IRELED...RVTTLAKDHTDVVN.............CCSTVSEGLSRLERHAETLRKTMLALVRKINVQTG..
Q1HTR9_9POXV/10-66 ..........rvtd----RNR..eRLKRLLEEQERVIE.............CCEHADDRLTRLEKHADTLRETMLKLARKIDVQTG..
A0A894ZSX4_9POXV/386-441 .............a-WNKIEE...RLERVEKDHIEIAK.............SCHVVAETLDRLERHADSLRHAMVNLAKKIDYQTG..
PG153_VACCW/417-473 ....adrirldnhi-------...-LNTLDHNLNFIGH............yCCDT--AAVDRLEHHIETLGQYAVILARKINMQT-l.
A0A223FMY9_9POXV/433-487 .........rmaln-----NR...IINILDKNLNTLGS............yCC--DSESVKRLQYHIETLGQYALILTRKINIQS-l.
A0A1B1MRG5_9POXV/39-94 ..............RLSLLEK...TVTDLLDTYKDLIK.............CTGAAEERMRRLEGHAASLRASILHLTHKIDVQTG..
Q6TVL6_ORFSA/33-86 ............es----VEE...RLVSLLDSYKTITD.............CCRETGNRLDRLEKHLETLRRALLDLNRKIDVQTG..
A0A097IVZ7_9POXV/165-233 ..............RLMVLEK...VFKMTYESYNNIDKiikrldeidmdikRLEVIDSDILRLENHFETIRRNMLTMAKKIDIQTG..
PG154_MONPV/50-105 ..............RLTNLEK...KITNITTKFEQIEK.............CCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTG..
Q90188_MONPV/50-105 ..............RLTNLEK...KITNITTKFEQIEK.............CCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTG..
A0A3F2YKS2_SHEVT/95-143 ..............RLVVLEK...LFQTSVKECNSLKN.............-------IIKRLENHIETIRKNMIVLTKKVDFQTG..
A0A7D0UCN1_9POXV/93-141 ..............RLMVLEK...LFTSSVYKCISLEK.............-------TIKRIENHTETIRKNMLLLAKKIDFQTN..
A0A650AJH2_9POXV/472-527 ..............RLQIAET...QMDLITDKIMTVAT.............SCFRNWRLAARIGHHVETMRQYCVMLARKTNIQTG..
A0A9E6RLP0_9POXV/30-85 .............a-LKRLER...RLARVEQDHVEVAK.............SCSIVAETLDRLERHADTLRQSMVNLAKKIDYQTG..
G3EI22_9POXV/438-492 ..............RMEINNK...IIDILDNNLNRLGS............yCCDH--DSVNRLQNHIETLGQYSLILARKVNIQS-l.
PG154_VAR67/50-105 ..............RLTNLEK...KITNVTTKFEQIEK.............CCKRNDDVLFRLENHAETLRAAMISLAKKIDVQTG..
Q1HTS0_9POXV/572-625 ..........kevr------E...EIEKLEKSLAKYRA.............ECAKRQARLARLEHHIETMRQLTVILSHKADIQTN..
Q775Q1_CAMPS/50-105 ..............RLTNLEK...KITNVTTKFEQIEK.............CCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTG..
A0A223FMX7_9POXV/57-112 ..............RLKNIET...KLNNITAKFSQIEK.............CCKKNDEIIYRLENHAETLRVAMLALAKKIDIQTG..
Q6TVL8_ORFSA/411-464 .............e---RVDK...LLAPLEKTLAEAKT.............CCESNRKAGKHLEHHIETMRQYAVLVSNKTDVHT-c.
A0A6B9R4Q9_9POXV/34-89 ..............KLSDIDK...IIDEIKSKYEELAT.............LIGENEKTLTRLEDHGETLKNTLLQLAKKIDAQT-l.
A0A6B9R212_9POXV/387-451 dnindiikqinefi--KDLNDdrvTTNSLFLNILDLQK.............------ERFYRLEHHLETMRQFSLILTRKVDRQSN..
A0A2C9DST2_9POXV/476-532 ..............MIKELET...KIKKLIADHMRIGK.............CCSEVSDNLGRLEKHADTLRNTMLALVRKIDVQT-ig
Q6VZ82_CNPV/413-468 .............a-LKRLER...RLARVEQDHVEVAK.............SCSIVAETLDRLERHADTLRQSMVNLAKKIDYQTG..
Q8V3I2_SWPV1/92-140 ..............RLLVLEK...IFQLSISNYKTLEN.............-------SMKRVENHLETIRRNMITLTKKIDVQTG..
A0AAE9NWP9_9POXV/412-467 .............a-LRRLER...RLARVEQDHVEVAK.............SCSIVAETLDRLERHADTLRQSMVNLAKKIDYQTG..
Q8QQ29_CAMPS/417-471 .........rirld-----NH...ILNTLDHNLNSIGH............yCCDT--AAVDRLEHHIETLGQYAVILARKINMQS-l.
A0A1B1MRN8_9POXV/539-594 ..............RLNILKE...KIAGYIPLIKHLKD.............TCKKENDAAKKLEHHIETMRQYMVMASNKVDYHT-c.
Q6TUQ2_YMTV5/94-142 ..............RLLVLEK...LFTLLFNKWSISND.............-------IIKRLENHTDTIRKNMIILSKKIDVQTG..
A0A514TRC1_9POXV/505-558 ........ihldre-------...IVRRLEDRYNKLNK.............YC-CNDEKVKALEHNFETMRQYAIVLSKKVDYQT-f.
Q9Q8W3_RFVKA/128-176 ..............RLMVLEK...LVRLTVKRQKKNNK.............-------SIHRIENHLETVRKGMLMLSKKIDAQTG..
#=GC seq_cons ...............l..lE+...hlsplhpphpplt+.............sCptstcslpRLEpHhETLRpsMlhLu+KIDlQTG..
//
