#=GF ID WRM1_N
#=GF AC PF30195.1
#=GF DE WRM-1 armadillo protein N-terminal domain
#=GF AU Morveli N;0000-0003-2496-881X
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE TED:A8X811_TED01
#=GF GA 27.00 27.00;
#=GF TC 28.40 56.50;
#=GF NC 22.10 20.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 8 -Z 90746521 HMM pfamseq
#=GF TP Repeat
#=GF CL CL0020
#=GF RC Function description for Q10953
#=GF RN [1]
#=GF RM 9288750
#=GF RT "Wnt signaling and an APC-related gene specify endoderm in early
#=GF RT C. elegans embryos.";
#=GF RA Rocheleau C.E., Downs W.D., Lin R., Wittmann C., Bei Y., Cha
#=GF RA Y.-H., Ali M., Priess J.R., Mello C.C.;
#=GF RL Cell 90:707-716(1997).
#=GF RC Function description for Q10953
#=GF RN [2]
#=GF RM 10380924
#=GF RT "WRM-1 activates the LIT-1 protein kinase to transduce
#=GF RT anterior/posterior polarity signals in C. elegans.";
#=GF RA Rocheleau C.E., Yasuda J., Shin T.H., Lin R., Sawa H., Okano H.,
#=GF RA Priess J.R., Davis R.J., Mello C.C.;
#=GF RL Cell 97:717-726(1999).
#=GF RC Function description for Q10953
#=GF RN [3]
#=GF RM 11560894
#=GF RT The divergent Caenorhabditis elegans beta-catenin proteins
#=GF RT BAR-1, WRM-1 and HMP-2 make distinct protein interactions but
#=GF RT retain functional redundancy in vivo.
#=GF RA Natarajan L., Witwer N.E., Eisenmann D.M.;
#=GF RL Genetics 159:159-172(2001).
#=GF RC Function description for Q10953
#=GF RN [4]
#=GF RM 11807036
#=GF RT "POP-1 controls axis formation during early gonadogenesis in C.
#=GF RT elegans.";
#=GF RA Siegfried K.R., Kimble J.;
#=GF RL Development 129:443-453(2002).
#=GF RC Function description for Q10953
#=GF RN [5]
#=GF RM 15066285
#=GF RT "Phosphorylation by the beta-catenin/MAPK complex promotes
#=GF RT 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive
#=GF RT cells in C. elegans.";
#=GF RA Lo M.-C., Gay F., Odom R., Shi Y., Lin R.;
#=GF RL Cell 117:95-106(2004).
#=GF RC Function description for Q10953
#=GF RN [6]
#=GF RM 15572126
#=GF RT "Multiple Wnt signaling pathways converge to orient the mitotic
#=GF RT spindle in early C. elegans embryos.";
#=GF RA Walston T., Tuskey C., Edgar L., Hawkins N., Ellis G., Bowerman
#=GF RA B., Wood W., Hardin J.;
#=GF RL Dev. Cell 7:831-841(2004).
#=GF RC Function description for Q10953
#=GF RN [7]
#=GF RM 16077003
#=GF RT "Asymmetric cortical and nuclear localizations of
#=GF RT WRM-1/beta-catenin during asymmetric cell division in C.
#=GF RT elegans.";
#=GF RA Takeshita H., Sawa H.;
#=GF RL Genes Dev. 19:1743-1748(2005).
#=GF RC Function description for Q10953
#=GF RN [8]
#=GF RM 16890160
#=GF RT "Crosstalk between a nuclear receptor and beta-catenin signaling
#=GF RT decides cell fates in the C. elegans somatic gonad.";
#=GF RA Asahina M., Valenta T., Silhankova M., Korinek V., Jindra M.;
#=GF RL Dev. Cell 11:203-211(2006).
#=GF RC Function description for Q10953
#=GF RN [9]
#=GF RM 17276345
#=GF RT "Cortical beta-catenin and APC regulate asymmetric nuclear
#=GF RT beta-catenin localization during asymmetric cell division in C.
#=GF RT elegans.";
#=GF RA Mizumoto K., Sawa H.;
#=GF RL Dev. Cell 12:287-299(2007).
#=GF RC Function description for Q10953
#=GF RN [10]
#=GF RM 17476329
#=GF RT "Cyclin E and CDK2 repress the terminal differentiation of
#=GF RT quiescent cells after asymmetric division in C. elegans.";
#=GF RA Fujita M., Takeshita H., Sawa H.;
#=GF RL PLoS ONE 2:E407-E407(2007).
#=GF DR SO; 0001068; polypeptide_repeat;
#=GF CC This entry represents the N-terminal TPR-like region of WRM-1
#=GF CC armadillo proteins. This domain is found in beta-catenin-like
#=GF CC proteins from Caenorhabditis nematodes involved in Wnt
#=GF CC signalling pathways. The domain directly interacts with LIT-1
#=GF CC kinase and activates its kinase activity, leading to
#=GF CC phosphorylation of transcription factor POP-1 [1,2]. WRM-1
#=GF CC proteins are components of the beta-catenin-lit-1 complex and
#=GF CC play roles in asymmetric cell division and embryogenesis. The
#=GF CC function of this domain remains to be determined.
#=GF SQ 19
#=GS A0A260ZCZ9_9PELO/173-373 AC A0A260ZCZ9.1
#=GS A0A8R1DVD6_CAEJA/112-317 AC A0A8R1DVD6.1
#=GS A0A9P1IJ18_9PELO/239-457 AC A0A9P1IJ18.1
#=GS E3LYX1_CAERE/163-363 AC E3LYX1.1
#=GS A0A8R1EUD0_CAEJA/1-140 AC A0A8R1EUD0.1
#=GS A0A2G5URU8_9PELO/161-369 AC A0A2G5URU8.1
#=GS A0A2G5VB16_9PELO/128-341 AC A0A2G5VB16.1
#=GS WRM1_CAEEL/167-379 AC Q10953.2
#=GS A0A2G5US54_9PELO/161-369 AC A0A2G5US54.1
#=GS WRM1_CAEBR/162-371 AC A8X811.1
#=GS A0A8S1HK19_9PELO/213-381 AC A0A8S1HK19.1
#=GS A0A0K3AUT2_CAEEL/113-325 AC A0A0K3AUT2.1
#=GS A0A2G5SWT2_9PELO/161-324 AC A0A2G5SWT2.1
#=GS G0MPG2_CAEBE/205-413 AC G0MPG2.1
#=GS A0A9P1AFP8_9PELO/169-378 AC A0A9P1AFP8.1
#=GS A0A8R1IUK7_CAEJA/114-210 AC A0A8R1IUK7.1
#=GS A0A2G5SX66_9PELO/161-308 AC A0A2G5SX66.1
#=GS A0A2G5VAS3_9PELO/88-301 AC A0A2G5VAS3.1
#=GS A0A8S1EJ82_9PELO/209-429 AC A0A8S1EJ82.1
A0A260ZCZ9_9PELO/173-373 ...................RMSIPEIIQSLASTEVSVQASAIRELEPLAKKN.LLEHTYGQADLKLIIRALFQVLYPREVENE...NVIRKTFEILHYSVMqTSRHARN..TDKIFLSLNAELMNSK..........S----------SIYEIVIKRAQRLDTVYESSAMVLLTHLCCKPYLMRHVFSEKL--..VSPAHQRLHHTVMEFAVKNLNNSETKPKNKGFSVSIIKNLSRTNVRIRCMAKQMD...............................
A0A8R1DVD6_CAEJA/112-317 ...................RMSIPEIIQNLRSPEMMNQVAAIRELEPVAKTY.QLENTWSKKDLQPIIFALFEVLLPRPVENE...NVIRKVFEILHHSVL.--RPSRV..IDKIFLNLNSELMEGR..........--IVFQSARPCSIYEIVISRAMKLDTKYEASAMVLLVHLCCKPYLMRHVYSDTL--..KSVPFQRLHHLVIDFAITMLRRPETKPKSRGLAVSIVKNLSLKNRTIKAMAQQMD...............................
A0A9P1IJ18_9PELO/239-457 ...................RMTLNEIVYSLKSNDSMKQMLALRELIPVAEQN.QLEMSVQKPDLKTLIYSLFEILIPREQEDE...KVVEATLYVLYHAVL.YPSKTRI..CLKIFETLNLEIMGRKvkermemggfSTNDFNFKHPIGIFYIIMFRASQIESRYVAKAWMLLTHLFCNTFFKRRFFAARYAR..PEDHN--IRAEVIRFAVESLK-KDLKSKPKGFAVSVIRNLSAANPDIMGMAMQLD...............................
E3LYX1_CAERE/163-363 ...................RMSIPEIIQSLASTEVSVQASAIRELEPLAKKW.LLEQTYGQADLKLIIRALFQVLYPREVENE...NVIRKTFEILHHSVMlTSRHARN..TDKIFLSLNAELMNSK..........S----------SIYEIVIKRAERLDTVYESSAMVLLTHLCCKPYLMRHVFSEKV--..ESPAHQRLHQTVMEFAVKNLNNSESKPKNKGFSVSIIKNLSRTNARIRYMAKQMD...............................
A0A8R1EUD0_CAEJA/1-140 ...................---------------------------------.------------------------------...-VIRKVFEILHHSVL.--RPSRV..IDKIFLNLNSELMEGR..........--IVFQSARPCSIYEIVISRAMKLDTKYEASAMVLLVHLCCKPYLMRHVYSDTL--..KSVPFQRLHHLVIDFAITMLRRPETKPKSRGLAVSIVKNLSLKNRRS--------krwhsr.........................
A0A2G5URU8_9PELO/161-369 ...................RMSIPEIEQSLASYVMSDQVAAIRELEPLAKAE.ALETTYDKTDLAPIINALFEVLVPRPQENE...NVIRKVFEILHRAAV.-PKHVRT..TEKIFHQLNLELMNPN..........SKHSFQVPRPYSIYELVIERASRLDTAYDQAAMLLLAQICCKPFFMKYVFSDNQ--..QSPGHKRLHEVVMRFAIKNLQQQETKRKSKGFSVSIIKNLSRRNRSIWRIVYELH...............................
A0A2G5VB16_9PELO/128-341 ...................RMTIPQIEQSLASYDMSVQVAAIRELEPLVKPKvVLEQTYCKSDLEKIIYALFEVLVPRPQENE...NMIRKVIEILHRAVV.-QKQVRR..TEKIFHKLNSELMDRN..........SKHTFQVPRPYSIYELVIERASRLDTAYDQAAMLLLTQICCKPFFMKYVFSEDQSKdkQSANHQRLHKVVMKFAIKNLRRQETKKKSKGFCVSIIKNLSMRNEEIFNIAYKLG...............................
WRM1_CAEEL/167-379 ...................PMTAPEIIENLESTELINQAAAIRALEPIVKAG.GMLQTWGPKGAEPIIRALFQVLIPRPVENE...NVIRKAFEILHHSILlSNKEIRR..IDRMFFRLNAALMDPN..........GPPVFNVPKPYSIYEIVMTRAIQLDTKFESSAMVLLVHLCCKPHFMKIFFGEDETQ..QSPAHRRLHKIVIEFAIGNLRRPETKSKNKGLCVSIIKNLSNKNATIKDMSERLG...............................
A0A2G5US54_9PELO/161-369 ...................RMSIPEIEQSLASYVMSDQVAAIRELEPLAKAE.ALETTYDKTDLAPIINALFEVLVPRPQENE...NVIRKVFEILHRAAV.-PKHVRT..TEKIFHQLNLELMNPN..........SKHSFQVPRPYSIYELVIERASRLDTAYDQAAMLLLAQICCKPFFMKYVFSDNQ--..QSPGHKRLHEVVMRFAIKNLQQQETKRKSKGFSVSIIKNLSRRNRSIWRIVYELH...............................
WRM1_CAEBR/162-371 ...................RMSIPEIVQSLASYEMSDQVAAIRELEPLAKAE.ALESTYCQADLGKIINALFEVLVPRPQENE...NVIRKVFEILHRAAV.-PKHVRM..TEKIFHSLNLELMNTN.........sSKHSFQVPRPYSIYELVIERASRLDTAYDQAAMLLLAQICCKPFFMKYVFSEKE--..QSAGHRRLHEVVMQFAIKNLQQQETKRKSKGFCVSIIKNLSRRNRSIWSIVYELH...............................
A0A8S1HK19_9PELO/213-381 mtkcrtggalateqfaigh---------------------------------.-----ASKKKLLDLVKCLFMQLVPRPNETEhseAVVSITLTVLYHAAT.---KSRT..CRAIIEKHNRDVKRSS..........--------NVFGLFPVIVQRVNQMNPRYVNKAWVLLSALLNQTKMRKDA-------..--QEDPRICPEIMRFLVEKLR-GELESTAKYLAVGALRVI---------------vqerrggec......................
A0A0K3AUT2_CAEEL/113-325 ...................PMTAPEIIENLESTELINQAAAIRALEPIVKAG.GMLQTWGPKGAEPIIRALFQVLIPRPVENE...NVIRKAFEILHHSILlSNKEIRR..IDRMFFRLNAALMDPN..........GPPVFNVPKPYSIYEIVMTRAIQLDTKFESSAMVLLVHLCCKPHFMKIFFGEDETQ..QSPAHRRLHKIVIEFAIGNLRRPETKSKNKGLCVSIIKNLSNKNATIKDMSERLG...............................
A0A2G5SWT2_9PELO/161-324 ...................RMSIPEIEQSLASYVMSDQVAAIRELEPLAKAE.ALETTYDKTDLAPIINALFEVLVPRPQENE...NVIRKVFEILHRAAV.-PKHVRT..TEKIFHQLNLELMNPN..........SKHSFQVPRPYSIYELVIERASRLDTAYDQAAMLLLAQICCKPFFMKYVFSDNQ--..Q------------------------------------------------------slvtnvsmk......................
G0MPG2_CAEBE/205-413 ...................RMSIQEICDNLRSTDYRIQAVAIRELEPPAKNK.ALELTYARTDLQQIIETLFEVLIPREGETD...NVIRKTCEILHHVLMvPQRQSRN..TDKIFVELNERLMTGR..........--TRFQEQTPYSIYEIVMKRAGNVDKVYAQTAMVLLTHLCCKMYLMKRVFLQER--..PSDTVLILQKTLMTFLIQSLKSPDTKMKVKGFAVSIIKNLSSRNPYIKQMAQKF-g..............................
A0A9P1AFP8_9PELO/169-378 ...................RMSVQDMIKNLKSADEENQRTALRMLGPIVQAS.QLDHKYPKDQLTDIIAALFELLL-RPVENE...PMIRKTFEILFQLLHsKTDHLGKfgFSRIFNSINTKWMKQP..........V---KTHKGSQSIFDAVVERARIVGTAYETRATLLLLHMCSDHYLMKKVFSDNL-F..CSSLHSDLARRIIEFAVQKIRSENINSKCQGFAVSIIRTLSSKSKHVRKAALSMD...............................
A0A8R1IUK7_CAEJA/114-210 ...................RMSIPEIIQNLRSPEMMNQVAAIRELEPVAKTY.QLENTWSKKDLQPIIFALFEVLLPRPVENE...NVS------------.-------..----------------..........--------------------------------------------------------..-------------------------------------------------------ifrfhmpycddlyhffvnksrlesvrkcpek
A0A2G5SX66_9PELO/161-308 ...................RMSIPEIEQSLASYVMSDQVAAIRELEPLAKAE.ALETTYDKTDLAPIINALFEVLVPRPQENE...NVIRKVFEILHRAAV.-PKHVRT..TEKIFHQLNLELMNPN..........SKHSFQVPRPYSIYELVIERASRLDTAYDQAAMLLLAQICCKPFFMN---------..-------------------------------------------------------v..............................
A0A2G5VAS3_9PELO/88-301 ...................RMTIPQIEQSLASYDMSVQVAAIRELEPLVKPKvVLEQTYCKSDLEKIIYALFEVLVPRPQENE...NMIRKVIEILHRAVV.-QKQVRR..TEKIFHKLNSELMDRN..........SKHTFQVPRPYSIYELVIERASRLDTAYDQAAMLLLTQICCKPFFMKYVFSEDQSKdkQSANHQRLHKVVMKFAIKNLRRQETKKKSKGFCVSIIKNLSMRNEEIFNIAYKLG...............................
A0A8S1EJ82_9PELO/209-429 ...................RMSINEIIMNLRSSDSMNKMLSLRELIPAAEQN.QLEMSLKKTDLRDLIYTLFENLLPRENEDE...KVVEATLYVLYHAVL.YPSKTRI..CLKIFDTLNLEIMGRIsreksgeigsQNVEFRFENPNGIFSIIMYRASQMESRYCTKAWMLLTHLLCNTSFKRRFIAAKYAR..PGDGNKPLRDEVTRFAVESLK-KDLKSKPKGFAVSIIRNLSQANPEILQLAMSLD...............................
#=GC seq_cons ...................RMSIPEI.psLtSh-h.sQsuAIRELEPlAKsp.tLEpTasKsDLpsIItALFEVLlPRP.ENE...NVIRKsFEILH+ull..s+csRp..s-KIFhpLNhELMssp..........u..sFph.+PhSIYElVlpRAppLDTtY-puAMlLLsplCCKPahM+hVFu-p.....pSssapRL+chVhcFAlpsLpp.EoK.KsKGhsVSIIKNLS.pN.pIhths.pht...............................
//
