#=GF ID WW
#=GF AC PF00397.30
#=GF DE WW domain
#=GF PI WW_rsp5_WWP;
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE Prosite
#=GF GA 26.90 26.90;
#=GF TC 26.90 26.90;
#=GF NC 26.80 26.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK WW_domain
#=GF CL CL0680
#=GF RC The identification of the WW domain
#=GF RN [1]
#=GF RM 7846762
#=GF RT The WW domain: a signalling site in dystrophin?
#=GF RA Bork P, Sudol M
#=GF RL Trends Biochem Sci 1994;19:531-533.
#=GF RN [2]
#=GF RM 8757138
#=GF RT Structure of the WW domain of a kinase-associated protein
#=GF RT complexed with a proline-rich peptide.
#=GF RA Macias MJ, Hyvonen M, Baraldi E, Schultz J, Sudol M, Saraste M,
#=GF RA Oschkinat H;
#=GF RL Nature 1996;382:646-649.
#=GF RN [3]
#=GF RM 11870222
#=GF RT Substrate proteolysis is inhibited by dominant-negative Nedd4
#=GF RT and Rsp5 mutants harboring alterations in WW domain 1.
#=GF RA Shcherbik N, Kumar S, Haines DS;
#=GF RL J Cell Sci 2002;115:1041-1048.
#=GF RN [4]
#=GF RM 11323714
#=GF RT Solution structure of a Nedd4 WW domain-ENaC peptide complex.
#=GF RA Kanelis V, Rotin D, Forman-Kay JD;
#=GF RL Nat Struct Biol 2001;8:407-412.
#=GF RN [5]
#=GF RM 10932238
#=GF RT Converging on proline: the mechanism of WW domain peptide
#=GF RT recognition.
#=GF RA Zarrinpar A, Lim WA;
#=GF RL Nat Struct Biol 2000;7:611-613.
#=GF RN [6]
#=GF RM 10744724
#=GF RT A novel pro-Arg motif recognized by WW domains.
#=GF RA Bedford MT, Sarbassova D, Xu J, Leder P, Yaffe MB;
#=GF RL J Biol Chem 2000;275:10359-10369.
#=GF RN [7]
#=GF RM 10037602
#=GF RT Function of WW domains as phosphoserine- or
#=GF RT phosphothreonine-binding modules.
#=GF RA Lu PJ, Zhou XZ, Shen M, Lu KP;
#=GF RL Science 1999;283:1325-1328.
#=GF RN [8]
#=GF RM 9407065
#=GF RT The WW domain of neural protein FE65 interacts with proline-rich
#=GF RT motifs in Mena, the mammalian homolog of Drosophila
#=GF RT enabled.
#=GF RA Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T,
#=GF RA Sudol M;
#=GF RL J Biol Chem 1998;272:32869-32877.
#=GF RN [9]
#=GF RM 8797792
#=GF RT Towards prediction of cognate complexes between the WW domain
#=GF RT and proline-rich ligands.
#=GF RA Einbond A, Sudol M;
#=GF RL FEBS Lett 1996;384:1-8.
#=GF RN [10]
#=GF RM 7644498
#=GF RT The WW domain of Yes-associated protein binds a proline-rich
#=GF RT ligand that differs from the consensus established for Src
#=GF RT homology 3-binding modules.
#=GF RA Chen HI, Sudol M;
#=GF RL Proc Natl Acad Sci U S A 1995;92:7819-7823.
#=GF RN [11]
#=GF RM 7641887
#=GF RT Characterization of a novel protein-binding module--the WW
#=GF RT domain.
#=GF RA Sudol M, Chen HI, Bougeret C, Einbond A, Bork P;
#=GF RL FEBS Lett 1995;369:67-71.
#=GF DR INTERPRO; IPR001202;
#=GF DR PROSITE; PDOC50020;
#=GF DR PRINTS; PR00403;
#=GF DR SCOP; 1pin; fa;
#=GF DR HOMSTRAD; WW;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The WW domain is a protein module with two highly conserved
#=GF CC tryptophans that binds proline-rich peptide motifs in vitro.
#=GF SQ 95256
#=GS A0A3Q2EBQ7_CYPVA/705-734 AC A0A3Q2EBQ7.1
#=GS A0A0C2E1J6_9BILA/117-146 AC A0A0C2E1J6.1
#=GS A0A068S7C0_9FUNG/369-398 AC A0A068S7C0.1
#=GS A0A2C5X0B5_9PEZI/554-584 AC A0A2C5X0B5.1
#=GS A0A7N4NKN7_SARHA/726-754 AC A0A7N4NKN7.1
#=GS A0A8C3ZXG9_9TELE/773-802 AC A0A8C3ZXG9.1
#=GS A0A812M7Q5_9DINO/1-31 AC A0A812M7Q5.1
#=GS A0A2P6QHR3_ROSCH/23-53 AC A0A2P6QHR3.1
#=GS A0A8M9PRJ6_DANRE/31-59 AC A0A8M9PRJ6.1
#=GS A0A7L2P5S7_PYCJO/155-183 AC A0A7L2P5S7.1
#=GS A0A3Q1I1S1_ANATE/374-403 AC A0A3Q1I1S1.2
#=GS A0A367YNC7_9ASCO/400-429 AC A0A367YNC7.1
#=GS A0A2K6RXH4_RHIRO/395-424 AC A0A2K6RXH4.1
#=GS A0A6Q2YC26_ESOLU/220-249 AC A0A6Q2YC26.1
#=GS A0A669F6Q3_ORENI/403-432 AC A0A669F6Q3.1
#=GS A0A813X513_9BILA/250-278 AC A0A813X513.1
#=GS A0A8H4VYC0_9HELO/577-606 AC A0A8H4VYC0.1
#=GS A0A8B9CLB4_9AVES/240-268 AC A0A8B9CLB4.1
#=GS A0A8C8F0T4_ONCTS/455-484 AC A0A8C8F0T4.1
#=GS A0A2R6S5Q7_9APHY/80-109 AC A0A2R6S5Q7.1
#=GS A0A0L0VHG4_9BASI/2-30 AC A0A0L0VHG4.1
#=GS A0A813T766_9BILA/114-142 AC A0A813T766.1
#=GS A0A669PPP3_PHACC/154-183 AC A0A669PPP3.1
#=GS A0A401NY79_SCYTO/348-377 AC A0A401NY79.1
#=GS A0A8J4P7Y2_APTPA/45-75 AC A0A8J4P7Y2.1
#=GS A0A0M8P422_9EURO/14-44 AC A0A0M8P422.1
#=GS A0A084GBD2_PSEDA/53-81 AC A0A084GBD2.1
#=GS A0A8C0B691_9AVES/248-277 AC A0A8C0B691.1
#=GS A0A3Q7TRB1_VULVU/220-249 AC A0A3Q7TRB1.1
#=GS A0A7N6BNW0_ANATE/338-367 AC A0A7N6BNW0.1
#=GS A0A8C6RSY1_NANGA/47-77 AC A0A8C6RSY1.1
#=GS A1CAA3_ASPCL/110-139 AC A1CAA3.1
#=GS A0A3Q2ZR58_KRYMA/246-275 AC A0A3Q2ZR58.1
#=GS A0A161Y065_DAUCS/18-48 AC A0A161Y065.1
#=GS A0A7K7L1I8_9AVES/12-41 AC A0A7K7L1I8.1
#=GS A0A8C8H5E4_ONCTS/40-68 AC A0A8C8H5E4.1
#=GS A0A662YGV6_9STRA/154-184 AC A0A662YGV6.1
#=GS A0A8C0EIC1_BUBBB/419-448 AC A0A8C0EIC1.1
#=GS A0A8B9XVB9_BOSMU/138-167 AC A0A8B9XVB9.1
#=GS A0A3Q7SC53_VULVU/74-103 AC A0A3Q7SC53.1
#=GS A0A8C4I4Y3_DICLA/241-270 AC A0A8C4I4Y3.1
#=GS A0A2Y9K333_ENHLU/701-730 AC A0A2Y9K333.1
#=GS V5FTD5_BYSSN/598-627 AC V5FTD5.1
#=GS A0A836DT83_9ROSI/265-293 AC A0A836DT83.1
#=GS A0A8P0T5P8_CANLF/505-534 AC A0A8P0T5P8.1
#=GS A0A6J3DD76_AYTFU/181-210 AC A0A6J3DD76.1
#=GS A0A165FDN8_9APHY/2-31 AC A0A165FDN8.1
#=GS A0A4W4DVN0_ELEEL/336-365 AC A0A4W4DVN0.1
#=GS A0A6Q2YCS2_ESOLU/75-104 AC A0A6Q2YCS2.1
#=GS A0A151PH40_ALLMI/463-492 AC A0A151PH40.1
#=GS A0A672JNH1_SALFA/235-263 AC A0A672JNH1.1
#=GS A0A430PYB8_SCHBO/7-37 AC A0A430PYB8.1
#=GS R0K596_ANAPL/361-390 AC R0K596.1
#=GS A0A6A5EVW3_PERFL/200-229 AC A0A6A5EVW3.1
#=GS A0A074WDZ8_9PEZI/126-156 AC A0A074WDZ8.1
#=GS WBP4_CHICK/136-165 AC Q5F457.1
#=GS A0A0V0X397_9BILA/13-42 AC A0A0V0X397.1
#=GS A0A2I1CGB0_ASPN1/53-83 AC A0A2I1CGB0.1
#=GS R1D455_EMIHU/74-103 AC R1D455.1
#=GS A0A3D8RBD3_9HELO/16-46 AC A0A3D8RBD3.1
#=GS A0A1S3ENP6_DIPOR/299-328 AC A0A1S3ENP6.1
#=GS A0A7J7U8Y6_PIPKU/240-269 AC A0A7J7U8Y6.1
#=GS A0A3Q1GZ63_9TELE/358-387 AC A0A3Q1GZ63.1
#=GS A0A4U5Q8U9_POPAL/182-212 AC A0A4U5Q8U9.1
#=GS A0A850TU41_GRUAM/16-45 AC A0A850TU41.1
#=GS U3JWJ1_FICAL/59-88 AC U3JWJ1.2
#=GS A0A8C5WX22_LATLA/290-319 AC A0A8C5WX22.1
#=GS A0A6J1NC36_BICAN/565-594 AC A0A6J1NC36.1
#=GS B8A857_ORYSI/295-325 AC B8A857.1
#=GS A0A6I8QAK8_XENTR/735-764 AC A0A6I8QAK8.2
#=GS A0A091WE58_OPIHO/69-98 AC A0A091WE58.1
#=GS A0A8J6EVJ5_ELECQ/123-152 AC A0A8J6EVJ5.1
#=GS A0A6P4FAB9_DRORH/579-608 AC A0A6P4FAB9.1
#=GS A0A8D2GK31_THEGE/830-859 AC A0A8D2GK31.1
#=GS A0A674GR81_TAEGU/200-229 AC A0A674GR81.1
#=GS A0A4W6CHC5_LATCA/549-578 AC A0A4W6CHC5.1
#=GS A0A8C9FC44_PAVCR/113-142 AC A0A8C9FC44.1
#=GS A0A087VES4_BALRE/288-317 AC A0A087VES4.1
#=GS A0A7R8UGL7_HERIL/385-414 AC A0A7R8UGL7.1
#=GS A0A1Q5UEP9_9EURO/11-41 AC A0A1Q5UEP9.1
#=GS A0A8C0IIH7_BUBBB/244-273 AC A0A8C0IIH7.1
#=GS A0A1S3Q990_SALSA/1064-1093 AC A0A1S3Q990.1
#=GS A0A5N5M1W6_PANHP/394-421 AC A0A5N5M1W6.1
#=GS A0A7J8HT77_ROUAE/362-391 AC A0A7J8HT77.1
#=GS A0A673U300_SURSU/268-296 AC A0A673U300.1
#=GS A0A6P6L1T5_CARAU/269-297 AC A0A6P6L1T5.1
#=GS A0A8C0QRY9_CHEAB/222-251 AC A0A8C0QRY9.1
#=GS A0A8J6DTJ8_GALPY/39-68 AC A0A8J6DTJ8.1
#=GS A0A665VNU6_ECHNA/264-298 AC A0A665VNU6.1
#=GS A0A6P8TU30_GYMAC/534-563 AC A0A6P8TU30.1
#=GS A0A5E4C550_MARMO/232-261 AC A0A5E4C550.1
#=GS A0A4Q4TUZ8_9PEZI/6-36 AC A0A4Q4TUZ8.1
#=GS A0A094ALZ3_9PEZI/45-73 AC A0A094ALZ3.1
#=GS A0A3Q2I9Z3_HORSE/457-486 AC A0A3Q2I9Z3.1
#=GS A0A1S3LU00_SALSA/194-223 AC A0A1S3LU00.1
#=GS A0A068RRB1_9FUNG/285-311 AC A0A068RRB1.1
#=GS A0A507EZD6_9FUNG/60-90 AC A0A507EZD6.1
#=GS A0A8H7AYM1_9PLEO/526-556 AC A0A8H7AYM1.1
#=GS A0A7N5JTF9_AILME/1-30 AC A0A7N5JTF9.1
#=GS A0A7L2LAZ6_9SYLV/503-533 AC A0A7L2LAZ6.1
#=GS A0A5B0P0W1_PUCGR/43-71 AC A0A5B0P0W1.1
#=GS A0A0V1NGH8_9BILA/2236-2263 AC A0A0V1NGH8.1
#=GS Q4N6G9_THEPA/107-133 AC Q4N6G9.1
#=GS A0A2P5YH82_GOSBA/430-459 AC A0A2P5YH82.1
#=GS A0A8C5SWW4_LATLA/1-24 AC A0A8C5SWW4.1
#=GS A0A1S3WIE0_ERIEU/90-118 AC A0A1S3WIE0.1
#=GS A0A2I0U378_LIMLA/31-59 AC A0A2I0U378.1
#=GS A0A0V0SCS6_9BILA/146-174 AC A0A0V0SCS6.1
#=GS A0A168IV69_CORDF/394-423 AC A0A168IV69.1
#=GS C1E321_MICCC/524-554 AC C1E321.1
#=GS F7BGT4_CIOIN/443-472 AC F7BGT4.2
#=GS A0A671S3C5_9TELE/406-435 AC A0A671S3C5.1
#=GS A0A453MT67_AEGTS/20-48 AC A0A453MT67.1
#=GS A0A8C6XVN8_NAJNA/111-139 AC A0A8C6XVN8.1
#=GS A0A8M1FMI9_URSMA/498-527 AC A0A8M1FMI9.1
#=GS NED4L_MOUSE/416-445 AC Q8CFI0.2
#=GS A0A401PIX6_SCYTO/78-104 AC A0A401PIX6.1
#=GS A0A6J0VWH2_ODOVR/443-471 AC A0A6J0VWH2.1
#=GS A0A8B9MTN6_9AVES/7-37 AC A0A8B9MTN6.1
#=GS A0A091FWX0_9AVES/159-188 AC A0A091FWX0.1
#=GS A0A8J5MHD5_9STRA/514-543 AC A0A8J5MHD5.1
#=GS A0A6P4F6Y6_DRORH/563-592 AC A0A6P4F6Y6.1
#=GS A0A7K7QLF0_POEAT/18-47 AC A0A7K7QLF0.1
#=GS A0A0F4YFE8_TALEM/10-39 AC A0A0F4YFE8.1
#=GS A0A7K4YYJ5_BUCAB/172-201 AC A0A7K4YYJ5.1
#=GS A0A2G2XTQ0_CAPAN/12-40 AC A0A2G2XTQ0.1
#=GS A0A8J5NWF6_FUSOX/389-418 AC A0A8J5NWF6.1
#=GS A0A550C6U4_9AGAR/233-263 AC A0A550C6U4.1
#=GS A0A672UA47_STRHB/59-88 AC A0A672UA47.1
#=GS A0A8C8ZME2_PROSS/15-44 AC A0A8C8ZME2.1
#=GS A0A6P8J9U6_ACTTE/663-692 AC A0A6P8J9U6.1
#=GS A0A3P9CV82_9CICH/64-93 AC A0A3P9CV82.1
#=GS A0A267FSH2_9PLAT/17-47 AC A0A267FSH2.1
#=GS A0A329S2C5_9STRA/942-972 AC A0A329S2C5.1
#=GS A0A8K0I014_COCNU/77-107 AC A0A8K0I014.1
#=GS A0A7K6TRR7_9AVES/18-47 AC A0A7K6TRR7.1
#=GS A0A165Y3C2_9AGAM/5-31 AC A0A165Y3C2.1
#=GS A0A8I3VZF0_CALJA/195-224 AC A0A8I3VZF0.1
#=GS H2NNB6_PONAB/475-504 AC H2NNB6.2
#=GS A0A2K5IFJ4_COLAP/207-236 AC A0A2K5IFJ4.1
#=GS A0A4S4EAN8_CAMSI/480-510 AC A0A4S4EAN8.1
#=GS A0A0R3QNV1_9BILA/75-103 AC A0A0R3QNV1.1
#=GS A0A2Y9N197_DELLE/117-145 AC A0A2Y9N197.1
#=GS A0A8B8WLY0_BALMU/266-294 AC A0A8B8WLY0.1
#=GS L9KUU5_TUPCH/145-174 AC L9KUU5.1
#=GS A0A7N5KEV7_AILME/204-233 AC A0A7N5KEV7.1
#=GS A0A674JML8_TERCA/241-270 AC A0A674JML8.1
#=GS A0A8C5HCH6_9TELE/120-149 AC A0A8C5HCH6.1
#=GS A0A8C6FI74_MOSMO/824-853 AC A0A8C6FI74.1
#=GS A0A673MZ93_9TELE/269-298 AC A0A673MZ93.1
#=GS A0A8J5DAX2_9CHEL/1787-1816 AC A0A8J5DAX2.1
#=GS A0A0V1LJ69_9BILA/23-53 AC A0A0V1LJ69.1
#=GS A0A2I3GRB6_NOMLE/421-450 AC A0A2I3GRB6.1
#=GS A0A6J3J517_SAPAP/358-387 AC A0A6J3J517.1
#=GS A0A8H4U7Y3_9HYPO/330-359 AC A0A8H4U7Y3.1
#=GS A0A8B9DY63_ANSCY/354-383 AC A0A8B9DY63.1
#=GS A0A836GAU8_9HYME/642-672 AC A0A836GAU8.1
#=GS A0A6P7Y6V7_9AMPH/19-49 AC A0A6P7Y6V7.1
#=GS A0A2Y9E3U4_TRIMA/173-202 AC A0A2Y9E3U4.1
#=GS A0A8H4UKU8_9HYPO/71-101 AC A0A8H4UKU8.1
#=GS A0A6P5BSX1_BOSIN/117-145 AC A0A6P5BSX1.1
#=GS A0A8C8ZN49_PROSS/303-332 AC A0A8C8ZN49.1
#=GS A0A7C8MYG7_9PEZI/6-36 AC A0A7C8MYG7.1
#=GS A0A3Q3MA23_9TELE/467-496 AC A0A3Q3MA23.2
#=GS A0A667ZQM0_9TELE/221-250 AC A0A667ZQM0.1
#=GS A0A674CEC8_SALTR/259-288 AC A0A674CEC8.1
#=GS A0A7L3ZCX0_FREGA/137-165 AC A0A7L3ZCX0.1
#=GS A0A8H7XZ65_PSICU/16-48 AC A0A8H7XZ65.1
#=GS A0A8B9U048_9AVES/240-269 AC A0A8B9U048.1
#=GS A0A3Q2W4M5_HAPBU/231-260 AC A0A3Q2W4M5.1
#=GS A0A1U8L3G6_GOSHI/178-208 AC A0A1U8L3G6.1
#=GS A0A6A5PQX8_LUPAL/303-331 AC A0A6A5PQX8.1
#=GS A0A8C3BXN7_CAIMO/256-285 AC A0A8C3BXN7.1
#=GS A0A8D2QLV8_ZOSLA/119-147 AC A0A8D2QLV8.1
#=GS A0A8C4A5I2_9TELE/414-449 AC A0A8C4A5I2.1
#=GS A0A087QVU0_APTFO/483-512 AC A0A087QVU0.1
#=GS A0A6J3KU53_9HYME/223-251 AC A0A6J3KU53.1
#=GS A0A4T0WYR3_9ASCO/216-245 AC A0A4T0WYR3.1
#=GS A0A3P9CY31_9CICH/652-681 AC A0A3P9CY31.1
#=GS A0A3B1K9U6_ASTMX/313-342 AC A0A3B1K9U6.1
#=GS A0A671QUP9_9TELE/185-214 AC A0A671QUP9.1
#=GS A0A2K5DHC6_AOTNA/264-293 AC A0A2K5DHC6.1
#=GS A0A667WKR9_9TELE/456-485 AC A0A667WKR9.1
#=GS A0A5N5PBX7_PANHP/177-206 AC A0A5N5PBX7.1
#=GS A0A3P8W9W0_CYNSE/236-265 AC A0A3P8W9W0.1
#=GS A0A7N8WQF1_9TELE/77-106 AC A0A7N8WQF1.1
#=GS A0A0V0YJ47_TRIPS/383-411 AC A0A0V0YJ47.1
#=GS A0A8C1B4F8_CYPCA/275-304 AC A0A8C1B4F8.1
#=GS A0A7L1FLT5_SYLBO/92-121 AC A0A7L1FLT5.1
#=GS A0A091N7W3_9PASS/144-173 AC A0A091N7W3.1
#=GS A0A3Q7SLT9_VULVU/32-60 AC A0A3Q7SLT9.1
#=GS A0A673ZF11_SALTR/224-253 AC A0A673ZF11.1
#=GS A0A3M0J0M0_HIRRU/828-857 AC A0A3M0J0M0.1
#=GS A0A6P7KD35_9TELE/55-84 AC A0A6P7KD35.1
#=GS A0A1U8D8G5_ALLSI/366-394 AC A0A1U8D8G5.1
#=GS A0A3M7P769_BRAPC/103-133 AC A0A3M7P769.1
#=GS A0A8C5NIW2_JUNHY/366-395 AC A0A8C5NIW2.1
#=GS A0A5N6KS02_9ROSI/6-35 AC A0A5N6KS02.1
#=GS A0A8C4RNM5_ERPCA/296-324 AC A0A8C4RNM5.1
#=GS A0A8C4NQ59_DICLA/619-648 AC A0A8C4NQ59.2
#=GS A0A8C9EGJ3_PAVCR/405-433 AC A0A8C9EGJ3.1
#=GS A0A4W5Q2B5_9TELE/277-305 AC A0A4W5Q2B5.1
#=GS A0A2I2ZQ50_GORGO/316-345 AC A0A2I2ZQ50.1
#=GS A0A2K6P113_RHIRO/2362-2391 AC A0A2K6P113.1
#=GS A0A8C9XBQ7_SANLU/132-160 AC A0A8C9XBQ7.1
#=GS A0A850ZXY8_SULDA/172-201 AC A0A850ZXY8.1
#=GS A0A8C3T0A0_CHESE/355-384 AC A0A8C3T0A0.1
#=GS W3A560_PHYPR/479-506 AC W3A560.1
#=GS A0A8R2GAB4_BOMMO/78-107 AC A0A8R2GAB4.1
#=GS A0A151GM61_9HYPO/110-139 AC A0A151GM61.1
#=GS A0A3Q3AA53_KRYMA/2932-2960 AC A0A3Q3AA53.1
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