GenomeNet

Database: Pfam
Entry: bCoV_NAR
LinkDB: bCoV_NAR
Original site: bCoV_NAR 
#=GF ID   bCoV_NAR
#=GF AC   PF16251.7
#=GF DE   Betacoronavirus nucleic acid-binding (NAR)
#=GF PI   NAR;
#=GF AU   Chang Y;0000-0002-2418-3433
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Jackhmmer JCSG taget SARS168 and PDB 2K87
#=GF GA   25.00 25.00;
#=GF TC   25.00 37.70;
#=GF NC   24.00 23.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12730500
#=GF RT   Characterization of a novel coronavirus associated with severe 
#=GF RT   acute respiratory syndrome
#=GF RA   Rota PA, Oberste MS, Monroe SS, Nix WA, Campagnoli R, Icenogle
#=GF RA   JP, Peñaranda S, Bankamp B, Maher K, Chen MH, Tong S, Tamin A,
#=GF RA   Lowe L, Frace M, DeRisi JL, Chen Q, Wang D, Erdman DD, Peret TC,
#=GF RA   Burns C, Ksiazek TG, Rollin PE, Sanchez A, Liffick S, Holloway
#=GF RA   B, Limor J, McCaustland K, Olsen-Rasmussen M, Fouchier R,
#=GF RA   Günther S, Osterhaus AD, Drosten C, Pallansch MA, Anderson LJ,
#=GF RA   Bellini WJ.
#=GF RL   Science 300 (5624), 1394-1399 (2003)
#=GF RN   [2]
#=GF RM   29128390
#=GF RT   Nsp3 of coronaviruses: Structures and functions of a large
#=GF RT   multi-domain protein.
#=GF RA   Lei J, Kusov Y, Hilgenfeld R;
#=GF RL   Antiviral Res. 2018;149:58-74.
#=GF RN   [3]
#=GF RM   19828617
#=GF RT   Nuclear magnetic resonance structure of the nucleic acid-binding
#=GF RT   domain of severe acute respiratory syndrome coronavirus
#=GF RT   nonstructural protein 3.
#=GF RA   Serrano P, Johnson MA, Chatterjee A, Neuman BW, Joseph JS,
#=GF RA   Buchmeier MJ, Kuhn P, Wüthrich K.
#=GF RL   J. Virol. 83 (24), 12998-13008 (2009).
#=GF DR   INTERPRO; IPR032592;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain, approximately 100 residues in length, is found in
#=GF CC   the multidomain nonstructural protein NSP3, and described as
#=GF CC   NSP3e domain. NSP3 is part of Orf1a polyproteins in SARS-CoV
#=GF CC   [1]. It is an essential component of the
#=GF CC   replication/transcription complex [2]. The global domain of the
#=GF CC   NAR represents a new fold, with a parallel four-strand
#=GF CC   beta-sheet holding two alpha-helices of three and four turns
#=GF CC   that are oriented antiparallel to the beta-strands and a group
#=GF CC   of residues form a positively charged patch on the protein
#=GF CC   surface as the binding site responsible for binding affinity for
#=GF CC   nucleic acids. When binding to ssRNA, the NAR prefers sequences
#=GF CC   with repeats of three consecutive Gs, such as (GGGA)5 and
#=GF CC   (GGGA)2. A positively charged surface patch (Lys75, Lys76,
#=GF CC   Lys99, and Arg106) is involved in RNA binding [2, 3].
#=GF SQ   52
#=GS R1A_CVMA5/1945-2061         AC P0C6V0.1
#=GS B8Q8U7_SARS/1883-1996       AC B8Q8U7.1
#=GS A0A0A7UXR0_9BETC/1952-2068  AC A0A0A7UXR0.1
#=GS A3EXC0_BCHK4/1882-2003      AC A3EXC0.1
#=GS R1A_CVM2/1892-2008          AC P0C6U9.1
#=GS R1AB_SARS2/1909-2019        AC P0DTD1.1
#=GS A0A023YA54_MERS/1938-2052   AC A0A023YA54.1
#=GS A3EXE7_BCHK5/1909-2030      AC A3EXE7.1
#=GS A0A0K2RW65_9BETC/1904-2020  AC A0A0K2RW65.1
#=GS H9BZX6_9BETC/1947-2063      AC H9BZX6.1
#=GS T2B9I2_MERS/1841-1952       AC T2B9I2.1
#=GS Q6UZF5_SARS/1883-1996       AC Q6UZF5.1
#=GS R1AB_CVHOC/1900-2016        AC P0C6X6.1
#=GS A0A0K2RVJ3_9BETC/1904-2020  AC A0A0K2RVJ3.1
#=GS Q06BE1_9BETC/1900-2016      AC Q06BE1.2
#=GS A3EXA2_BCHK4/1872-1993      AC A3EXA2.1
#=GS A0A088DIE1_9BETC/2027-2147  AC A0A088DIE1.1
#=GS U5LR11_9BETC/1897-2014      AC U5LR11.1
#=GS H9BZX5_9BETC/1947-2063      AC H9BZX5.1
#=GS R1A_BC279/1889-2002         AC P0C6F5.1
#=GS R1AB_CVMA5/1945-2061        AC P0C6X9.1
#=GS H9AA60_9BETC/1916-2032      AC H9AA60.1
#=GS A0A0K1YZY7_SARS/1883-1996   AC A0A0K1YZY7.1
#=GS R1A_SARS/1883-1996          AC P0C6U8.1
#=GS R1A_SARS/1883-1996          DR PDB; 2K87 A; 1-114;
#=GS A0A0U1WHG0_SARS/1878-1991   AC A0A0U1WHG0.1
#=GS R1AB_SARS/1883-1996         AC P0C6X7.1
#=GS B8Q8S4_SARS/1883-1996       AC B8Q8S4.1
#=GS R1A_SARS2/1909-2019         AC P0DTC1.1
#=GS R1AB_CVMJH/1944-2060        AC P0C6Y0.1
#=GS R1AB_BC279/1889-2002        AC P0C6V9.1
#=GS R1A_BCHK4/1872-1993         AC P0C6T4.1
#=GS R1AB_BCHK5/1910-2031        AC P0C6W4.1
#=GS B8Q8U6_SARS/1883-1996       AC B8Q8U6.1
#=GS R1A_CVMJH/1944-2060         AC P0C6V1.1
#=GS F2YDB2_SARS/1883-1996       AC F2YDB2.1
#=GS R9QTB2_SARS/1875-1988       AC R9QTB2.1
#=GS A0A0U1WHK4_SARS/1883-1996   AC A0A0U1WHK4.1
#=GS B8Q8S5_SARS/1883-1996       AC B8Q8S5.1
#=GS A0A0U1UZ65_BCHK4/1882-2003  AC A0A0U1UZ65.1
#=GS E0XIZ2_9BETC/1873-1986      AC E0XIZ2.1
#=GS C0KYZ6_9BETC/1944-2060      AC C0KYZ6.1
#=GS B7U2M9_9BETC/1900-2016      AC B7U2M9.1
#=GS Q0ZJB1_CVHK1/1985-2101      AC Q0ZJB1.1
#=GS Q9J3E9_9BETC/1942-2058      AC Q9J3E9.1
#=GS R1AB_CVM2/1892-2008         AC P0C6X8.1
#=GS R1AB_BCHK4/1872-1993        AC P0C6W3.1
#=GS T2B9U0_MERS/1841-1952       AC T2B9U0.1
#=GS R1A_CVHOC/1900-2016         AC P0C6U7.1
#=GS F2YDB1_SARS/1883-1996       AC F2YDB1.1
#=GS A0A0K1Z0N1_SARS/1883-1996   AC A0A0K1Z0N1.1
#=GS R1A_BCHK5/1910-2031         AC P0C6T5.1
#=GS U5KNA9_9BETC/1897-2014      AC U5KNA9.1
R1A_CVMA5/1945-2061                    .................YYTKPIIKAQFRTFE.KVDGVYTNFKLV.......GHSIAEKLNAKLGFDCNSPFV.EYKITEWPTATGDVVLASDDLYVSRYSSGCITFGKPVVWLGHEEASLKSLTYFNRPSVVC.ENKFNVLPV........................
B8Q8U7_SARS/1883-1996                  ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--TKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWClRCLWSTKPV........................
A0A0A7UXR0_9BETC/1952-2068             .................YYTQRIVKAQFKTFE.AVDGVYTNFELV.......GHALCDTLNVKLGFDSTKDSV.QYKVTVWPDATGDVVLADDDLYVKRYKKGCITFGKPVIWQSHMEASLASLTYFNRPSLID.KNKFDVLTV........................
A3EXC0_BCHK4/1882-2003                 ................yYTSKPTIKYSPATI-.LPGSVYSNSCLVgvdgtpgSDTISKFFNDLLGFDETKPISkKLTYSLLPNEDGDVLLSEFSNYNPVYKKGVMLKGKPILW---VNNGVCDSAL-NKPNRASlRQLYDVAPI........................
R1A_CVM2/1892-2008                     .................YYTKPIIKAQFRTFE.KVEGVYTNFKLV.......GHSIAEKFNAKLGFDCNSPFT.EYKITEWPTATGDVVLASDDLYVSRYSGGCVTFGKPVIWLGHEEASLKSLTYFNRPSVVC.ENKFNVLPV........................
R1AB_SARS2/1909-2019                   ....eqpidlvpnqpyp-------NAS-----.-----FDNFKFVc.....dNIKFADDLNQLTGY--KKPASrELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVW--HVNNATNKATY--KPNTWCiRCLWSTKPV........................
A0A023YA54_MERS/1938-2052              .....vsyspatviags---------------.----VYTNSCLIaadgqvsGDPISLAFNNMLGYDPSKPTSkKYTYSVLPDENGDILMAEYSTYDPIYKNGAMLNGKPVLWVSN------------------.---------glfdaalsrfnrasirqiydpepv
A3EXE7_BCHK5/1909-2030                 ..............yft--KKPVIEYSPATI-.LSGSVYTNSCLVghdgtigSDAISSSFNNLLGFDNSKPVSkKLTYSFFPDFEGDVILTEYSTYDPIYKNGAMLHGKPILW---VNNSKFDSAL-NKFNRATlRQVYDVAPV........................
A0A0K2RW65_9BETC/1904-2020             .................YYTQRIVKAQFRTFE.KVDGAYINFKLV.......GHTVCDSLNAKLGFDSSKEFV.EYKVTEWPTATGDVVLANDDLYVKRYERGCITFGKPVIWYNHEQASLNSLTYFNRPSLVD.VNKFDVLKV........................
H9BZX6_9BETC/1947-2063                 .................YYTKPIIKAQFRTFE.KVDGVYTNFKLV.......GHSIAEKLNAKLGFDCNSPFV.EYKITEWPTATGDVVLASDDLYVSRYSSGCITFGKPVVWLGHEEASLKSLTYFNRPSVVC.ENKFNVLPV........................
T2B9I2_MERS/1841-1952                  .........spatilag---------------.---SVYTNSCLVssdgqpgGDAISLSFNNLLGFDSSKPVTkKYTYSFLPKEDGDVLLAEFDTYDPIYKNGAMYKGKPILWV---NKASYDTNL-NKFNRASlRQIFDVAP-i.......................
Q6UZF5_SARS/1883-1996                  ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--TKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWClRCLWSTKPV........................
R1AB_CVHOC/1900-2016                   .................YYTQRIIKAQFKTFE.KVDGVYTNFKLI.......GHTVCDSLNSKLGFDSSKEFV.EYKITEWPTATGDVVLANDDLYVKRYERGCITFGKPVIWLSHEKASLNSLTYFNRPLLVD.DNKFDVLKV........................
A0A0K2RVJ3_9BETC/1904-2020             .................YYTQRIVKAQFRTFE.KVDGAYINFKLV.......GHTVCDSLNAKLGFDSSKEFV.EYKVTEWPTATGDVVLANDDLYVKRYERGCITFGKPVIWYNHEQASLNSLTYFNRPSLVD.VNKFDVLKV........................
Q06BE1_9BETC/1900-2016                 .................YYTQRIIKAQFKTFE.KVDGVYTNFKLI.......GHTICDILNVKLGFDSSKEFV.EYKVTEWPTATGDVVLATDDLYVKRYERGCITFGKPVIWLSHEQASLNSLTYFNRPLLVD.ENKFDVLKV........................
A3EXA2_BCHK4/1872-1993                 ................yYTSKPTIKYSPATI-.LPGSVYSNSCLVgvdgtpgSDTISKFFNDLLGFDETKPISkKLTYSLLPNEDGDVLLSEFSNYNPVYKKGVMLKGKPILW---VNNGVCDSAL-NKPNRASlRQLYDVAPI........................
A0A088DIE1_9BETC/2027-2147             .....yytsapidltpt---EPLSGAEYDNFHlKLVGTLDDN---.......KVKFVQEFNHMVKYDKTKPTR.PVTISFYPEMEGDVVALSADKLQQHFKKGAKFGSKFIVW--HTGYKITRDLV--KPNMAAmRCITTSKPV........................
U5LR11_9BETC/1897-2014                 yytnkpsleftpatvss---------------.--GVVYTNSCFIv....ndGDAIGSAFNKLLGFDKNKPASkQLTYSLLPNEDGDVLLAEFKSYDPMYKNGAAYKGKPILW---VNNGLYDSKL-NKYNRASlRQIFDIQPV........................
H9BZX5_9BETC/1947-2063                 .................YYTKPIIKAQFRTFE.KVDGVYTNFKLV.......GHSIAEKLNAKLGFDCNSPFV.EYKITEWPTATGDVVLASDDLYVSRYSSGCITFGKPVVWLGHEEASLKSLTYFNRPSVVC.ENKFNVLPV........................
R1A_BC279/1889-2002                    ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--KKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIIW--HINQTTNKTTY--KPNTWClRCLWSTKPV........................
R1AB_CVMA5/1945-2061                   .................YYTKPIIKAQFRTFE.KVDGVYTNFKLV.......GHSIAEKLNAKLGFDCNSPFV.EYKITEWPTATGDVVLASDDLYVSRYSSGCITFGKPVVWLGHEEASLKSLTYFNRPSVVC.ENKFNVLPV........................
H9AA60_9BETC/1916-2032                 .................YYTQRIIKAQFRTFE.KVDGVYTNFKLV.......GHTICDSLNAKLGFDANKHFE.EFKVTEWPIATGDVVLVTDDMYVKRYEKGCITFGKPVIWYNHDQASLNSLTYFNRPSLVD.VNKFDVLKV........................
A0A0K1YZY7_SARS/1883-1996              ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--TKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWClRCLWSTKPV........................
R1A_SARS/1883-1996                     ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--TKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWClRCLWSTKPV........................
#=GR R1A_SARS/1883-1996          SS    ......------SS-EE------TT-B-----.-------SEEEEE.....SSHHHHHHHHHHTT----SS-SEEEEEEETT---SSEEEEEGGG--GGGTT-EE-SSSB--E--EBTTB--HHHH--HHHHHHHHHH-B----........................
A0A0U1WHG0_SARS/1878-1991              ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNSKFADDLNQMTGF--KKPASrELFVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIIW--HINQTTNKTTY--KPNTWClRCLWSTKPV........................
R1AB_SARS/1883-1996                    ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--TKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWClRCLWSTKPV........................
B8Q8S4_SARS/1883-1996                  ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--TKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWClRCLWSTKPV........................
R1A_SARS2/1909-2019                    ....eqpidlvpnqpyp-------NAS-----.-----FDNFKFVc.....dNIKFADDLNQLTGY--KKPASrELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVW--HVNNATNKATY--KPNTWCiRCLWSTKPV........................
R1AB_CVMJH/1944-2060                   .................YYTKPIIKAQFRTFE.KVEGVYTNFKLV.......GHDIAEKLNAKLGFDCNSPFM.EYKITEWPTATGDVVLASDDLYVSRYSGGCVTFGKPVIWRGHEEASLKSLTYFNRPSVVC.ENKFNVLPV........................
R1AB_BC279/1889-2002                   ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--KKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIIW--HINQTTNKTTY--KPNTWClRCLWSTKPV........................
R1A_BCHK4/1872-1993                    ................yYTSKPTIKYSPATI-.LPGSVYSNSCLVgvdgtpgSDTISKFFNDLLGFDETKPISkKLTYSLLPNEDGDVLLSEFSNYNPVYKKGVMLKGKPILW---VNNGVCDSAL-NKPNRASlRQLYDVAPI........................
R1AB_BCHK5/1910-2031                   ..............yft--KKPVIEYSPATI-.LSGSVYTNSCLVghdgtigSDAISSSFNNLLGFDNSKPVSkKLTYSFFPDFEGDVILTEYSTYDPIYKNGAMLHGKPILWV---NNSKFDSAL-NKFNRATlRQVYDIAP-v.......................
B8Q8U6_SARS/1883-1996                  ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--TKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWClRCLWSTKPV........................
R1A_CVMJH/1944-2060                    .................YYTKPIIKAQFRTFE.KVEGVYTNFKLV.......GHDIAEKLNAKLGFDCNSPFM.EYKITEWPTATGDVVLASDDLYVSRYSGGCVTFGKPVIWRGHEEASLKSLTYFNRPSVVC.ENKFNVLPV........................
F2YDB2_SARS/1883-1996                  ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--TKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWClRCLWSTKPV........................
R9QTB2_SARS/1875-1988                  ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....aNTKFADDLNQMTGF--KKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIIW--HINQTTNKTTY--KPNTWClRCLWSTKPV........................
A0A0U1WHK4_SARS/1883-1996              ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--TKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWClRCLWSTKPV........................
B8Q8S5_SARS/1883-1996                  ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--TKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWClRCLWSTKPV........................
A0A0U1UZ65_BCHK4/1882-2003             ................yYTSKPTIKYSPATI-.LSGSVYSNSCLVgvdgtpgSDTISKFFNDLLGFDETKPISkKLSYSLLPDEDGDVLLSEFSNYNPVYKKGVMLKGKPILW---VNNGVCDSAL-NKPNRASlRQLYDVAPI........................
E0XIZ2_9BETC/1873-1986                 ......yyteqpidlvp--TQPLPNASF----.------DNFRFVc.....aNTKFADDLNQMTGF--KKPPSrDLTITFFPDLNGDVVAIDYRHYTPTFKKGAKLVHKPILW--HVNQTTTKSTF--KPNMWClRCLYSTKPV........................
C0KYZ6_9BETC/1944-2060                 .................YYTKPIIKAQFRTFE.KVEGVYTNFKLV.......GHDIAEKLNAKLGFDCNSPFM.EYKITEWPTATGDVVLASDDLYVSRYSGGCVTFGKPVIWRGHEEASLKSLTYFNRPSVVC.ENKFNVLPV........................
B7U2M9_9BETC/1900-2016                 .................YYTQRIIKAQFKTFE.KVDGVYTNFKLI.......GHTICDILNAKLGFDSSKEFV.EYKVTEWPTATGDVVLATDDLYVKRYERGCITFGKPVIWLSHEQASLNSLTYFNRPLLVD.ENKFDVLKV........................
Q0ZJB1_CVHK1/1985-2101                 .................YYTKPIIKAQFKPFA.KVDGVYTNFKLV.......GHDICAQLNDKLGFNVDLPFV.EYKVTVWPVATGDVVLASDDLYVKRYFKGCETFGKPVIWLCHDEASLNSLTYFNKPSFKS.ENRYSVLSV........................
Q9J3E9_9BETC/1942-2058                 .................YYTKPIIKAQFRTFE.KVDGVYTNFKLV.......GHSIAEKLNAKLGFDCNSPFV.EYKITEWPTATGDVVLASDDLYVSRYSSGCITFGKPVVWLGHEEASLKSLTYFNRPSVVC.ENKFNVLPV........................
R1AB_CVM2/1892-2008                    .................YYTKPIIKAQFRTFE.KVEGVYTNFKLV.......GHSIAEKFNAKLGFDCNSPFT.EYKITEWPTATGDVVLASDDLYVSRYSGGCVTFGKPVIWLGHEEASLKSLTYFNRPSVVC.ENKFNVLPV........................
R1AB_BCHK4/1872-1993                   ................yYTSKPTIKYSPATI-.LPGSVYSNSCLVgvdgtpgSDTISKFFNDLLGFDETKPISkKLTYSLLPNEDGDVLLSEFSNYNPVYKKGVMLKGKPILW---VNNGVCDSAL-NKPNRASlRQLYDVAPI........................
T2B9U0_MERS/1841-1952                  .........spatilag---------------.---SVYTNSCLVssdgqpgGDAISLSFNNLLGFDSSKPVTkKYTYSFLPKEDGDVLLAEFDTYDPIYKNGAMYKGKPILWV---NKASYDTNL-NKFNRASlRQIFDVAP-i.......................
R1A_CVHOC/1900-2016                    .................YYTQRIIKAQFKTFE.KVDGVYTNFKLI.......GHTVCDSLNSKLGFDSSKEFV.EYKITEWPTATGDVVLANDDLYVKRYERGCITFGKPVIWLSHEKASLNSLTYFNRPLLVD.DNKFDVLKV........................
F2YDB1_SARS/1883-1996                  ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--TKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWClRCLWSTKPV........................
A0A0K1Z0N1_SARS/1883-1996              ......yyteqpidlvp--TQPLPNASF----.------DNFKLTc.....sNTKFADDLNQMTGF--TKPASrELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWClRCLWSTKPV........................
R1A_BCHK5/1910-2031                    ..............yft--KKPVIEYSPATI-.LSGSVYTNSCLVghdgtigSDAISSSFNNLLGFDNSKPVSkKLTYSFFPDFEGDVILTEYSTYDPIYKNGAMLHGKPILWV---NNSKFDSAL-NKFNRATlRQVYDIAP-v.......................
U5KNA9_9BETC/1897-2014                 yytnkpsleftpatvss---------------.--GVVYTNSCFIv....ndGDAIGSAFNKLLGFDKNKPASkQLTYSLLPNEDGDVLLAEFKSYDPMYKNGAAYKGKPILW---VNNGLYDSKL-NKYNRASlRQIFDIQPV........................
#=GC SS_cons                           ......------SS-EE------TT-B-----.-------SEEEEE.....SSHHHHHHHHHHTT----SS-SEEEEEEETT---SSEEEEEGGG--GGGTT-EE-SSSB--E--EBTTB--HHHH--HHHHHHHHHH-B----........................
#=GC seq_cons                          ...................TpPl.pApF........ssYsNFKLls.....sucslu-sLNphLGFD.sKPho+EhplThaPshsGDVVhs-acpYsspYK+GshhhGKPIlW..H.stuhscsTa..KPNhhshRslasstPV........................
//
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