#=GF ID bacHORMA_2
#=GF AC PF18173.4
#=GF DE Bacterial HORMA domain 2
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Burroughs AM;0000-0002-2229-8771
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE Laks
#=GF GA 27.30 27.30;
#=GF TC 30.20 60.20;
#=GF NC 26.00 25.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0651
#=GF RN [1]
#=GF RM 26590262
#=GF RT Comparative genomic analyses reveal a vast, novel network of
#=GF RT nucleotide-centric systems in biological conflicts, immunity and
#=GF RT signaling.
#=GF RA Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;
#=GF RL Nucleic Acids Res. 2015;43:10633-10654.
#=GF RN [2]
#=GF RM 32839535
#=GF RT Diversity and classification of cyclic-oligonucleotide-based
#=GF RT anti-phage signalling systems.
#=GF RA Millman A, Melamed S, Amitai G, Sorek R;
#=GF RL Nat Microbiol. 2020;5:1608-1615.
#=GF RN [3]
#=GF RM 31932165
#=GF RT HORMA Domain Proteins and a Trip13-like ATPase Regulate
#=GF RT Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity.
#=GF RA Ye Q, Lau RK, Mathews IT, Birkholz EA, Watrous JD, Azimi CS,
#=GF RA Pogliano J, Jain M, Corbett KD;
#=GF RL Mol Cell. 2020;77:709-722.
#=GF DR INTERPRO; IPR040649;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Family of bacterial HORMA domains found in conserved genome
#=GF CC contexts with Pch2/TRIP13 P-loop NTPases. Acts as a 'third
#=GF CC component' in broad class of conflict systems reliant on the
#=GF CC production of second messenger nucleotide or nucleotide
#=GF CC derivatives. Together with Pch2/TRIP13, could act as
#=GF CC co-effectors or in regulation of other effectors of the systems
#=GF CC [1]. This domain found in bacterial proteins from the
#=GF CC cyclic-oligonucleotide-based anti-phage signalling system
#=GF CC (CBASS), such us CD-NTase-associated protein 7 from P.
#=GF CC aeruginosa (Cap7), which is part of the type III-CBASS. CBSSs
#=GF CC are a family of defence systems against bacteriophages [2,3].
#=GF SQ 53
#=GS A0A259TTR4_9BACT/1-164 AC A0A259TTR4.1
#=GS A0A196Q0P7_9RHOB/1-166 AC A0A196Q0P7.1
#=GS A0A2C9D4Z0_9RHIZ/1-166 AC A0A2C9D4Z0.1
#=GS A0A1V9GAE9_9BACT/1-166 AC A0A1V9GAE9.1
#=GS A0A5B8G2D6_9RHOB/1-166 AC A0A5B8G2D6.1
#=GS S9ZNV9_9RHOO/1-166 AC S9ZNV9.1
#=GS A0A4U8Z3Y6_METTU/1-166 AC A0A4U8Z3Y6.1
#=GS J2VBX3_9RHIZ/1-166 AC J2VBX3.1
#=GS A0A366H3X2_9BURK/1-166 AC A0A366H3X2.1
#=GS E8V4E3_TERSS/4-167 AC E8V4E3.1
#=GS A0A3P3DP94_9RHOB/1-167 AC A0A3P3DP94.1
#=GS A0A6L9S2M0_9ACTN/3-167 AC A0A6L9S2M0.1
#=GS A0A2C6Z874_9PROT/1-166 AC A0A2C6Z874.1
#=GS A0A1C6SAT8_9ACTN/2-171 AC A0A1C6SAT8.1
#=GS A0A6N1XH21_9RHOO/1-166 AC A0A6N1XH21.1
#=GS C7Q3J5_CATAD/2-171 AC C7Q3J5.1
#=GS A0A3R8S6G0_9BURK/1-166 AC A0A3R8S6G0.1
#=GS A0A238JIX0_9RHOB/1-166 AC A0A238JIX0.1
#=GS A0A4Q9RBQ5_9PSED/1-166 AC A0A4Q9RBQ5.1
#=GS A0A438M003_9ACTN/1-167 AC A0A438M003.1
#=GS A0A1M6J7R7_9PROT/1-166 AC A0A1M6J7R7.1
#=GS A0A1N7PUZ4_9PROT/1-166 AC A0A1N7PUZ4.1
#=GS A0A2Z6E3T4_9GAMM/1-151 AC A0A2Z6E3T4.1
#=GS A0A3S0Q5J4_9GAMM/1-166 AC A0A3S0Q5J4.1
#=GS A0A202DRF6_9BACT/8-161 AC A0A202DRF6.1
#=GS A0A2T0RH44_9RHOB/1-166 AC A0A2T0RH44.1
#=GS A0A0A0HE83_9RHOB/1-166 AC A0A0A0HE83.1
#=GS A1W5G8_ACISJ/1-166 AC A1W5G8.1
#=GS A0A095VL24_9RHIZ/2-165 AC A0A095VL24.1
#=GS A0A1I5TC17_9BACT/1-166 AC A0A1I5TC17.1
#=GS A0A4V2U864_9RHIZ/5-167 AC A0A4V2U864.1
#=GS A0A6V8KNA8_9ACTN/2-171 AC A0A6V8KNA8.1
#=GS A0A238LLH5_9RHOB/1-166 AC A0A238LLH5.1
#=GS A0A328AN90_9CAUL/1-167 AC A0A328AN90.1
#=GS A0A1X0DUD3_9MYCO/3-165 AC A0A1X0DUD3.1
#=GS Q120L5_POLSJ/1-166 AC Q120L5.1
#=GS A0A246K0D3_9SPHN/1-166 AC A0A246K0D3.1
#=GS A0A429B4F8_9ACTN/1-166 AC A0A429B4F8.1
#=GS A0A2A2Z569_9ACTN/2-171 AC A0A2A2Z569.1
#=GS A7HU62_PARL1/1-166 AC A7HU62.1
#=GS A0A5S4ZB40_9ACTN/1-171 AC A0A5S4ZB40.1
#=GS A0A6M4A218_9BURK/1-166 AC A0A6M4A218.1
#=GS Q1LKV8_CUPMC/52-217 AC Q1LKV8.1
#=GS A0A2L0A7X0_9SPHN/1-166 AC A0A2L0A7X0.1
#=GS A0A4R0YGI6_9PROT/1-165 AC A0A4R0YGI6.1
#=GS Q07NS8_RHOP5/1-166 AC Q07NS8.1
#=GS A0A6N2ICC1_9ACTN/1-167 AC A0A6N2ICC1.1
#=GS I3TV71_TISMK/1-166 AC I3TV71.1
#=GS A0A0D7KAX5_9BURK/1-166 AC A0A0D7KAX5.1
#=GS A0A109CEU6_9BURK/1-166 AC A0A109CEU6.1
#=GS A0A2U1G201_9SPHN/1-164 AC A0A2U1G201.1
#=GS N6Y7F4_9RHOO/1-166 AC N6Y7F4.1
#=GS A0A369TH38_9RHOB/1-166 AC A0A369TH38.1
A0A259TTR4_9BACT/1-164 ......MSVVAVNTF..THSVTYVSDQMLRSLKTIVVRSGLSAAKLGREWE.S.IDLALRTWLGTRDLERVVLEVLHPT...TGALVTRWDATLTYSY.D-G.EGEMWA.DTDALRFAIAKAGAVASTCDYRVLLH.TKSGRPDVAGWSPTTYTSTDGFVRHSVGTTIGTHAIGSDFAYWR--p..............
A0A196Q0P7_9RHOB/1-166 ......MTTVITYSR..TQSVTYVADNILKSLKDIIRLSGMDPTNFVNDTE.I.NMRGIKAWLESEDLEKITLEIYDPA...TNGLILRWDIDVNYSW.SAG.DGNFWT.DTDQLRWAIRKAGVAPASAKYDLLLR.TKPGRPDVPGWHRTTARSTDGMVRQSLGSTIEHNGLGATAAYWRQ-a..............
A0A2C9D4Z0_9RHIZ/1-166 ......MTNVAVNTY..THSVTYVADNILKSLKDIIRLVGLDPTEFVGDWE.L.HMRGVQTWLNTGDLETVKLEIYNPK...TDALIFRWDIDIAYGW.SGG.DGSFWT.DTEQLKYAIRKAGLVPSEARYRLLLQ.SKPGRPDVAGWSKASGRSTEGMVRQSLGTTVEHSGLGASTSYLRRA...............
A0A1V9GAE9_9BACT/1-166 ....ms-TLVSVNTY..AHTVTFVTDKMLKSLRYIITSTGLDPNKFVNDWK.T.YELGVQTWLTSKHLKGITLEIVSP-...TGALVTRCDFEINYTY.GNG.EGSMWL.DTDALKFAITKFGTIPSSCTYSIILT.TDPNRSDVAGWGPASYLSTEGFTKQSLGTTIGTSSIGAQASYWRK-s..............
A0A5B8G2D6_9RHOB/1-166 ......MTTVSVNTY..THSVTYVADNMLKSLKDIIRLSGLDPTNFIEDWD.V.NMRGIKRWLETQDLERVDLEIYDPK...TDALLFRWDMDVVYGW.SSG.DGNFWV.DTEQLKYAIRKAGLVPSQAKYRLLVR.TKPGRPDVDGWSKVTARSTTGFTRQSLGTTIDHSGLGANTSYWRQ-t..............
S9ZNV9_9RHOO/1-166 ......MSAVAVFSY..TQSVVYVADNILKSLKDIIRLSGLDPTKLVNDWA.V.LLRGLSAWIESRHLESVTLEIFDPK...TDGLLFRWDIEVVYTW.DVS.AGTFWT.DTDQLKWAIKKAGLVPSQADYRVSVH.NKPGRPDVSGWSNCTLRSTDGMVRQSLGTTVEHNGLSANTTYWRKA...............
A0A4U8Z3Y6_METTU/1-166 ......MTNVAVNTY..THSVTYVADNILKSLKDIIRLSGLDPSEFVGDWE.T.HMRGVQTWLNTGDLETVKLEIYDPK...TDALIFRWDIDISYGW.SGD.DGNFWT.DTEQLKYAIRKAGLAPSEARYRFLLH.TKPGRPDVIGWSKATGRSTDGMVRQSLGTTVEHSGLGASTSYLRRA...............
J2VBX3_9RHIZ/1-166 ......MTNVAVNTY..THSVTYVADNILKSLKDIIRLVGLDPTEFVGDWE.L.HMRGVQTWLNTGDLETVKLEIYNPK...TDALIFRWDIDIAYGW.SGG.DGSFWT.DTEQLKYAIRKAGLVPSEARYRLLLQ.NKPGRPDVAGWSKASGRSTEGMVRQSLGTTVEHSGLGASTSYLRRA...............
A0A366H3X2_9BURK/1-166 ......MSTVATYSY..THSVTYVTDNILKSLKDIIRLSGLDPEFFADRWE.S.NTRAIKTWLGTGDLRKVILEVYDPA...TDKLVTRWDIDIVYGW.SDG.DGSFWT.DTEQLKYAIKKAGLLPSQAKYKLLLD.TKPERPDVDGWSKGSYRSTDGMVKQSLGSTVEHSGLAGQAGYWRQR...............
E8V4E3_TERSS/4-167 ...sty---SQVFSQ..THSIVFLSDNLRNTLREVIREYGLSPDKLMQDWD.T.IERGIKTWLSSQHLKTVTVEFFKPG...YSIASAKWEFPVVYTG.SGV.DDDMWL.DKNYLRQLIAKAARPSLDCTYRIVLS.NHPGAATVNGFVDTDFLSTGQLAARHSGTVIATGHLTAGATYWR--...............
A0A3P3DP94_9RHOB/1-167 ......MSTVSVNTY..THSATYLADNMLKSVKDIIVLSGLDPTTFVGDWE.F.YKTGMRTWLQSGHLEKVVLEVFDPV...TDALIVRWDIEVAYGWsANG.DGSFWT.DTDQLRYAIKKSGIHQSRLRYRFIVT.RAAGFGEVAGWAPATLRSTDGMVRQSLGTTVEHNGLGASTSYYRR-s..............
A0A6L9S2M0_9ACTN/3-167 .stsvg---VHATTR..THTANHLSDVIMSSIGDILTTLGISTSRFYKDWS.Q.DFTAISNWIEEGTLKTVALECHRPD...GT-VKPVFDFDVTYAPgGVG.DRKFTA.DNASLLKYMAKLERVPAGTTYRLVCSfNSTWHSDQVGWSPGSKASTSGLRIRTVGTLA---------------ggpdatattri....
A0A2C6Z874_9PROT/1-166 ......MTSVAVNTY..THSVTYVADNILKSLKDIIRLVGLDPTEFVGDWE.L.HMRGVQTWLNTGDLETVKLEIYNPR...TDALIVRWDIDIAYGW.SGG.DGGFWT.DTEQLKYAIRKAGLVPSEARYRLLLQ.SKPGRPDVAGWSKASGRSTEGMVRQSLGTTVEHSGLGASTSYLRRA...............
A0A1C6SAT8_9ACTN/2-171 .....t-TAVRVNTY..AHTTTHVATNMLRGMKQIIQQSGLSTSKIMGDWA.V.LEAGIAAWLNSGHLNGLVLEIYDPGkraGDDLAGRFDFTIDYSYyGDG.DGELWL.DPDTVSYTVLKNGSYPSRCSYRLIAD.TAPGYPAVDGWSTTTFRSTAGFTRHSVGTAIGGGSLGAGLHYYTR-s..............
A0A6N1XH21_9RHOO/1-166 ......MSTVAVFSY..TQSVVYVADNILKSLKDIIRLSGLDPTRLVNDWA.V.LLRGLSTWIESRHXESVMLEIFDSK...TDGLLFRWDIEVIYTW.DVS.AGTFWT.DTEQLKWAIKKAGLVPAQADYRVSVH.NKPGRPDVSGWSSCTLRSTDGMVRQSLGTTVEHNGLSANTTYWRKA...............
C7Q3J5_CATAD/2-171 ......ATSVRVNTT..THAATHVATNMIRSLKQIIRAAGLDPAGLLGQWA.L.LESGVSTWLQSGHLTTLVMEVFDPSdrtVTSLVGRFDFTIEYDYgADS.DGDLWL.DPDVIDYVIRKNGAYPSQCEYDFTVV.NKPGRPAVPGWGKGQLRSSDHLTRRTAGTAITGGTIGASISYYTRN...............
A0A3R8S6G0_9BURK/1-166 ......MSTVATYSY..THSVTYVTDNILKSLKDIILLSGLDPEHFADRWE.S.NTRAIKTWLGTGDLRKVILEIYNPA...TDKLVTRWDIDIVYGW.SDG.DGSFWT.DTEQLKYAIKKAGLLPSQAKYKLMLD.TKPGRPDVEGWSKGSYRSTDGMVKQSLGSTVEHSGLAGQAGYWRQR...............
A0A238JIX0_9RHOB/1-166 ......MTSVITYSR..TQSVTYVADNILKSLKDIIRLSGMDPTNFVNDTE.I.NMRGIKAWLESEDLEKITLDIYNPT...TDSLILRWDIDVTYSW.SAG.DGNFWT.DTDQLRWAIRKAGVAPASAKYDLLLR.TKPGRPDVPGWYRTTARSTDGMVRQSLGSTIEHNGLGATASYWRQ-a..............
A0A4Q9RBQ5_9PSED/1-166 ......MSSVATYSY..THSVTYVADNILKSLKDIIRLSGLDPSGFVNDWA.T.NLLAVKTWLDSEDLEKVILEIYNPS...SNNLITRWDIDVIYSW.SSG.DGSFWT.DTEQLKYAILKAGVLPSQAKYTLLLK.TKPGRPDVPGWSKGSYRSTDGMVKQSLGSTVEHSGLGAQAGYWRQR...............
A0A438M003_9ACTN/1-167 mtstyt----YSYTR..THTATHLTDVILGTITDILADLGINMDRLHRDWV.Q.NENAIKAWIEEGSLDTVVLECHQPS...G-AVAPVIEFPVSYTTsGDG.NAEFTA.SRARAARFRAKFDRVPMGTTYRLFCT.FNGPRTPQPGWGTGHRASIDGLRGITFGTL----------------gsaphastgmryfhn
A0A1M6J7R7_9PROT/1-166 ......MTSVAVNTY..THSVTYVADNILKSLKDIIRLVGLDPTEFVGDWE.L.HMRGVQTWLNTGDLETVKLEIYNPR...TDALIVRWDIDIAYGW.SGG.DGGFWT.DTEQLKYAIRKAGLVPSEARYRLLLQ.SKPGRPDVAGWSKASGRSTEGMVRQSLGTTVEHSGLGASTSYLRRA...............
A0A1N7PUZ4_9PROT/1-166 ......MTSVAVNTF..THSVTYVADNILKSLKDIIRLSGLDPSEFVGDWE.T.HMRGVQAWLNSGDLETVKLEIYNPK...TDALIFRWDIDIFYGW.SGG.DGNFWT.DTEQLKYAIRKAGLVPSEARYRFLLH.TKPGRPDVIGWSRTSERSTDGMVRQSLGTTVEHSGLGASTSYLRRA...............
A0A2Z6E3T4_9GAMM/1-151 .....m---------..-------TDNILKSLKDIILLSGLDPEHFADRWE.S.NTRAIKTWLGTGDLRKVILEIYNPA...TDKLVTRWDIDIVYGW.SDG.DGSFWT.DTEQLKYAIKKAGLLPSQAKYKLMLD.TKPGRPDVEGWSKGSYRSTDGMVKQSLGSTVEHSGLAGQAGYWRQR...............
A0A3S0Q5J4_9GAMM/1-166 ......MTTVSVYSY..THSVTYVADNILKSLKDIVRLSGLDPGKFANDWD.T.YQRGIRTWLESEHLEQVTLEVYHPT...TDALITRWDITINYQW.TSG.DGSFWT.DTEQLRYAIQKAGVVPSQADYRLIVH.NKSGKPAVDGWSSATFRATDGMVRQSLGGTVQHQGLSGSASYWRKA...............
A0A202DRF6_9BACT/8-161 ....kv--EVGVNMM..EKSITFMANTLFQMAFKIANARRLSPDYLVQNRE.L.LESGFFTWFAEGMLESLHFEVLSPD...GKKALERWDIYFSYSA.N-P.DPSVKKpPIGEIEEVAARLKALPPGTSYRIVIQ.TKPGASNVQGWQQTDFLSFDQ-------------------------ksehafsgwgygh..
A0A2T0RH44_9RHOB/1-166 ......MTSVITYSR..TQSVTYVADNILKSLKDIIRLSGMDPANFVNDTE.I.NMRGIKVWLESEDLEKITLEIYDPA...SNNLILRWDIDVAYSW.SAG.DGNFWT.DTDQLRWAIRKAGVAPASAKYDLLLR.TKPGRPDVPGWYRTTARSTDGMVRQSLGSTIEHNGLGATASYWRQ-a..............
A0A0A0HE83_9RHOB/1-166 ......MTTVITYSR..TQSVTYVADNILKSLKDIIRLSGMDPTNFVNNTE.I.NMRGIKAWLESEDLEKITLEIYDPA...TNELILRWDIDVNYSW.SAG.DGNFWT.DTDQLRWAIRKAGVAPSSAKYDLLLR.TKPGRPDVPGWYRTTARSTDGMVRQSLGSTIEHNGLGATASYWRQ-a..............
A1W5G8_ACISJ/1-166 ......MSTVATYSY..THSVTYVTDNILKSLKDIILLSGLDPEHFADRWE.S.NTRAIKTWLGTGDLRKVILEIYNPA...ADKLVTRWDIDIVYGW.SDG.DGSFWT.DTEQLKYAIKKAGLLPSQAKYKLMLD.TKPGRPDVEGWSKGSYRSTDGMVKQSLGSTVEHSGLAGQAGYWRQR...............
A0A095VL24_9RHIZ/2-165 ..avst----HNYTR..TNTAIYVSDKVRNLMRLLIINYGLDPTELVDAWSdW.VQDAARQWMEDGDLRGFAIEFYKPG...ASAVSARWEFPIRYDG.SDI.D-QMWI.DTDFLKGTFAKAPAPPAGCTYRILLQ.PTANARPLPGIGDASKLSLAGLTAREAGTVIGTPDIMASARYYR--...............
A0A1I5TC17_9BACT/1-166 ....ms-TLVSVNTY..THSVTYVTDQMLRSLKYIIVNTGLNPENFVGEWS.S.YELAVKTWLQSRHLKKVVLEVVSPA...-GNLVTRTDFDIDYSY.GDG.EGSMWV.DTDALKFAIAKFGIYPSSCTYNIKLL.NSPGRPDVEGWGACTFLSTEGYIKQSLGTTIGTNSIGASASYWRKN...............
A0A4V2U864_9RHIZ/5-167 ..ntya----QSYAR..TQTAIFVADKMRNLMKTLVLDAGLNPTALMDAWS.KwLYDAARKLMETGHLTNLIIEFYQPG...SAEACGRWDFPIRYDG.ADI.D-DMWV.DVDYFRQSFAKAPRPPAGCSYRVLLQ.HAPGAPSV-GLATVQLMGLGSLAAREAGTVIATPDIMASATYYK--...............
A0A6V8KNA8_9ACTN/2-171 .....s-TSVRVNTY..THATTHVATNMLRSVKQIIRESGLSTDKIRNQWG.V.LESGVATWLGSRHLKSLVLEVYDPGkpaGADLVGRFDFTIDYTYyGDG.DGELWL.DPDTVSYTVRKNGSYPSRCEYRIVAE.TASGRPDVAGWSSTTLRSTAGFTRHSVGTAIGGGSLGAGLSYYTR-s..............
A0A238LLH5_9RHOB/1-166 ......MTTVITYSR..TQSVTYVADNILKSLKDIIRLSGMDPTNFVNDTE.I.NMRGIKAWLESEDLQKITLEIYDPA...TNGLILRWDIDVNYSW.SAG.DGNFWT.DTDQLRWAIRKAGVAPASAKYDLLLR.TKPGRPDVPGWYRTTARSTDGMVRQSLGSTIEHNGLGATAAYWRQ-a..............
A0A328AN90_9CAUL/1-167 .msvst----FTYTR..THTATYVADNMRNQLKRIIQAAGLSPEDLADSWN.V.LGEAVRTWLRSGHLRKVILEFYKPG...SDKLEGRWDFDIDYDG.SGV.DDDMWV.DREHLRRTIEKAGQPPPGCVYRVVLR.HDPEAPMVTGMSSTDLRATDGFTSRAAGTSIATSDIMAGLNYWRR-s..............
A0A1X0DUD3_9MYCO/3-165 ..ttnt--ATYSYTR..THTATHLSDTIMASISDILVTLGIDTARHFQRWQ.L.NANAITRWIEEGSLEQVAVECVRPD...GT-VAPVFEFVVTYTAgGIG.DRKFTA.DNASLLTYLAKIQSVPLGTTFRLFCS.YRWTPSEQPGWTDGTRASTSGLRTRSIGTL----------------agapdaiatar....
Q120L5_POLSJ/1-166 ......MTTVAAYSY..THSVTYVADNVLKSLKDIIRLSGMDPTKLTDEWD.S.THRAIKTWLESEHLEKVVLEVYNPA...TGSLVLRWDIDIVYQW.SSS.DGAFYT.DTDQLRYHIKKAGVAPAEARYDILLK.NKPGRPDVAGWGPGSFRATDGMVRQSLGSTIDHSGLGGSAAYWRTR...............
A0A246K0D3_9SPHN/1-166 ......MTVVSAYSY..THSVTFVADNILRSFKEIIREAGLSPAQFVADWE.K.NQRAIRSWMESGHLRRVVLEIFHPV...TDELIHRWDLDIAYEW.SGG.DGSFYA.DMEQLKYAMKKAGVAPSHAKYDIVLQ.VTPGHPSVSGWGDGACRSTAGLTRHALGSTIDHNGLGASAAYWRRA...............
A0A429B4F8_9ACTN/1-166 .....m-TSTHTYSYtrTHTATHLTDVILGTITDILADLGINMDQLHRDWV.Q.NENAIKAWIEEGSLDTVVLECHQPS..gTVAPV--IEFPVSYTT.SGNgNTEFTA.SRARAARFRAKFDRVPTSTTYRLFCT.FNGPRTPQPGWGPGRRASIDGLRGITFGT-----------------lgsaphastgmrylh
A0A2A2Z569_9ACTN/2-171 .....s-TAVHVNTH..AHAVTHVSTGLIRSLRQIIKESGLDPAKMTNQWP.T.LENGVEVWLTSRHLRSLVLEIHDPSrrhGDDLVGRFDFTINYGYyPDA.DGELWL.DPDTVYYTVRKAGAFPSLCDYRIVAD.NEPGRPDVAGWSTTSLRSTAGFTRHEVGTAIGGGSLGAGLSYYTR-t..............
A7HU62_PARL1/1-166 ......MTSVAVNTY..TYSVTYVADNILKSLKDIIRLSGLNPSEFVGDWE.T.NMRGIQTWLSTGDLETVKLEIYDPK...TNTLIFRWDIDISYGS.SDG.DGSFWT.DTEQLKYAIKKAGLAPSEARYRMLVH.TKPGRPDVIGWSRTSGRSTEGMVRQSLGTTVEHSGLGARTSYLRRA...............
A0A5S4ZB40_9ACTN/1-171 ....ms-TRVSVSTY..THATTFVANNLLRSIKRLVTGAGLPADNLIGNWE.V.MERGVATWLGTGHLSALVLEIYTAGsavPRGLVARFDFTIDYGYsPDG.DGDLWL.DSDAVAFALKKAGVSAVRCNYRVVAD.AAFGYPAVDGWSDTTLRSTTGFTRHSLGTSITGGALGADLSYYGR-t..............
A0A6M4A218_9BURK/1-166 ......MSAVSVYTY..THSVTYVADNILKSFRDIIRLSGLNPKELTDSWQ.S.KLLALSTWIASQDLEKVILEIYHPV...TGALVVRWDLDIVYNW.STD.EGTFYT.DTDQLRYAIQKAGVVPSEAKYDVLLK.TKPGRPDVQGWGPVEFRSTTGMVKQSLGSTVEHNGLGAQAAYWRKA...............
Q1LKV8_CUPMC/52-217 ......MSTVATYSY..THSVTYVTDNILKSLKDIILLSGLDPEHFADRWE.S.NTRAIKTWLGTGDLRKVILEIYNPA...TDKLVTRWDIDIVYGW.SDG.DGSFWT.DTEQLKYAIKKAGLLPSQAKYKLMLD.TKPGRPDVEGWSKGSYRSTDGMVKQSLGSTVEHSGLAGQAGYWRQR...............
A0A2L0A7X0_9SPHN/1-166 ......MTNVAVNTY..THSVTYVADNILKSLKDIIRLVGLDPSEFVGDWA.L.HMRGVQTWLNTGDLETVKLEIYNPK...TDALIFRWDIDIAYGW.SGG.DGSFWT.DTEQLKYAIRKAGLVPSEARYRLLLQ.NKPGRPDVVGWGKASGRSAEGMVRQSLGTTVEHSGLGASTSYLRRA...............
A0A4R0YGI6_9PROT/1-165 ......MTLVAVNLF..THSVTYLADNILKSFKDIIRLSGLDPSKLVNDWE.V.YMRALKVWLETQDLERAVLEVYDPR...NNTLIVRWDIDVIYSW.T-G.DGSFWT.DTEQLKYAIRKAGVAPGHASYDILLK.TKPGRPDVPGWGAGSYRPTDGFVRHSLGSTIDHYGLGGHAAYWRK-s..............
Q07NS8_RHOP5/1-166 ......MTNVAVNTY..THSVTYVADNILKSLKDIIRLVGLDPTEFVGDWE.L.HMRGVQTWLNTGDLETVKLEIYNPK...TDALIFRWDIDIAYGW.SGG.DGSFWT.DTEQLKYAIRKAGLVPSEARYRLLLQ.TRPGRPDVVGWSKASGRSTEGMVRQSLGTTVEHSGLGASTSYLRRA...............
A0A6N2ICC1_9ACTN/1-167 mtstyt----YTYTR..THTATHLTDVILGTITDILADLGINMDRLHRDWV.Q.NENAIKAWIEEASLDTVVLECHQPS..gTVAPV--IEFPVSYTTsGDG.NAEFTA.SRARAARFRAKFDRVPAGTTYRLFCTfNRP-RTPQPGWGPGHRASTDGLRGITFGTLGSAPHAST--------gmryyht........
I3TV71_TISMK/1-166 ......MSTVATYSY..THSVTYVTDNILKSLKDIILLSGLDPEHFADRWE.S.NTRAIKTWLGTGDLRKVILEIYNPA...TDKLVTRWDIDIVYGW.SDG.DGSFWT.DTEQLKYAIKKAGLLPSQAKYKLMLD.TKPGRPDVEGWSKGSYRSTDGMVKQSLGSTVEHSGLAGQAGYWRQR...............
A0A0D7KAX5_9BURK/1-166 ......MSTVATYSY..THSVTYVTDNILKSLKDIILLSGLDPEHFADRWE.S.NTRAIKTWLGTGDLRKVILEIYNPA...TDKLVTRWDIDIVYGW.SDG.DGSFWT.DTEQLKYAIKKAGLLPSQAKYKVMLD.TKPGRPDVDGWSKGSYRSTDGMVKQSLGSTVEHSGLAGQAGYWRQR...............
A0A109CEU6_9BURK/1-166 ......MSTVATYSY..THSVTYVTDNILKSLKDIILLSGLDPEHFADRWE.S.NTRAIKTWLGTGDLRKVILEIYNPA...TDKLVTRWDIDIVYGW.SDG.DGSFWT.DTEQLKYAIKKAGLLPSQAKYKLMLD.TKPGRPDVEGWSKGSYRSTDGMVKQSLGSTVEHSGLAGQAGYWRQR...............
A0A2U1G201_9SPHN/1-164 ......MSSVSVYSY..THSVTYVTDNILKSFREIIRLSGLDPSMFVDNWQ.D.YHRAINAWLSSEHLIRVVLEIYNPK...TDALIKRWDIDIAYEW.SSG.DGSFYA.DVDQLRYAIQKAGIAPSEAKYSITLV.HKPGAPAVYGWGAGSLRSTAGLVRQSLGSTVDHNGLGASAAYWR--...............
N6Y7F4_9RHOO/1-166 ......MSAVAVFSY..TQSVVYVADNILKSLKDIIRLSGLDPTKLVNDWA.V.LLRGLSAWIESRHLESVTLEIFDPK...TDGLLLRWDIEVVYTW.DVS.AGTFWT.DTEQLKWAIKKAGLVPAQADYRVSVH.NKPGRPDVNGWSSCTLRSTDGMVRQSLGTTVEHNGLSANTTYWRKA...............
A0A369TH38_9RHOB/1-166 ......MTTVITYSR..TQSVTYVADNILKSLKDIIRLSGMDPTNFVNDTE.I.NMRGIKAWLESEDLEKITLEIYDPA...TNGLILRWDIDVNYSW.SAG.DGNFWT.DTDQLRWAIRKAGVAPASAKYDLLLR.TKPGRPDVPGWHRTTARSTDGMVRQSLGSTIEHNGLGATAAYWRQ-a..............
#=GC seq_cons ......MosVus.oY..THSVTYVADNILKSLKDIIpLSGLDPscFss-W-.h.phRulpoWLpotcLcpVhLEIYsPs...TssLlhRWDIDIsYuW.SsG.DGsFWT.DT-QL+aAI+KAGlsPSpAcY+llLc.sKPGRPDVsGWupsohRST-GhV+QSLGoTl-HsGLuAssuYaRp................
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