#=GF ID   baeRF_family8
#=GF AC   PF18851.7
#=GF DE   Bacterial archaeo-eukaryotic release factor family 8
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Iyer LM
#=GF GA   27.00 27.00;
#=GF TC   27.10 27.00;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 90746521 -E 1000 --cpu 8 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0267
#=GF RN   [1]
#=GF RM   29632312
#=GF RT   Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains
#=GF RT   from stalled ribosomes.
#=GF RA   Verma R, Reichermeier KM, Burroughs AM, Oania RS, Reitsma JM,
#=GF RA   Aravind L, Deshaies RJ;
#=GF RL   Nature. 2018;557:446-451.
#=GF DR   INTERPRO; IPR040830;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Bacterial family of the archaeo-eukaryotic release factor
#=GF CC   superfamily. Likely to play roles in biological conflicts or
#=GF CC   regulation under stress conditions at the ribosome [1].
#=GF SQ   28
#=GS Q1QPS7_NITHX/129-269      AC Q1QPS7.1
#=GS A0A1G7RP66_9LACT/124-279  AC A0A1G7RP66.1
#=GS A0A3A9BCN5_UNCXX/148-301  AC A0A3A9BCN5.1
#=GS A0A1J0PDK6_9SYNE/127-267  AC A0A1J0PDK6.1
#=GS A0A7L6N773_9BACT/127-276  AC A0A7L6N773.1
#=GS F7V131_EEGSY/128-281      AC F7V131.1
#=GS A0A9W6HCN5_9MICO/129-269  AC A0A9W6HCN5.1
#=GS A0A143XBH0_9ACTN/129-283  AC A0A143XBH0.1
#=GS A0A0F5FFC0_9HYPH/129-268  AC A0A0F5FFC0.1
#=GS C8WHU2_EGGLE/130-284      AC C8WHU2.1
#=GS A0A2I0N0Z5_9CLOT/126-270  AC A0A2I0N0Z5.1
#=GS Q1QGB5_NITHX/129-269      AC Q1QGB5.1
#=GS A0A1R4HP02_9MICO/128-268  AC A0A1R4HP02.1
#=GS H3NKZ0_9FIRM/120-265      AC H3NKZ0.1
#=GS V5SCW5_9HYPH/129-268      AC V5SCW5.1
#=GS A0A4T9T8K4_9ACTN/141-302  AC A0A4T9T8K4.1
#=GS A0A0Q8UZM9_9MICO/129-269  AC A0A0Q8UZM9.1
#=GS A0A369LRQ8_9ACTN/129-283  AC A0A369LRQ8.1
#=GS A0A1P8PZZ5_9LACO/126-275  AC A0A1P8PZZ5.1
#=GS A0A1I7N4C1_9HYPH/129-268  AC A0A1I7N4C1.1
#=GS A0A2K2UDG5_9ACTN/129-283  AC A0A2K2UDG5.1
#=GS R9L553_9ACTN/143-304      AC R9L553.1
#=GS A0A222VTF1_9PSEU/130-270  AC A0A222VTF1.1
#=GS A0A3S5D3J5_9HYPH/129-268  AC A0A3S5D3J5.1
#=GS A3Z1X8_9SYNE/127-267      AC A3Z1X8.1
#=GS A0A9E7BPQ4_9MICO/129-269  AC A0A9E7BPQ4.1
#=GS A0A6G7Y7U8_9ACTN/126-268  AC A0A6G7Y7U8.1
#=GS A0A4R5ND53_9LACO/123-268  AC A0A4R5ND53.1
Q1QPS7_NITHX/129-269                 ...........................................................................PNACYVLALAQ.RSVRLVEVSA.....................DL.PA..V...P.V.E..V...EA..M..P..Q..DAGR..................AV.R....G..V..G.....E...I...D.HWP....................SGR.I.......Q.......G...A...E....G........Q....K....V....L....L...RQ.FARKV....D.RA.L.R.P.L.L....G....G.S..G....LPLILAAAEPLAS.IYR.S.V...N.TYS.QL.A..E.A..G.I...E...GSPEG..LT...E...AQLA.E.R.ARPILDELYRDEL.....................................
A0A1G7RP66_9LACT/124-279             .........................................................................ln--EVIIADISK.DAVSLFDANQfnse.............plalDG.DI..D...I.K.Q..F...SE..I..Y..D..DLDPd................sQV.N....V..H..S.....Y...G...G.RQEpg................mhHGH.R.......A.......T...P...E....E........K....D....L....D....R...GK.YFTYL....N.KK.M.H.E.L.S....K....H.Y..H....RPILLAGTVENLG.HYQ.K.V...N.GTD.SI.Y..F.E..K.T...I...DKPFQ..SI..dS...KEKT.K.V.LKEILSQ------dhqsfa...............................
A0A3A9BCN5_UNCXX/148-301             .........................................................................gi--RYYLLMLSN.DRFGFVEGDQtsl...............rrmPL.PK..S...V.H.D..E..fSE..L..F..A..DYDGh...............egAL.D....Y..E..T.....L...E...G.HMSp..................yHGW.L.......S.......R...N...D....V........K....K....E....E....G...EK.FFRYV....N.KA.V.N.D.T.F....K...kL.D..P....TPVILVSLPEHQT.EFR.R.I...S.TIH.DL.V..D.Q..G.I...E...KDPGA..LD...Y...PDLL.K.D.AIAIMESKRQTEI.....................................
A0A1J0PDK6_9SYNE/127-267             ..........................................................................n-QSAYVLALAQ.NSVRLVGVSS.....................DL.PA..V...E.L.N..L...DG..M..P..K..DVAS..................SA.R....K..T..S.....I...K...D.RSP....................SGR.L.......Q.......G...S...E....G........M....K....V....H....Q...VQ.YARKI....D.QA.L.R.V.L.L....V....G.K..E....TPLILAAAEPMQS.IYR.E.L...Q.SYP.HL.A..R.T..A.I...Q...HNPET..QS...D...AELA.S.N.ARSILDELFRDEL.....................................
A0A7L6N773_9BACT/127-276             .........................................................................gk---HYLIDLAK.DRFKMYSINQdk.................idEM.ND..I...E.I.K..Ts.fSE..L..Y..D..DFDTd................sNI.N....V..G..I.....Y...G...G.LSGm..................yHGH.R.......E.......K...S...E....E........N....K....K....D....R...EK.YFRYL....D.RE.F.K.K.L.H....Q....L.D..D....SHFIFAGTSENIA.IFK.S.I...S.QES.YY.H..E.L..T.I...N...HPLAS..LK...P...EDVK.D.F.IRDILT-------pleeekr..............................
F7V131_EEGSY/128-281                 ..........................................................................g-THYYLLGLNT.DRFSFVHGDFstl...............ervEL.PH..I...K.D.E..F...SE..L..Y..P..IVYDdh..............eaAL.D....Y..T..S.....L...E...N.HMPp..................yHGY.K.......S.......R...N...D....V........K....K....E....E....A...EK.FFRYV....D.KA.I.R.A.Y.M....E...tA.L..E....LPVILVSVPEHQE.MFR.K.L...S.TIP.TL.L..D.E..G.I...E...KNING..IE...A...PELL.N.L.ATGIIKHERERR-t....................................
A0A9W6HCN5_9MICO/129-269             ...........................................................................PQTALVLALAG.NSVRLIRVSP.....................EA.PA..T...T.V.D..V...PG..M..P..R..DVAS..................AV.G....L..S..S.....V...S...G.RTA....................DGR.I.......Q.......G...S...E....G........Q....K....V....R....L...LE.YVQAI....D.RA.L.R.P.M.L....A....N.S..T....EPLILAAAEPLIG.IFR.G.A...N.SYQ.HL.V..D.Q..V.I...A...GNPEE..KT...D...EELA.Q.A.ARLVLDAVYAKKI.....................................
A0A143XBH0_9ACTN/129-283             ..........................................................................g-SRYLLLGLSA.DRFALIRGSFgsl...............ervKL.PA..D...V.P.G..T..ySE..E..F..P..DIYDgw..............pgAL.D....Y..P..S.....L...E...N.HLPp..................yHGH.K.......S.......R...N...D....V........R....N....E....E....A...EK.FFRSV....N.EA.V.S.E.R.L....A...rE.T..E....VPVILVALPEHQT.SFR.R.I...S.TIP.HL.L..D.E..G.I...E...KDVGG..LS...A...RELL.D.E.AKGVIERERARRA.....................................
A0A0F5FFC0_9HYPH/129-268             ..........................................................................r-NAAHVLAVSE.NSVRLIEIAA.....................DL.PA..T...V.V.N..V...PD..F..P..D..GAAD..................AV.N....K..S..T.....I...N...D.RSH....................ARR.I.......H.......G...S...E....G........E....K....V....Q....L...TK.YVRRI....D.AA.L.R.P.V.I....G....A.Q..D....LPLILAATEPVAS.LVR.S.V...S.GF-.DF.E..P.D..I.I...A...GSPDR..LS...E...TELA.D.A.ARAVLDARYARKL.....................................
C8WHU2_EGGLE/130-284                 ..........................................................................g-SHYFLLGLSA.DRFAFVHGDFgsl...............ervEL.PR..D...V.L.D..A..fSE..E..F..P..LVYDgh..............egAL.D....Y..S..S.....L...E...N.HMPp..................yHGW.K.......S.......R...N...D....V........R....K....E....E....A...GK.FFQYV....N.KA.V.T.D.Y.L....V...aG.T..D....LPVILVSLPEHQS.AFR.R.I...S.TIP.HL.L..D.E..G.I...E...KDIGG..IE...A...PELL.S.D.AKAVIEHVREARA.....................................
A0A2I0N0Z5_9CLOT/126-270             .........................................................................ga--EMLLVDLAK.DRFRLFSVGPyhv...............relEQ.DE..I...K.T.H..F...NE..L..F..E..DLDSe................sNV.N....T..G..S.....Y...A...G.TSGa..................fHGH.R.......A.......K...P...E....E........V....R....K....D....R...EK.YFRYL....D.AS.L.S.R.F.N....K....-.D..R....LPVILAGTTENVA.AFR.E.W...A.KGD.FY.A..K.E..A.L...T...QPLE-..--...-...----.-.-.-------------svtedqvqqlvqkrlqee...................
Q1QGB5_NITHX/129-269                 ...........................................................................PNACYVLALAQ.RSVRLVEVSA.....................DL.PA..V...P.V.E..V...EA..M..P..Q..DAGR..................AV.R....G..V..G.....E...I...D.HWP....................SGR.I.......Q.......G...A...E....G........Q....K....V....L....L...RQ.FARKV....D.RA.L.R.P.L.L....G....G.S..G....LPLILAAAEPLAS.IYR.S.V...N.TYS.QL.A..E.A..G.I...E...GSPEG..LT...E...AQLA.E.R.ARPILDELYRDEL.....................................
A0A1R4HP02_9MICO/128-268             ...........................................................................PHEATVLALSQ.NAVRLIAIGP.....................DH.RG..T...E.L.P..V...AE..L..P..T..DLLD..................AF.N....V..E..D.....P...G...V.DSH....................RRR.L.......H.......G...P...E....G........Q....T....A....R....L...LA.YARAV....D.RA.V.I.P.A.L....R....G.N..P....HPLILATTQPLDG.AFR.S.V...T.SAA.NL.L..P.T..S.I...E...GNPDD..RS...A...ADLD.E.A.ARCILDAHYAAEL.....................................
H3NKZ0_9FIRM/120-265                 ...........................................................................PNNYYFLDLSK.DRFSLYSFIN....................gEL.DK..E...D.P.D..I..yQK..F..T..D..LFSDk...............dyEI.E....A..S..P.....T...R...G.TSNs..................mHNY.H.......T.......S...S...S....V........E....E....K....E....K...DK.YFRYL....K.DN.L.G.K.F.L....K....E.K..E....AKLILFGTRENVL.EFK.N.-...-.-YV.DF.D..I.Y..G.I...I...DKPFN..SI..lT...NDLY.K.E.LREALLDKYIENI.....................................
V5SCW5_9HYPH/129-268                 ...........................................................................PQTALVLALSE.NAVRLIEIFP.....................EL.PP..S...R.V.R..V...QD..F..P..K..DASD..................AV.G....R..A..S.....V...N...N.LTQ....................NTR.I.......A.......N...A...E....G........Q....T....V....L....L...RQ.YARKV....D.AA.L.R.-.V.L....A....G.R..D....TPLILAATEPLGP.IFR.N.L...N.SYP.AL.L..S.G..G.I...S...ESPDR..MT...D...AELA.S.A.ARPVLDGYYKAQI.....................................
A0A4T9T8K4_9ACTN/141-302             .........................................................................gt--QYYILELGN.DRFSWVKGNRngv...............krqHL.PQ..E...V.H.D..Y..fSQ..L..F..A..NSDDtvadm.......rkdeegSL.D....Y..I..T.....L...E...G.HLSp..................yHDR.K.......S.......R...K...E....V........S....Q....E....E....F...EK.FARYV....N.KA.V.D.D.Y.L....V...dK.D..T....TPIILCCAPEHVS.FFR.K.I...S.TLR.HL.L..P.V..G.I...E...KDPAG..LD...G...KMLL.E.D.ALTIMDTQREAN-v....................................
A0A0Q8UZM9_9MICO/129-269             ...........................................................................PQTALILALAQ.NSVRLIQVSP.....................QA.PA..A...T.I.D..V...PG..L..P..K..DVAS..................AA.G....L..A..S.....I...S...G.RAP....................DGR.I.......Q.......G...S...E....G........Q....K....V....R....M...LE.YVQAI....E.RA.L.H.P.I.L....A....N.S..T....DPLILAAAEPLVG.IFR.N.A...N.TYP.KL.V..S.E..T.I...T...GNPEE..KT...D...EDLA.A.E.ARLVLDQVYAAKA.....................................
A0A369LRQ8_9ACTN/129-283             ..........................................................................g-SHYFLLGLSA.DRFALVRGDFdsl...............ervKL.PA..D...V.L.N..E..fSE..E..F..P..LVYDgr..............egAL.D....Y..S..S.....L...E...N.HMPp..................yHGY.K.......S.......R...N...D....V........R....K....E....E....A...GK.FFQHV....N.KA.V.T.D.Y.L....A...aG.T..E....LPVILVSLPEHQT.AFR.R.I...S.TVP.NL.L..D.E..G.I...E...KDIGG..VD...A...PELL.D.A.AKAVIEHAREARA.....................................
A0A1P8PZZ5_9LACO/126-275             ..........................................................................d-APQYIINISR.DRINIVDVKTlk.................aiNT.EK..I...Y.T.K..F...AD..Y..Y..S..DFDVd................sNL.N....T..G..S.....Y...G...G.LNTs.................nyHGH.R.......S.......K...P...E....E........Q....E....K....D....Q...LI.YYRYL....N.RE.L.T.K.L.S....K....E.N..G....YSFIISGLPEVLD.TYL.N.N...Y.GNS.SY.I..Y.D..V.I...R...GSVLN..LS...Q...NELK.N.K.LNQLSVDKRMHNA.....................................
A0A1I7N4C1_9HYPH/129-268             ..........................................................................r-NAAHVLAISE.NAVRLVEVAA.....................DL.PP..T...E.V.K..V...QD..F..P..D..SAAD..................AV.G....K..S..T.....I...N...D.RSH....................ARR.I.......H.......G...S...E....G........E....K....V....Q....L...AK.YIRRV....D.AA.L.R.P.V.L....N....G.S..D....LPIILAATEPVAS.LVR.S.I...S.GF-.DY.E..P.E..I.I...A...GSPDR..LT...E...SELA.E.A.ARPVLDTRYARKI.....................................
A0A2K2UDG5_9ACTN/129-283             ..........................................................................g-SRYFLLGLSA.DRFAFVRGDFgsl...............drvEL.PA..D...V.L.D..E..fSE..E..F..P..LVYDgh..............egAL.D....Y..S..S.....L...E...N.HLPp..................yHGY.K.......S.......R...K...E....V........R....K....E....E....A...GK.FFQHV....N.EV.V.T.D.H.L....V...rG.T..D....LPVILVSLPEHQT.AFR.R.I...S.TIP.HL.L..D.E..G.I...E...KDIGG..LE...A...PELL.D.A.AKGVLERERAARA.....................................
R9L553_9ACTN/143-304                 ..........................................................................g-TEYYILELGN.DRFSWVKGDRthv...............erqQL.PR..E...V.H.D..F..fSE..L..F..A..NSDDtaadm.......kkdelgAL.D....Y..I..T.....L...E...G.HMGq..................yHDH.Q.......S.......R...N...D....V........K....K....E....D....A...AQ.WFRYV....N.KA.V.N.D.Y.L....V...rD.D..T....TPIILCCDEEYEH.AFR.K.V...C.TLR.HL.L..P.E..G.I...K...KDPAG..LD...G...KALL.E.E.SLAVMDGIRDANI.....................................
A0A222VTF1_9PSEU/130-270             ...........................................................................PQAAFVLALAS.GSVRLVEVTR.....................EG.PP..F...T.V.E..V...PG..L..P..T..DAAS..................AA.G....K..A..S.....I...T...E.RSP....................IGR.L.......Q.......G...S...E....G........Q....K....V....R....L...RQ.FARKV....D.QA.L.R.G.V.L....T....G.L..E....LPLILAAAEPLNG.IYR.S.L...N.SYP.HL.A..E.T..G.I...P...GSPEG..AS...D...AELA.D.A.ARTVLDEIYARRL.....................................
A0A3S5D3J5_9HYPH/129-268             ..........................................................................r-NAAHVLAISE.NKVRLVEIAA.....................DL.PA..S...E.V.D..V...SG..F..P..D..GAAD..................AV.N....K..S..T.....I...N...D.RSH....................SRR.I.......H.......G...S...E....G........Q....K....V....Q....L...AK.YIRRV....D.AA.L.R.P.V.L....A....N.Q..D....LPLILAATEPVAS.LVR.S.V...S.GL-.DF.E..P.D..I.I...A...GSPDR..LT...E...GELA.D.A.ARKVLDARYARKI.....................................
A3Z1X8_9SYNE/127-267                 ...........................................................................PQSAYVLALAQ.NSVRLVAVSS.....................DL.PA..V...E.I.K..L...NG..M..P..K..DVAS..................SA.G....K..A..S.....I...R...D.RSP....................SGR.L.......Q.......G...S...E....G........M....K....V....R....Q...AQ.YARKI....D.QA.L.R.L.L.L....V....G.R..E....TPLILAASEPMQS.IYR.E.V...Q.SYP.HL.A..R.A..V.I...L...ENPET..QS...D...ADLA.A.S.ARAILDELFRDEL.....................................
A0A9E7BPQ4_9MICO/129-269             ...........................................................................PQSALILALAQ.NSVRLIRIAA.....................EA.PP..T...V.V.E..V...EG..M..P..Q..DVAS..................AA.G....L..A..S.....I...S...G.RSP....................DGR.I.......Q.......G...S...E....G........Q....K....V....R....M...LE.YVQAI....D.RA.L.H.P.L.L....A....N.S..T....EPLILAAAEPLSG.IFR.G.A...S.AYP.HL.V..E.E..T.I...G...GNPED..KT...D...EELS.A.A.ARGVLDAVYARR-t....................................
A0A6G7Y7U8_9ACTN/126-268             ...........................................................................PQEAYALTLSA.DGWNLWHATA.....................TT.RA..V...E.L.E..I..eRT..G..I..A..DVAE..................AT.N....R..A..T.....V...R...D.RDH....................VRR.L.......V.......G...D...E....G........L....K....V....L....L...ST.YIRRV....S.DA.V.T.A.E.L....Rg..vD.R..D....IPLFLFAAQPLLD.LYR.N.A...H.ASG.HP.-..L.V..T.V...Q...GSPDA..LA...G...HEID.E.A.IRVRL--------pghnaaqv.............................
A0A4R5ND53_9LACO/123-268             ..........................................................................h-QADYLIDLSR.DRIQVYNVRTlk.................kaNL.AG..L...H.T.H..F...DD..Y..Y..D..DFDVs................aNL.N....S..R..S.....V...G...E.VIF...................yHGH.R.......A.......K...S...E....Q........Q....Q....K....N....Q...VI.YYRYL....D.KE.L.R.N.L.H....L....E.Y..G....YEFLIAGLPEVVD.AFL.K.L...Y.AKR.KY.L..N.G..V.I...H...QSVIN..LS...Q...AELK.Q.R.V------------seyyaferia...........................
#=GC seq_cons                        ............................................................................pptalLuLup.cphpLlclss.....................-L.Ps..s...h.l.c..h...sc..h.....s..Dsss..................Al.s....h..u..o.....l...p...s.+ts....................cG+.h.......p.......t...s...E....s........p....K....h....c....h...tc.YhRtl....-.cA.l.c.s.h.L....s....s.s..c....hPlILAusp.htu.hFR.p.l...s.ohs.cL.h..p.p..s.I...p...tsPts..ls...s...sELt.c.s.A+slL-phhttch.....................................
//