GenomeNet

Database: Pfam
Entry: cEGF
LinkDB: cEGF
Original site: cEGF 
#=GF ID   cEGF
#=GF AC   PF12662.10
#=GF DE   Complement Clr-like EGF-like
#=GF AU   Wouters M;0000-0002-2121-912X
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Wouters M
#=GF GA   26.60 26.60;
#=GF TC   26.60 26.60;
#=GF NC   26.50 26.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   EGF-like_domain
#=GF CL   CL0001
#=GF RN   [1]
#=GF RM   15772310
#=GF RT   Evolution of distinct EGF domains with specific functions.
#=GF RA   Wouters MA, Rigoutsos I, Chu CK, Feng LL, Sparrow DB, Dunwoodie
#=GF RA   SL;
#=GF RL   Protein Sci. 2005;14:1091-1103.
#=GF DR   INTERPRO; IPR026823;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   cEGF, or complement Clr-like EGF, domains have six conserved
#=GF CC   cysteine residues disulfide-bonded into the characteristic
#=GF CC   pattern 'ababcc'. They are found in blood coagulation proteins
#=GF CC   such as fibrillin, Clr and Cls, thrombomodulin, and the LDL
#=GF CC   receptor. The core fold of the EGF domain consists of two small
#=GF CC   beta-hairpins packed against each other. Two major structural
#=GF CC   variants have been identified based on the structural context of
#=GF CC   the C-terminal cysteine residue of disulfide 'c' in the
#=GF CC   C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal
#=GF CC   thiol resides on the C-terminal beta-sheet, resulting in long
#=GF CC   loop-lengths between the cysteine residues of disulfide 'c',
#=GF CC   typically C[10+]XC. These longer loop-lengths may have arisen by
#=GF CC   selective cysteine loss from a four-disulfide EGF template such
#=GF CC   as laminin or integrin.  Tandem cEGF domains have five linking
#=GF CC   residues between terminal cysteines of adjacent domains. cEGF
#=GF CC   domains may or may not bind calcium in the linker region. cEGF
#=GF CC   domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated
#=GF CC   exclusively on the asparagine residue.
#=GF SQ   17925
#=GS A0A6J0XI93_ODOVR/1209-1232  AC A0A6J0XI93.1
#=GS A0A2Y9L1U7_ENHLU/777-798    AC A0A2Y9L1U7.1
#=GS G3NHL4_GASAC/336-360        AC G3NHL4.1
#=GS A0A669B125_ORENI/732-755    AC A0A669B125.1
#=GS A0A498NXA1_LABRO/275-297    AC A0A498NXA1.1
#=GS A0A5D2RXZ7_GOSMU/499-520    AC A0A5D2RXZ7.1
#=GS W5M706_LEPOC/93-116         AC W5M706.1
#=GS A0A1S3MQS0_SALSA/2924-2947  AC A0A1S3MQS0.1
#=GS A0A3B0KSW2_DROGU/462-481    AC A0A3B0KSW2.1
#=GS A0A5F9D757_RABIT/60-83      AC A0A5F9D757.1
#=GS B4MF28_DROVI/609-635        AC B4MF28.2
#=GS A0A667XGF9_9TELE/750-771    AC A0A667XGF9.1
#=GS A0A2G8L911_STIJA/710-733    AC A0A2G8L911.1
#=GS M3YK40_MUSPF/1261-1284      AC M3YK40.1
#=GS A0A674GUW7_TAEGU/181-204    AC A0A674GUW7.1
#=GS M3YKJ4_MUSPF/689-712        AC M3YKJ4.1
#=GS A0A093H9Y4_STRCA/20-42      AC A0A093H9Y4.1
#=GS A0A2U9C306_SCOMX/400-423    AC A0A2U9C306.1
#=GS A0A663MK34_ATHCN/2819-2842  AC A0A663MK34.1
#=GS A0A5C6NJZ6_9TELE/326-348    AC A0A5C6NJZ6.1
#=GS A0A3P8VRM0_CYNSE/92-115     AC A0A3P8VRM0.1
#=GS A0A2K6KY92_RHIBE/273-296    AC A0A2K6KY92.1
#=GS A0A672P5P6_SINGR/91-114     AC A0A672P5P6.1
#=GS A0A674GXQ0_TAEGU/545-568    AC A0A674GXQ0.1
#=GS A0A6P8HGQ1_ACTTE/382-405    AC A0A6P8HGQ1.1
#=GS A0A061AKU0_CAEEL/301-324    AC A0A061AKU0.1
#=GS A0A2K6QTU6_RHIRO/2962-2985  AC A0A2K6QTU6.1
#=GS A0A087YIW7_POEFO/261-284    AC A0A087YIW7.2
#=GS A0A5F8A9E3_MACMU/956-979    AC A0A5F8A9E3.1
#=GS A0A1R3HET2_COCAP/505-523    AC A0A1R3HET2.1
#=GS A0A452QXM2_URSAM/953-976    AC A0A452QXM2.1
#=GS A0A7N9AU50_9TELE/96-119     AC A0A7N9AU50.1
#=GS H2ZJD3_CIOSA/939-962        AC H2ZJD3.1
#=GS A0A0Q9XQY0_DROMO/289-310    AC A0A0Q9XQY0.1
#=GS A0A3Q1APM2_AMPOC/373-395    AC A0A3Q1APM2.1
#=GS A0A2K5QGE4_CEBIM/460-484    AC A0A2K5QGE4.1
#=GS H2NN62_PONAB/593-616        AC H2NN62.1
#=GS A0A6I9L3J8_PERMB/969-992    AC A0A6I9L3J8.1
#=GS A0A091M7K7_CARIC/158-181    AC A0A091M7K7.1
#=GS A0A3P9AJ99_ESOLU/202-225    AC A0A3P9AJ99.1
#=GS A0A2K5ENE1_AOTNA/233-256    AC A0A2K5ENE1.1
#=GS A0A4W3JWW6_CALMI/5374-5397  AC A0A4W3JWW6.1
#=GS A0A5A9NDY1_9TELE/1038-1061  AC A0A5A9NDY1.1
#=GS A0A6P4Z1X2_BRABE/400-423    AC A0A6P4Z1X2.1
#=GS A0A2K5IKA5_COLAP/477-501    AC A0A2K5IKA5.1
#=GS A0A2K6LX72_RHIBE/956-979    AC A0A2K6LX72.1
#=GS A0A1Q3BV48_CEPFO/500-520    AC A0A1Q3BV48.1
#=GS A0A4W6D129_LATCA/92-115     AC A0A4W6D129.1
#=GS A0A2K5ZZ91_MANLE/98-121     AC A0A2K5ZZ91.1
#=GS A7SSL3_NEMVE/519-542        AC A7SSL3.1
#=GS A0A1S3WAY6_ERIEU/240-263    AC A0A1S3WAY6.1
#=GS W5P0X6_SHEEP/249-272        AC W5P0X6.1
#=GS A0A2I3SZJ0_PANTR/193-216    AC A0A2I3SZJ0.1
#=GS A0A2R9C2V9_PANPA/638-661    AC A0A2R9C2V9.1
#=GS A0A212F9W8_DANPL/3106-3129  AC A0A212F9W8.1
#=GS A0A663MMR8_ATHCN/580-602    AC A0A663MMR8.1
#=GS A0A668ACZ5_9TELE/2948-2971  AC A0A668ACZ5.1
#=GS A0A2K5D407_AOTNA/2561-2584  AC A0A2K5D407.1
#=GS A0A4Z2DCC1_SCHJA/147-170    AC A0A4Z2DCC1.1
#=GS A0A667Z9Y0_9TELE/67-90      AC A0A667Z9Y0.1
#=GS A0A445BF67_ARAHY/521-543    AC A0A445BF67.1
#=GS A0A671SC81_9TELE/93-116     AC A0A671SC81.1
#=GS A0A091EDT7_CORBR/218-241    AC A0A091EDT7.1
#=GS A0A2K5LPD0_CERAT/733-756    AC A0A2K5LPD0.1
#=GS A0A6P6LNR1_CARAU/2547-2570  AC A0A6P6LNR1.1
#=GS A0A2K6CT08_MACNE/273-296    AC A0A2K6CT08.1
#=GS A0A6P3GXS7_BISBI/183-206    AC A0A6P3GXS7.1
#=GS L5KB21_PTEAL/966-989        AC L5KB21.1
#=GS A0A663EUU3_AQUCH/458-481    AC A0A663EUU3.1
#=GS A0A6P7M226_BETSP/92-115     AC A0A6P7M226.1
#=GS A0A1X7TGV8_AMPQE/1938-1961  AC A0A1X7TGV8.1
#=GS A0A3Q1GXV1_9TELE/180-203    AC A0A3Q1GXV1.1
#=GS A0A668A0K0_9TELE/91-114     AC A0A668A0K0.1
#=GS A0A672HSG1_SALFA/391-414    AC A0A672HSG1.1
#=GS A0A402G440_9SAUR/19-42      AC A0A402G440.1
#=GS V8NU92_OPHHA/191-214        AC V8NU92.1
#=GS A0A4W5L1G6_9TELE/254-277    AC A0A4W5L1G6.1
#=GS A0A674A7W3_SALTR/68-91      AC A0A674A7W3.1
#=GS H3D9U0_TETNG/385-408        AC H3D9U0.1
#=GS A0A2I3GVD1_NOMLE/473-493    AC A0A2I3GVD1.1
#=GS A0A4W4HGQ6_ELEEL/1173-1196  AC A0A4W4HGQ6.1
#=GS H2XYP0_CIOIN/730-753        AC H2XYP0.1
#=GS A0A671ENR5_RHIFE/466-490    AC A0A671ENR5.1
#=GS A0A7M7Q1F8_NASVI/1675-1698  AC A0A7M7Q1F8.1
#=GS A0A4Z2HHK6_9TELE/2804-2827  AC A0A4Z2HHK6.1
#=GS A0A6P6N0Z8_CARAU/603-626    AC A0A6P6N0Z8.1
#=GS L5JZ39_PTEAL/2192-2215      AC L5JZ39.1
#=GS A0A093HKY6_GAVST/558-580    AC A0A093HKY6.1
#=GS A0A6I9WAR6_9HYME/3145-3168  AC A0A6I9WAR6.1
#=GS A0A6J2JDG0_BOMMA/2063-2086  AC A0A6J2JDG0.1
#=GS A0A7N4P3U5_SARHA/96-119     AC A0A7N4P3U5.1
#=GS A0A6P6K921_CARAU/439-461    AC A0A6P6K921.1
#=GS G3W1X0_SARHA/236-259        AC G3W1X0.2
#=GS B1WC21_RAT/423-446          AC B1WC21.1
#=GS K1R9J7_CRAGI/1638-1661      AC K1R9J7.1
#=GS F1M4Q3_RAT/5452-5475        AC F1M4Q3.3
#=GS A0A5F4C884_CANLF/268-291    AC A0A5F4C884.1
#=GS A0A287AH02_PIG/867-890      AC A0A287AH02.1
#=GS A0A3Q1LRZ3_BOVIN/98-121     AC A0A3Q1LRZ3.1
#=GS A0A4W6CVV3_LATCA/489-513    AC A0A4W6CVV3.1
#=GS H3AZ49_LATCH/5257-5280      AC H3AZ49.2
#=GS A0A2Y9IKT0_ENHLU/1261-1284  AC A0A2Y9IKT0.1
#=GS A0A671N5N9_9TELE/167-190    AC A0A671N5N9.1
#=GS A0A2K6F4I1_PROCO/97-120     AC A0A2K6F4I1.1
#=GS A0A674JKS1_TERCA/221-244    AC A0A674JKS1.1
#=GS A0A671EW87_RHIFE/387-410    AC A0A671EW87.1
#=GS A0A674AYG5_SALTR/1244-1267  AC A0A674AYG5.1
#=GS A0A2Y9K4A1_ENHLU/92-115     AC A0A2Y9K4A1.1
#=GS A0A3Q7MI48_CALUR/781-802    AC A0A3Q7MI48.1
#=GS A0A6P9DQK7_PANGU/54-77      AC A0A6P9DQK7.1
#=GS W9S8N8_9ROSA/503-524        AC W9S8N8.1
#=GS A0A1U8DNL7_ALLSI/115-138    AC A0A1U8DNL7.1
#=GS A0A665WY09_ECHNA/581-604    AC A0A665WY09.1
#=GS A0A3R7H1X8_CLOSI/213-236    AC A0A3R7H1X8.1
#=GS E4XXT3_OIKDI/15-37          AC E4XXT3.1
#=GS A7RF88_NEMVE/67-99          AC A7RF88.1
#=GS A0A4U5U0E8_COLLU/2954-2977  AC A0A4U5U0E8.1
#=GS A0A671DSP2_RHIFE/103-126    AC A0A671DSP2.1
#=GS A0A0V1CK09_TRIBR/3119-3142  AC A0A0V1CK09.1
#=GS B8A4X3_DANRE/217-240        AC B8A4X3.1
#=GS A0A670KEG4_PODMU/384-407    AC A0A670KEG4.1
#=GS G1MG02_AILME/209-232        AC G1MG02.2
#=GS A7RVK3_NEMVE/192-215        AC A7RVK3.1
#=GS L5MG72_MYODS/369-392        AC L5MG72.1
#=GS A0A1W4X7B0_AGRPL/1491-1513  AC A0A1W4X7B0.1
#=GS A0A2K6DUB7_MACNE/73-96      AC A0A2K6DUB7.1
#=GS W5MPB2_LEPOC/2161-2184      AC W5MPB2.1
#=GS A0A5E4CNX9_MARMO/1212-1235  AC A0A5E4CNX9.1
#=GS A0A5N4CJ38_CAMDR/2675-2698  AC A0A5N4CJ38.1
#=GS A0A2K5DTT0_AOTNA/506-530    AC A0A2K5DTT0.1
#=GS A0A452CKC1_BALAS/307-330    AC A0A452CKC1.1
#=GS A0A1L8FML6_XENLA/295-317    AC A0A1L8FML6.1
#=GS A0A2K6UQ62_SAIBB/964-987    AC A0A2K6UQ62.1
#=GS A0A672GCI4_SALFA/708-729    AC A0A672GCI4.1
#=GS A0A674JLF8_TERCA/1086-1109  AC A0A674JLF8.1
#=GS I3KNZ9_ORENI/751-772        AC I3KNZ9.2
#=GS A0A671W3H3_SPAAU/91-114     AC A0A671W3H3.1
#=GS A0A6P5BWF0_BOSIN/507-531    AC A0A6P5BWF0.1
#=GS A0A2K6DQ52_MACNE/236-259    AC A0A2K6DQ52.1
#=GS W5P565_SHEEP/5407-5430      AC W5P565.1
#=GS A0A672Z3X0_9TELE/256-279    AC A0A672Z3X0.1
#=GS A0A1X7STM4_AMPQE/424-447    AC A0A1X7STM4.1
#=GS A0A2U3Y938_LEPWE/183-206    AC A0A2U3Y938.1
#=GS A0A663FBL8_AQUCH/71-94      AC A0A663FBL8.1
#=GS A0A0J7L1W8_LASNI/3069-3092  AC A0A0J7L1W8.1
#=GS A0A1D5RJX9_MACMU/268-291    AC A0A1D5RJX9.2
#=GS A0A452QAC0_URSAM/65-88      AC A0A452QAC0.1
#=GS A0A2I2ZDD6_GORGO/423-446    AC A0A2I2ZDD6.1
#=GS A0A5F4D9E0_CANLF/514-538    AC A0A5F4D9E0.1
#=GS A0A7M7SVG6_STRPU/631-653    AC A0A7M7SVG6.1
#=GS A0A6P6KMK2_CARAU/2916-2939  AC A0A6P6KMK2.1
#=GS Q9V4B8_DROME/721-744        AC Q9V4B8.3
#=GS G1RT74_NOMLE/477-501        AC G1RT74.2
#=GS A0A0R3U960_9CEST/412-435    AC A0A0R3U960.2
#=GS Q54YP0_DICDI/422-445        AC Q54YP0.1
#=GS A0A3P9PJ53_POERE/367-390    AC A0A3P9PJ53.1
#=GS A0A2K6UC62_SAIBB/183-206    AC A0A2K6UC62.1
#=GS A0A6P6K714_CARAU/93-116     AC A0A6P6K714.1
#=GS A0A2K6T286_SAIBB/877-897    AC A0A2K6T286.1
#=GS F7FGP4_ORNAN/1047-1070      AC F7FGP4.3
#=GS A0A668U8E2_OREAU/731-754    AC A0A668U8E2.1
#=GS A0A3Q2X5A8_HAPBU/890-913    AC A0A3Q2X5A8.1
#=GS A0A671X508_SPAAU/161-184    AC A0A671X508.1
#=GS A0A091GCF9_9AVES/64-87      AC A0A091GCF9.1
#=GS A0A6P5K4C3_PHACI/5460-5483  AC A0A6P5K4C3.1
#=GS A0A6I9NA24_9TELE/358-380    AC A0A6I9NA24.1
#=GS A0A4Z2CSM4_SCHJA/718-740    AC A0A4Z2CSM4.1
#=GS A0A3Q3XIQ4_MOLML/261-283    AC A0A3Q3XIQ4.1
#=GS A0A670YC96_PSETE/109-132    AC A0A670YC96.1
#=GS A0A2K6DIS4_MACNE/725-747    AC A0A2K6DIS4.1
#=GS A0A2K5Y247_MANLE/192-215    AC A0A2K5Y247.1
#=GS E7FDJ3_DANRE/10-33          AC E7FDJ3.3
#=GS A0A1L8HA12_XENLA/2960-2983  AC A0A1L8HA12.1
#=GS A0A665WL03_ECHNA/400-424    AC A0A665WL03.1
#=GS A0A485MCE3_LYNPA/200-223    AC A0A485MCE3.1
#=GS A0A673G0E8_9TELE/642-663    AC A0A673G0E8.1
#=GS A0A1U8BW98_MESAU/593-616    AC A0A1U8BW98.1
#=GS A0A6P4Z2F0_BRABE/555-578    AC A0A6P4Z2F0.1
#=GS A0A671UUD1_SPAAU/376-398    AC A0A671UUD1.1
#=GS A0A2K5IZ64_COLAP/254-277    AC A0A2K5IZ64.1
#=GS A0A673G2G3_9TELE/2708-2731  AC A0A673G2G3.1
#=GS A0A151WY85_9HYME/657-680    AC A0A151WY85.1
#=GS A0A663DVZ1_AQUCH/914-937    AC A0A663DVZ1.1
#=GS W5PSC8_SHEEP/227-250        AC W5PSC8.1
#=GS A0A3Q3E225_9LABR/334-357    AC A0A3Q3E225.1
#=GS A0A668TSI8_OREAU/845-866    AC A0A668TSI8.1
#=GS A0A3Q1G1Z8_9TELE/254-277    AC A0A3Q1G1Z8.1
#=GS A0A2A3EIG6_APICC/2408-2431  AC A0A2A3EIG6.1
#=GS A0A669PD56_PHACC/1216-1239  AC A0A669PD56.1
#=GS H2UYG2_TAKRU/319-342        AC H2UYG2.3
#=GS A0A4W4GP42_ELEEL/374-397    AC A0A4W4GP42.1
#=GS A0A3Q1BFI7_AMPOC/168-191    AC A0A3Q1BFI7.1
#=GS A0A3Q0G241_ALLSI/145-167    AC A0A3Q0G241.1
#=GS A0A154P0K8_DUFNO/1135-1158  AC A0A154P0K8.1
#=GS A0A2I2YP07_GORGO/178-201    AC A0A2I2YP07.1
#=GS A0A6G1A949_CROCR/206-229    AC A0A6G1A949.1
#=GS A0A0G2KAI7_RAT/73-96        AC A0A0G2KAI7.1
#=GS A0A0L0FJ31_9EUKA/444-465    AC A0A0L0FJ31.1
#=GS A0A6P6CMC3_PTEVA/260-283    AC A0A6P6CMC3.1
#=GS A0A1L8G9Q2_XENLA/1446-1467  AC A0A1L8G9Q2.1
#=GS A0A6J3BN02_VICPA/715-738    AC A0A6J3BN02.1
#=GS A0A0L7QUY6_9HYME/1239-1262  AC A0A0L7QUY6.1
#=GS A0A3Q2VCC0_HAPBU/254-277    AC A0A3Q2VCC0.1
#=GS B4QKV7_DROSI/623-644        AC B4QKV7.1
#=GS A0A4W2CTD4_BOBOX/302-325    AC A0A4W2CTD4.1
#=GS A0A6J1I538_CUCMA/500-522    AC A0A6J1I538.1
#=GS A0A2I4B4G3_9TELE/4017-4040  AC A0A2I4B4G3.1
#=GS A0A668S6R4_OREAU/2948-2971  AC A0A668S6R4.1
#=GS A0A455C5B9_PHYMC/63-86      AC A0A455C5B9.1
#=GS A0A7N9AWE8_9TELE/625-648    AC A0A7N9AWE8.1
#=GS A0A4W5NE52_9TELE/383-406    AC A0A4W5NE52.1
#=GS A0A443QV85_9ACAR/725-748    AC A0A443QV85.1
#=GS A0A099ZTK9_TINGU/559-581    AC A0A099ZTK9.1
#=GS A0A2B4SW57_STYPI/1838-1861  AC A0A2B4SW57.1
#=GS A0A6J2J918_BOMMA/1163-1186  AC A0A6J2J918.1
#=GS A0A2G8KB66_STIJA/472-495    AC A0A2G8KB66.1
#=GS A0A5E4B4S6_MARMO/102-125    AC A0A5E4B4S6.1
#=GS A0A6I8RXV1_XENTR/471-493    AC A0A6I8RXV1.2
#=GS G5E8D6_MOUSE/242-265        AC G5E8D6.1
#=GS A0A6P7XNS5_9AMPH/193-215    AC A0A6P7XNS5.1
#=GS A0A5E4C3W4_MARMO/217-239    AC A0A5E4C3W4.1
#=GS A0A2I4CN44_9TELE/1179-1202  AC A0A2I4CN44.1
#=GS A0A4W5NGR0_9TELE/65-88      AC A0A4W5NGR0.1
#=GS A0A315VB21_GAMAF/162-185    AC A0A315VB21.1
#=GS A0A3P8TW60_AMPPE/542-563    AC A0A3P8TW60.1
#=GS A0A2K6NJ72_RHIRO/234-257    AC A0A2K6NJ72.1
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