#=GF ID   m04gp34like
#=GF AC   PF12216.11
#=GF DE   Immune evasion protein
#=GF AU   Assefa S;0000-0003-2178-533X
#=GF AU   Gavin OL;
#=GF SE   PFAM-B_2496 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   33.10 32.20;
#=GF NC   24.50 24.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10644360
#=GF RT   The putative natural killer decoy early gene m04 (gp34) of
#=GF RT   murine cytomegalovirus encodes an antigenic peptide recognized
#=GF RT   by protective antiviral CD8 T cells.
#=GF RA   Holtappels R, Thomas D, Podlech J, Geginat G, Steffens HP,
#=GF RA   Reddehase MJ;
#=GF RL   J Virol. 2000;74:1871-1884.
#=GF DR   INTERPRO; IPR022022;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This protein is found in archaea and viruses. Proteins in this
#=GF CC   family are typically between 265 to 342 amino acids in length.
#=GF CC   The proteins in this family are or are related to the m04
#=GF CC   encoded protein gp34 of pathogenic microorganisms such as murine
#=GF CC   cytomegalovirus. m06 and m152 genes are expressed earlier in the
#=GF CC   intracellular replication phases of these microorganism' life
#=GF CC   cycles. They function to inhibit MHC-1 loading and export. gp34
#=GF CC   is theorized to prevent immune reactions from NK cells which
#=GF CC   would ordinarily recognise and attack cells lacking MHC.
#=GF SQ   36
#=GS B3UWV7_MUHV1/1-260   AC B3UWV7.1
#=GS B3UWV7_MUHV1/1-260   DR PDB; 4PN6 B; 19-186;
#=GS B3UWV7_MUHV1/1-260   DR PDB; 4PN6 A; 19-185;
#=GS A8E1I4_MUHVK/7-276   AC A8E1I4.1
#=GS A8E1I7_MUHVK/19-330  AC A8E1I7.1
#=GS B3UWW2_MUHV1/1-272   AC B3UWW2.1
#=GS B3UWV5_MUHV1/6-276   AC B3UWV5.1
#=GS A8E1E5_MUHVK/1-189   AC A8E1E5.1
#=GS A8E1I8_MUHVK/3-276   AC A8E1I8.1
#=GS A8E1I6_MUHVK/8-318   AC A8E1I6.1
#=GS A8E1I3_MUHVK/26-305  AC A8E1I3.1
#=GS B3UWW1_MUHV1/5-219   AC B3UWW1.1
#=GS A8E1E7_MUHVK/35-169  AC A8E1E7.1
#=GS A8E1J0_MUHVK/2-274   AC A8E1J0.1
#=GS H2A240_MUHV1/1-272   AC H2A240.1
#=GS B3UWW0_MUHV1/2-277   AC B3UWW0.1
#=GS H2A239_MUHV1/6-220   AC H2A239.1
#=GS B3UWW8_MUHV1/13-173  AC B3UWW8.1
#=GS H2A245_MUHV1/2-207   AC H2A245.1
#=GS B3UWV9_MUHV1/19-332  AC B3UWV9.1
#=GS H2A233_MUHV1/4-253   AC H2A233.1
#=GS B3UWV8_MUHV1/8-319   AC B3UWV8.1
#=GS B3UWW3_MUHV1/4-272   AC B3UWW3.1
#=GS H2A237_MUHV1/19-329  AC H2A237.1
#=GS B3UWW4_MUHV1/3-259   AC B3UWW4.1
#=GS A3R008_MUHV1/8-320   AC A3R008.1
#=GS A8E1I9_MUHVK/5-210   AC A8E1I9.1
#=GS A8E1J3_MUHVK/30-219  AC A8E1J3.1
#=GS A8E1I5_MUHVK/1-259   AC A8E1I5.1
#=GS H2A235_MUHV1/9-258   AC H2A235.1
#=GS A8E1J2_MUHVK/3-261   AC A8E1J2.1
#=GS H2A247_MUHV1/25-179  AC H2A247.1
#=GS H2A242_MUHV1/3-259   AC H2A242.1
#=GS H2A234_MUHV1/15-301  AC H2A234.1
#=GS H2A241_MUHV1/4-270   AC H2A241.1
#=GS H2A238_MUHV1/3-280   AC H2A238.1
#=GS B3UWV6_MUHV1/7-280   AC B3UWV6.1
#=GS A8E1J1_MUHVK/4-272   AC A8E1J1.1
B3UWV7_MUHV1/1-260              ................................................................MSLVCR....LVLVTVVL-SSLFTFAISSNNDA..................CK.---KLQKEYEEKMKYRHP..........LGC.YFKGINP.....TKVPSS..GSH-T.ILKCTLP-..VVKVNASWTLEWVV..VKLQNS......VDVTSYYESSPNSGPTFLRAILNFTPMHGLRT....KNLLKVKDGFQVDNSTdngngGNLYVYPNAT-..T...GSADSVRCRLRMCPW...........TSNSKMT--AP.........DEEMLRKMSEVLNLPNYGVPDLTP........................PRRDEF-YTKNESP-NTI..............------VTTLTVIVTLLF..VGLLLV..LIYLYG..........PSLYRRFFSNDCCSNF......................................................................
#=GR B3UWV7_MUHV1/1-260   SS    ................................................................XXXXXX....XXXXXXXX-XXXXXXXXXXXXXX..................XX.---XXXXXXXXXXX--EE..........--E.EEEEE--.....EEE--S..SSS-E.EEE-----..---SSEEEEEEEEE..TTTTEE......BSEEEEEEEETTEEEEEEEEEE-SS-TT-TTT....TSSB-GGGTEEE---STTS-TT-EEE-TTS--..T...TSCCCEEEEEEEEEE...........ES-TT----S-.........-HHHHHHTHHHHTS-B-S--SCE-........................--TTXX-XXXXXXX-XXX..............------XXXXXXXXXXXX..XXXXXX..XXXXXX..........XXXXXXXXXXXXXXXX......................................................................
A8E1I4_MUHVK/7-276              ...........................................................sypsa-----H....VRLRLTRLLLLFVFCVVISYAQE..................CP.-NYGGKKTDDSVWKYRKD..........LGC.LFRRII-.....NITLYE..NKGIK.TAYFILPGpaAVYVNASWTFEWFI..KPLFAS......VDAASYFTSTTTSAAKSATDTVPIFSYYDMHSg.rlKKTVGLKDGFKADHS-.....GKLYIFQNASVagN...ITVNDTICVLRLCLW...........TTKDSTI-SID.........DAGLKNNLSSILSLPTYDEIRGVL........................YMRPQYNYSIPIKRIVQR..............SNDAGLVAAILFFIATIF..VAA-LL..LGYSYN..........PTLFRCFS--------ilid..................................................................
A8E1I7_MUHVK/19-330             ....................................rsrpvqllalvtvlasmtfqmgeslipi------....IPDFSSFMMNPLPMPQIMPPSTNetketkesyvkteepivgCNvSRTEINRLKNQMKKIPNT..........FKC.FKKDGVR.....TSLDMQ..TTGEK.RFACEIPN..NVYVNATWYVHWVV..GKIAAS......VSPIVYFTSTTSSPPTLDGNMHPFYR------....RKIVTAANGFKVDEKT.....GDITVARSNA-..-...SLADSVRCRLIVCLW...........TKNDSISDLPD.........DDPQMKNMSGVIKLPDYSGPDTLL........................T--VPFDYAAWRQRMRTEme.........epsRRRRQLLLVISVIASLLW..LAVGAM..LFYTYGre......plARLLKRYGKRLAAVR-i.....................................................................
B3UWW2_MUHV1/1-272              mklffsshmyflifaviaakslitsaatcdavrdraffgantpgqcrtvsvnlkdvyglgsgst------....-----------------------..................--.------------------..........---.-------.....------..----W.VYTCEFP-..TMCINATWRVEWLL..NKNP--......INVSVLYESTTSTPPRFKQLIRNNATTR----....----PPPTGFELNSEN.....GYLYIYPSAG-..-...-NNFYLSCTGFVCVPpk.......piTTTPSTTRSRS.........STETRTTRSGTKFIPHKITPSRSQ........................PVSPQVDD---TTQLDIDtaii.....vasaeMQTSNTPTAIAVSLVVIV..VVTVIV..LGLLYHygflgkwallDSYVDRFRVRF-----mghn..................................................................
B3UWV5_MUHV1/6-276              ...............................................................s-SCASRprgvCRLRVLLLVCAAVVPVVSSAPL-..................-P.-----------------G..........YYC.YAKNATEr..rtPNIDRDywRPGVS.VFGCRMPK..GVCIEGEWTIEWYI..PSLQAS......VINQVFFKSQTWLGPSMQYIIPSYERGKE---....---VTCKQGFCVDRAE.....GNLIITDDDKRkeEwarKPTRDVVCKLTACLR...........ATSVSLSSRTT.........YEECNGTLEDYLSLPDFENIYDISkvvp................yvppPKAPAVPPKVPGKAEDAPpdes......cigcDNPGLNAAAIAVPVVTVI..VLVSGV..------..........GYLCRSTESRQRTLE-l.....................................................................
A8E1E5_MUHVK/1-189              .....................................................mrrlgivivia------....---------------SLLSAVE-..................--.STETERRECDTYNVTIKP..........ETCdFFDNLYEv...rVRVDEK..DTNRV.HYSCQFKW..NICTQATWYGTWIR..MSFDEEmnpsprVLAHVQLMSTPTSPPTLVGFWNDSSSDKQYVL....SHNS--SAEIWHDPVT.....DNVYISSQVS-..-...SNQLGLICQLTGCLN...........SKMDETY----.........------------------------........................------------------..............------------------..------..------..........----------------pafarekietqtaiaig.....................................................
A8E1I8_MUHVK/3-276              ........................................................gytgdtma------....---LMVLCVWLAYVFSVESRANG..................CD.----PS--LAANYSNLTQ..........GQC.VTIKGV-.....---KND..TEG-R.SYSCL-TD..AICIPASWEGTWLV..DGWPL-......-PFGVYFKSSNSSPPLFSMTFNQTQPTT----....TPPTINATDYTLDPTS.....GRLIVSSNLTR..-...--SVSVTCKLTICRQ...........TDGYGPK--PPpr.....rpKKRTTTVLPTTTSYTTLSVTHTSTirklittrratesptvnhtspiptSSRVNV-----------SvdsntddettgsmeRQKRSNMIAIVMLVCFSF..GACVLLvgLAYYYG..........----------------ffddtqsha.............................................................
A8E1I6_MUHVK/8-318              ................................................................CTVMWR....SVLVFLLF-SSWLTTSGDSPHRSrrppqspk.sgittwiggSS.RTRFPSASFDKYKTIALGgdklspwkytSKC.FNSKDATr..flKKSVDS..KTGDK.TFTCMPTE..NVYANASWRIEWVL..GNGTTW......LTPAIRFVSTDRSPPTFNGTLSVAYSTRLVYTd.ekDNPNPNKTGLRVDKSG.....--LHISSAVRAdlV...KDVHDVKCTLSVCLW...........TDRISVYNTSDgyietrvevDSTAVANLSIIATLDDFVYPLGYPm.....................eyTKKSAYSWPSETSQPQMS..............--MSVFFGILSVYIVLII..GEVYIC..LKCHYN..........---HKHKSAADVAVEY......................................................................
A8E1I3_MUHVK/26-305             .............................................erlemrhrsswyasrprgv------....CRLRVLLLVCAAVVPIVSSAPL-..................-P.-----------------G..........YYC.YAKNATEr..rtPNIDRDywRPGVS.VFGCRMPK..GVCIEGEWTIEWYI..PSLQAS......VINQVFFKSQTWLGPSMQYIIPSYERGKE---....---VTCKQGFCVDRAE.....GNLIITDDDKRkeEwarKPTRDVVCKLTACLR...........ATSVSLSSRTT.........YEECNGTLEDYLSLPDFENIYDISkvvp................yvppPKAPAVPPKVPGKAEDAPpdes......cigcDNPGLNAAAIAVPVVTVI..VLVSGI..------..........GYLCRSTESRQRTLE-l.....................................................................
B3UWW1_MUHV1/5-219              ...............................ldlsqflllavivtesvvlsmicdtnahsdlpq------....-----------------------..................--.------------------..........GKC.TILSKTP....vRNDSNL..GVDGW.GYECPLG-..LICIPASWQVKWYI..GAY--Y......MDMGGYFRSSLTKPPTFQGLSMYVKD------....-KNNARPDGFDIKHED.....GRLIVTVDAGR..-...--PFTVGCKVTVCKRepd.....ygpA----------.........------------------------........................------------------..............------------------..------..------..........----------------teepttkersttepvpipttqrittrsepqttarpttrptttvspttrptttvssttrptttv.......
A8E1E7_MUHVK/35-169             .................................................laakcrtyeldfgld------....-----------------------..................--.------------------..........-NC.TENDGG-.....-TSQRQ..SGGEC.IFSCNIDR..TVCASASWYATWVV.iSSGTQS......VLGFASYTSSSTSGATFTALWTNATDTRPRL-....-----TTTDLRLNNKT.....GQVHLSPSCT-..-...SGGYSIECHMTVCR-...........-----------.........------------------------........................------------------..............------------------..------..------..........----------------vsatpfp...............................................................
A8E1J0_MUHVK/2-274              ..........................................................klffss-----H....LLLHFLIFVVIAAKSLITSAAT-..................CD.SVRDMA--FYGA---NTP..........GQC.RTVSVNL.....KDVYGL..GSGSTwVYTCEFP-..TMCINATWRVEWLL..NKSP--......INVSVLYESTTSTPPRFKQLIRNNATTR----....----PPPTGFELNSDN.....GYLYIYPSAG-..-...-NNFYLSCTGFVCVPpk.......piTTTPSTTRSRS.........STETRTTRSGTKFIPHKITPSRSQ........................PVSPQVDD---TTQLDIDtaii.....vasaeMQTSNTPTAIAVSLVVIV..VVTVIV..LGLLYHygflgkwallDSYVNRFRVRFM----ghn...................................................................
H2A240_MUHV1/1-272              ....mklffsshlyflifaviaakslitsaapcdtardmafsstvtpghcrsivvtlkdlyglg------....-----------------------..................--.------------------..........---.-------.....------..SSSTW.VYKCEFP-..IFCINATWRVEWLL..NKSP--......INVSVLYESTTSTPPRFKQLITNNATTR----....----PPPTGFEINRDN.....GYLYIYPDAG-..-...-NNFYLSCTGFVCVPpk.......piTTTPSTTRSRS.........STETRTTRSGTKFIPHKITPSGSQ........................PVSPQVDDTTQLDI-DTAiiv.......asaeMQTSNTPTAIAVSLVVIV..VVTVIV..LGLLYHygflgkwallDSYVDRFRVRF-----mgnt..................................................................
B3UWW0_MUHV1/2-277              ..........................................................rgytgd------....TMLLVVFCVWLVYVFSVESRANE..................CD.----PS--LAANYSNLTQ..........GQC.VTRKGA-.....---KND..TEG-G.SYSCL-TD..GICIPASWEGTWLV..DGWPL-......-PFGVYFKSSNSSPPVFSMTFNKTQPTT----....TPPTINATDYTVDPTS.....GRLIVSSNAT-..-...-TSVSVTCELKICRQtddygptaprrRTKKRTTTVPP.........TTTSHTTLSSTHTSTTKKTITTRRatesptvn.......htspiptssRVNV-------------SvnfnsddettgsmeRQKRSNMIAIVMFVCFSSgaCVLLVG..LAYYYG..........--L-------------fddtrshap.............................................................
H2A239_MUHV1/6-220              ................................dlsqflllavivtesvvlsmicdtnahsdlpq------....-----------------------..................--.------------------..........GKC.TILSKTP....vRNDSNL..GVDGW.GYECPLG-..DICIPASWQVKWYI..GLYQM-......-DTGGFFRSSLTKPPTFQGLSMYVKD------....-KTNARPDGFAIKDED.....GRLIVTVDANR..-...--PFTLGCKVTVCKR...........E----------.........------------------------........................------------------..............------------------..------..------..........----------------pdygpateepttaersttepvpipttqrittrsepqttarpttrptttvspttrptttvssttrptttvr
B3UWW8_MUHV1/13-173             ..........................................lqrfscttakcrpsdldvpldt------....-----------------------..................--.------------------..........--C.AEHDA--.....GTLQKQ..DTGKC.IFSCNIDT..TLCVYASWYATWVV.sSSGTQY......VLGFVSYTSSSTSGATFTALWTNDTDTRPRL-....-----TTGNLRLDNKT.....GKVHLSPCTS-..-...-GGYSIECHMTVCRV...........-----------.........------------------------........................------------------..............------------------..------..------..........----------------satsfpptvphpptllrssatipklsn...........................................
H2A245_MUHV1/2-207              .....................................................rrlgivivias------....------------FLSAVESTETE..................CD.----------TYNVTIKP..........ETCdFFDNLYEv...rVRVDEK..DTNRV.HYSCQFKW..NICTQATWYGTWIR..MSFDEEmnpsprVLAHVQLMSTPTSPPTLVGFWNDSSSNKQYVL....SHNS--SAEIWQDPVT.....DNVYISSQVS-..-...SNQLGLICQLTGCLN...........SKMDETYP---.........------------------------........................------------------..............------------------..------..------..........----------------afarekietqtaiaiakpadkqselasqslakptssr.................................
B3UWV9_MUHV1/19-332             ....................................rsrpvqllalvtvlasmtfqmgeslipi------....IPDFSSFMMNPLPMPQIMPPSTNetketkesyvkteepivgCNvSRTEINRLKNQMKNIPNT..........FKC.FKKDGVR.....TSLDMQ..TTGEK.RFACEIPN..NVYVNATWYVHWVV..GKIAAS......VSPIVYFTSTTSSPPTFDGNMHPFYQ------....RKIVTAANGFKVDEKT.....GDITVARSNA-..-...SLADSVRCRLIVCLW...........TKNDSISDLPD.........DDPQMKNMSGVIKLPDYSGPDTLL........................TDGVPFDYAAWRQRMRTEme.........epsRRRRQLLLVISVIASLLW..LAVGVM..LFYTYGre......plARLLKRYGKQLAAVR-i.....................................................................
H2A233_MUHV1/4-253              ...................................rsrwcasrprgvcrlrvlllvcaamfpvv------....-----------------S-----..................--.-------------SVPLP.........kIYC.YSKNATVarkpaRDR--DywTPSVT.VLGCRIPK..GVCIEGDWSIEWVI..HSMDAV......VIYQALFRSTAWLGPSMQRLILAMPK------....RRLVGCGQGFCVDRAD.....GNLIITDNDTRkdEwarKPPRDAVCKLKACLT...........ATSVPMSSRL-.........YEGCDGNLTEYLNLPDYENWFGTQ........................NVVQDVPPVVGC------..............DNPALNTAVIAVGVLTVV..AFVSVV..------..........AYLCRSAESRQLTWE-v.....................................................................
B3UWV8_MUHV1/8-319              ................................................................CTVMWR....SVIVFLLF-SSWLTTSGDSSHRSrrpplqspksgittwiggSS.RTRFPSTSFGTYKTVALGgdkcspwkytSKC.FNSKDATr..flKKSVNP..KTGDK.TFTCMPAE..NVYANASWRIEWIL..GNGTTW......LTPAIRFVSTDRSPPTFNGTLSVAYSSRLVYTd.enNNTNSNKTGLRVDKSG.....--LHISSAVRAdlV...KDVHDVKCILSVCLW...........TDRISVYNTSDgyiethvevDSTAVANLSIIATLDDFVYPLGYPm.....................eyTKKSAYSWPSETSQPQMS..............--MSVFFGILSVYIVLII..GEVYIC..LKCHYN..........---HKHKSAADVAVEY......................................................................
B3UWW3_MUHV1/4-272              .......................................................spdrllqls------....------LVLAVFAPHLVIFASRR..................CD.----PNTSRAYSSRIP-P..........GTC.TGVSVHL....eIKEKNY..RTQTW.VYECELP-..LACIDATWQVKWTV..NQIPMN......--ATALYNSTDSSLPKFDKLYIINAT------....--TKPPPKGFTVNPHD.....GYLYLVSSPE-..E...TVSVHLQCEGSVCLP...........NKTIHVTTNP-.........PTTISRTKRDTTKFISISS-RSQP........................VTRQATDATVSNTASSTDnavi.....vanaeMQTSNTTVAIVVPLMVIL..VATVIV..LGFLYHygflrkwallD---------------sylarvrghfttsd........................................................
H2A237_MUHV1/19-329             ..................................rsrpvqllalvtvlasmtfqmgesliippi------....IPEFSSFMMNPLPIPQIIPPSTNetkesyv...kteepivgCNvSRTEINRLKNQMKKIPNT..........FKC.FKKDGVR.....TSLDMQ..TTGEK.RFACEIPN..NVYVNATWYVHWVV..GKIAAS......VSPIVYFTSTTSSPPTLDGNMHPFYQ------....RKIVTAANGFKVDEKT.....GDITVARSNA-..-...SLADSVRCRLIVCLW...........TKNDSISDLPD.........DDPQMKNMSGVIKLPDYSGPDTLL........................T--VPFDYAAWRQRMRTEme.........epsRRRRQLLLVISVIASLLW..LAVGAM..LFYTYGre......plAKLLKRYGKRLAAVR-i.....................................................................
B3UWW4_MUHV1/3-259              ................................................................HRYLGR....SLFILVIYFVALSISRVTPAAR-..................APaPKTNNCTKFSYPGVDP--..........GYC.TERRDM-.....TLITKS..KNGTK.VYSCPLQ-..TVCVNARLSGIWCV.nNSAFGS......----LFFTSTSTSPPKFQGLTGTPRP------....------RPGLRIDPGT.....GYLYVYPNAT-..K...RPEKDIYCTLTICITa.........iTTRRPTTTRS-.........SRGVSTGISTTGLWTDETS-----........................---VVFPFVSAGENFGVSa............sSQTASSGTIVAIVIVIAI..CVGLVV..LAVLYYrgyighsrrlNLYRERLRARFLVSH-s.....................................................................
A3R008_MUHV1/8-320              ................................................................CTVMWR....SVLVFLLFSSSWLTTSGDSPHRSrrpplqspksgittwiggSS.RTRFPSASFDNYKTTVSGkhpfspwksiSKC.FNSKDATp..flKKSVNQ..KTGDK.TFTCMPAE..NVYANASWRIEWVL..GNGTTW......LTPAIRFVSTDRLPPTFNGTLSVAYSTRLLYTd.ekDNQNANNTGLYVDKSG.....--LHISSAVRAdlV...KDVHDVKCTLSVCLW...........TDKISLYNTSDgyvethvevDPIAVANLSIIATLDDFVYPLGYPm.....................eyTKKSAYSWPSETSQPQMS..............--MSVFFGILSVYIVLII..GEVYIC..LKCHYN..........---HKHESAADVAVEY......................................................................
A8E1I9_MUHVK/5-210              ...............................ldlsqflllavivtdsvvlsmicdtnahsdlpq------....-----------------------..................--.------------------..........GKC.TILSKTP....vRNDSNL..GVDGW.GYECPLG-..LICIPASWQVKWYI..GAY--Y......MDTGGYFRSSLTKPPTFQGLSMYVKD------....-KNNARPDGFDIKHED.....GRLIVTVDAGR..-...--PFTVGCKVTVCKR...........E----------.........------------------------........................------------------..............------------------..------..------..........----------------pdygpateepttkersttkpvpipttqrrttrsepqttvrpttrptttvrpttrptttvs..........
A8E1J3_MUHVK/30-219             ....................................................raemfrhhltsf------....--ITVTFSLASISITLPLAQATNv...............laAP.KNTSCVKKFTVSERRPPPepgkcmsllgSTL.VNKQAAN.....KQVDKP..VTILK.IFRCPVEE..YLCMNATWSGRLFVrtQDNREI......IFGNISFTSTDSSPTTLTGISTLKPW------....----PLSSDLWIHSGT.....GDIYMFSNAS-..-...--FSDPKCYITLCVL...........RKNAH------.........------------------------........................------------------..............------------------..------..------..........----------------ipvqran...............................................................
A8E1I5_MUHVK/1-259              ................................................................MSLTHR....PLLVIVIV-SVVISFVGSYNNDQ..................CK.---KDEEAFKKKMQYRHP..........LGC.YFKGITP.....TKIPSK..--GDT.LLTCKLP-..DVKVNASWTLEWVV..VKLQNS......VDVTSYYESSPNSEPRFLRAILNFTPIHGLRT....NNLLTVKDGFQVDNSTdngngGNLYVYSNAS-..T...GSADSVRCRLRMCPW...........TSNSKMT--AP.........DEEMLRKMSEVLNLPNYGVPDLTP........................PRRDEF-YTKNESP-NTI..............------VTTLTVIVTLLF..VGLLLV..LIYLYG..........PSLYRRFFSNDCCSNF......................................................................
H2A235_MUHV1/9-258              ................................................................MSLASH....LPLVALFFLPY-ILMIYASNDQ-..................CK.---ADDKVLKELLS-RHQ..........VGC.WYKRAD-.....TTISTS..GSE-T.ILSCTLP-..NVYVNATWFTEWIM..ERISAS......ANMRSYYVSSTSSRPTFKKTELLSVYKGNGRR....TKIVGPKEGFRVNDTN.....GNLHIYPNAS-..Y...SDTGSVICHLLICAW...........TYNKDIC----.........KEDIFKNLSNVLSLPDYGVPSIE-........................RSRIDYDSTTKSPP-DVT..............------VTALSVIVTLLY..VAAFCV..LAYVFG..........PSLCRRFFTNDCCSTF......................................................................
A8E1J2_MUHVK/3-261              ................................................................HRYLGR....SLFILVIYFVALSISRVTPAAR-..................APaPKTNNCTKFSYPGVSP--..........GYC.TERRDM-.....KLITKF..KNGTK.VFSCPLLT..DICVNARMSGVWCV.nNSAIGS......----LFFTSTSHTPPMFHGFTPTHHR------....-----RLSGLWVDYQT.....GYLYVYPNAT-..K...KPEKEIYCTLTICITa.........iTTRRPTTTRS-.........SRGVSTGISTTGLWTDETS-----........................---VVFPFVSAGENFGVSa............sPQTASSGTIAAIVIVIVI..CVGLVV..LAVLYYrgyighsrrlNLYRERLRARFLVSH-s.....................................................................
H2A247_MUHV1/25-179             ..............................kmtvnimlffalflhrflclaakcrtyefdigfd------....-----------------------..................--.------------------..........-NC.TENDGG-.....-TSRRQ..SGSEC.IFSCNIDT..TICVYASWYATWVV.sSSGTQY......VLGFVSYTSSSTSGATFTALWTNDTDTRPRL-....-----TTGNLRLDNKT.....GKVHLSPCTS-..-...-GGYSIECHMTVCR-...........-----------.........------------------------........................------------------..............------------------..------..------..........----------------vsatpfppt.............................................................
H2A242_MUHV1/3-259              ................................................................HRYLGR....SLFILVIYFVALSISRVTPAAR-..................APaPKTNNCTKFSYPGVDP--..........GYC.TERRDM-.....TKINTF..KNGTK.VYSCPLQ-..TVCINARLSGIWCV.nNSAVGS......----LFFTSTSTSPPKFQGLTGTPRP------....------RPGLRIDPGT.....GYLYVYPNAT-..K...RPEKEIYCTLTICITa.........iTTRRPTTTRS-.........SRGVSTGISTTGLWTDETS-----........................---VVFPFGSADENFGVSa............sPQTASSGTIAAIVIVIAI..CVGLVV..LAVLYYrgyighsrrlNLYRERLRARFLVSH-s.....................................................................
H2A234_MUHV1/15-301             ...............................................................s-SPSVR....VSLRSAWLFWSFVLCVVTSYVCEssan..........anqwCSgLNDTIHKKLEEIN-YMNMks.....svqLGC.LSPRRIT.....DVSLMI..HNNVT.KAYFTLPS.tGIYVNATWLFEWIV..VPLLAL......VGETGCYTSTTSSIPRMLTKFTSPIFSSYNTSgtriIRTVGLNDGFKIDSSS.....GELHIFSNASVvaN...ITAKDILCILKLCTW...........KLSDSMI-SVN.........DTTLNNNLSTIISLPIYNESAALS........................DTQSRHNYGISQRHVTRR..............SNTAVLVAVLVFIIVTLF..VAA--I..FGYFYR..........STLVRHLS--------glttlq................................................................
H2A241_MUHV1/4-270              ......................................................spdrllqlsl------....---------VLAVFASPRVASRK..................CD.----PVISKSY-SSRTPP..........GTC.TGASVYL.....EIISKS.hSTQTW.KYECQLP-..EACIEATWQVKWTV..NRIPMN......--ATALYNSTDSSLPKFDKILVINAT------....--TKPPPKGFTVNPHD.....GYLYLVSSPD-..E...TVSVHLQCEGFVCLP...........NKTIHVTTNPPt.......tISRTKRDTTKFISLSSRSQPVTRQ.......................aTDTTVSNTASSTDNAV-Iva.........naeMQTSNTTVAIVVPLMVIL..VATVVV..LGFLYHygflrkwallD---------------sylarvrghfttsd........................................................
H2A238_MUHV1/3-280              ........................................................gytgdtma------....---LMVLCVWLAYVFSVESRANG..................CD.----PS--LAANYSNLTQ..........GQC.VTIKGV-.....---KND..TEG-R.SYSCRTD-..AICIPASWEGTWLV..DGWPLP......--LGVYFKSSNSSPPLFSMTFNQTQPNTTP--....--PTINSTDYTLDPTS.....GRLIVSSNLTR..-...--SVSVTCKLTVCRQ...........TDGYGPK--PPpr.....rpKKRTTTVLPTTTSYTTLSVTHTSTirklittrqatesptvnhtspiptSSRVNV-----------SvdsntddettgsmeRQKRSNMIAIVMLVCFSF..GACVLLvgLAYYYG..........--LFDDTQS-------hahghg................................................................
B3UWV6_MUHV1/7-280              ................................................................SSPSVR....TYLRSTRLLLLFVFCVVISYAQE..................CPnYDGRNQ--HESVWKYRKE..........LGC.LYRRIT-.....NITLYD..NNGIK.TAYFTLPGpaAVYVNASWTFEWFI..KPLFAS......VDAAGYYTSSTTSVAK-SDKNTVHIFSYYDPYsgrlKKTVGLKDGFKADPS-.....GNLYIFQNASVagN...ITVNDTICVLRLCLW...........TTKDSTI-SID.........DVGIKNNLSSILSLPTYDEIRGVL........................YMRPQYNYSIPIKRIVQR..............SNDAGLVAAILFFIAAIF..VAV-LL..LGYSYK..........PTLFRRISTLIHGQQ-l.....................................................................
A8E1J1_MUHVK/4-272              ......................................................spdrllqlsl------....-------VLAVFAPHLVIFASRK..................CD.--PVIS---KSYSSRTPP..........GTC.TGASVYL.....EIISKS.hSTQTW.KYECQLP-..EACIEATWQVKWTV..NRIPMN......--ATALYNSTDSSLPKFDKILVINAT------....--TKPPPKGFTVNPHD.....GYLYLVSSPE-..E...TVSVHLQCEVFVCLP...........NKTIHVTTNPPt.......tISRTKRDTTKFISLSSRSQPVTRQ.......................aTDTTVSNTASSTDNAV-Iva.........naeMQTSNTTVAIVVPLLVIL..VATVIV..LGFLYHygflrkwallD---------------sylarvrghfttsd........................................................
#=GC SS_cons                    ................................................................XXXXXX....XXXXXXXX-XXXXXXXXXXXXXX..................XX.---XXXXXXXXXXX--EE..........--E.EEEEE--.....EEE--S..SSS-E.EEE-----..---SSEEEEEEEEE..TTTTEE......BSEEEEEEEETTEEEEEEEEEE-SS-TT-TTT....TSSB-GGGTEEE---STTS-TT-EEE-TTS--..T...TSCCCEEEEEEEEEE...........ES-TT----S-.........-HHHHHHTHHHHTS-B-S--SCE-........................--TTXX-XXXXXXX-XXX..............------XXXXXXXXXXXX..XXXXXX..XXXXXX..........XXXXXXXXXXXXXXXX......................................................................
#=GC seq_cons                   .............................................................................h..hh...h.h..h.s.sp...................ss......t..ht..................htC.htppss......pp.spp..ssutp.hasCpls...slClsAoWpscWll..sshst.......l.stlhapSosoSsPpFpthhsssts..............ssssGaplDsss.....GpLalsssss........sshsltCpLplClh...........spp.phh..............pth.tshothh.hssh..................................s.hs.....p......................t..hhhlsh.lshlh..shs.hh..LhhhY..............hpp................................................................................
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