GenomeNet

Database: Pfam
Entry: m04gp34like
LinkDB: m04gp34like
Original site: m04gp34like 
#=GF ID   m04gp34like
#=GF AC   PF12216.10
#=GF DE   Immune evasion protein
#=GF AU   Assefa S;0000-0003-2178-533X
#=GF AU   Gavin OL;
#=GF SE   PFAM-B_2496 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   33.10 32.20;
#=GF NC   24.50 24.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10644360
#=GF RT   The putative natural killer decoy early gene m04 (gp34) of
#=GF RT   murine cytomegalovirus encodes an antigenic peptide recognized
#=GF RT   by protective antiviral CD8 T cells.
#=GF RA   Holtappels R, Thomas D, Podlech J, Geginat G, Steffens HP,
#=GF RA   Reddehase MJ;
#=GF RL   J Virol. 2000;74:1871-1884.
#=GF DR   INTERPRO; IPR022022;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This protein is found in archaea and viruses. Proteins in this
#=GF CC   family are typically between 265 to 342 amino acids in length.
#=GF CC   The proteins in this family are or are related to the m04
#=GF CC   encoded protein gp34 of pathogenic microorganisms such as murine
#=GF CC   cytomegalovirus. m06 and m152 genes are expressed earlier in the
#=GF CC   intracellular replication phases of these microorganism' life
#=GF CC   cycles. They function to inhibit MHC-1 loading and export. gp34
#=GF CC   is theorized to prevent immune reactions from NK cells which
#=GF CC   would ordinarily recognise and attack cells lacking MHC.
#=GF SQ   12
#=GS H2A235_MUHV1/9-258   AC H2A235.1
#=GS H2A233_MUHV1/4-253   AC H2A233.1
#=GS H2A240_MUHV1/1-272   AC H2A240.1
#=GS H2A247_MUHV1/25-179  AC H2A247.1
#=GS H2A237_MUHV1/19-329  AC H2A237.1
#=GS H2A242_MUHV1/3-259   AC H2A242.1
#=GS H2A239_MUHV1/6-220   AC H2A239.1
#=GS H2A241_MUHV1/4-270   AC H2A241.1
#=GS H2A238_MUHV1/3-280   AC H2A238.1
#=GS H2A234_MUHV1/15-301  AC H2A234.1
#=GS H2A245_MUHV1/2-207   AC H2A245.1
#=GS A3R008_MUHV1/8-320   AC A3R008.1
H2A235_MUHV1/9-258              ............................................................MSLASHLPLVALFFLPY-ILMIYASNDQ-..................CK.---ADDKVLKELLS-RHQ..........VGC.WYKRAD-.....TTISTS..GSE-TILSCTLP-.NVYVNATWFTEWIM.ERISAS......ANMRSYYVSSTSSRPTFKKTELLSVYKGNGRR....TKIVGPKEGFRVNDTNGNLHIYPNAS-..Y...SDTGSVICHLLICAW....TYNKDIC----.........KEDIFKNLSNVLSLPDYGVPSIE-........................RSRIDYDSTTKSPP-DVT..............------VTALSVIVTLLYVAAFCV..LAYVFG..........PSLCRRFFTNDCCSTF......................................................................
H2A233_MUHV1/4-253              ...............................rsrwcasrprgvcrlrvlllvcaamfpvv-----------------------S-----..................--.-------------SVPLP.........kIYC.YSKNATVarkpaRDR--DywTPSVTVLGCRIPK.GVCIEGDWSIEWVI.HSMDAV......VIYQALFRSTAWLGPSMQRLILAMPK------....RRLVGCGQGFCVDRADGNLIITDNDTRkdEwarKPPRDAVCKLKACLT....ATSVPMSSRL-.........YEGCDGNLTEYLNLPDYENWFGTQ........................NVVQDVPPVVGC------..............DNPALNTAVIAVGVLTVVAFVSVV..------..........AYLCRSAESRQLTWE-v.....................................................................
H2A240_MUHV1/1-272              mklffsshlyflifaviaakslitsaapcdtardmafsstvtpghcrsivvtlkdlyglg-----------------------------..................--.------------------..........---.-------.....------..SSSTWVYKCEFP-.IFCINATWRVEWLL.NKSP--......INVSVLYESTTSTPPRFKQLITNNATTR----....----PPPTGFEINRDNGYLYIYPDAG-..-...-NNFYLSCTGFVCVPpkpiTTTPSTTRSRS.........STETRTTRSGTKFIPHKITPSGSQ........................PVSPQVDDTTQLDI-DTAiiv.......asaeMQTSNTPTAIAVSLVVIVVVTVIV..LGLLYHygflgkwallDSYVDRFRVRF-----mgnt..................................................................
H2A247_MUHV1/25-179             ..........................kmtvnimlffalflhrflclaakcrtyefdigfd-----------------------------..................--.------------------..........-NC.TENDGG-.....-TSRRQ..SGSECIFSCNIDT.TICVYASWYATWVVsSSGTQY......VLGFVSYTSSSTSGATFTALWTNDTDTRPRL-....-----TTGNLRLDNKTGKVHLSPCTS-..-...-GGYSIECHMTVCR-....-----------.........------------------------........................------------------..............------------------------..------..........----------------vsatpfppt.............................................................
H2A237_MUHV1/19-329             ..............................rsrpvqllalvtvlasmtfqmgesliippi------IPEFSSFMMNPLPIPQIIPPSTNetkesyv...kteepivgCNvSRTEINRLKNQMKKIPNT..........FKC.FKKDGVR.....TSLDMQ..TTGEKRFACEIPN.NVYVNATWYVHWVV.GKIAAS......VSPIVYFTSTTSSPPTLDGNMHPFYQ------....RKIVTAANGFKVDEKTGDITVARSNA-..-...SLADSVRCRLIVCLW....TKNDSISDLPD.........DDPQMKNMSGVIKLPDYSGPDTLL........................T--VPFDYAAWRQRMRTEme.........epsRRRRQLLLVISVIASLLWLAVGAM..LFYTYGre......plAKLLKRYGKRLAAVR-i.....................................................................
H2A242_MUHV1/3-259              ............................................................HRYLGRSLFILVIYFVALSISRVTPAAR-..................APaPKTNNCTKFSYPGVDP--..........GYC.TERRDM-.....TKINTF..KNGTKVYSCPLQ-.TVCINARLSGIWCVnNSAVGS......----LFFTSTSTSPPKFQGLTGTPRP------....------RPGLRIDPGTGYLYVYPNAT-..K...RPEKEIYCTLTICITa..iTTRRPTTTRS-.........SRGVSTGISTTGLWTDETS-----........................---VVFPFGSADENFGVSa............sPQTASSGTIAAIVIVIAICVGLVV..LAVLYYrgyighsrrlNLYRERLRARFLVSH-s.....................................................................
H2A239_MUHV1/6-220              ............................dlsqflllavivtesvvlsmicdtnahsdlpq-----------------------------..................--.------------------..........GKC.TILSKTP....vRNDSNL..GVDGWGYECPLG-.DICIPASWQVKWYI.GLYQM-......-DTGGFFRSSLTKPPTFQGLSMYVKD------....-KTNARPDGFAIKDEDGRLIVTVDANR..-...--PFTLGCKVTVCKR....E----------.........------------------------........................------------------..............------------------------..------..........----------------pdygpateepttaersttepvpipttqrittrsepqttarpttrptttvspttrptttvssttrptttvr
H2A241_MUHV1/4-270              ..................................................spdrllqlsl---------------VLAVFASPRVASRK..................CD.----PVISKSY-SSRTPP..........GTC.TGASVYL.....EIISKS.hSTQTWKYECQLP-.EACIEATWQVKWTV.NRIPMN......--ATALYNSTDSSLPKFDKILVINAT------....--TKPPPKGFTVNPHDGYLYLVSSPD-..E...TVSVHLQCEGFVCLP....NKTIHVTTNPPt.......tISRTKRDTTKFISLSSRSQPVTRQ.......................aTDTTVSNTASSTDNAV-Iva.........naeMQTSNTTVAIVVPLMVILVATVVV..LGFLYHygflrkwallD---------------sylarvrghfttsd........................................................
H2A238_MUHV1/3-280              ....................................................gytgdtma---------LMVLCVWLAYVFSVESRANG..................CD.----PS--LAANYSNLTQ..........GQC.VTIKGV-.....---KND..TEG-RSYSCRTD-.AICIPASWEGTWLV.DGWPLP......--LGVYFKSSNSSPPLFSMTFNQTQPNTTP--....--PTINSTDYTLDPTSGRLIVSSNLTR..-...--SVSVTCKLTVCRQ....TDGYGPK--PPpr.....rpKKRTTTVLPTTTSYTTLSVTHTSTirklittrqatesptvnhtspiptSSRVNV-----------SvdsntddettgsmeRQKRSNMIAIVMLVCFSFGACVLLvgLAYYYG..........--LFDDTQS-------hahghg................................................................
H2A234_MUHV1/15-301             ...........................................................s-SPSVRVSLRSAWLFWSFVLCVVTSYVCEssan..........anqwCSgLNDTIHKKLEEIN-YMNMks.....svqLGC.LSPRRIT.....DVSLMI..HNNVTKAYFTLPStGIYVNATWLFEWIV.VPLLAL......VGETGCYTSTTSSIPRMLTKFTSPIFSSYNTSgtriIRTVGLNDGFKIDSSSGELHIFSNASVvaN...ITAKDILCILKLCTW....KLSDSMI-SVN.........DTTLNNNLSTIISLPIYNESAALS........................DTQSRHNYGISQRHVTRR..............SNTAVLVAVLVFIIVTLFVAA--I..FGYFYR..........STLVRHLS--------glttlq................................................................
H2A245_MUHV1/2-207              .................................................rrlgivivias------------------FLSAVESTETE..................CD.----------TYNVTIKP..........ETCdFFDNLYEv...rVRVDEK..DTNRVHYSCQFKW.NICTQATWYGTWIR.MSFDEEmnpsprVLAHVQLMSTPTSPPTLVGFWNDSSSNKQYVL....SHNS--SAEIWQDPVTDNVYISSQVS-..-...SNQLGLICQLTGCLN....SKMDETYP---.........------------------------........................------------------..............------------------------..------..........----------------afarekietqtaiaiakpadkqselasqslakptssr.................................
A3R008_MUHV1/8-320              ............................................................CTVMWRSVLVFLLFSSSWLTTSGDSPHRSrrpplqspksgittwiggSS.RTRFPSASFDNYKTTVSGkhpfspwksiSKC.FNSKDATp..flKKSVNQ..KTGDKTFTCMPAE.NVYANASWRIEWVL.GNGTTW......LTPAIRFVSTDRLPPTFNGTLSVAYSTRLLYTd.ekDNQNANNTGLYVDKSG--LHISSAVRAdlV...KDVHDVKCTLSVCLW....TDKISLYNTSDgyvethvevDPIAVANLSIIATLDDFVYPLGYPm.....................eyTKKSAYSWPSETSQPQMS..............--MSVFFGILSVYIVLIIGEVYIC..LKCHYN..........---HKHESAADVAVEY......................................................................
#=GC seq_cons                   ...............................................................................h...ts..p...................s..............................htC.httpsh......pp.ppp..ssstphasCpls..slClsAoW.scWll.sphst.......h.htshapSTsoSsPpFpthhssshs.............sssssGaplDsssGpLalsssss........sshslhCpLplCh.....spp.shh..............p.h.tshothh.hsph....h...............................hs.s..........................t..hhhlsh.lhhhhshs.hh..hhhha..............hcp................................................................................
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