#=GF ID   zf-C2H2
#=GF AC   PF00096.29
#=GF DE   Zinc finger, C2H2 type
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Boehm S;0000-0002-9538-9279
#=GF AU   Sonnhammer ELL;0000-0002-9015-5588
#=GF AU   Gago F;0000-0002-3071-4878
#=GF SE   Boehm S
#=GF GA   25.20 15.80;
#=GF TC   25.20 15.80;
#=GF NC   25.10 15.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Zinc_finger
#=GF CL   CL0361
#=GF RN   [1]
#=GF RM   9171100
#=GF RT   Variations of the C2H2 zinc finger motif in the yeast genome and
#=GF RT   classification of yeast zinc finger proteins. 
#=GF RA   Boehm S, Frishman D, Mewes HW; 
#=GF RL   Nucleic Acids Res 1997;25:2464-2469.
#=GF RN   [2]
#=GF RM   12683994
#=GF RT   Assessment by molecular dynamics simulations of the structural
#=GF RT   determinants of DNA-binding specificity for transcription factor
#=GF RT   Sp1. 
#=GF RA   Marco E, Garcia-Nieto R, Gago F; 
#=GF RL   J Mol Biol 2003;328:9-32.
#=GF DR   INTERPRO; IPR013087;
#=GF DR   PROSITE; PDOC00028;
#=GF DR   PRINTS; PR00048;
#=GF DR   SCOP; 1zaa; fa;
#=GF DR   HOMSTRAD; zf-CCHH;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The C2H2 zinc finger is the classical zinc finger domain. The
#=GF CC   two conserved cysteines and histidines co-ordinate a zinc ion.
#=GF CC   The following pattern describes the zinc finger.
#=GF CC   #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any
#=GF CC   amino acid, and numbers in brackets indicate the number of
#=GF CC   residues. The positions marked # are those that are important
#=GF CC   for the stable fold of the zinc finger. The final position can
#=GF CC   be either his or cys. The C2H2 zinc finger is composed of two
#=GF CC   short beta strands followed by an alpha helix. The amino
#=GF CC   terminal part of the helix binds the major groove in DNA binding
#=GF CC   zinc fingers. The accepted consensus binding sequence for Sp1 is
#=GF CC   usually defined by the asymmetric hexanucleotide core GGGCGG but
#=GF CC   this sequence does not include, among others, the GAG (=CTC)
#=GF CC   repeat that constitutes a high-affinity  site for Sp1 binding to
#=GF CC   the wt1 promoter [2].
#=GF SQ   1201914
#=GS F7EWL9_MONDO/496-518        AC F7EWL9.2
#=GS A0A2Y9R9J0_TRIMA/520-542    AC A0A2Y9R9J0.1
#=GS A0A5F7ZDX8_MACMU/635-657    AC A0A5F7ZDX8.1
#=GS A0A4W6F6D6_LATCA/192-214    AC A0A4W6F6D6.1
#=GS A0A6J3K296_9HYME/243-265    AC A0A6J3K296.1
#=GS A0A455AT52_PHYMC/258-280    AC A0A455AT52.1
#=GS A0A6J3GMJ7_SAPAP/215-237    AC A0A6J3GMJ7.1
#=GS A0A484BFN4_DRONA/424-446    AC A0A484BFN4.1
#=GS A0A6P3VZ89_CLUHA/341-363    AC A0A6P3VZ89.1
#=GS ZNF22_MOUSE/139-161         AC Q9ERU3.2
#=GS A0A6I9M256_PERMB/608-630    AC A0A6I9M256.1
#=GS A0A2Y9S107_TRIMA/333-355    AC A0A2Y9S107.1
#=GS A0A2G5B1Q5_COERN/22-46      AC A0A2G5B1Q5.1
#=GS A0A1S3JPN1_LINUN/535-560    AC A0A1S3JPN1.1
#=GS A0A6I8RZY7_XENTR/32-54      AC A0A6I8RZY7.2
#=GS A0A6G0IGP2_LARCR/380-402    AC A0A6G0IGP2.1
#=GS K7ETV8_PONAB/308-330        AC K7ETV8.1
#=GS A0A7E6FUB9_OCTVU/77-99      AC A0A7E6FUB9.1
#=GS A0A671KM65_9TELE/204-226    AC A0A671KM65.1
#=GS A0A673W1D1_SALTR/258-280    AC A0A673W1D1.1
#=GS A0A7E6FUN0_OCTVU/338-360    AC A0A7E6FUN0.1
#=GS B3MKK8_DROAN/981-1003       AC B3MKK8.2
#=GS A0A6P5JQM9_PHACI/392-414    AC A0A6P5JQM9.1
#=GS A0A6J2WJ84_CHACN/3085-3107  AC A0A6J2WJ84.1
#=GS A0A7N9IHC6_MACFA/388-410    AC A0A7N9IHC6.1
#=GS A0A2Y9PTL2_DELLE/822-846    AC A0A2Y9PTL2.1
#=GS A0A087YBN1_POEFO/276-298    AC A0A087YBN1.2
#=GS A0A6I8V1T3_DROPS/696-719    AC A0A6I8V1T3.1
#=GS A0A3Q7SIS9_VULVU/413-436    AC A0A3Q7SIS9.1
#=GS A0A6J3AVF9_VICPA/483-505    AC A0A6J3AVF9.1
#=GS A0A6J0XDK1_ODOVR/372-394    AC A0A6J0XDK1.1
#=GS A0A452SEE8_URSAM/87-109     AC A0A452SEE8.1
#=GS A0A4W5LWQ3_9TELE/564-586    AC A0A4W5LWQ3.1
#=GS A0A498M6J8_LABRO/622-644    AC A0A498M6J8.1
#=GS A0A1S3RXB5_SALSA/269-291    AC A0A1S3RXB5.1
#=GS A0A6P7GP28_DIAVI/205-227    AC A0A6P7GP28.1
#=GS A0A2P8ZF57_BLAGE/135-157    AC A0A2P8ZF57.1
#=GS A0A6P8SJU7_GEOSA/496-518    AC A0A6P8SJU7.1
#=GS A2A799_MOUSE/285-307        AC A2A799.1
#=GS A0A6J1XAI3_ACIJB/350-372    AC A0A6J1XAI3.1
#=GS A0A218UUQ2_9PASE/206-229    AC A0A218UUQ2.1
#=GS A0A1B7TE53_9ASCO/119-141    AC A0A1B7TE53.1
#=GS A0A6P6ESY7_OCTDE/142-164    AC A0A6P6ESY7.1
#=GS A0A485PM37_LYNPA/510-532    AC A0A485PM37.1
#=GS A0A668V0T7_OREAU/533-554    AC A0A668V0T7.1
#=GS A0A452GMG8_9SAUR/130-152    AC A0A452GMG8.1
#=GS A0A3B5R8N2_XIPMA/106-128    AC A0A3B5R8N2.1
#=GS A0A672NHV8_SINGR/81-105     AC A0A672NHV8.1
#=GS A0A670ZKU0_PSETE/235-257    AC A0A670ZKU0.1
#=GS A0A673STN3_SURSU/231-253    AC A0A673STN3.1
#=GS A0A6P3V964_OCTDE/217-239    AC A0A6P3V964.1
#=GS A5DUH2_LODEL/139-162        AC A5DUH2.1
#=GS A0A2K6QC09_RHIRO/793-815    AC A0A2K6QC09.1
#=GS M3Y3Q5_MUSPF/503-525        AC M3Y3Q5.1
#=GS A0A2G9RV89_LITCT/190-212    AC A0A2G9RV89.1
#=GS A0A199UJ12_ANACO/265-290    AC A0A199UJ12.1
#=GS A0A0L8G402_OCTBM/248-270    AC A0A0L8G402.1
#=GS A0A653C6Q1_CALMS/433-455    AC A0A653C6Q1.1
#=GS A0A6G1B518_CROCR/241-265    AC A0A6G1B518.1
#=GS A0A340Y7P2_LIPVE/604-626    AC A0A340Y7P2.1
#=GS A0A0L8FV23_OCTBM/59-81      AC A0A0L8FV23.1
#=GS A0A673U096_SURSU/456-478    AC A0A673U096.1
#=GS A0A0L8HSF2_OCTBM/510-532    AC A0A0L8HSF2.1
#=GS A0A6P5DAX9_BOSIN/439-461    AC A0A6P5DAX9.1
#=GS A0A674DKT2_SALTR/209-231    AC A0A674DKT2.1
#=GS F7B6R4_MONDO/435-457        AC F7B6R4.2
#=GS A0A4W6F0V1_LATCA/657-679    AC A0A4W6F0V1.1
#=GS A0A0G2KC95_DANRE/120-142    AC A0A0G2KC95.1
#=GS A0A3Q7TLK3_URSAR/289-311    AC A0A3Q7TLK3.1
#=GS A0A674K296_TERCA/366-388    AC A0A674K296.1
#=GS V4BAL9_LOTGI/51-73          AC V4BAL9.1
#=GS U3KNC1_RABIT/301-323        AC U3KNC1.2
#=GS A0A315W6V4_GAMAF/243-267    AC A0A315W6V4.1
#=GS H0VB87_CAVPO/321-343        AC H0VB87.2
#=GS F7GMR6_CALJA/346-368        AC F7GMR6.3
#=GS A0A1U7SVX9_ALLSI/240-262    AC A0A1U7SVX9.2
#=GS S7PCI1_MYOBR/512-534        AC S7PCI1.1
#=GS A0A6A5FQ94_PERFL/312-335    AC A0A6A5FQ94.1
#=GS B4GST2_DROPE/452-472        AC B4GST2.1
#=GS A0A2G9QJL0_LITCT/160-182    AC A0A2G9QJL0.1
#=GS A0A672HYN3_SALFA/204-226    AC A0A672HYN3.1
#=GS A0A6J1N8T3_BICAN/394-417    AC A0A6J1N8T3.1
#=GS A0A2K5HUZ4_COLAP/308-330    AC A0A2K5HUZ4.1
#=GS A0A2K6LPH2_RHIBE/277-299    AC A0A2K6LPH2.1
#=GS A0A4W6FAN9_LATCA/916-938    AC A0A4W6FAN9.1
#=GS A0A3Q7VC04_URSAR/425-447    AC A0A3Q7VC04.1
#=GS J9JWR5_ACYPI/521-543        AC J9JWR5.2
#=GS A0A1L1RMB1_CHICK/334-356    AC A0A1L1RMB1.2
#=GS A0A3Q7XD35_URSAR/367-389    AC A0A3Q7XD35.1
#=GS I3N8Y0_ICTTR/499-521        AC I3N8Y0.2
#=GS A0A671F1R9_RHIFE/427-449    AC A0A671F1R9.1
#=GS A0A6P7XAY0_9AMPH/652-674    AC A0A6P7XAY0.1
#=GS A0A2I4BU78_9TELE/243-265    AC A0A2I4BU78.1
#=GS A0A667XED1_9TELE/149-171    AC A0A667XED1.1
#=GS A0A6P3S5S1_PTEVA/501-523    AC A0A6P3S5S1.1
#=GS A0A286ZK54_PIG/474-496      AC A0A286ZK54.2
#=GS A0A2A2M0C6_9BILA/37-59      AC A0A2A2M0C6.1
#=GS A0A2I3LGC3_PAPAN/455-477    AC A0A2I3LGC3.1
#=GS A0A2K6Q4Y2_RHIRO/268-290    AC A0A2K6Q4Y2.1
#=GS A0A1X6P9B5_PORUM/481-503    AC A0A1X6P9B5.1
#=GS A0A087XP33_POEFO/393-415    AC A0A087XP33.2
#=GS A0A074SAN8_9AGAM/235-259    AC A0A074SAN8.1
#=GS A0A096P473_PAPAN/495-517    AC A0A096P473.2
#=GS A0A3N0XQY7_ANAGA/405-427    AC A0A3N0XQY7.1
#=GS I3K1T0_ORENI/175-197        AC I3K1T0.2
#=GS A0A0L8I5G5_OCTBM/263-285    AC A0A0L8I5G5.1
#=GS A0A2Y9J5V4_ENHLU/330-352    AC A0A2Y9J5V4.1
#=GS A0A6J2N344_9CHIR/293-315    AC A0A6J2N344.2
#=GS A0A0L0HEL5_SPIPD/35-58      AC A0A0L0HEL5.1
#=GS A0A2K5D386_AOTNA/265-287    AC A0A2K5D386.1
#=GS A0A674CPF5_SALTR/250-270    AC A0A674CPF5.1
#=GS A0A6P6QZI9_CARAU/395-417    AC A0A6P6QZI9.1
#=GS L5KV85_PTEAL/168-190        AC L5KV85.1
#=GS Q6WGJ9_NEMVE/208-230        AC Q6WGJ9.1
#=GS A0A2I2YX66_GORGO/291-313    AC A0A2I2YX66.1
#=GS D2HRB7_AILME/393-415        AC D2HRB7.1
#=GS A0A673A1B1_9TELE/1466-1489  AC A0A673A1B1.1
#=GS A0A7E6FRY4_OCTVU/371-393    AC A0A7E6FRY4.1
#=GS A0A7E6FIY4_OCTVU/284-306    AC A0A7E6FIY4.1
#=GS A0A2K5MHN8_CERAT/307-329    AC A0A2K5MHN8.1
#=GS A0A6J2UBE9_DROLE/435-457    AC A0A6J2UBE9.1
#=GS A0A6P3XAF8_DINQU/90-112     AC A0A6P3XAF8.1
#=GS A0A6J0VYF2_ODOVR/356-380    AC A0A6J0VYF2.1
#=GS A0A0L8FFJ0_OCTBM/82-104     AC A0A0L8FFJ0.1
#=GS A0A2I3T9V9_PANTR/544-566    AC A0A2I3T9V9.1
#=GS A0A6P5M1C7_PHACI/503-525    AC A0A6P5M1C7.1
#=GS A0A087UQ94_STEMI/11-32      AC A0A087UQ94.1
#=GS A0A0N4STU4_DANRE/80-102     AC A0A0N4STU4.2
#=GS A0A2R8Q568_DANRE/101-123    AC A0A2R8Q568.1
#=GS A0A3S2NL31_CHISP/290-312    AC A0A3S2NL31.1
#=GS A0A2K6UID7_SAIBB/265-287    AC A0A2K6UID7.1
#=GS A0A6P8ETG0_CLUHA/680-702    AC A0A6P8ETG0.1
#=GS T1GC17_MEGSC/351-373        AC T1GC17.1
#=GS A0A6P5DSJ2_BOSIN/765-787    AC A0A6P5DSJ2.1
#=GS A0A3B1JFW3_ASTMX/370-394    AC A0A3B1JFW3.1
#=GS F1PQQ8_CANLF/281-303        AC F1PQQ8.3
#=GS A0A2G9RU94_LITCT/777-799    AC A0A2G9RU94.1
#=GS H2PRD8_PONAB/235-257        AC H2PRD8.1
#=GS A0A6P9CWF3_PANGU/265-287    AC A0A6P9CWF3.1
#=GS A0A3Q3KL67_9TELE/919-941    AC A0A3Q3KL67.2
#=GS V2XBU2_MONRO/48-73          AC V2XBU2.1
#=GS A0A6P7GIL0_DIAVI/498-520    AC A0A6P7GIL0.1
#=GS A0A6P6L4C3_CARAU/246-267    AC A0A6P6L4C3.1
#=GS A0A2K6NB98_RHIRO/528-550    AC A0A2K6NB98.1
#=GS A0A667W8X8_9TELE/176-198    AC A0A667W8X8.1
#=GS A0A6J3HDY5_SAPAP/429-451    AC A0A6J3HDY5.1
#=GS A0A670Z5N3_PSETE/255-277    AC A0A670Z5N3.1
#=GS OSR1_XENTR/196-218          AC Q66JF8.1
#=GS A0A0L8HVK7_OCTBM/119-141    AC A0A0L8HVK7.1
#=GS S7PB44_MYOBR/380-402        AC S7PB44.1
#=GS A0A672ZXC4_9TELE/394-416    AC A0A672ZXC4.1
#=GS F1SH30_PIG/232-254          AC F1SH30.3
#=GS G1QLB7_NOMLE/132-154        AC G1QLB7.2
#=GS A0A5F5XVK6_FELCA/222-244    AC A0A5F5XVK6.1
#=GS A0A6P4YJM5_BRABE/166-188    AC A0A6P4YJM5.1
#=GS A0A2I3TR30_PANTR/136-158    AC A0A2I3TR30.1
#=GS F0ZPG0_DICPU/119-141        AC F0ZPG0.1
#=GS A0A1L8FUS0_XENLA/530-552    AC A0A1L8FUS0.1
#=GS A0A673YQ68_SALTR/236-258    AC A0A673YQ68.1
#=GS A0A6J3HC85_SAPAP/797-819    AC A0A6J3HC85.1
#=GS A0A6I9XVJ2_9SAUR/348-370    AC A0A6I9XVJ2.1
#=GS A0A6P8F5U7_CLUHA/627-649    AC A0A6P8F5U7.1
#=GS A0A3S2N0J4_ORYJA/282-304    AC A0A3S2N0J4.1
#=GS A0A1D5RGA2_MACMU/517-539    AC A0A1D5RGA2.2
#=GS A0A2K6PRN1_RHIRO/249-271    AC A0A2K6PRN1.1
#=GS A0A5B0QJ60_PUCGR/50-72      AC A0A5B0QJ60.1
#=GS B0XB58_CULQU/346-367        AC B0XB58.1
#=GS A0A6P7JTA9_9TELE/720-742    AC A0A6P7JTA9.1
#=GS A0A0L8GAT2_OCTBM/66-88      AC A0A0L8GAT2.1
#=GS A0A669PP00_PHACC/254-276    AC A0A669PP00.1
#=GS A0A2K5M0A9_CERAT/968-990    AC A0A2K5M0A9.1
#=GS A0A6P7GNT5_DIAVI/425-447    AC A0A6P7GNT5.1
#=GS A0A6J1PU77_9HYME/16-38      AC A0A6J1PU77.1
#=GS A0A6J3HAF6_SAPAP/313-335    AC A0A6J3HAF6.1
#=GS A0A168NG55_MUCCL/11-34      AC A0A168NG55.1
#=GS A0A026VV19_OOCBI/493-515    AC A0A026VV19.1
#=GS A0A6J0SIK6_9SAUR/132-154    AC A0A6J0SIK6.1
#=GS F7CB94_HORSE/268-290        AC F7CB94.3
#=GS ZN574_PONAB/523-545         AC Q5R4P8.1
#=GS A0A674CF24_SALTR/391-413    AC A0A674CF24.1
#=GS A0A6J1QHS0_9HYME/1118-1140  AC A0A6J1QHS0.1
#=GS A0A6P9BDP7_PANGU/435-457    AC A0A6P9BDP7.1
#=GS A0A3B5QB45_XIPMA/94-116     AC A0A3B5QB45.1
#=GS A0A5F4D6Z1_CANLF/455-477    AC A0A5F4D6Z1.1
#=GS A0A093PNT4_PHACA/652-674    AC A0A093PNT4.1
#=GS A0A0J7KDR7_LASNI/186-209    AC A0A0J7KDR7.1
#=GS A0A0L8GY06_OCTBM/134-156    AC A0A0L8GY06.1
#=GS A0A3Q3A1T2_KRYMA/397-421    AC A0A3Q3A1T2.1
#=GS A0A286XV44_CAVPO/211-233    AC A0A286XV44.1
#=GS A0A672MT12_SINGR/157-179    AC A0A672MT12.1
#=GS A0A3P4S6J5_GULGU/254-276    AC A0A3P4S6J5.1
#=GS G3IBE4_CRIGR/10-34          AC G3IBE4.1
#=GS A0A3B1JSS3_ASTMX/104-126    AC A0A3B1JSS3.1
#=GS A0A4W2EK55_BOBOX/478-500    AC A0A4W2EK55.1
#=GS A0A2T7PQD6_POMCA/355-377    AC A0A2T7PQD6.1
#=GS A0A6P6J106_CARAU/77-98      AC A0A6P6J106.1
#=GS A0A3B1IUM1_ASTMX/273-295    AC A0A3B1IUM1.1
#=GS A0A662YSY0_ACIRT/56-78      AC A0A662YSY0.1
#=GS H2PYS1_PANTR/268-290        AC H2PYS1.1
#=GS A0A0R4IYH2_DANRE/329-351    AC A0A0R4IYH2.1
#=GS A0A2U3ZL43_ODORO/280-302    AC A0A2U3ZL43.1
#=GS A0A3P9MXV8_POERE/260-282    AC A0A3P9MXV8.1
#=GS A0A3Q3EW73_9LABR/331-353    AC A0A3Q3EW73.1
#=GS A0A1W4WJ96_AGRPL/179-201    AC A0A1W4WJ96.1
#=GS A0A6P6MDI6_CARAU/1183-1205  AC A0A6P6MDI6.1
#=GS A0A087XHC5_POEFO/214-236    AC A0A087XHC5.2
#=GS A0A341CBJ9_NEOAA/865-887    AC A0A341CBJ9.1
#=GS A0A2K6UI16_SAIBB/526-548    AC A0A2K6UI16.1
#=GS A0A0D9R3T2_CHLSB/821-843    AC A0A0D9R3T2.1
#=GS A0A7F8Q4C9_LEPWE/131-155    AC A0A7F8Q4C9.1
#=GS A0A287AP59_PIG/711-733      AC A0A287AP59.1
#=GS A0A0L8GY80_OCTBM/90-112     AC A0A0L8GY80.1
#=GS A0A6P7H999_DIAVI/16-38      AC A0A6P7H999.1
#=GS A0A2Y9LHF3_DELLE/383-405    AC A0A2Y9LHF3.1
#=GS M3VUY0_FELCA/94-116         AC M3VUY0.2
#=GS A0A672YC81_9TELE/211-233    AC A0A672YC81.1
#=GS A0A2K6FRZ9_PROCO/376-398    AC A0A2K6FRZ9.1
#=GS A0A4W2D934_BOBOX/461-483    AC A0A4W2D934.1
#=GS M3Y9C4_MUSPF/752-773        AC M3Y9C4.1
#=GS A0A7N5K4Q6_AILME/330-352    AC A0A7N5K4Q6.1
#=GS L8IRU6_9CETA/423-445        AC L8IRU6.1
#=GS A0A673MJJ2_9TELE/291-315    AC A0A673MJJ2.1
#=GS A0A5J5DCG4_9PERO/682-705    AC A0A5J5DCG4.1
#=GS A0A2G8JRH5_STIJA/190-212    AC A0A2G8JRH5.1
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