KEGG   Phyllostomus hastatus (greater spear-nosed bat): 123814917
Entry
123814917         CDS       T07912                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
phas  Phyllostomus hastatus (greater spear-nosed bat)
Pathway
phas00562  Inositol phosphate metabolism
phas01100  Metabolic pathways
phas04015  Rap1 signaling pathway
phas04020  Calcium signaling pathway
phas04022  cGMP-PKG signaling pathway
phas04062  Chemokine signaling pathway
phas04070  Phosphatidylinositol signaling system
phas04071  Sphingolipid signaling pathway
phas04072  Phospholipase D signaling pathway
phas04081  Hormone signaling
phas04082  Neuroactive ligand signaling
phas04261  Adrenergic signaling in cardiomyocytes
phas04270  Vascular smooth muscle contraction
phas04310  Wnt signaling pathway
phas04371  Apelin signaling pathway
phas04540  Gap junction
phas04611  Platelet activation
phas04613  Neutrophil extracellular trap formation
phas04621  NOD-like receptor signaling pathway
phas04713  Circadian entrainment
phas04720  Long-term potentiation
phas04723  Retrograde endocannabinoid signaling
phas04724  Glutamatergic synapse
phas04725  Cholinergic synapse
phas04726  Serotonergic synapse
phas04728  Dopaminergic synapse
phas04730  Long-term depression
phas04742  Taste transduction
phas04750  Inflammatory mediator regulation of TRP channels
phas04911  Insulin secretion
phas04912  GnRH signaling pathway
phas04915  Estrogen signaling pathway
phas04916  Melanogenesis
phas04918  Thyroid hormone synthesis
phas04919  Thyroid hormone signaling pathway
phas04921  Oxytocin signaling pathway
phas04922  Glucagon signaling pathway
phas04924  Renin secretion
phas04925  Aldosterone synthesis and secretion
phas04926  Relaxin signaling pathway
phas04927  Cortisol synthesis and secretion
phas04928  Parathyroid hormone synthesis, secretion and action
phas04929  GnRH secretion
phas04933  AGE-RAGE signaling pathway in diabetic complications
phas04934  Cushing syndrome
phas04935  Growth hormone synthesis, secretion and action
phas04961  Endocrine and other factor-regulated calcium reabsorption
phas04970  Salivary secretion
phas04971  Gastric acid secretion
phas04972  Pancreatic secretion
phas04973  Carbohydrate digestion and absorption
phas05010  Alzheimer disease
phas05016  Huntington disease
phas05017  Spinocerebellar ataxia
phas05022  Pathways of neurodegeneration - multiple diseases
phas05142  Chagas disease
phas05143  African trypanosomiasis
phas05146  Amoebiasis
phas05163  Human cytomegalovirus infection
phas05200  Pathways in cancer
phas05415  Diabetic cardiomyopathy
phas05417  Lipid and atherosclerosis
Module
phas_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:phas00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123814917 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    123814917 (PLCB4)
   04310 Wnt signaling pathway
    123814917 (PLCB4)
   04371 Apelin signaling pathway
    123814917 (PLCB4)
   04020 Calcium signaling pathway
    123814917 (PLCB4)
   04070 Phosphatidylinositol signaling system
    123814917 (PLCB4)
   04072 Phospholipase D signaling pathway
    123814917 (PLCB4)
   04071 Sphingolipid signaling pathway
    123814917 (PLCB4)
   04022 cGMP-PKG signaling pathway
    123814917 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    123814917 (PLCB4)
   04081 Hormone signaling
    123814917 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    123814917 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123814917 (PLCB4)
   04613 Neutrophil extracellular trap formation
    123814917 (PLCB4)
   04621 NOD-like receptor signaling pathway
    123814917 (PLCB4)
   04062 Chemokine signaling pathway
    123814917 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    123814917 (PLCB4)
   04922 Glucagon signaling pathway
    123814917 (PLCB4)
   04929 GnRH secretion
    123814917 (PLCB4)
   04912 GnRH signaling pathway
    123814917 (PLCB4)
   04915 Estrogen signaling pathway
    123814917 (PLCB4)
   04921 Oxytocin signaling pathway
    123814917 (PLCB4)
   04926 Relaxin signaling pathway
    123814917 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    123814917 (PLCB4)
   04918 Thyroid hormone synthesis
    123814917 (PLCB4)
   04919 Thyroid hormone signaling pathway
    123814917 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    123814917 (PLCB4)
   04916 Melanogenesis
    123814917 (PLCB4)
   04924 Renin secretion
    123814917 (PLCB4)
   04925 Aldosterone synthesis and secretion
    123814917 (PLCB4)
   04927 Cortisol synthesis and secretion
    123814917 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    123814917 (PLCB4)
   04270 Vascular smooth muscle contraction
    123814917 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    123814917 (PLCB4)
   04971 Gastric acid secretion
    123814917 (PLCB4)
   04972 Pancreatic secretion
    123814917 (PLCB4)
   04973 Carbohydrate digestion and absorption
    123814917 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    123814917 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    123814917 (PLCB4)
   04725 Cholinergic synapse
    123814917 (PLCB4)
   04728 Dopaminergic synapse
    123814917 (PLCB4)
   04726 Serotonergic synapse
    123814917 (PLCB4)
   04720 Long-term potentiation
    123814917 (PLCB4)
   04730 Long-term depression
    123814917 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    123814917 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    123814917 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    123814917 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    123814917 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123814917 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    123814917 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    123814917 (PLCB4)
   05142 Chagas disease
    123814917 (PLCB4)
   05143 African trypanosomiasis
    123814917 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123814917 (PLCB4)
   05016 Huntington disease
    123814917 (PLCB4)
   05017 Spinocerebellar ataxia
    123814917 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    123814917 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123814917 (PLCB4)
   05415 Diabetic cardiomyopathy
    123814917 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    123814917 (PLCB4)
   04934 Cushing syndrome
    123814917 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:phas04131]
    123814917 (PLCB4)
Enzymes [BR:phas01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     123814917 (PLCB4)
Membrane trafficking [BR:phas04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    123814917 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    123814917 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 123814917
NCBI-ProteinID: XP_045689018
Position
Unknown
AA seq 1214 aa
MEQVLNITMAKPYEFNWQKEVPSFLQEGAIFDRYEEESFLFEPNCLFKVDEFGFFLTWKS
EGKEGQVLECSLINSIRLGATPKDPKILAALEAVGKLESDLEGRIVCVCSGIDLVNISFT
YMVAENLEVTKQWVDGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRT
FASGKTEKVIFQALKELGLPSGKNDEIEPAAFTFEKFYELTQKICPRTDIEDLFKKINGD
KTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIEMYEPDEDLKQKGLISSDGF
CRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLA
GCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC
SKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEQK
QLEALKSMMEAGESAAPVSILEDYNEEETENADQEEEAHPEYKYGNELSADDLGHKEAVA
NSVKKVSDDLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGF
HVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFW
NAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIA
ATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFR
KVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL
KTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANT
AKTNVTPQSSSELRPTTTAALGSGMEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELN
SLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEI
KIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQ
QTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLE
ERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDG
PQTSNSSMKLQNTN
NT seq 3645 nt   +upstreamnt  +downstreamnt
atggaacaggtcttgaatataaccatggccaaaccttatgaatttaactggcagaaggaa
gttccttcctttttgcaagaaggagcaatttttgacagatatgaagaggaatcctttctg
tttgaacccaactgcctcttcaaagtggatgaatttggcttctttctaacctggaaaagt
gaaggcaaggaaggacaagtgctagaatgctccctcatcaacagtattcggttgggagcc
acaccaaaggatcccaaaatcctggctgcccttgaagctgttggaaaattagaaagtgac
ctggaagggcggatagtttgtgtctgcagtggaatagatctggtgaacatcagtttcact
tacatggtggctgaaaacctagaagtaactaagcaatgggtagatggcctaagatcaatc
atacacaatttcagggccaacaacgtcagtccgatgacatgcctcaagaaacactggatg
aaattggcatttatgaccaacaccaatggtaaaatcccagttaggagtattactagaacc
tttgcatcggggaaaacagaaaaggtgatctttcaagcactcaaggagttaggtcttccc
agtggaaagaatgatgaaattgagcctgcagcatttacttttgaaaagttctatgaactg
acacaaaagatttgtcctcggacagatatagaggatctttttaaaaaaatcaatggagac
aaaactgattatttaacggtagaccaattagtgagctttctaaatgaacatcaacgagac
cctagactgaatgaaattttattcccattttacgacactaaaagggcgatgcagatcatt
gagatgtatgagcctgatgaagacttgaagcaaaaaggccttatatcaagtgatggattt
tgcagatatctgatgtcggatgaaaatgcacctgtcttcctagatcgtttagaactttac
caagaaatggatcatcctctggctcactacttcatcagttcttcccacaacacctatctc
actggccgacaatttggcgggaaatcttcagtagaaatgtacagacaggttctcctggct
gggtgcagatgtgtggaactcgactgttgggacgggaaaggcgaagaccaggaaccaata
ataactcacggaaaggcgatgtgcacagacatcctcttcaaggatgttattcaagccatc
aaggaaactgcatttgtcacatctgaatatcctgtaattctctcctttgaaaatcactgc
agcaaatatcaacagtacaagatgtccaaatattgcgaagatctatttggggatctcctg
ttgaaacaagcgcttgaatcccatccactcgaaccaggcaggccgttgccatcccccaat
gacctcaaaagaaaaatactcatcaaaaataaacgactgaaacctgaggttgaacaaaag
cagctcgaagctttgaaaagcatgatggaagctggagaatccgctgctccagttagcatc
ttagaggattataatgaggaggaaacagaaaatgctgaccaagaagaagaagctcaccct
gaatacaaatatggaaatgaactttctgctgatgacttgggtcacaaggaagctgttgca
aatagtgtcaagaaggtttctgatgaccttgaacatgaaatcaacaaaaagggcctggtt
actgtagaagatgagcaggcatggatggcatcttataaatatgtaggtgctaccactaat
atccatccgtatttgtccacaatgatcaactatgcacagcccgtaaagtttcaaggtttc
catgttgctgaagaacgcaacattcattataacatgtcttcttttaatgagtctgtgggt
ctaggctacttgaagacacacgcgattgaatttgtgaattataacaaacggcaaatgagt
cgcatttaccccaagggaggccgagttgattccagtaattacatgccacagattttctgg
aacgctggctgccagatggtttcactgaactatcaaaccccagatttagcgatgcaattg
aatcagggaaaatttgagtataatggatcatgcgggtaccttctcaaaccagattttatg
agacggcctgatcgaacgtttgatcctttctctgagactccagttgatggggttattgca
gccacgtgctcagtgcaggtcatatcaggtcaattcttatcagataagaaaatcggcaca
tatgtagaagtggacatgtatgggttgcccaccgacactatacgtaaggaattccgaact
cgcatggtgatgaacaacggactcaatccagtttacaatgaagaatccttcgtatttcgg
aaggtaatcctccctgacctggcagtcttgagaatagcagtgtatgatgacaacaacaag
ctcattggccagaggattctcccactagacggcctccaagccggctatcgacacatttct
cttcgaaatgaggggaataaaccattatcactgccaacaattttctgcaatattgttctt
aaaacatatgtgcctgatggatttggagatattgtggatgctttatcagatccaaagaag
tttctttcaattacggaaaaaagagcagaccaaatgagagctatgggcatcgaaactagt
gacatagccgatgttcccagtgacacttctaagaatgacaagaaaggaaaggccaacact
gccaaaacaaatgtgactccgcagagcagctctgaactcagaccaaccaccacagctgcc
ctggggtctggcatggaagccaagaaaggtatcgaacttatccctcaagtgaggatagaa
gatttaaagcagatgaaggcttacttgaagcatttaaagaaacagcagaaggagttgaat
tctttaaaaaagaaacatgcaaaggagcacagtaccatgcaaaagttacactgcacacaa
gtggacaaaattgtggcacagtatgacaaagagaagtctactcatgaaaaaatcctggag
aaggcaatgaagaagaaagggggaagtaattgccttgaaatgaaaaaagaaacagaaatt
aaaattcagacactgacatcagatcacaaatctaaggtcaaggagattgtggcgcagcac
acaaaagagtggtcagagatgatcaacacgcacagtgctgaagagcaggaaatccgggac
ctgcacctgagccagcagtgcgagctgctgagaaagctcctgatcaatgcccatgaacag
caaacccagcagctgaaactgtcccatgacagggaaagcaaggaaatgagagcacaccag
gctaagatttctatggaaaatagcaaagccatcagccaagataaatctattaagaacaaa
gcagaacgggaaaggcgagtcagggagttaaacagcagcaacactaaaaagtttctggaa
gaaagaaagagactcgcaatgaaacagtccaaagaaatggatcagttgaaaaaagtccag
cttgaacacctagaattcctagagaagcagaatgagcagcttttgaaatcctgtcatgca
gtgtcccaaactcaaggcgaaggagatgcagcagatggtgaaattggaagccgagatgga
ccgcagaccagcaacagtagtatgaaactccagaacacaaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (9)   
   RefSeq(pep) (9)   
DNA sequence (9)   
   RefSeq(nuc) (9)   
Protein domain (9)   
   Pfam (9)   
All databases (29)   

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