KEGG   Panthera leo (lion): 122207924
Entry
122207924         CDS       T10741                                 
Symbol
AP2A1
Name
(RefSeq) AP-2 complex subunit alpha-1 isoform X1
  KO
K11824  AP-2 complex subunit alpha
Organism
plez  Panthera leo (lion)
Pathway
plez04142  Lysosome biogenesis
plez04144  Endocytosis
plez04721  Synaptic vesicle cycle
plez04961  Endocrine and other factor-regulated calcium reabsorption
plez05016  Huntington disease
Brite
KEGG Orthology (KO) [BR:plez00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    122207924 (AP2A1)
   04142 Lysosome biogenesis
    122207924 (AP2A1)
 09150 Organismal Systems
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    122207924 (AP2A1)
  09156 Nervous system
   04721 Synaptic vesicle cycle
    122207924 (AP2A1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    122207924 (AP2A1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:plez04131]
    122207924 (AP2A1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:plez04147]
    122207924 (AP2A1)
Membrane trafficking [BR:plez04131]
 Endocytosis
  Clathrin-mediated endocytosis
   AP-2 complex
    122207924 (AP2A1)
Exosome [BR:plez04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   122207924 (AP2A1)
SSDB
Motif
Pfam: Adaptin_N Alpha_adaptin_C Alpha_adaptinC2 Cnd1 HEAT_GCN1 HEAT_2 RIX1 HEAT_MROH2B_1st TOR1L1_N DUF4003
Other DBs
NCBI-GeneID: 122207924
NCBI-ProteinID: XP_042774235
UniProt: A0A8C8WZA7
Position
E2:complement(8254814..8285006)
AA seq 978 aa
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVC
KLLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDL
ASRNPTFMCLALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASP
DLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKKNPDDFKTCISLAVSRLSRIVSSA
STDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKV
QHSNAKNAILFETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSE
FSHEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAI
REEIVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAA
KTVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRAL
LLSTYIKFINLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLE
EMPPFPERESSILAKLKRKKGPGAGSALDDGRRDPSSNDVNGGVEPTPSTVSTPSPSADL
LGLRAAPPPAAPPATSGAGNLLVDVFSDGPAAQPGLGPTPEEAFLSELEPPAPESPMALL
ADPAPAADPGPEDIGPPIPEADELLNKFVCKNNGVLFENQLLQIGVKSEFRQNLGRMYLF
YGNKTSVQFQNFSPTVVHPGDLQTQLAVQTKRVAAQVDGGAQVQQVLNIECLRDFLTPPL
LSVRFRYGGAPQSLTLKLPVTINKFFQPTEMAAQDFFQRWKQLSLPQQEAQKIFKANHPM
DAEVTKAKLLGFGSALLDNVDPNPENFVGAGIIQTKALQVGCLLRLEPNAQAQMYRLTLR
TSKEPVSRHLCELLAQQF
NT seq 2937 nt   +upstreamnt  +downstreamnt
atgccggccgtctccaagggcgatgggatgcgggggctcgcggtgttcatctccgacatc
cggaactgtaagagcaaggaggcggagattaagagaatcaataaggaactggccaatatc
cgctctaagttcaaaggggacaaagccttggacggctacagtaagaaaaagtatgtgtgt
aaactgctgttcatcttcctgctggggcatgacattgactttgggcacatggaagctgtg
aacctgctcagctccaacaagtacacggagaagcaaataggttacctgttcatctcggtt
ctggtgaactcaaactccgagctgatccggctcatcaataacgccatcaagaatgacctg
gccagccgtaacccgaccttcatgtgcctagccctgcattgcatcgccaacgtgggcagc
cgggagatgggcgaggcctttgccgctgacatcccacgcatcctggtggctggggacagc
atggacagcgtgaaacagagcgcggccctgtgcctgctgcgactctacaaggcctcgcct
gacttagtgcccatgggcgagtggacggcccgcgtggtgcacctgctcaacgaccagcac
atgggtgtggtcacggctgctgtcagcctcatcacctgtctctgcaagaagaacccggac
gactttaagacctgcatctctctggccgtgtctcgcctgagccggatcgtctcctcggcc
tccaccgacctccaggactatacctactacttcgtcccggcgccctggctctcggtgaag
cttctgcgtctgctgcagtgctacccgccgccagaggatgctgccgtgaagggacggctg
gtggagtgtctggagaccgtgctcaacaaggcccaggagccgcccaagtccaagaaggtc
cagcactccaacgccaagaacgccatcctcttcgagaccattagcctcatcatccactac
gacagtgagcccaacctcctggtgcgagcctgcaaccagctgggccagttcctgcagcac
cgggagaccaacctccgctacctggccctggagagcatgtgcacgctggccagctccgag
ttctcccacgaggcggtcaagacccacatcgacacggtcatcaatgccctcaagacggag
cgggacgtcagcgtgcgacagcgggcggccgacctcctctacgccatgtgcgaccggagc
aacgccaagcagatcgtgtcggagatgcttcggtacctggagacggccgactacgccatc
cgcgaagagatcgtcctgaaggtggccatcctggcggagaagtacgcggtagactacagc
tggtacgtggacaccatcctcaacctcatccgcatcgcgggcgactacgtgagtgaggag
gtgtggtaccgcgtgctgcagatcgtcaccaaccgcgacgacgtccagggctacgcggcc
aagaccgtcttcgaggcgctccaggccccggcctgccacgagaacatggtgaaggtcggc
ggctacatcctcggggagttcgggaatctgattgctggggacccccgctccagccccccg
gtgcagttctctctgctgcactccaagttccacctgtgcagcgtggccacgcgggccctg
ctgctgtccacctacatcaagttcatcaacctcttcccggagaccaaggccaccatccag
ggcgtgctgcgggcgggctcccagctgcgcaacgctgacgtggagctgcagcagcgcgcc
gtcgagtacctcacgctcagctcggtggccagcacggacgtcctggccacggtgctggag
gagatgccgcccttccccgagcgcgagtcgtccatcctggccaagctgaaacgcaagaag
ggccccggggccggcagcgccctggatgatggcaggagggaccccagcagcaatgacgtc
aacgggggcgtggagcccacccctagcactgtgtcaacgccctcgccctccgccgacctc
ctggggctgcgggcagcccctcccccagccgcacccccagcgacctcgggtgcggggaac
ctcctggtggacgtcttctccgacggcccggctgcccagcccggcctggggcccacgccc
gaggaggccttcctcagcgagctggagccgcctgcccccgagagccccatggctttgctg
gctgacccagctccagctgctgacccaggtcctgaggacatcggcccgcccatcccagaa
gcggatgagctgctgaataagttcgtgtgcaagaacaatggggtcctgtttgagaaccag
ctgctgcagattggagtcaagtccgagttccggcagaacttgggccgcatgtatctgttc
tatggcaacaagacatctgtgcagttccagaacttctcgcccactgtcgtccaccccggc
gacctccagactcagctggcggtgcagaccaagcgcgtggccgcgcaggtggacggcggg
gcgcaggtgcagcaggtgctcaacatcgagtgtctgcgggacttcctgacgcccccgctc
ctatccgtgcgcttccggtacgggggcgccccccagtccctcaccctgaagctccccgtg
accatcaacaagttcttccagcccacggagatggcggcccaggacttcttccagcgctgg
aagcagctgagcctcccccaacaggaggctcagaaaatcttcaaagccaaccaccccatg
gatgcggaagtcactaaggcaaaactcttggggtttggctctgctctcctggacaatgtg
gacccgaaccccgagaacttcgtgggggctggaatcatccaaacgaaagccctgcaggtg
ggctgtctgctccggctggagcccaatgcccaggctcagatgtaccggctgaccctgcgc
acgagcaaggaacccgtctcccgtcacctgtgtgagctgctggcccagcagttctga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (10)   
   Pfam (10)   
All databases (17)   

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