KEGG   Panthera leo (lion): 122229202
Entry
122229202         CDS       T10741                                 
Symbol
MECOM
Name
(RefSeq) histone-lysine N-methyltransferase MECOM isoform X1
  KO
K04462  [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]
Organism
plez  Panthera leo (lion)
Pathway
plez00310  Lysine degradation
plez01100  Metabolic pathways
plez04010  MAPK signaling pathway
plez05200  Pathways in cancer
plez05220  Chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:plez00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    122229202 (MECOM)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122229202 (MECOM)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122229202 (MECOM)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    122229202 (MECOM)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:plez03000]
    122229202 (MECOM)
   03036 Chromosome and associated proteins [BR:plez03036]
    122229202 (MECOM)
Enzymes [BR:plez01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.367  [histone H3]-lysine9 N-methyltransferase
     122229202 (MECOM)
Transcription factors [BR:plez03000]
 Eukaryotic type
  Zinc finger
   Cys2His2 PRDM
    122229202 (MECOM)
Chromosome and associated proteins [BR:plez03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     122229202 (MECOM)
SSDB
Motif
Pfam: zf-C2H2 zf-H2C2_2 zf-C2H2_4 PRDM2_PR zf-C2H2_6 SET zf-C2H2_jaz zf-H2C2_5 zf-BED C2CH-3rd_BIRD-IDD Zap1_zf1 zf-C2H2_8 CEP104_ZnF
Other DBs
NCBI-GeneID: 122229202
NCBI-ProteinID: XP_042810242
Position
C2:96063022..96620460
AA seq 1240 aa
MRSKGRARKLATNNECVYGSYPEIPLEEMPDADGVAITPSLNIQEPCSPATSSEAFTPKE
GSPYKAPIYIPDDIPIPAEFELRESNMPGAGLGIWTKRKIEAGEKFGPYVGEQRSNLKDP
SYGWEILDEFCNVKFCVDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRVVTDIA
PGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFS
MVEEDFQQKLESENDLREIHAIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAF
NWKSNLIRHQMSHDSGKHYECENCAKQVFTDPSNLQRHIRSQHVGARAHACPECGKTFAT
SSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSS
LNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGL
TFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQ
DILKALSKHPPVGDNKPVELQPERSSEERPLEKISDQSESSDLDDVSTPSGSDLETTSGS
DLESDIESDKEKFKENGKMFKDKVSPLQNLASIHNKKEYSNHSIFSPSLEEQTAVSGAVN
DSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLP
LKMEPQSPSEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPATPATSQDQPLDLSMGS
RSRASGTKLTEPRKNHVFGEKKGSGIEPRPASDGSLQHARPTPFFMDPIYRVEKRKLTDP
LEALKEKYLRPSPGFLFHPQFQLPDQRTWMSAIENMAEKLENFSALKPEASELLQSVPSM
FNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFS
ISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELES
TGAILDDKEDAYFTEIRNFIGNSNHSSQSPRNTEERMNGSHFKDEKALVTSQNSDLLDDE
EVEDEVLLDEEDEDNDITGKTGKEPMTSNLHEGNPEDEYEEASALEMSCKTSPVRYKEEE
YKTGLSALDHIRHFTDSLKMRKMEDNQYTEAELSSFSASHVPEELKQPLHRKSKSQAYAM
MLSLSDKESLHSTSHSSSNVWHSMARAAAESSAIQSISHV
NT seq 3723 nt   +upstreamnt  +downstreamnt
atgagatccaaaggcagggcaaggaaactggccacaaataatgagtgtgtatatggcagc
taccctgaaattcctttggaagaaatgccagatgcagatggagtagccatcactccctcc
ctcaatattcaagagccatgctctccagccacatccagcgaagcgttcactccaaaggag
ggctctccgtacaaagcccccatctacatccctgatgatatccccattcctgctgaattt
gaacttcgagagtcaaatatgcctggagctggactaggaatatggaccaaaaggaagatt
gaagcaggtgaaaagtttgggccttatgtgggagagcagcggtcaaatctgaaagacccc
agctacggatgggagatcttagatgagttttgcaatgtgaagttctgcgtagatgctagt
caaccagatgtaggaagctggctcaagtacatcaggttcgctggctgttatgatcagcac
aacctcgttgcatgccagataaatgatcagatattttatagagtagtcacagacattgca
ccaggagaggagctcctgctgttcatgaagagtgaagactatccccatgaaactatggcg
ccggatattcacgaagaacggcagtatcgctgtgaggactgtgaccagctcttcgagtcc
aaggcggagctagcagatcaccaaaagttcccgtgcagcacccctcactcagcattttcg
atggtggaagaggacttccaacaaaaactcgaaagtgagaacgatctccgagagatacat
gcgatccaggagtgtaaggaatgtgaccaagtgttccccgatttgcaaagcctggagaaa
cacatgttgtcacatactgaagagagggaatacaagtgcgatcagtgtcccaaggcattt
aactggaagtccaatttaattcgccaccagatgtcacatgacagtggaaagcactatgaa
tgtgaaaactgtgccaagcaggttttcacggaccctagcaacctccagcggcacattcgc
tctcagcatgttggtgcccgggcccacgcatgcccggagtgtggcaaaacgtttgccact
tcgtcgggcctcaaacaacacaagcacatccacagcagtgtgaagccctttatctgtgag
gtctgccataaatcctatactcagttttcaaacctttgtcgtcataagcgcatgcatgct
gattgcagaacccaaatcaagtgcaaagactgtggacaaatgttcagcactacgtcttcc
ttaaataaacacaggaggttttgtgagggcaagaaccattttgcggcaggtggatttttt
ggccaaggcatttcacttcctggaaccccagctatggataaaacgtccatggttaatatg
agtcatgccaacccgggccttgctgactattttggtgccaataggcatcctgctggtctt
acctttccaacagctcctggattttcttttagcttccctggtctgtttccttccggcttg
taccacaggcctcctttgatacctgctagttctcctgttaaaggactatcaagtactgaa
cagacaaacaaaagtcaaagtcccctcatgacacatcctcagatactgccagctacacag
gatattttgaaggcactatctaaacacccacctgtaggggacaataagccagtggagctc
cagcccgagaggtcctctgaagagaggccccttgagaaaatcagtgaccagtcagagagt
agtgaccttgatgatgtcagtacgccaagtggcagtgacctggaaacaacctcgggctct
gatctggaaagtgacattgaaagtgataaagagaaatttaaagaaaatggtaaaatgttc
aaagacaaagtaagccctcttcagaatctggcttcaatacataataagaaagaatacagc
aatcattccattttctcaccatctttagaggagcaaactgcggtgtcaggagctgtgaat
gattctataaaagctattgcttctattgctgaaaaatactttggttcaacaggactggtg
gggctgcaagacaaaaaagttggagctttaccttacccttccatgtttcccctcccgttt
tttccagcattctctcaatcaatgtacccatttcctgatagagacttgagatcgttacct
ttgaaaatggaaccccaatcaccaagtgaagtaaagaaactgcagaagggaagctctgag
tctccctttgatctcaccactaagcgaaaggacgagaagcccttgactccagtcccctcc
aagcctccagcaacacctgccacaagccaagaccagcccctggatctaagtatgggcagt
aggagtagagccagtgggacaaagctgaccgagcctcgtaaaaaccacgtgtttggggaa
aagaaaggaagcggcattgaaccaagaccagcatcagatggttccttgcagcatgctaga
cccactcctttctttatggaccctatttacagagtagagaaaagaaaactaactgaccca
cttgaagctttaaaagagaaatacttgagaccttcgccaggattcttatttcacccacaa
ttccaactgcctgatcagagaacttggatgtcagctattgaaaacatggcagagaagctc
gagaacttcagtgccctgaaaccagaggccagtgaacttctgcagtcagttccctccatg
ttcaatttcagagcgcctcccaatgccctgccagagaacctcctgcggaaaggaaaagaa
cgctacacgtgcagatactgtggcaagatttttccaaggtctgcgaacttaacacggcac
ctgagaacccacacaggagagcagccttacagatgcaaatactgtgaccgatcatttagc
atctcttccaacttgcaaaggcatgttcgtaatatccacaataaggagaagccctttaag
tgtcacttatgtgataggtgttttggtcaacaaaccaacttagacagacacctaaagaaa
catgagaatgggaacatgtcgggtacggccacgtcgtcgcctcattccgaactggaaagt
acaggcgcgattcttgatgacaaagaagatgcttacttcacagaaattcgcaatttcatt
gggaacagcaaccacagcagccagtctcccaggaacacagaggagaggatgaacggcagt
cattttaaggatgagaaggctttggtgaccagtcaaaattcagatttactggatgacgaa
gaagtagaagacgaggtgttgttagatgaggaggacgaagacaatgatattactggaaaa
acaggaaaggaacccatgacaagcaatttacatgaaggaaatcctgaggatgagtatgaa
gaagccagtgccctggagatgagttgcaaaacgtctccagtgaggtataaagaggaagaa
tataaaactggactttctgctctagatcatataaggcacttcacagatagcctcaaaatg
aggaaaatggaagataatcaatatactgaagctgagctgtcttcttttagtgcttcccat
gtgccggaggaacttaaacagccgttacacagaaagtccaagtcacaggcatatgctatg
atgttgtcattgtccgacaaggagtccctccattctacatcccacagttcttccaacgtg
tggcacagtatggcaagggctgctgcggaatccagtgccatccagtccataagccacgta
tga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (6)   
   RefSeq(pep) (6)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
Protein domain (13)   
   Pfam (13)   
All databases (27)   

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