KEGG   Plecotus auritus (brown big-eared bat): 308245550
Entry
308245550         CDS       T11911                                 
Symbol
MAPK12, AC0HY7_012383
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
pots  Plecotus auritus (brown big-eared bat)
Pathway
pots01522  Endocrine resistance
pots04010  MAPK signaling pathway
pots04015  Rap1 signaling pathway
pots04068  FoxO signaling pathway
pots04071  Sphingolipid signaling pathway
pots04114  Oocyte meiosis
pots04148  Efferocytosis
pots04218  Cellular senescence
pots04261  Adrenergic signaling in cardiomyocytes
pots04370  VEGF signaling pathway
pots04380  Osteoclast differentiation
pots04517  IgSF CAM signaling
pots04519  Cadherin signaling
pots04550  Signaling pathways regulating pluripotency of stem cells
pots04611  Platelet activation
pots04613  Neutrophil extracellular trap formation
pots04620  Toll-like receptor signaling pathway
pots04621  NOD-like receptor signaling pathway
pots04622  RIG-I-like receptor signaling pathway
pots04625  C-type lectin receptor signaling pathway
pots04657  IL-17 signaling pathway
pots04658  Th1 and Th2 cell differentiation
pots04659  Th17 cell differentiation
pots04660  T cell receptor signaling pathway
pots04664  Fc epsilon RI signaling pathway
pots04668  TNF signaling pathway
pots04670  Leukocyte transendothelial migration
pots04714  Thermogenesis
pots04722  Neurotrophin signaling pathway
pots04723  Retrograde endocannabinoid signaling
pots04728  Dopaminergic synapse
pots04750  Inflammatory mediator regulation of TRP channels
pots04912  GnRH signaling pathway
pots04914  Progesterone-mediated oocyte maturation
pots04917  Prolactin signaling pathway
pots04926  Relaxin signaling pathway
pots04932  Non-alcoholic fatty liver disease
pots04933  AGE-RAGE signaling pathway in diabetic complications
pots04935  Growth hormone synthesis, secretion and action
pots04936  Alcoholic liver disease
pots05014  Amyotrophic lateral sclerosis
pots05020  Prion disease
pots05022  Pathways of neurodegeneration - multiple diseases
pots05132  Salmonella infection
pots05133  Pertussis
pots05135  Yersinia infection
pots05140  Leishmaniasis
pots05142  Chagas disease
pots05145  Toxoplasmosis
pots05152  Tuberculosis
pots05161  Hepatitis B
pots05163  Human cytomegalovirus infection
pots05167  Kaposi sarcoma-associated herpesvirus infection
pots05169  Epstein-Barr virus infection
pots05170  Human immunodeficiency virus 1 infection
pots05171  Coronavirus disease
pots05205  Proteoglycans in cancer
pots05208  Chemical carcinogenesis - reactive oxygen species
pots05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pots05415  Diabetic cardiomyopathy
pots05417  Lipid and atherosclerosis
pots05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pots00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    308245550 (MAPK12)
   04015 Rap1 signaling pathway
    308245550 (MAPK12)
   04370 VEGF signaling pathway
    308245550 (MAPK12)
   04668 TNF signaling pathway
    308245550 (MAPK12)
   04068 FoxO signaling pathway
    308245550 (MAPK12)
   04071 Sphingolipid signaling pathway
    308245550 (MAPK12)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    308245550 (MAPK12)
   04519 Cadherin signaling
    308245550 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    308245550 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    308245550 (MAPK12)
   04218 Cellular senescence
    308245550 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    308245550 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    308245550 (MAPK12)
   04613 Neutrophil extracellular trap formation
    308245550 (MAPK12)
   04620 Toll-like receptor signaling pathway
    308245550 (MAPK12)
   04621 NOD-like receptor signaling pathway
    308245550 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    308245550 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    308245550 (MAPK12)
   04660 T cell receptor signaling pathway
    308245550 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    308245550 (MAPK12)
   04659 Th17 cell differentiation
    308245550 (MAPK12)
   04657 IL-17 signaling pathway
    308245550 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    308245550 (MAPK12)
   04670 Leukocyte transendothelial migration
    308245550 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    308245550 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    308245550 (MAPK12)
   04917 Prolactin signaling pathway
    308245550 (MAPK12)
   04926 Relaxin signaling pathway
    308245550 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    308245550 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    308245550 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    308245550 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    308245550 (MAPK12)
   04722 Neurotrophin signaling pathway
    308245550 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    308245550 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    308245550 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    308245550 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    308245550 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    308245550 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    308245550 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    308245550 (MAPK12)
   05161 Hepatitis B
    308245550 (MAPK12)
   05171 Coronavirus disease
    308245550 (MAPK12)
   05163 Human cytomegalovirus infection
    308245550 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    308245550 (MAPK12)
   05169 Epstein-Barr virus infection
    308245550 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    308245550 (MAPK12)
   05135 Yersinia infection
    308245550 (MAPK12)
   05133 Pertussis
    308245550 (MAPK12)
   05152 Tuberculosis
    308245550 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    308245550 (MAPK12)
   05140 Leishmaniasis
    308245550 (MAPK12)
   05142 Chagas disease
    308245550 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    308245550 (MAPK12)
   05020 Prion disease
    308245550 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    308245550 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    308245550 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    308245550 (MAPK12)
   05415 Diabetic cardiomyopathy
    308245550 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    308245550 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    308245550 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    308245550 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    308245550 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pots01001]
    308245550 (MAPK12)
Enzymes [BR:pots01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     308245550 (MAPK12)
Protein kinases [BR:pots01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   308245550 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 308245550
NCBI-ProteinID: XP_080519104
Position
3:complement(227695417..227704629)
AA seq 367 aa
MSSSPPARRGYYRQEVTKTAWEVRVVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELYAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHETLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMITGKTLFKGNDHLDQLKEILK
VTGTPPDEFVQRLQSADAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAAEALTHPYFESLHDAEDEPQAQKYDESFDDVDRTLDEWKRDTYKEVLSFRPPRQLGAK
SSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctcctcgccgcccgcccgcaggggctactaccgccaggaggtgaccaagaccgcc
tgggaggtgcgcgtcgtgtaccaggacctgcagcccgtgggctcgggcgcctatggcgcg
gtgtgctcggccgtggacagccgcacgggcgccaaggtggccatcaagaagctgtaccgg
cccttccagtcggagctgtacgccaagcgcgcctaccgcgagctgcgcctcctcaagcac
atgcgccacgagaacgtgatcgggctgctggacgtgttcactccagatgagaccctggat
gacttcacagacttttacctggtcatgccgttcatgggcacggacctgggtaagctcatg
aagcacgagacgctgagcgaggaccgcatccagttcctcgtctaccagatgctgaaaggg
ctgaagtatatccacgcggccggcatcattcacagggacctgaagcccggcaacctggcc
gtgaacgaggactgtgagctgaagatcctggacttcggcctggccaggcaggcggacagc
gagatgactggatacgtagtgactcggtggtatcgggcgcctgaggtcatcttgaattgg
atgcactacacacagacagtggacatctggtctgtgggctgcatcatggcggagatgatc
acagggaagacgctgttcaagggcaatgaccacctggaccagctgaaggagatcttgaag
gtgacgggcacgccacccgatgagtttgtccagaggctgcagagtgcggatgcgaagaac
tacatgaagggcctccccgagttggagaagaaggattttgcctccattctgaccaatgca
agccctctggccgtgaacctcctggagaaaatgctggtgctggacgcggagcagcgggtg
acggcggccgaggccctgacccacccgtatttcgagtcgctgcacgacgccgaggatgag
ccccaggcccagaagtacgacgagtccttcgatgacgtggaccgcaccctggacgagtgg
aagcgtgacacgtataaagaggtgctcagcttcaggcctccccggcagctgggggccaag
tcctccaaggagacagccctgtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (11)   

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