KEGG   PATHWAY: pps04020
Entry
pps04020                    Pathway                                

Name
Calcium signaling pathway - Pan paniscus (bonobo)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pps04020  Calcium signaling pathway
pps04020

Other DBs
GO: 0019722
Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100969645  SLC8A1; sodium/calcium exchanger 1 [KO:K05849]
100972309  SLC8A1; sodium/calcium exchanger 1 [KO:K05849]
100986811  SLC8A3; solute carrier family 8 member A3 [KO:K05849]
100980273  SLC8A2; solute carrier family 8 member A2 [KO:K05849]
100988724  ATP2B4; ATPase plasma membrane Ca2+ transporting 4 [KO:K05850] [EC:7.2.2.10]
100982359  ATP2B2; ATPase plasma membrane Ca2+ transporting 2 [KO:K05850] [EC:7.2.2.10]
100973331  ATP2B1; ATPase plasma membrane Ca2+ transporting 1 [KO:K05850] [EC:7.2.2.10]
100978284  ATP2B3; ATPase plasma membrane Ca2+ transporting 3 [KO:K05850] [EC:7.2.2.10]
100970743  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
100989641  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
100969893  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
100970926  ADORA2A; adenosine A2a receptor [KO:K04266]
100994290  ADORA2B; adenosine A2b receptor [KO:K04267]
100978740  ADRB1; adrenoceptor beta 1 [KO:K04141]
100983950  ADRB2; adrenoceptor beta 2 [KO:K04142]
100972927  ADRB3; adrenoceptor beta 3 [KO:K04143]
100988335  DRD1; dopamine receptor D1 [KO:K04144]
100994450  DRD5; dopamine receptor D5 [KO:K05840]
100989107  HRH2; histamine receptor H2 [KO:K04150]
100983386  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
100990391  5-hydroxytryptamine receptor 5B-like [KO:K04161]
100989351  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
100978121  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
100981020  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
100978090  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
100990650  neuroendocrine secretory protein 55 [KO:K04632]
100975164  GNAL; G protein subunit alpha L [KO:K04633]
100984585  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
100992014  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
100995134  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
100978200  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
100984225  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
100994715  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
100972356  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
100982589  PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100968237  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100970917  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
100973367  PLN; phospholamban [KO:K05852]
100987290  ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10]
100993633  ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10]
100979248  ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10]
100968452  HRC; histidine rich calcium binding protein [KO:K23450]
100990966  STIM1; stromal interaction molecule 1 [KO:K16059]
100969937  STIM2; stromal interaction molecule 2 [KO:K18196]
100987781  ORAI1; ORAI calcium release-activated calcium modulator 1 [KO:K16056]
100988709  ORAI2; ORAI calcium release-activated calcium modulator 2 [KO:K16057]
100972631  ORAI3; ORAI calcium release-activated calcium modulator 3 [KO:K16058]
100971701  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
100975108  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
100988624  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
100982136  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
100971898  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
100979369  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
100973580  CACNA1E; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
100983419  CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
100983134  CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
100972510  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
100977072  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit [KO:K04809]
100994570  P2RX1; purinergic receptor P2X 1 [KO:K05215]
100973505  P2RX2; purinergic receptor P2X 2 [KO:K05216]
100970270  P2RX3; purinergic receptor P2X 3 [KO:K05217]
100990374  P2RX4; purinergic receptor P2X 4 [KO:K05218]
100987979  P2RX5; purinergic receptor P2X 5 [KO:K05219]
100990943  P2RX7; purinergic receptor P2X 7 [KO:K05220]
100976042  P2RX6; purinergic receptor P2X 6 [KO:K05221]
100987673  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
100977852  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
100989438  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100977548  GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D [KO:K05212]
100992272  RYR1; ryanodine receptor 1 [KO:K04961]
100974705  RYR2; ryanodine receptor 2 [KO:K04962]
100969544  RYR3; ryanodine receptor 3 [KO:K04963]
100981711  TRDN; triadin [KO:K23449]
100994461  CASQ1; calsequestrin 1 [KO:K23468]
100994765  CASQ2; calsequestrin 2 [KO:K23445]
100977040  ASPH; aspartate beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
100988950  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
100976535  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
103782638  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
100986808  ADRA1A; adrenoceptor alpha 1A [KO:K04135]
106634821  ADRA1B; adrenoceptor alpha 1B [KO:K04136]
100978396  ADRA1D; adrenoceptor alpha 1D [KO:K04137]
100992718  AGTR1; angiotensin II receptor type 1 [KO:K04166]
100968812  EDNRA; endothelin receptor type A [KO:K04197]
100986370  EDNRB; endothelin receptor type B [KO:K04198]
100986369  F2R; coagulation factor II thrombin receptor [KO:K03914]
100968079  GRM1; glutamate metabotropic receptor 1 [KO:K04603]
100988134  GRM5; glutamate metabotropic receptor 5 [KO:K04604]
100983802  GRPR; gastrin releasing peptide receptor [KO:K04169]
100979999  HRH1; histamine receptor H1 [KO:K04149]
100985583  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
100970741  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
100986689  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
100989161  LHCGR; luteinizing hormone/choriogonadotropin receptor [KO:K04248]
100992141  NTSR1; neurotensin receptor 1 [KO:K04211]
100977222  OXTR; oxytocin receptor [KO:K04229]
100993523  AVPR1A; arginine vasopressin receptor 1A [KO:K04226]
100995333  AVPR1B; arginine vasopressin receptor 1B [KO:K04227]
100980919  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
100984964  PTAFR; platelet activating factor receptor [KO:K04279]
100975934  PTGER1; prostaglandin E receptor 1 [KO:K04258]
100993214  PTGER3; prostaglandin E receptor 3 [KO:K04260]
100977391  PTGFR; prostaglandin F receptor [KO:K04262]
100972709  BDKRB1; bradykinin receptor B1 [KO:K03915]
100972150  BDKRB2; bradykinin receptor B2 [KO:K03916]
100982037  TACR1; tachykinin receptor 1 [KO:K04222]
100970551  TACR2; tachykinin receptor 2 [KO:K04223]
100983956  TACR3; tachykinin receptor 3 [KO:K04224]
100988035  TBXA2R; thromboxane A2 receptor [KO:K04264]
100992440  TRHR; thyrotropin releasing hormone receptor [KO:K04282]
100995235  CCKAR; cholecystokinin A receptor [KO:K04194]
100992776  CCKBR; cholecystokinin B receptor [KO:K04195]
100968161  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
100986730  GNAQ; G protein subunit alpha q [KO:K04634]
100972605  GNA11; G protein subunit alpha 11 [KO:K04635]
100987065  GNA14; G protein subunit alpha 14 [KO:K04636]
100987012  GNA15; G protein subunit alpha 15 [KO:K04637]
100975632  EGF; epidermal growth factor [KO:K04357]
100991389  PDGFA; platelet derived growth factor subunit A [KO:K04359]
100984583  PDGFB; platelet derived growth factor subunit B [KO:K17386]
100982459  PDGFC; platelet derived growth factor C [KO:K05450]
100992738  PDGFD; platelet derived growth factor D [KO:K05450]
100972676  FGF1; fibroblast growth factor 1 [KO:K18496]
100968351  FGF2; fibroblast growth factor 2 [KO:K18497]
100980043  FGF5; fibroblast growth factor 5 [KO:K04358]
100992612  FGF10; fibroblast growth factor 10 [KO:K04358]
100968963  FGF22; fibroblast growth factor 22 [KO:K04358]
100969230  FGF8; fibroblast growth factor 8 [KO:K04358]
100992953  FGF18; fibroblast growth factor 18 [KO:K04358]
100967638  FGF4; fibroblast growth factor 4 [KO:K04358]
100982572  FGF17; fibroblast growth factor 17 [KO:K04358]
100970008  FGF20; fibroblast growth factor 20 [KO:K04358]
100967980  FGF3; fibroblast growth factor 3 [KO:K04358]
100989491  FGF6; fibroblast growth factor 6 [KO:K04358]
100979704  FGF9; fibroblast growth factor 9 [KO:K04358]
100995394  FGF7; fibroblast growth factor 7 [KO:K04358]
100985264  FGF16; fibroblast growth factor 16 [KO:K04358]
100967291  FGF19; fibroblast growth factor 19 [KO:K22603]
100975521  FGF21; fibroblast growth factor 21 [KO:K22429]
100989835  FGF23; fibroblast growth factor 23 [KO:K22428]
100970217  VEGFA; vascular endothelial growth factor A [KO:K05448]
100990660  VEGFC; vascular endothelial growth factor C [KO:K05449]
100969999  VEGFD; vascular endothelial growth factor D [KO:K05449]
100995667  NGF; nerve growth factor [KO:K02582]
100983117  HGF; hepatocyte growth factor [KO:K05460]
100969352  GDNF; glial cell derived neurotrophic factor [KO:K05452]
100974885  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100977227  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
100974494  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
100996186  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
100982337  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100975853  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100988115  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
100981139  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100976551  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100991315  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100977352  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
100969442  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
100986594  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
100995426  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
100994887  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
100994282  NTRK3; neurotrophic receptor tyrosine kinase 3 [KO:K05101] [EC:2.7.10.1]
100991777  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
100982426  MST1R; macrophage stimulating 1 receptor [KO:K05100] [EC:2.7.10.1]
100994039  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
100975083  uncharacterized LOC100975083 [KO:K10785]
100985012  uncharacterized LOC100985012 [KO:K10785]
100988366  uncharacterized LOC100988366 [KO:K10785]
100982662  uncharacterized LOC100982662 [KO:K10785]
100983000  uncharacterized LOC100983000 [KO:K10785]
100995080  uncharacterized LOC100995080 [KO:K10785]
100988045  uncharacterized LOC100988045 [KO:K10785]
100983622  Ig heavy chain Mem5-like [KO:K06856]
100979030  putative V-set and immunoglobulin domain-containing-like protein IGHV1OR21-1 [KO:K06856]
100970186  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103785315  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103785316  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
100989153  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
100988032  PLCD4; phospholipase C delta 4 [KO:K05857] [EC:3.1.4.11]
100969236  PLCD1; phospholipase C delta 1 [KO:K05857] [EC:3.1.4.11]
100980795  PLCD3; phospholipase C delta 3 [KO:K05857] [EC:3.1.4.11]
100969344  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
100987524  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
100969660  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
100978643  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
100995010  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
100984694  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
100992707  PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
100988020  PLCZ1; phospholipase C zeta 1 [KO:K05861] [EC:3.1.4.11]
100984884  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100980378  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100982024  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100974952  CD38; CD38 molecule [KO:K01242] [EC:3.2.2.6 2.4.99.20]
100990039  TPCN1; two pore segment channel 1 [KO:K16896]
100971084  TPCN2; two pore segment channel 2 [KO:K14077]
100985054  MCOLN1; mucolipin 1 [KO:K04992]
100975357  MCOLN2; mucolipin 2 [KO:K04993]
100975689  MCOLN3; mucolipin 3 [KO:K04994]
100977890  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
100992056  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
100990265  MCU; mitochondrial calcium uniporter [KO:K20858]
100983168  VDAC1; voltage dependent anion channel 1 [KO:K05862]
100987711  VDAC3; voltage dependent anion channel 3 [KO:K15041]
100971042  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
100984012  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
100981051  ADP/ATP translocase 3-like [KO:K05863]
100991246  SLC25A5; solute carrier family 25 member 5 [KO:K05863]
100970528  PPIF; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
100984453  TNNC1; troponin C1, slow skeletal and cardiac type [KO:K05865]
100968994  TNNC2; troponin C2, fast skeletal type [KO:K12042]
100979074  CALML6; calmodulin like 6 [KO:K02183]
100980454  CALM2; calmodulin 2 [KO:K02183]
100990795  CALML3; calmodulin like 3 [KO:K02183]
100990459  CALML5; calmodulin like 5 [KO:K02183]
100968473  CALM1; calmodulin 1 [KO:K02183]
100977014  CALM3; calmodulin 3 [KO:K02183]
100996176  CALML4; calmodulin like 4 [KO:K02183]
100986631  PHKG1; phosphorylase kinase catalytic subunit gamma 1 [KO:K00871] [EC:2.7.11.19]
100983464  PHKG2; phosphorylase kinase catalytic subunit gamma 2 [KO:K00871] [EC:2.7.11.19]
100976010  PHKB; phosphorylase kinase regulatory subunit beta [KO:K07190]
100981775  PHKA2; phosphorylase kinase regulatory subunit alpha 2 [KO:K07190]
100987241  PHKA1; phosphorylase kinase regulatory subunit alpha 1 [KO:K07190]
100995666  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
100974667  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
100978891  MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
100979422  MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
100980159  CAMK1G; calcium/calmodulin dependent protein kinase IG [KO:K08794] [EC:2.7.11.17]
100995267  CAMK1; calcium/calmodulin dependent protein kinase I [KO:K08794] [EC:2.7.11.17]
100979439  CAMK1D; calcium/calmodulin dependent protein kinase ID [KO:K08794] [EC:2.7.11.17]
100973727  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
100983859  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
100986246  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
100982179  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
100970371  CAMK4; calcium/calmodulin dependent protein kinase IV [KO:K05869] [EC:2.7.11.17]
100976987  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100976831  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
100968593  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
100995767  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
100996089  NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
100976546  NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
100974638  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
100981582  PDE1A; phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
100989825  PDE1C; phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
100995565  PDE1B; phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
100991936  PTK2B; protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
100974308  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
100988859  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
100976198  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
100967981  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
100970296  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
100990245  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
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pathway
pps04010  MAPK signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04210  Apoptosis
pps04720  Long-term potentiation
pps04730  Long-term depression
KO pathway
ko04020   

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