KEGG   Pongo pygmaeus (Bornean orangutan): 129020685
Entry
129020685         CDS       T10128                                 
Symbol
APC2
Name
(RefSeq) adenomatous polyposis coli protein 2 isoform X3
  KO
K02085  adenomatosis polyposis coli protein
Organism
ppyg  Pongo pygmaeus (Bornean orangutan)
Pathway
ppyg04310  Wnt signaling pathway
ppyg04390  Hippo signaling pathway
ppyg04519  Cadherin signaling
ppyg04550  Signaling pathways regulating pluripotency of stem cells
ppyg04810  Regulation of actin cytoskeleton
ppyg04934  Cushing syndrome
ppyg05010  Alzheimer disease
ppyg05022  Pathways of neurodegeneration - multiple diseases
ppyg05165  Human papillomavirus infection
ppyg05200  Pathways in cancer
ppyg05206  MicroRNAs in cancer
ppyg05210  Colorectal cancer
ppyg05213  Endometrial cancer
ppyg05217  Basal cell carcinoma
ppyg05224  Breast cancer
ppyg05225  Hepatocellular carcinoma
ppyg05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ppyg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    129020685 (APC2)
   04390 Hippo signaling pathway
    129020685 (APC2)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    129020685 (APC2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    129020685 (APC2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129020685 (APC2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129020685 (APC2)
   05206 MicroRNAs in cancer
    129020685 (APC2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129020685 (APC2)
   05225 Hepatocellular carcinoma
    129020685 (APC2)
   05226 Gastric cancer
    129020685 (APC2)
   05217 Basal cell carcinoma
    129020685 (APC2)
   05213 Endometrial cancer
    129020685 (APC2)
   05224 Breast cancer
    129020685 (APC2)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    129020685 (APC2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129020685 (APC2)
   05022 Pathways of neurodegeneration - multiple diseases
    129020685 (APC2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    129020685 (APC2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:ppyg01009]
    129020685 (APC2)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:ppyg03036]
    129020685 (APC2)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:ppyg04812]
    129020685 (APC2)
Protein phosphatases and associated proteins [BR:ppyg01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     129020685 (APC2)
Chromosome and associated proteins [BR:ppyg03036]
 Eukaryotic type
  Centrosome formation proteins
   Other centrosome associated proteins
    129020685 (APC2)
Cytoskeleton proteins [BR:ppyg04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    EB / APC
     129020685 (APC2)
SSDB
Motif
Pfam: APC_basic APC_rep APC_N_CC APC_r Arm Arm_APC_u3 Suppressor_APC SAMP ARM_ARMC5 ZER1-like_2nd SSNA1 PEA2_C Sec7-like_HUS bZIP_1 Par-4_C PDC10_C HALZ RHIP1 CCDC138_cc
Other DBs
NCBI-GeneID: 129020685
NCBI-ProteinID: XP_054321343
Position
20:1204514..1232289
AA seq 2351 aa
MTRGTKKLAALAEPRDGAGAAGASRDQLKAAQGVRATQTLQELKMASSVAPYEQLVRQVE
ALKAENSHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVLVSSGQTEVLEQL
KALQMEITSLYNLKFQPPTLGPEPAARTPEGSPVHGSGPSKDSFGELSRATIRLLEELDR
ERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQFSMQMDLIRQQLEFEAQHIRS
LMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQALLAVKSVPVDEDPETE
VPTHPEDGTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPL
LLQILHGTEAVAGGRAGAPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQ
IRAYCETCWDWLQARDGGPEGGGAGGAPIPIEPQICQATCAVMKLSFDEEYRRAMNELGG
LQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVA
QLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKESTLKSVLSA
LWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLIATRED
YRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQELLWDLGAVGMLRNLV
HSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYVRKQRALEAELDARHLA
QALEHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSSLAAAAATGEP
ASPAALSLFLGSPFLQGQALARTLPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARIDQ
LVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLK
AANASLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRCGQPRPSRLDLDLPGGQA
EPPAREATSADARVRTIKLSPTYQHVPLLEGASRAGAELLAGPGTSPGARKQAWLPADHL
SKVPEKLAAAPLSVASKALQKLVAQEGPLSLSRCSSLSSLSSAGRPGPSEGGDLDDSDSS
LEGLEEAGPGEAELDSAWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETP
LVLSRCSSVSSLGSFESPSIASSIPSDPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPL
APAPQGPPEASQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCAS
SLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAA
DQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAPAPAPAQEDDSCTDSAE
GTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRSTGRPTSARQAMGHRHKAGGAGRSTEQ
SRGAGKNPAGLELPLGRSPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDS
DEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPAWTQPSLIADETP
PCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCIS
SALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGAN
SIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKR
GATSAKTSGSPRSPAGPQKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRAT
PRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPGKTSELATLSQPPRSATPPARLAKTPSS
SSSQTSPASQPLPRKRPPVTQAAGPLPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQ
RPARRGPPPLARAVPESGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQ
LTFIKESPGLRRRRSELSSAESAASAPQGAPPRRGRPALPAVFLCSSRCEELRAAPRQAP
APAPARQRPPAARPGPGERPARRTSSESPSRLPVRAPAARPETVKRYASLPHISVARRPD
GAVPAAPAPADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGS
MPEDALAGPAPRKTSDAVVQTEEVAAPKTNSSTSPSLEIREPPGAPVGGQLSLLGSDVDG
PSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPMVVAATTDSAAEK
APATASATLLE
NT seq 7056 nt   +upstreamnt  +downstreamnt
atgaccagaggcacaaagaagctagcggcgctggcagagccaagggatggggcaggggct
gccggggccagcagggaccagctgaaggctgcgcagggggtgcgggccacacagacgctg
caggagctgaagatggcgagctccgtggcgccctacgagcagctggtgcggcaggtggag
gccttgaaggctgagaacagccacctgaggcaggagctaagggacaactccagccacctg
tccaagctggagacagagacgtcgggcatgaaggaggtcctgaagcacctacagggaaaa
ctggagcaggaggcccgagtgctggtgtcctcggggcagacggaggtgctggagcagctg
aaggccctacagatggaaattaccagcctgtacaacctcaagttccagccgcccaccctg
ggcccggagcctgccgcccggaccccggagggcagcccagtacatggctccgggccctcc
aaggacagctttggggagctgagccgggccaccatccggctgctggaagaactggaccgg
gaacggtgtttcctgctgaatgagattgagaaggaggagaaggagaagctctggtactac
tctcagctgcagggcctgtccaagcgccttgacgagctgccgcacgtggagacgcagttc
tcgatgcagatggacctgatccggcagcagcttgagttcgaggcccagcacatccgctct
ctgatggaggagcgcttcggcacctcggacgagatggtgcagcgggcccagatccgcgct
tcgcgcctggagcagattgacaaggagctgctggaggcgcaggaccgagtgcagcagacg
gagccccaggccttgctggcggtgaagtcggtgccggtggacgaggaccccgagacagag
gtccccacacaccctgaggatggcacccctcagccgggcaacagcaaggtggaggtggtc
ttctggctgttgtcgatgttggctacgcgtgaccaggaggatacagcgcgcacgctgctg
gccatgtccagctcgcccgagagctgcgtggccatgcgccgctcgggctgtctgcctctg
ctgctgcaaatcctccacggcaccgaggctgtggccgggggtcgcgccggggccccagga
gcaccgggcgccaaggacgcacgcatgcgcgccaacgcggcgctgcacaacatcgtcttc
tcgcagccggaccagggcctggcgcgcaaggagatgcgcgtcctgcacgtgctggagcag
atccgggcctactgcgagacctgctgggactggttgcaggcccgagacggcgggcccgag
ggaggcggcgccggcggcgccccgatccccatcgagccgcagatctgccaggccacctgt
gctgttatgaagctgtcctttgacgaggagtaccgccgtgccatgaacgagctaggtggg
ctgcaggccgtggcagagctgctgcaggttgactacgagatgcacaagatgacccgggac
ccgctgaacctggcgctgcgccgctatgcgggcatgaccctcaccaacctcacctttggg
gacgttgccaacaaggccaccttgtgtgcgcgccgcggctgcatggaggccatcgtggcc
cagctggcctccgacagtgaggagctccaccaggtggtgtccagcatccttcggaacttg
tcctggagggccgacatcaacagcaagaaggtgctgagggaggcgggcagcgtgactgcc
ctggtgcagtgtgtcctgcgggccaccaaggagtccaccctgaagagcgtgctgagcgcc
ctgtggaatctgtctgcacacagcacagagaacaaggcggccatctgccaggtggatggc
gccctgggcttcctggtgagcaccctgacctacaagtgccagagcaactcgctggccatc
atcgagagtggcggcggcatcctccgcaacgtgtccagcctcatcgccacccgtgaggac
tacaggcaggtgctccgggatcacaactgtctgcagacgctgctgcagcatctgacttcg
cacagcctgaccatagtgagcaacgcgtgcggcacgctctggaacctgtcggcccgcagt
gcccgtgaccaggagctgctgtgggacctgggcgccgtgggcatgctgcgtaatctggtg
cactccaagcacaagatgatcgccatgggcagcgccgccgccctgcgcaacctgctggcc
catcggcccgccaagcaccaggcggccgccaccgccgtgtccccaggcagctgcgtgccc
agcctgtacgtgcgcaagcagcgggctctggaggccgagctggacgcacggcacctcgcg
caggcgctggagcacctggagaagcagggcccgccggcagccgaggccgccactaagaag
ccgctgccgcccctgcgacacctggacggcctggcccaagactatgcttccgattcgggc
tgctttgacgacgacgatgcaccgtcatccctggctgcggccgcggccaccggggagcca
gccagccctgccgcgctgtccctcttcctgggcagccccttcctgcaggggcaagctctg
gctcgcaccctgcccacccgccgaggcggcaaggaggcggagaaggacaccagtggggag
gcagccgtggcggccaaggccaaggccaagctggcgcttgcagtggcgcgcatcgaccag
ctggtggaggacatctccgccctgcacacctcgtccgacgatagcttcagcctcagctct
ggagacccggggcaggaggcgccacgggagggccgcgcccagtcttgctcgccatgccgc
ggcccagagggcgggcggcgagaggcaggaagccgggcgcacccgctgctgcggctcaag
gcggccaacgccagcctctccaacgacagcctcaacagcggcagtgccagcgacgggtac
tgcccacgcgaacatatgctgccctgcccgctggccgcactggcttcgcgccgcgaggac
cccaggtgtgggcagcctcggcccagccggcttgaccttgacctgccgggcggccaggcc
gagcccccggcccgcgaggccacatccgccgacgcccgcgtgcgcaccatcaagctgtcg
cctacctatcagcacgtgccactgctcgagggtgcctcaagggcgggtgcagagctcctc
gcggggcctggaacctctccaggggcccggaagcaggcctggctgccggccgaccacctg
agcaaggttcccgagaagctggcggccgccccgctgtccgtggccagcaaggcactgcag
aaactggtggcgcaagaggggccgctctcgctgtcccgatgcagctccctttcctcgctg
tcctcggccggccgcccaggccccagcgagggcggtgacctggatgacagtgactcctcc
ctggaggggctggaggaggccggcccaggcgaggctgagctggacagcgcgtggcgggcg
cccggggccacctcgctgcccgtagccattccggctccccggcgtaaccgaggccggggc
ctcggggtggaagacgccacgccgtccagctcgtcggagaactacgtgcaggagacaccg
cttgtgctgagccgctgcagctctgtgagctcgctgggcagcttcgagagcccgtccatc
gccagctccatccccagtgacccttgcagcgggcagggcagcggcaccatcagccctagt
gaactgcctgacagccccgggcagaccatgcctcccagccggagcaagacgccgccgctg
gcccccgcgccacagggtccccccgaggccagccagttcagcctgcagtgggagagctac
gtgaagcgcttcctggacatcgccgactgccgggagcgctgccggctgccatctgagttg
gacgcaggcagcgtgcgctttacggtggagaagccagacgagaacttctcgtgcgcctcc
agcctcagcgcgctggccttacacgagcactacgtgcagcaggacgtggagctgcggctg
ctgccctcggcctgcccggagcgcggcgggggcgctgggggcgccggcctccactttgca
gggcaccggcggcgggaggaggggccggcgcccacgggttctcgcccccgcggcgccgcg
gaccaggagctggaactgctgcgggagtgcctgggagccgccgtgcctgcccggctgcgc
aaggtggcctccgcgctggtgccaggtcgccgcgcactccccgtgcccgtctacatgttg
gtgccggccccggccccggccccggcccaggaggacgactcctgcactgactccgcggag
ggcacgccggtcaacttctccagcgccgcctcgctcagcgacgagacgctgcagggaccc
cccagggaccagcccgggggaccagcgggtaggcaaagatccaccggccgccccacctct
gccaggcaggccatggggcaccggcacaaggcgggaggcgccggccgcagcacagagcag
tctcggggcgcgggcaagaacccagcagggctggagctgcccctgggccggtctccgagc
gcccccgcagacaaggacggctcaaagcccggccggactcgcggggacggggcgctccag
tcgctgtgcctcacgacgcccaccgaggaggccgtgtactgcttctacggcaacgactcg
gacgaggagcccccggcggccgcgcccacgcccacccaccggcgcacatcggccatcccc
cgcgcttttacgcgggagcgcccgcagggccggaaggaggcccctgccccatccaaggcc
gcaccagccgccccgccgcccgcctggacccagcccagcctcattgctgacgagaccccg
ccctgctactccctgagctcctccgccagctccctcagcgagcccgagccctcagagccg
ccggccgtccatccacgaggccgggagcccgcggtcaccaaggacccaggcccaggaggc
ggacgcgacagctcacccagtccgcgggccgcggaggagcttctgcagcggtgcatcagc
tcggccctgcccaggcgccggccccccgtgtctggcctgcggcgccgcaagccccgagcc
acccggctggatgagcggcccgcggaggggtcccgggaacgcggcgaggaggcagcgggc
tcggaccgggcctccgacctggatagcgtggagtggcgcgccatccaggagggcgccaat
tcaatcgtcacgtggctgcaccaggcagcagctgccacgcgggaggcctcctccgagtcc
gactccatcctgtccttcgtatccgggctgtcggtggggtccaccctacagccccccaag
cacaggaagggacgacaggcggagggagaaatgggcagtgctcggcggccagagaaaagg
ggcgcaacctcagccaagaccagcgggagcccccgttcccctgcaggcccccagaagcca
cgtggcacacagaagaccacgcccggggtgccagctgtgcttcggggacgaacagtgatc
tacgtgcccagcccggcaccccgtgcccagcccaaagggacccccggcccccgcgccaca
ccgcggaaggtggcgcccccttgcctggcacagcccgcggctccagccaaagtccccagc
cccggacagcagcggtcgcggagcctacaccggcctggcaagacctcggagctggcgacg
ctgagccagccccccagaagcgccacaccgcccgcccgcctcgccaagaccccctcctcc
agctcctcccagacctcgcccgcctcccagcccctgcccagaaagcgccccccggtcacc
caggctgcagggcccctgcccggccccggggcctccccggtgcccaagacgccggcgcgc
acccttctggcgaagcagcacaagacgcagagatcgcccgtgcggatcccgttcatgcag
aggccggcccggcgtgggccgccaccgctggctcgggcagtcccggagtcgggccccagg
ggccgggcggggaccgaggcgggcccgggggcgcgcgggggccgcctgggcctggtgcgt
gtggcctcagccctctccagcggcagcgagtcctccgaccgctcgggcttccggcgacag
ctgaccttcatcaaggagtcgccgggcttgcggcgccgccgctccgagctgtcctcggcc
gagtccgcggcctctgcgccccagggcgccccgccccgccgcggccggcccgcgctgccc
gccgtcttcctctgctcctcacgctgcgaagagctccgagcggcaccccggcaggccccg
gccccggccccggcccggcagcggccccccgcggcccgacccggccctggcgagcgccct
gcccggcgcaccagctccgagagcccgtcccgcctgcccgtgcgcgcgcccgccgcccgg
ccggagactgtcaagcgctacgcgtcgctgccgcacatcagcgtggcccgcaggcccgac
ggcgccgtccccgcggcccctgccccagccgacgccgcgcgccgcagcagcgacggggag
ccccggccgctccccagggtggccgcgccgggcacgacgtggcggcgcatccgagatgag
gacgtgccccatatcctgcgcagcacgctgcccgccacggccctgccactgcggggctcc
atgcccgaggacgccctggccgggcccgcgccgcgcaagaccagcgacgccgtggtccag
accgaggaggtcgccgcccccaagaccaactccagcacgtccccgagcctggagatcagg
gagccccccggggcccccgtcggcggccagctctcccttctcggcagcgacgtggacggt
cccagcctcgccaaggctcccatctccgcacccttcgtgcacgagggcctgggggtcgcc
gtggggggcttccccgccagccggcacggctcccccagccgctcggcccgagtacccccc
ttcaactatgtgcccagccccatggtggtcgcagccaccaccgactcggccgcggagaaa
gccccggccactgcctccgccaccctcctggaatag

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (6)   
   RefSeq(pep) (6)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
Protein domain (19)   
   Pfam (19)   
All databases (33)   

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