KEGG   Pongo pygmaeus (Bornean orangutan): 129023434
Entry
129023434         CDS       T10128                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X7
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
ppyg  Pongo pygmaeus (Bornean orangutan)
Pathway
ppyg01522  Endocrine resistance
ppyg04010  MAPK signaling pathway
ppyg04015  Rap1 signaling pathway
ppyg04068  FoxO signaling pathway
ppyg04071  Sphingolipid signaling pathway
ppyg04114  Oocyte meiosis
ppyg04148  Efferocytosis
ppyg04218  Cellular senescence
ppyg04261  Adrenergic signaling in cardiomyocytes
ppyg04370  VEGF signaling pathway
ppyg04380  Osteoclast differentiation
ppyg04517  IgSF CAM signaling
ppyg04519  Cadherin signaling
ppyg04550  Signaling pathways regulating pluripotency of stem cells
ppyg04611  Platelet activation
ppyg04613  Neutrophil extracellular trap formation
ppyg04620  Toll-like receptor signaling pathway
ppyg04621  NOD-like receptor signaling pathway
ppyg04622  RIG-I-like receptor signaling pathway
ppyg04625  C-type lectin receptor signaling pathway
ppyg04657  IL-17 signaling pathway
ppyg04658  Th1 and Th2 cell differentiation
ppyg04659  Th17 cell differentiation
ppyg04660  T cell receptor signaling pathway
ppyg04664  Fc epsilon RI signaling pathway
ppyg04668  TNF signaling pathway
ppyg04670  Leukocyte transendothelial migration
ppyg04714  Thermogenesis
ppyg04722  Neurotrophin signaling pathway
ppyg04723  Retrograde endocannabinoid signaling
ppyg04728  Dopaminergic synapse
ppyg04750  Inflammatory mediator regulation of TRP channels
ppyg04912  GnRH signaling pathway
ppyg04914  Progesterone-mediated oocyte maturation
ppyg04917  Prolactin signaling pathway
ppyg04926  Relaxin signaling pathway
ppyg04932  Non-alcoholic fatty liver disease
ppyg04933  AGE-RAGE signaling pathway in diabetic complications
ppyg04935  Growth hormone synthesis, secretion and action
ppyg04936  Alcoholic liver disease
ppyg05014  Amyotrophic lateral sclerosis
ppyg05020  Prion disease
ppyg05022  Pathways of neurodegeneration - multiple diseases
ppyg05132  Salmonella infection
ppyg05133  Pertussis
ppyg05135  Yersinia infection
ppyg05140  Leishmaniasis
ppyg05142  Chagas disease
ppyg05145  Toxoplasmosis
ppyg05152  Tuberculosis
ppyg05161  Hepatitis B
ppyg05163  Human cytomegalovirus infection
ppyg05167  Kaposi sarcoma-associated herpesvirus infection
ppyg05169  Epstein-Barr virus infection
ppyg05170  Human immunodeficiency virus 1 infection
ppyg05171  Coronavirus disease
ppyg05205  Proteoglycans in cancer
ppyg05208  Chemical carcinogenesis - reactive oxygen species
ppyg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ppyg05415  Diabetic cardiomyopathy
ppyg05417  Lipid and atherosclerosis
ppyg05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppyg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    129023434 (MAPK12)
   04015 Rap1 signaling pathway
    129023434 (MAPK12)
   04370 VEGF signaling pathway
    129023434 (MAPK12)
   04668 TNF signaling pathway
    129023434 (MAPK12)
   04068 FoxO signaling pathway
    129023434 (MAPK12)
   04071 Sphingolipid signaling pathway
    129023434 (MAPK12)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    129023434 (MAPK12)
   04519 Cadherin signaling
    129023434 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    129023434 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    129023434 (MAPK12)
   04218 Cellular senescence
    129023434 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    129023434 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129023434 (MAPK12)
   04613 Neutrophil extracellular trap formation
    129023434 (MAPK12)
   04620 Toll-like receptor signaling pathway
    129023434 (MAPK12)
   04621 NOD-like receptor signaling pathway
    129023434 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    129023434 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    129023434 (MAPK12)
   04660 T cell receptor signaling pathway
    129023434 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    129023434 (MAPK12)
   04659 Th17 cell differentiation
    129023434 (MAPK12)
   04657 IL-17 signaling pathway
    129023434 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    129023434 (MAPK12)
   04670 Leukocyte transendothelial migration
    129023434 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    129023434 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    129023434 (MAPK12)
   04917 Prolactin signaling pathway
    129023434 (MAPK12)
   04926 Relaxin signaling pathway
    129023434 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    129023434 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    129023434 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    129023434 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    129023434 (MAPK12)
   04722 Neurotrophin signaling pathway
    129023434 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    129023434 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    129023434 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    129023434 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    129023434 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    129023434 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129023434 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    129023434 (MAPK12)
   05161 Hepatitis B
    129023434 (MAPK12)
   05171 Coronavirus disease
    129023434 (MAPK12)
   05163 Human cytomegalovirus infection
    129023434 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129023434 (MAPK12)
   05169 Epstein-Barr virus infection
    129023434 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129023434 (MAPK12)
   05135 Yersinia infection
    129023434 (MAPK12)
   05133 Pertussis
    129023434 (MAPK12)
   05152 Tuberculosis
    129023434 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    129023434 (MAPK12)
   05140 Leishmaniasis
    129023434 (MAPK12)
   05142 Chagas disease
    129023434 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    129023434 (MAPK12)
   05020 Prion disease
    129023434 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    129023434 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129023434 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    129023434 (MAPK12)
   05415 Diabetic cardiomyopathy
    129023434 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    129023434 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    129023434 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    129023434 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    129023434 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ppyg01001]
    129023434 (MAPK12)
Enzymes [BR:ppyg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     129023434 (MAPK12)
Protein kinases [BR:ppyg01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   129023434 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kinase-like
Other DBs
NCBI-GeneID: 129023434
NCBI-ProteinID: XP_054326112
Position
23:complement(61439733..61449023)
AA seq 381 aa
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSDLFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDLKVPCSGPWHQVCGRY
LVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE
LKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLF
KGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVN
LLEKMLVLDAEQRVTAAEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYK
EVLSFKPPQQLGARVSKETAL
NT seq 1146 nt   +upstreamnt  +downstreamnt
atgagctctccgccgcccgcccgcagtggcttttaccgccaggaggtgaccaagacggcc
tgggaggtgcgcgccgtgtaccgggacctgcagcccgtgggctcgggcgcctatggcgcg
gtgtgctcggccgtggacagccgcaccggcgctaaggtagccatcaagaagctgtatcgg
cccttccagtccgacctgttcgccaagcgcgcctaccgcgagctgcgcctgctcaagcac
atgcgccacgagaacgtgatcgggctgctggacgtattcactcctgatgagaccctggat
gacttcacggacttgaaggtcccgtgctcaggaccctggcaccaagtgtgtggccgttac
ctggtgatgccgttcatgggcaccgacctgggcaagctcatgaaacatgagaagctaggc
gaggaccggatccagtttctcgtgtaccagatgctgaaggggctgaggtatatccacgct
gctggcatcatccacagagacctgaagcccggcaacctggctgtgaacgaagactgtgag
ctgaagatcctggacttcggcctggccaggcaggcagacagtgagatgactgggtacgtg
gtgacccggtggtaccgggctcccgaggtcatcttgaattggatgcgctacacgcagacg
gtggacatctggtctgtgggctgcatcatggcagagatgatcacaggcaagacgctgttc
aagggcagcgaccacctggaccagctgaaggagatcatgaaggtgacggggacgcctccg
gctgagtttgtgcagcggctgcagagcgatgaggccaagaactacatgaagggcctcccc
gaattggagaagaaggattttgcctccatcctcaccaatgcaagccctctggctgtgaac
ctcctggagaagatgctggtgctggatgcggagcagcgggtgacagcggccgaggcgctg
gcccatccctactttgagtccctgcacgacacggaagatgagccccaggtccagaagtat
gatgactcctttgacgacgtggaccgcacactggatgaatggaagcgtgttacttacaaa
gaggtgctcagcttcaagcctccccagcagctgggggccagggtctccaaggagacggct
ctgtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (15)   
   RefSeq(pep) (15)   
DNA sequence (15)   
   RefSeq(nuc) (15)   
Protein domain (5)   
   Pfam (5)   
All databases (37)   

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