KEGG   Pongo pygmaeus (Bornean orangutan): 129033450
Entry
129033450         CDS       T10128                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ppyg  Pongo pygmaeus (Bornean orangutan)
Pathway
ppyg00562  Inositol phosphate metabolism
ppyg01100  Metabolic pathways
ppyg01521  EGFR tyrosine kinase inhibitor resistance
ppyg01522  Endocrine resistance
ppyg01524  Platinum drug resistance
ppyg04012  ErbB signaling pathway
ppyg04014  Ras signaling pathway
ppyg04015  Rap1 signaling pathway
ppyg04024  cAMP signaling pathway
ppyg04062  Chemokine signaling pathway
ppyg04066  HIF-1 signaling pathway
ppyg04068  FoxO signaling pathway
ppyg04070  Phosphatidylinositol signaling system
ppyg04071  Sphingolipid signaling pathway
ppyg04072  Phospholipase D signaling pathway
ppyg04081  Hormone signaling
ppyg04140  Autophagy - animal
ppyg04145  Phagocytosis
ppyg04150  mTOR signaling pathway
ppyg04151  PI3K-Akt signaling pathway
ppyg04152  AMPK signaling pathway
ppyg04210  Apoptosis
ppyg04211  Longevity regulating pathway
ppyg04213  Longevity regulating pathway - multiple species
ppyg04218  Cellular senescence
ppyg04360  Axon guidance
ppyg04370  VEGF signaling pathway
ppyg04380  Osteoclast differentiation
ppyg04510  Focal adhesion
ppyg04517  IgSF CAM signaling
ppyg04518  Integrin signaling
ppyg04550  Signaling pathways regulating pluripotency of stem cells
ppyg04611  Platelet activation
ppyg04613  Neutrophil extracellular trap formation
ppyg04620  Toll-like receptor signaling pathway
ppyg04625  C-type lectin receptor signaling pathway
ppyg04630  JAK-STAT signaling pathway
ppyg04650  Natural killer cell mediated cytotoxicity
ppyg04660  T cell receptor signaling pathway
ppyg04662  B cell receptor signaling pathway
ppyg04664  Fc epsilon RI signaling pathway
ppyg04666  Fc gamma R-mediated phagosome formation
ppyg04668  TNF signaling pathway
ppyg04670  Leukocyte transendothelial migration
ppyg04722  Neurotrophin signaling pathway
ppyg04725  Cholinergic synapse
ppyg04750  Inflammatory mediator regulation of TRP channels
ppyg04810  Regulation of actin cytoskeleton
ppyg04910  Insulin signaling pathway
ppyg04914  Progesterone-mediated oocyte maturation
ppyg04915  Estrogen signaling pathway
ppyg04917  Prolactin signaling pathway
ppyg04919  Thyroid hormone signaling pathway
ppyg04923  Regulation of lipolysis in adipocytes
ppyg04926  Relaxin signaling pathway
ppyg04929  GnRH secretion
ppyg04930  Type II diabetes mellitus
ppyg04931  Insulin resistance
ppyg04932  Non-alcoholic fatty liver disease
ppyg04933  AGE-RAGE signaling pathway in diabetic complications
ppyg04935  Growth hormone synthesis, secretion and action
ppyg04960  Aldosterone-regulated sodium reabsorption
ppyg04973  Carbohydrate digestion and absorption
ppyg05010  Alzheimer disease
ppyg05017  Spinocerebellar ataxia
ppyg05020  Prion disease
ppyg05100  Bacterial invasion of epithelial cells
ppyg05132  Salmonella infection
ppyg05135  Yersinia infection
ppyg05142  Chagas disease
ppyg05146  Amoebiasis
ppyg05160  Hepatitis C
ppyg05161  Hepatitis B
ppyg05162  Measles
ppyg05163  Human cytomegalovirus infection
ppyg05164  Influenza A
ppyg05165  Human papillomavirus infection
ppyg05166  Human T-cell leukemia virus 1 infection
ppyg05167  Kaposi sarcoma-associated herpesvirus infection
ppyg05168  Herpes simplex virus 1 infection
ppyg05169  Epstein-Barr virus infection
ppyg05170  Human immunodeficiency virus 1 infection
ppyg05171  Coronavirus disease
ppyg05200  Pathways in cancer
ppyg05203  Viral carcinogenesis
ppyg05205  Proteoglycans in cancer
ppyg05206  MicroRNAs in cancer
ppyg05207  Chemical carcinogenesis - receptor activation
ppyg05208  Chemical carcinogenesis - reactive oxygen species
ppyg05210  Colorectal cancer
ppyg05211  Renal cell carcinoma
ppyg05212  Pancreatic cancer
ppyg05213  Endometrial cancer
ppyg05214  Glioma
ppyg05215  Prostate cancer
ppyg05218  Melanoma
ppyg05220  Chronic myeloid leukemia
ppyg05221  Acute myeloid leukemia
ppyg05222  Small cell lung cancer
ppyg05223  Non-small cell lung cancer
ppyg05224  Breast cancer
ppyg05225  Hepatocellular carcinoma
ppyg05226  Gastric cancer
ppyg05230  Central carbon metabolism in cancer
ppyg05231  Choline metabolism in cancer
ppyg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ppyg05415  Diabetic cardiomyopathy
ppyg05417  Lipid and atherosclerosis
ppyg05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppyg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    129033450 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    129033450 (PIK3CB)
   04014 Ras signaling pathway
    129033450 (PIK3CB)
   04015 Rap1 signaling pathway
    129033450 (PIK3CB)
   04370 VEGF signaling pathway
    129033450 (PIK3CB)
   04630 JAK-STAT signaling pathway
    129033450 (PIK3CB)
   04668 TNF signaling pathway
    129033450 (PIK3CB)
   04066 HIF-1 signaling pathway
    129033450 (PIK3CB)
   04068 FoxO signaling pathway
    129033450 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    129033450 (PIK3CB)
   04072 Phospholipase D signaling pathway
    129033450 (PIK3CB)
   04071 Sphingolipid signaling pathway
    129033450 (PIK3CB)
   04024 cAMP signaling pathway
    129033450 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    129033450 (PIK3CB)
   04152 AMPK signaling pathway
    129033450 (PIK3CB)
   04150 mTOR signaling pathway
    129033450 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    129033450 (PIK3CB)
   04517 IgSF CAM signaling
    129033450 (PIK3CB)
   04518 Integrin signaling
    129033450 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    129033450 (PIK3CB)
   04140 Autophagy - animal
    129033450 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    129033450 (PIK3CB)
   04218 Cellular senescence
    129033450 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    129033450 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    129033450 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129033450 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129033450 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    129033450 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    129033450 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    129033450 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    129033450 (PIK3CB)
   04660 T cell receptor signaling pathway
    129033450 (PIK3CB)
   04662 B cell receptor signaling pathway
    129033450 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    129033450 (PIK3CB)
   04666 Fc gamma R-mediated phagosome formation
    129033450 (PIK3CB)
   04670 Leukocyte transendothelial migration
    129033450 (PIK3CB)
   04062 Chemokine signaling pathway
    129033450 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129033450 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    129033450 (PIK3CB)
   04929 GnRH secretion
    129033450 (PIK3CB)
   04915 Estrogen signaling pathway
    129033450 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    129033450 (PIK3CB)
   04917 Prolactin signaling pathway
    129033450 (PIK3CB)
   04926 Relaxin signaling pathway
    129033450 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    129033450 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    129033450 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    129033450 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    129033450 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    129033450 (PIK3CB)
   04722 Neurotrophin signaling pathway
    129033450 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    129033450 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    129033450 (PIK3CB)
   04380 Osteoclast differentiation
    129033450 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    129033450 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    129033450 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129033450 (PIK3CB)
   05206 MicroRNAs in cancer
    129033450 (PIK3CB)
   05205 Proteoglycans in cancer
    129033450 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    129033450 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    129033450 (PIK3CB)
   05203 Viral carcinogenesis
    129033450 (PIK3CB)
   05230 Central carbon metabolism in cancer
    129033450 (PIK3CB)
   05231 Choline metabolism in cancer
    129033450 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129033450 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129033450 (PIK3CB)
   05212 Pancreatic cancer
    129033450 (PIK3CB)
   05225 Hepatocellular carcinoma
    129033450 (PIK3CB)
   05226 Gastric cancer
    129033450 (PIK3CB)
   05214 Glioma
    129033450 (PIK3CB)
   05221 Acute myeloid leukemia
    129033450 (PIK3CB)
   05220 Chronic myeloid leukemia
    129033450 (PIK3CB)
   05218 Melanoma
    129033450 (PIK3CB)
   05211 Renal cell carcinoma
    129033450 (PIK3CB)
   05215 Prostate cancer
    129033450 (PIK3CB)
   05213 Endometrial cancer
    129033450 (PIK3CB)
   05224 Breast cancer
    129033450 (PIK3CB)
   05222 Small cell lung cancer
    129033450 (PIK3CB)
   05223 Non-small cell lung cancer
    129033450 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    129033450 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    129033450 (PIK3CB)
   05161 Hepatitis B
    129033450 (PIK3CB)
   05160 Hepatitis C
    129033450 (PIK3CB)
   05171 Coronavirus disease
    129033450 (PIK3CB)
   05164 Influenza A
    129033450 (PIK3CB)
   05162 Measles
    129033450 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    129033450 (PIK3CB)
   05163 Human cytomegalovirus infection
    129033450 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129033450 (PIK3CB)
   05169 Epstein-Barr virus infection
    129033450 (PIK3CB)
   05165 Human papillomavirus infection
    129033450 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129033450 (PIK3CB)
   05135 Yersinia infection
    129033450 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    129033450 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    129033450 (PIK3CB)
   05142 Chagas disease
    129033450 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129033450 (PIK3CB)
   05017 Spinocerebellar ataxia
    129033450 (PIK3CB)
   05020 Prion disease
    129033450 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129033450 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    129033450 (PIK3CB)
   05415 Diabetic cardiomyopathy
    129033450 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    129033450 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    129033450 (PIK3CB)
   04931 Insulin resistance
    129033450 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    129033450 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129033450 (PIK3CB)
   01524 Platinum drug resistance
    129033450 (PIK3CB)
   01522 Endocrine resistance
    129033450 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppyg04131]
    129033450 (PIK3CB)
Enzymes [BR:ppyg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     129033450 (PIK3CB)
Membrane trafficking [BR:ppyg04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    129033450 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 LepB_N DUF4381
Other DBs
NCBI-GeneID: 129033450
NCBI-ProteinID: XP_054338029
Position
2:complement(147325396..147509598)
AA seq 1070 aa
MCFSFIMPPAMADILDIWAVDSQIASDGSILVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLQQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcggtg
gattcacagatagcatctgatggctccatacttgtggatttccttttgcccactgggatt
tacatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatgg
aagcaagttcacaattacccaatgttcaacctccttatggatattgactcctatatgttt
gcatgtgtgaatcagactgctgtatatgaggagcttgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattggactcaaaaattggagtccttataggaaaaggtctgcatgaatttgattccttg
aaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagcgaggaaaaaatc
ctgtcacttgtgggattgtcttggatggactggctaaaacaaacatatccaccagagcat
gaaccatccatccctgaaaacttagaagataaactttatgggggaaagctcattgtagct
gttcattttgaaaactgccaggacgtgtttagctttcaagtgtctcctaatatgaatcct
atcaaagtaaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaa
gttagcccctatgattatgtgttgcaagtcagcgggagagtagaatatgtttttggtgat
catccactaattcagttccagtatatccggaactgtgtgatgaacaggaccctgccccat
tttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaggaaatgattgccata
gaggctgccataaatcgaaattcatctaatcttcctcttccattaccaccaaagaaaaca
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtctttttcatggt
actgagctcctgtgtaaaaccatcgtaagctcagaggtatcagggaaaaatgatcatatt
tggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctgtttatgcagttttggataaagtaaaaacgaagaaatcaacgaaaactatt
aatccctcaaaatatcagaccatcaggaaagctggaaaagtgcattatcctgtagcgtgg
gtaaatacgatggtttttgactttaaaggacaattgagaactggagacataatattacac
agctggtcttcatttcctgatgaactcgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatgttaaatttccagagaataaaaaa
caaccttattattaccctcccttcgataagattattgaaaaggcagctgagattgcaagc
agtgatagtgctaatgtgtcaagtcgaggtggaaaaaagtttcttcctgtattgaaagaa
atcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatttggact
ttgcgacaagactgccgagagattttcccacaatcactgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcgctgcttcagatttggcctaaa
ctgcccccccgggaggccctagagcttctggatttcaactatccagaccagtacgttcga
gaatatgctgtaggctgcctgcaacagatgagtgatgaagaactttctcaatatctttta
caactggtgcaagtgttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttggtaatcggaggatagggcagtttctattttggcatcttaggtca
gaagtgcacattcctgctgtctcagtacaatttggtgtcatccttgaagcatactgccgg
ggaagtgtggggcacatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttgaatagtttaatcaaactgaatgccgtgaagttaaacagagccaaagggaaggag
gccatgcatacctgtttaaaacagagtgcttaccgggaagccctctctgacctgcagtca
cccctgaacccatgtgttatcctctcagaactctatgttgaaaagtgcaaatacatggat
tccaaaatgaagcctttgtggctggtatacaataacaaggtatttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccaaatgttg
cgcctgatggatttactctggaaagaagctggtttggatcttcggatgttgccttatggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggaa
tttacactgtcctgtgctggctactgtgtagcttcttatgtccttggcattggtgacaga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacac
attcttggaaatttcaaatctaagtttggcattaaaagggagcgagtgccttttattctt
acctatgatttcatccatgtcattcaacaaggaaaaacaggaaatacagaaaagtttggc
cgtttccgccagtgttgtgaagatgcatatctgattttacgacggcatgggaatctcttc
atcactctctttgcgctgatgttgactgcagggcttcctgaactcacatcagtcaaagat
atacagtatcttaaggactctcttgcattagggaagagtgaagaagaagcactcaaacag
tttaagcaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (7)   
   RefSeq(pep) (7)   
DNA sequence (8)   
   RefSeq(nuc) (8)   
Protein domain (7)   
   Pfam (7)   
All databases (24)   

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