KEGG   Phodopus roborovskii (desert hamster): 127221392
Entry
127221392         CDS       T08852                                 
Symbol
Plcb1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
prob  Phodopus roborovskii (desert hamster)
Pathway
prob00562  Inositol phosphate metabolism
prob01100  Metabolic pathways
prob04015  Rap1 signaling pathway
prob04020  Calcium signaling pathway
prob04022  cGMP-PKG signaling pathway
prob04062  Chemokine signaling pathway
prob04070  Phosphatidylinositol signaling system
prob04071  Sphingolipid signaling pathway
prob04072  Phospholipase D signaling pathway
prob04081  Hormone signaling
prob04082  Neuroactive ligand signaling
prob04261  Adrenergic signaling in cardiomyocytes
prob04270  Vascular smooth muscle contraction
prob04310  Wnt signaling pathway
prob04371  Apelin signaling pathway
prob04540  Gap junction
prob04611  Platelet activation
prob04613  Neutrophil extracellular trap formation
prob04621  NOD-like receptor signaling pathway
prob04713  Circadian entrainment
prob04720  Long-term potentiation
prob04723  Retrograde endocannabinoid signaling
prob04724  Glutamatergic synapse
prob04725  Cholinergic synapse
prob04726  Serotonergic synapse
prob04728  Dopaminergic synapse
prob04730  Long-term depression
prob04742  Taste transduction
prob04750  Inflammatory mediator regulation of TRP channels
prob04911  Insulin secretion
prob04912  GnRH signaling pathway
prob04915  Estrogen signaling pathway
prob04916  Melanogenesis
prob04918  Thyroid hormone synthesis
prob04919  Thyroid hormone signaling pathway
prob04921  Oxytocin signaling pathway
prob04922  Glucagon signaling pathway
prob04924  Renin secretion
prob04925  Aldosterone synthesis and secretion
prob04926  Relaxin signaling pathway
prob04927  Cortisol synthesis and secretion
prob04928  Parathyroid hormone synthesis, secretion and action
prob04929  GnRH secretion
prob04933  AGE-RAGE signaling pathway in diabetic complications
prob04934  Cushing syndrome
prob04935  Growth hormone synthesis, secretion and action
prob04961  Endocrine and other factor-regulated calcium reabsorption
prob04970  Salivary secretion
prob04971  Gastric acid secretion
prob04972  Pancreatic secretion
prob04973  Carbohydrate digestion and absorption
prob05010  Alzheimer disease
prob05016  Huntington disease
prob05017  Spinocerebellar ataxia
prob05022  Pathways of neurodegeneration - multiple diseases
prob05142  Chagas disease
prob05143  African trypanosomiasis
prob05146  Amoebiasis
prob05163  Human cytomegalovirus infection
prob05200  Pathways in cancer
prob05415  Diabetic cardiomyopathy
prob05417  Lipid and atherosclerosis
Module
prob_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:prob00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    127221392 (Plcb1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    127221392 (Plcb1)
   04310 Wnt signaling pathway
    127221392 (Plcb1)
   04371 Apelin signaling pathway
    127221392 (Plcb1)
   04020 Calcium signaling pathway
    127221392 (Plcb1)
   04070 Phosphatidylinositol signaling system
    127221392 (Plcb1)
   04072 Phospholipase D signaling pathway
    127221392 (Plcb1)
   04071 Sphingolipid signaling pathway
    127221392 (Plcb1)
   04022 cGMP-PKG signaling pathway
    127221392 (Plcb1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    127221392 (Plcb1)
   04081 Hormone signaling
    127221392 (Plcb1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    127221392 (Plcb1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    127221392 (Plcb1)
   04613 Neutrophil extracellular trap formation
    127221392 (Plcb1)
   04621 NOD-like receptor signaling pathway
    127221392 (Plcb1)
   04062 Chemokine signaling pathway
    127221392 (Plcb1)
  09152 Endocrine system
   04911 Insulin secretion
    127221392 (Plcb1)
   04922 Glucagon signaling pathway
    127221392 (Plcb1)
   04929 GnRH secretion
    127221392 (Plcb1)
   04912 GnRH signaling pathway
    127221392 (Plcb1)
   04915 Estrogen signaling pathway
    127221392 (Plcb1)
   04921 Oxytocin signaling pathway
    127221392 (Plcb1)
   04926 Relaxin signaling pathway
    127221392 (Plcb1)
   04935 Growth hormone synthesis, secretion and action
    127221392 (Plcb1)
   04918 Thyroid hormone synthesis
    127221392 (Plcb1)
   04919 Thyroid hormone signaling pathway
    127221392 (Plcb1)
   04928 Parathyroid hormone synthesis, secretion and action
    127221392 (Plcb1)
   04916 Melanogenesis
    127221392 (Plcb1)
   04924 Renin secretion
    127221392 (Plcb1)
   04925 Aldosterone synthesis and secretion
    127221392 (Plcb1)
   04927 Cortisol synthesis and secretion
    127221392 (Plcb1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    127221392 (Plcb1)
   04270 Vascular smooth muscle contraction
    127221392 (Plcb1)
  09154 Digestive system
   04970 Salivary secretion
    127221392 (Plcb1)
   04971 Gastric acid secretion
    127221392 (Plcb1)
   04972 Pancreatic secretion
    127221392 (Plcb1)
   04973 Carbohydrate digestion and absorption
    127221392 (Plcb1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    127221392 (Plcb1)
  09156 Nervous system
   04724 Glutamatergic synapse
    127221392 (Plcb1)
   04725 Cholinergic synapse
    127221392 (Plcb1)
   04728 Dopaminergic synapse
    127221392 (Plcb1)
   04726 Serotonergic synapse
    127221392 (Plcb1)
   04720 Long-term potentiation
    127221392 (Plcb1)
   04730 Long-term depression
    127221392 (Plcb1)
   04723 Retrograde endocannabinoid signaling
    127221392 (Plcb1)
  09157 Sensory system
   04742 Taste transduction
    127221392 (Plcb1)
   04750 Inflammatory mediator regulation of TRP channels
    127221392 (Plcb1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    127221392 (Plcb1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    127221392 (Plcb1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    127221392 (Plcb1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    127221392 (Plcb1)
   05142 Chagas disease
    127221392 (Plcb1)
   05143 African trypanosomiasis
    127221392 (Plcb1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    127221392 (Plcb1)
   05016 Huntington disease
    127221392 (Plcb1)
   05017 Spinocerebellar ataxia
    127221392 (Plcb1)
   05022 Pathways of neurodegeneration - multiple diseases
    127221392 (Plcb1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    127221392 (Plcb1)
   05415 Diabetic cardiomyopathy
    127221392 (Plcb1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    127221392 (Plcb1)
   04934 Cushing syndrome
    127221392 (Plcb1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:prob04131]
    127221392 (Plcb1)
Enzymes [BR:prob01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     127221392 (Plcb1)
Membrane trafficking [BR:prob04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    127221392 (Plcb1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    127221392 (Plcb1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 127221392
NCBI-ProteinID: XP_051039269
Position
Unknown
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTSEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVEQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYISLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETSSEAPSETRTTPAENGVNHTTSLAPKPPSQAPHSQPAPGSVKAPAKTEDLVQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKTEPGSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQMDLEQEYQDKFKRLPLEILEFVQEAMKGKISEESNHGSAPPSLTSDPGKGNHKSPSS
EEVEGENQGREFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggctggggctcagcccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgttactccc
attattttgaggactgatcctcagggatttttcttttactggacagatcaaaataaggag
acagagctgttagatctcagccttgtcaaggatgccaggtgtgggaagcatgccaaagct
cccaaggaccccaagttacgtgaacttctggatgttgggaacatcgggcacttggagcag
cgcatgatcacagtggtgtatgggcctgacctggtgaacatctctcacttgaatcttgtg
gctttccaagaggaagtggccaaggaatggacaagtgaggtttttagcttggcaacaaac
ctcctggctcagaacatgtccagggacgcatttctggagaaagcatatacgaagctcaag
cttcaggtcactccagaagggcgcattcctctaaaaaacatctaccgattgttttcagca
gatcggaaacgagttgaaactgcactagaggcttgtagtcttccatcttcaaggaacgat
tctatacctcaagaggatttcactccagatgtatacagagttttcctgaacaatctttgt
ccccgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccgtacctt
actgtggagcagatgatggatttcatcaacctcaagcagagagacccccggctcaatgag
atactttacccacctctgaagcaagaacaggtccaagtgttgattgagaagtatgagccc
aacagcagccttgccaagaaagggcagatgtcagtggatggattcatgcgctacctgagt
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagacatgtctcag
cccctgtctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctgggaactcctctgtagagatgtatcgtcaggtgctcctgtctggatgtcgctgtgtg
gagctggactgctggaagggaaggacagcagaggaagagcctgtcatcacccatggattt
accatgacaacagaaatatccttcaaggaagtcatagaagccatcgcagagtgtgcgttc
aagacttcaccttttcccatcctcctgtcctttgagaaccacgtggattcccccaagcag
caagccaagatggccgagtattgccgattaatctttggtgatgccctccttatggagcca
ctggaaaaatacccactggagtctggagttcctcttccaagccctatggatttgatgtat
aaaatcttggtgaaaaacaagaagaaatcacacaagtcatcagaggggagtggcaaaaag
aagctgtctgagcaagcctccaacacgtacagcgactcctccagtgtgttcgagccctca
tctccaggagctggggaagcagatacggagagtgacgacgatgatgacgatgatgactgt
aaaaagtcttccatggatgagggaactgcgggcagtgaggccatggccacagaagagatg
tcaaacctcgtgaactatattcagcctgtcaagtttgagtcctttgaaatttcaaaaaaa
agaaataaaagctttgaaatgtcttccttcgtggaaaccaaaggacttgaacaacttaca
aagtctccagtggaatttgtagaatacaacaagatgcaacttagcaggatataccccaaa
ggaacacgtgtggactcctctaactacatgccacagctcttctggaatgctggctgtcag
atggtggcactcaatttccagacagtggatctagctatgcagataaacatgggcatgtat
gaatacaatggtaagagtggctacagactaaaaccagagtttatgaggaggccggacaag
cattttgatccatttactgaaggaatcgtagatgggatagtagccaacactttatccgtt
aagattatttcaggtcagtttctttctgataagaaggttgggacttatgtggaagtggac
atgtttggtttgcctgtggacacaaggaggaaagcatttaagaccaagacatcccaagga
aatgctgtaaatcctgtctgggaagaagaacctattgtgttcaaaaaggtagttctgcct
tctctggcctgtttgagaatagcagcctatgaagaaggaggtaaatttattggccaccgg
atcttgcctgtgcaggctattcggccaggctatcactatatctccctgcggaatgagagg
aaccagcccctgatgctcccagctgtctttgtctacatagaagtcaaagactatgtgcca
gacacatatgcagatgtgattgaagctctgtcgaacccaatccgatatgtcaatctgatg
gagcagagagctaagcagctggctgcactgacgctggaggatgaagaggaagtaaagaaa
gaggctgaccctggagaaacatcatcagaggcaccaagtgaaaccaggacaactccggca
gaaaatggggtgaatcacacaacatcccttgcacccaaaccaccttcccaggctccacac
agccagccagctccaggttctgtaaaggcacccgccaaaacagaagacctggtccagagt
gtgttaacagaagtagaggcacagaccattgaagagctcaagcaacagaaatcatttgtg
aaacttcaaaagaagcactacaaggaaatgaaagacctggtcaagagacaccacaagaaa
accacggagctcatcaaggagcacaccaccaagtacaatgagattcagaatgactacttg
cgacggagggcggccttggaaaagtctgccaagaaggacagcaagaaaaaaactgaaccc
ggcagccctgaccatggttcatcggccattgagcaagacctcgctgctctggatgcagaa
atgacccagaagttaatagacttgaaggacaagcagcaacagcagctgcttaatcttcgg
caagagcagtattacagcgagaagtaccagaagcgagagcacatcaaactgcttattcag
aagctgacagatgttgctgaagagtgtcagaataaccagctaaagaagctcaaggagatc
tgtgagaaagagaagaaggaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagccaagtccaaagacaaaagccagatggaagaggagaagacagagatgatccgg
tcctacatccaggaggtggtacagtacatcaagaggttagaggaagcacaaagtaaaaga
caagaaaaacttgtggagaaacacaaagagatacgccagcagatcctggatgagaagccc
aagctgcaaatggatctggaacaagaataccaagacaagtttaaaagactgcccctggag
attctggagttcgtacaagaggccatgaaagggaagatcagtgaagagagcaaccacggt
tctgcccctccttccctgacctcagaccctggaaaggggaaccacaagtctccctccagt
gaggaagtagaaggagaaaaccaaggaagagagtttgatactcctctgtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (6)   
   Pfam (6)   
All databases (12)   

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