KEGG   Piliocolobus tephrosceles (Ugandan red Colobus): 111546451
Entry
111546451         CDS       T07491                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pteh  Piliocolobus tephrosceles (Ugandan red Colobus)
Pathway
pteh00562  Inositol phosphate metabolism
pteh01100  Metabolic pathways
pteh04015  Rap1 signaling pathway
pteh04020  Calcium signaling pathway
pteh04022  cGMP-PKG signaling pathway
pteh04062  Chemokine signaling pathway
pteh04070  Phosphatidylinositol signaling system
pteh04071  Sphingolipid signaling pathway
pteh04072  Phospholipase D signaling pathway
pteh04081  Hormone signaling
pteh04082  Neuroactive ligand signaling
pteh04261  Adrenergic signaling in cardiomyocytes
pteh04270  Vascular smooth muscle contraction
pteh04310  Wnt signaling pathway
pteh04371  Apelin signaling pathway
pteh04540  Gap junction
pteh04611  Platelet activation
pteh04613  Neutrophil extracellular trap formation
pteh04621  NOD-like receptor signaling pathway
pteh04713  Circadian entrainment
pteh04720  Long-term potentiation
pteh04723  Retrograde endocannabinoid signaling
pteh04724  Glutamatergic synapse
pteh04725  Cholinergic synapse
pteh04726  Serotonergic synapse
pteh04728  Dopaminergic synapse
pteh04730  Long-term depression
pteh04742  Taste transduction
pteh04750  Inflammatory mediator regulation of TRP channels
pteh04911  Insulin secretion
pteh04912  GnRH signaling pathway
pteh04915  Estrogen signaling pathway
pteh04916  Melanogenesis
pteh04918  Thyroid hormone synthesis
pteh04919  Thyroid hormone signaling pathway
pteh04921  Oxytocin signaling pathway
pteh04922  Glucagon signaling pathway
pteh04924  Renin secretion
pteh04925  Aldosterone synthesis and secretion
pteh04926  Relaxin signaling pathway
pteh04927  Cortisol synthesis and secretion
pteh04928  Parathyroid hormone synthesis, secretion and action
pteh04929  GnRH secretion
pteh04933  AGE-RAGE signaling pathway in diabetic complications
pteh04934  Cushing syndrome
pteh04935  Growth hormone synthesis, secretion and action
pteh04961  Endocrine and other factor-regulated calcium reabsorption
pteh04970  Salivary secretion
pteh04971  Gastric acid secretion
pteh04972  Pancreatic secretion
pteh04973  Carbohydrate digestion and absorption
pteh05010  Alzheimer disease
pteh05016  Huntington disease
pteh05017  Spinocerebellar ataxia
pteh05022  Pathways of neurodegeneration - multiple diseases
pteh05142  Chagas disease
pteh05143  African trypanosomiasis
pteh05146  Amoebiasis
pteh05163  Human cytomegalovirus infection
pteh05200  Pathways in cancer
pteh05415  Diabetic cardiomyopathy
pteh05417  Lipid and atherosclerosis
Module
pteh_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pteh00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    111546451 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    111546451 (PLCB4)
   04310 Wnt signaling pathway
    111546451 (PLCB4)
   04371 Apelin signaling pathway
    111546451 (PLCB4)
   04020 Calcium signaling pathway
    111546451 (PLCB4)
   04070 Phosphatidylinositol signaling system
    111546451 (PLCB4)
   04072 Phospholipase D signaling pathway
    111546451 (PLCB4)
   04071 Sphingolipid signaling pathway
    111546451 (PLCB4)
   04022 cGMP-PKG signaling pathway
    111546451 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    111546451 (PLCB4)
   04081 Hormone signaling
    111546451 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    111546451 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    111546451 (PLCB4)
   04613 Neutrophil extracellular trap formation
    111546451 (PLCB4)
   04621 NOD-like receptor signaling pathway
    111546451 (PLCB4)
   04062 Chemokine signaling pathway
    111546451 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    111546451 (PLCB4)
   04922 Glucagon signaling pathway
    111546451 (PLCB4)
   04929 GnRH secretion
    111546451 (PLCB4)
   04912 GnRH signaling pathway
    111546451 (PLCB4)
   04915 Estrogen signaling pathway
    111546451 (PLCB4)
   04921 Oxytocin signaling pathway
    111546451 (PLCB4)
   04926 Relaxin signaling pathway
    111546451 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    111546451 (PLCB4)
   04918 Thyroid hormone synthesis
    111546451 (PLCB4)
   04919 Thyroid hormone signaling pathway
    111546451 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    111546451 (PLCB4)
   04916 Melanogenesis
    111546451 (PLCB4)
   04924 Renin secretion
    111546451 (PLCB4)
   04925 Aldosterone synthesis and secretion
    111546451 (PLCB4)
   04927 Cortisol synthesis and secretion
    111546451 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    111546451 (PLCB4)
   04270 Vascular smooth muscle contraction
    111546451 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    111546451 (PLCB4)
   04971 Gastric acid secretion
    111546451 (PLCB4)
   04972 Pancreatic secretion
    111546451 (PLCB4)
   04973 Carbohydrate digestion and absorption
    111546451 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    111546451 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    111546451 (PLCB4)
   04725 Cholinergic synapse
    111546451 (PLCB4)
   04728 Dopaminergic synapse
    111546451 (PLCB4)
   04726 Serotonergic synapse
    111546451 (PLCB4)
   04720 Long-term potentiation
    111546451 (PLCB4)
   04730 Long-term depression
    111546451 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    111546451 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    111546451 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    111546451 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    111546451 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    111546451 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    111546451 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    111546451 (PLCB4)
   05142 Chagas disease
    111546451 (PLCB4)
   05143 African trypanosomiasis
    111546451 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    111546451 (PLCB4)
   05016 Huntington disease
    111546451 (PLCB4)
   05017 Spinocerebellar ataxia
    111546451 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    111546451 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    111546451 (PLCB4)
   05415 Diabetic cardiomyopathy
    111546451 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    111546451 (PLCB4)
   04934 Cushing syndrome
    111546451 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pteh04131]
    111546451 (PLCB4)
Enzymes [BR:pteh01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     111546451 (PLCB4)
Membrane trafficking [BR:pteh04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    111546451 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    111546451 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 111546451
NCBI-ProteinID: XP_031790556
Ensembl: ENSPTEG00000002566
UniProt: A0A8C9GFF1
Position
20:complement(52662309..52928364)
AA seq 1187 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGIDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPTAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV
NT seq 3564 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatacgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgagtttggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgcta
gaatgctccctcatcaacagtattcggtcaggagccataccaaaggatcccaaaatcttg
gctgctcttgaagctgttggaaaatcagaaaatgatctggaaggtcggatagtttgtgtc
tgcagtggcatagatctagtgaacattagttttacctacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacgtgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cccacggcatttacttacgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattt
ccattttatgatgccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagat
ttgaagaaaaaaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aatgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacttatctgactggcagacagtttggtgggaag
tcttcggtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgctgggatggaaaaggtgaagaccaggaaccaataataactcatgggaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcgcttgaatcacat
ccacttgaaccaggcaggcctttgccatcccccaatgacctcaaaagaaaaatactcata
aaaaacaagcggctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatg
atggaagctggagaatctgcctccccagcaaacatcttagaggatgataatgaagaggag
atcgaaagtgctgaccaagaggaggaagctcaccccgaattcaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcctcagat
gaccttgaacatgaaaacaacaaaaagggcctggtaactgtagaagatgagcaggcatgg
atggcgtcttataaatatgtaggtgctaccactaatatccatccatatttgtccacaatg
atcaactacgcccagcctgtaaagtttcaaggtttccatgtggcagaagaacgcaatatt
cattataacatgtcttcttttaatgaatcagtcggtcttggctacttgaagacacatgca
attgaatttgtcaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaattcgagtataat
ggatcgtgcgggtaccttctcaaaccagatttcatgaggcggcctgatcgaacatttgac
cccttctctgaaactcccgttgatggcgttattgcagccacttgctcagtgcaggttata
tcaggtcaattcttatcagataagaaaattggcacctatgtagaagtggatatgtatggg
ttgcccacggacaccatacgtaaggaattccgaactcgtatggttatgaataatggactg
aatccagtttacaatgaagagtcattcgtatttcggaaggtgatcctgccagacctggct
gtcttgagaatagcagtgtatgatgataacaacaagctgattggccagaggatcctccca
cttgatggcctccaagcaggataccgacacatttcccttcgaaatgagggaaataaacca
ttatcactgccaaccattttctgcaatattgttcttaaaacatacgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctctcaattacagaaaagaga
gcagaccaaatgagagctatgggaattgaaactagtgacatagccgatgtgcccagtgac
acttccaaaaatgacaagaaaggaaaggccaacaccgccaaagcaaatgtgacccctcag
agcagctctgagctcagaccaaccaccacagctgccctggcctctggtgtggaagccaag
aaaggtattgaacttatccctcaagtaaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacagcagaaagagctaaattctttaaagaagaaacatgcaaag
gagcacagtaccatgcagaagttacactgcacgcaagttgacaaaattgtggcacagtat
gacaaagagaagtcgactcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtcttgaaatgaaaaaagaaacagaaattaaaattcagacgctgacatcagat
cacaaatctaaggtcaaagagattgtagcacagcacacaaaggaatggtcagaaatgatc
aatacccacagtgctgaggagcaagaaatccgagacctgcacctcagccagcagtgtgag
ctgctgaaaaagctactcatcagtgcccacgagcagcaaacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaggcagaacgggaaaggcgagtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaagagactcgcaatgaag
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacatctagaattcctagag
aaacagaatgagcaggcgaaggagatgcagcagatggtgaaattggaagccgagatggac
cgcagaccagcaacagtagtatga

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (9)   
   Pfam (9)   
All databases (15)   

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