KEGG   Panthera tigris altaica (Amur tiger): 102961121
Entry
102961121         CDS       T02988                                 
Symbol
PLCB1
Name
(RefSeq) phospholipase C beta 1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
ptg00562  Inositol phosphate metabolism
ptg01100  Metabolic pathways
ptg04015  Rap1 signaling pathway
ptg04020  Calcium signaling pathway
ptg04022  cGMP-PKG signaling pathway
ptg04062  Chemokine signaling pathway
ptg04070  Phosphatidylinositol signaling system
ptg04071  Sphingolipid signaling pathway
ptg04072  Phospholipase D signaling pathway
ptg04081  Hormone signaling
ptg04082  Neuroactive ligand signaling
ptg04261  Adrenergic signaling in cardiomyocytes
ptg04270  Vascular smooth muscle contraction
ptg04310  Wnt signaling pathway
ptg04371  Apelin signaling pathway
ptg04540  Gap junction
ptg04611  Platelet activation
ptg04613  Neutrophil extracellular trap formation
ptg04621  NOD-like receptor signaling pathway
ptg04713  Circadian entrainment
ptg04720  Long-term potentiation
ptg04723  Retrograde endocannabinoid signaling
ptg04724  Glutamatergic synapse
ptg04725  Cholinergic synapse
ptg04726  Serotonergic synapse
ptg04728  Dopaminergic synapse
ptg04730  Long-term depression
ptg04742  Taste transduction
ptg04750  Inflammatory mediator regulation of TRP channels
ptg04911  Insulin secretion
ptg04912  GnRH signaling pathway
ptg04915  Estrogen signaling pathway
ptg04916  Melanogenesis
ptg04918  Thyroid hormone synthesis
ptg04919  Thyroid hormone signaling pathway
ptg04921  Oxytocin signaling pathway
ptg04922  Glucagon signaling pathway
ptg04924  Renin secretion
ptg04925  Aldosterone synthesis and secretion
ptg04926  Relaxin signaling pathway
ptg04927  Cortisol synthesis and secretion
ptg04928  Parathyroid hormone synthesis, secretion and action
ptg04929  GnRH secretion
ptg04933  AGE-RAGE signaling pathway in diabetic complications
ptg04934  Cushing syndrome
ptg04935  Growth hormone synthesis, secretion and action
ptg04961  Endocrine and other factor-regulated calcium reabsorption
ptg04970  Salivary secretion
ptg04971  Gastric acid secretion
ptg04972  Pancreatic secretion
ptg04973  Carbohydrate digestion and absorption
ptg05010  Alzheimer disease
ptg05016  Huntington disease
ptg05017  Spinocerebellar ataxia
ptg05022  Pathways of neurodegeneration - multiple diseases
ptg05142  Chagas disease
ptg05143  African trypanosomiasis
ptg05146  Amoebiasis
ptg05163  Human cytomegalovirus infection
ptg05200  Pathways in cancer
ptg05415  Diabetic cardiomyopathy
ptg05417  Lipid and atherosclerosis
Module
ptg_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ptg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102961121 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    102961121 (PLCB1)
   04310 Wnt signaling pathway
    102961121 (PLCB1)
   04371 Apelin signaling pathway
    102961121 (PLCB1)
   04020 Calcium signaling pathway
    102961121 (PLCB1)
   04070 Phosphatidylinositol signaling system
    102961121 (PLCB1)
   04072 Phospholipase D signaling pathway
    102961121 (PLCB1)
   04071 Sphingolipid signaling pathway
    102961121 (PLCB1)
   04022 cGMP-PKG signaling pathway
    102961121 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    102961121 (PLCB1)
   04081 Hormone signaling
    102961121 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102961121 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102961121 (PLCB1)
   04613 Neutrophil extracellular trap formation
    102961121 (PLCB1)
   04621 NOD-like receptor signaling pathway
    102961121 (PLCB1)
   04062 Chemokine signaling pathway
    102961121 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    102961121 (PLCB1)
   04922 Glucagon signaling pathway
    102961121 (PLCB1)
   04929 GnRH secretion
    102961121 (PLCB1)
   04912 GnRH signaling pathway
    102961121 (PLCB1)
   04915 Estrogen signaling pathway
    102961121 (PLCB1)
   04921 Oxytocin signaling pathway
    102961121 (PLCB1)
   04926 Relaxin signaling pathway
    102961121 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    102961121 (PLCB1)
   04918 Thyroid hormone synthesis
    102961121 (PLCB1)
   04919 Thyroid hormone signaling pathway
    102961121 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    102961121 (PLCB1)
   04916 Melanogenesis
    102961121 (PLCB1)
   04924 Renin secretion
    102961121 (PLCB1)
   04925 Aldosterone synthesis and secretion
    102961121 (PLCB1)
   04927 Cortisol synthesis and secretion
    102961121 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102961121 (PLCB1)
   04270 Vascular smooth muscle contraction
    102961121 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    102961121 (PLCB1)
   04971 Gastric acid secretion
    102961121 (PLCB1)
   04972 Pancreatic secretion
    102961121 (PLCB1)
   04973 Carbohydrate digestion and absorption
    102961121 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    102961121 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    102961121 (PLCB1)
   04725 Cholinergic synapse
    102961121 (PLCB1)
   04728 Dopaminergic synapse
    102961121 (PLCB1)
   04726 Serotonergic synapse
    102961121 (PLCB1)
   04720 Long-term potentiation
    102961121 (PLCB1)
   04730 Long-term depression
    102961121 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    102961121 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    102961121 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    102961121 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    102961121 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102961121 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    102961121 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102961121 (PLCB1)
   05142 Chagas disease
    102961121 (PLCB1)
   05143 African trypanosomiasis
    102961121 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102961121 (PLCB1)
   05016 Huntington disease
    102961121 (PLCB1)
   05017 Spinocerebellar ataxia
    102961121 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    102961121 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102961121 (PLCB1)
   05415 Diabetic cardiomyopathy
    102961121 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102961121 (PLCB1)
   04934 Cushing syndrome
    102961121 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ptg04131]
    102961121 (PLCB1)
Enzymes [BR:ptg01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102961121 (PLCB1)
Membrane trafficking [BR:ptg04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102961121 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102961121 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PI-PLC-Y PLCB1-4-like_EFh EF-hand_like PH_14
Other DBs
NCBI-GeneID: 102961121
NCBI-ProteinID: XP_015395086
Position
Un
AA seq 1115 aa
MITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKL
QVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP
RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN
DSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA
GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK
TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK
ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCK
KSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFETSKKRNRSFEMSSFVETKGLEQLTK
SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYE
YNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDM
FGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRI
LPVQAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLME
QRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQAPHS
QPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKPFVKLQKKHYKEMKDLVKRHHKKT
TDLIKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEM
TQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEIC
EKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQ
EKLVEKHKEIRQQILDEKPKLQMDLEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSS
APPSLASDPGKLNHRPPSSEELEGDNPGKEFDTPL
NT seq 3348 nt   +upstreamnt  +downstreamnt
atgataacggtggtgtacgggcctgacttagttaacatctcccatttgaatctcgtggct
ttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaacctg
ctggcccaaaacatgtccagagacgcatttctggaaaaagcctatacgaagcttaagctg
caagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagcagac
cggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgattca
atacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgccct
cgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccataccttacg
gttgatcagatgatggattttatcaacctgaagcagcgagatcctcggctaaatgaaata
ctttacccacctttaaagcaagagcaagtccaagtactgattgagaagtatgagcctaac
gatagccttgccaaaaaaggacagatatcagtggatggctttatgcgctatctgagtgga
gaagaaaatggagtcgtttcgcctgagaaactggatttgaatgaagatatgtctcagccc
ctttctcactatttcatcaattcctcacacaacacctacctcacagctggccagttggct
ggaaattcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtggag
ttggactgctggaaaggacggactgcagaagaggaaccagtcatcacccatgggttcacc
atgacaactgaaatatccttcaaggaagtgatagaagcaattgctgagtgtgcatttaag
acgtcaccttttccaattctgctttcatttgagaaccacgtagattccccaaagcagcaa
gccaagatggcagagtattgccgactgatctttggagatgctcttctcatggaaccactg
gaaaaatacccactggaatctggagttcctcttccaagccctatggatttaatgtacaaa
attttggtgaaaaataagaagaaatcgcataagtcatcagaaggaagtggcaaaaagaag
ctctcagaacaagcctccaacacgtacagtgactcgtccagcgtgtttgagccctcatct
ccaggagccggggaagctgatactgagagtgacgacgatgatgatgatgacgactgtaaa
aaatcttcaatggacgagggtactgctggcagtgaggccatggccacagaagagatgtct
aacctggtgaactatattcagccagtcaagtttgagtcctttgaaacttcaaaaaaaaga
aatagaagttttgaaatgtcttccttcgtggaaaccaaaggacttgagcaactgacaaag
tctccagtggaatttgtagaatataacaaaatgcagctcagcaggatatatccaaaagga
acccgtgtggattcatccaactacatgcctcagctcttctggaatgctggttgccaaatg
gttgcacttaattttcaaactgtggacctggctatgcaaataaatatggggatgtatgaa
tacaatgggaaaagtggctacagattaaagccagagttcatgaggagacccgacaagcac
tttgatccattcaccgaaggcatcgtagatgggatagtggccaacactttatctgtgaag
attatttcaggtcagtttctttctgataagaaagttgggacctatgtggaagtggatatg
tttggtttgcctgtggacacaaggaggaaggcatttaagaccaaaacatcacaaggaaat
gctgtaaatcctgtctgggaagaagagcccattgtgttcaaaaaggtggttcttccttct
ctggcctgtttgaggatagcagtttatgaagaaggaggtaaatttatcggtcaccggatc
ttgcctgtacaggcaattcggccaggctatcactacatctgtctgcggaatgagaggaac
cagcctctgatgctcccagctgtctttgtctacatagaggtgaaagactatgtcccagat
acatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatggag
cagagagcaaagcaactggctgctttgacactggaagatgaagaagaagtaaagaaagag
gctgatcctggggaaacaccatcagaagctccaagtgaagccaggacaactccagcagaa
aacggagtgaatcacactacatctctggcacccaaaccaccctcccaggctccccacagc
caaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagtgtt
ttaacagaagtggaagcacagactatcgaagagctaaagcaacagaaaccgtttgtgaaa
cttcaaaagaagcactacaaagaaatgaaagacctggtgaaaagacaccacaagaaaacc
actgaccttatcaaagaacacactacaaaatataatgaaattcagaatgactacttgaga
aggagggcagctttggaaaagacagccaaaaaggatagtaagaaaaaatcagaacccagc
agtcctgaccatggttcatcaacaattgagcaagatcttgctgccctagatgctgaaatg
acccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcgacaa
gaacagtattacagtgagaaataccagaagcgagaacatattaaactgcttattcagaaa
ttgacggatgttgccgaagaatgtcagaacaatcagctgaagaagctcaaagaaatctgt
gagaaggagaagaaggaattaaagaagaaaatggataaaaaaaggcaggagaagatcaca
gaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccggtca
tacatccaggaggtggtacagtacatcaagaggttagaagaggcacaaagtaaacggcaa
gaaaaacttgtagagaaacacaaggagatccgtcagcagatcctggatgaaaagcccaag
ctgcagatggatctggagcaagagtaccaagacaagttcaaaaggctgcccctggagatc
ttggagttcgtgcaggaagccatgaaagggaagatcagtgaagacagcaatcacagttct
gcccctccctccctggcctcagaccctggaaaactgaaccacaggcctccttccagtgag
gagctagaaggggacaacccaggaaaagagtttgatactcctctgtga

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (6)   
   Pfam (6)   
All databases (11)   

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