KEGG   Panthera tigris altaica (Amur tiger): 102961437
Entry
102961437         CDS       T02988                                 
Symbol
PLCB3
Name
(RefSeq) phospholipase C beta 3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
ptg00562  Inositol phosphate metabolism
ptg01100  Metabolic pathways
ptg04015  Rap1 signaling pathway
ptg04020  Calcium signaling pathway
ptg04022  cGMP-PKG signaling pathway
ptg04062  Chemokine signaling pathway
ptg04070  Phosphatidylinositol signaling system
ptg04071  Sphingolipid signaling pathway
ptg04072  Phospholipase D signaling pathway
ptg04081  Hormone signaling
ptg04082  Neuroactive ligand signaling
ptg04261  Adrenergic signaling in cardiomyocytes
ptg04270  Vascular smooth muscle contraction
ptg04310  Wnt signaling pathway
ptg04371  Apelin signaling pathway
ptg04540  Gap junction
ptg04611  Platelet activation
ptg04613  Neutrophil extracellular trap formation
ptg04621  NOD-like receptor signaling pathway
ptg04713  Circadian entrainment
ptg04720  Long-term potentiation
ptg04723  Retrograde endocannabinoid signaling
ptg04724  Glutamatergic synapse
ptg04725  Cholinergic synapse
ptg04726  Serotonergic synapse
ptg04728  Dopaminergic synapse
ptg04730  Long-term depression
ptg04742  Taste transduction
ptg04750  Inflammatory mediator regulation of TRP channels
ptg04911  Insulin secretion
ptg04912  GnRH signaling pathway
ptg04915  Estrogen signaling pathway
ptg04916  Melanogenesis
ptg04918  Thyroid hormone synthesis
ptg04919  Thyroid hormone signaling pathway
ptg04921  Oxytocin signaling pathway
ptg04922  Glucagon signaling pathway
ptg04924  Renin secretion
ptg04925  Aldosterone synthesis and secretion
ptg04926  Relaxin signaling pathway
ptg04927  Cortisol synthesis and secretion
ptg04928  Parathyroid hormone synthesis, secretion and action
ptg04929  GnRH secretion
ptg04933  AGE-RAGE signaling pathway in diabetic complications
ptg04934  Cushing syndrome
ptg04935  Growth hormone synthesis, secretion and action
ptg04961  Endocrine and other factor-regulated calcium reabsorption
ptg04970  Salivary secretion
ptg04971  Gastric acid secretion
ptg04972  Pancreatic secretion
ptg04973  Carbohydrate digestion and absorption
ptg05010  Alzheimer disease
ptg05016  Huntington disease
ptg05017  Spinocerebellar ataxia
ptg05022  Pathways of neurodegeneration - multiple diseases
ptg05142  Chagas disease
ptg05143  African trypanosomiasis
ptg05146  Amoebiasis
ptg05163  Human cytomegalovirus infection
ptg05200  Pathways in cancer
ptg05415  Diabetic cardiomyopathy
ptg05417  Lipid and atherosclerosis
Module
ptg_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ptg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102961437 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    102961437 (PLCB3)
   04310 Wnt signaling pathway
    102961437 (PLCB3)
   04371 Apelin signaling pathway
    102961437 (PLCB3)
   04020 Calcium signaling pathway
    102961437 (PLCB3)
   04070 Phosphatidylinositol signaling system
    102961437 (PLCB3)
   04072 Phospholipase D signaling pathway
    102961437 (PLCB3)
   04071 Sphingolipid signaling pathway
    102961437 (PLCB3)
   04022 cGMP-PKG signaling pathway
    102961437 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    102961437 (PLCB3)
   04081 Hormone signaling
    102961437 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102961437 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102961437 (PLCB3)
   04613 Neutrophil extracellular trap formation
    102961437 (PLCB3)
   04621 NOD-like receptor signaling pathway
    102961437 (PLCB3)
   04062 Chemokine signaling pathway
    102961437 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    102961437 (PLCB3)
   04922 Glucagon signaling pathway
    102961437 (PLCB3)
   04929 GnRH secretion
    102961437 (PLCB3)
   04912 GnRH signaling pathway
    102961437 (PLCB3)
   04915 Estrogen signaling pathway
    102961437 (PLCB3)
   04921 Oxytocin signaling pathway
    102961437 (PLCB3)
   04926 Relaxin signaling pathway
    102961437 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    102961437 (PLCB3)
   04918 Thyroid hormone synthesis
    102961437 (PLCB3)
   04919 Thyroid hormone signaling pathway
    102961437 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    102961437 (PLCB3)
   04916 Melanogenesis
    102961437 (PLCB3)
   04924 Renin secretion
    102961437 (PLCB3)
   04925 Aldosterone synthesis and secretion
    102961437 (PLCB3)
   04927 Cortisol synthesis and secretion
    102961437 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102961437 (PLCB3)
   04270 Vascular smooth muscle contraction
    102961437 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    102961437 (PLCB3)
   04971 Gastric acid secretion
    102961437 (PLCB3)
   04972 Pancreatic secretion
    102961437 (PLCB3)
   04973 Carbohydrate digestion and absorption
    102961437 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    102961437 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    102961437 (PLCB3)
   04725 Cholinergic synapse
    102961437 (PLCB3)
   04728 Dopaminergic synapse
    102961437 (PLCB3)
   04726 Serotonergic synapse
    102961437 (PLCB3)
   04720 Long-term potentiation
    102961437 (PLCB3)
   04730 Long-term depression
    102961437 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    102961437 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    102961437 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    102961437 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    102961437 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102961437 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    102961437 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102961437 (PLCB3)
   05142 Chagas disease
    102961437 (PLCB3)
   05143 African trypanosomiasis
    102961437 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102961437 (PLCB3)
   05016 Huntington disease
    102961437 (PLCB3)
   05017 Spinocerebellar ataxia
    102961437 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    102961437 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102961437 (PLCB3)
   05415 Diabetic cardiomyopathy
    102961437 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102961437 (PLCB3)
   04934 Cushing syndrome
    102961437 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ptg04131]
    102961437 (PLCB3)
Enzymes [BR:ptg01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102961437 (PLCB3)
Membrane trafficking [BR:ptg04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102961437 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102961437 (PLCB3)
SSDB
Motif
Pfam: PI-PLC-X PI-PLC-Y PH_14 PLCB1-4-like_EFh PLC-beta_C EF-hand_like C2
Other DBs
NCBI-GeneID: 102961437
NCBI-ProteinID: XP_015397448
Position
Un
AA seq 1075 aa
MGVSKWQEHWGGWPEGVQGSSLGHSPHSLTPAFPSRPQEASSRNLVTLRVDPNGFFLYWT
GPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNT
TFLNFMAVQDDTAKVWTEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNI
LKMFSADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGA
KGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEG
FSRYLGGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTGEXATLGQLERWHXXLLW
GCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHV
DSAKQQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHQPSTG
VPNSSIRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCLGLSNGEELGLEKPSLEPRK
SLGEEGLQRGPDALGSADREDEEEDEEEEEQADPKKPTSDEVSPAGGKRQTQRVLIPQAF
AEHLLCARHSTVYWPPERNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTR
VDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFD
PFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFN
PVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPL
CLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQVGPETCQ
ETPSQQPVTPNPTPSTLDISPRRPPGEHVFPATGAHTGSRHSDGTDGPRCWHNRHRPPSP
SPCDNLSVTQRGSSCRGGEDEKAEEEEVKRYREFQKRQVQSLLELREAQADTEAERRLEH
LRQAQQRLREIVLDAHATQFKRLKETNERCNGHAPGSGGHLSGADSESQEENTKL
NT seq 3228 nt   +upstreamnt  +downstreamnt
atgggcgtcagcaaatggcaggagcactggggtggatggccggagggagtccagggatca
agcctcggccacagccctcactcactgacccctgccttcccgtcccgtccccaggaggct
tccagtcggaacctggtgaccctgcgtgtggaccccaatggcttcttcctgtactggaca
ggacccaacatggaggtggacaccctggacatcagttccatcagggacacgcggacggga
cgttatgcccgcctgcccaaggaccccaagatccgagaggtgctgggctttggaggccct
gacacccggctggaggagaagttgatgacagtggtggccgggccagacccggtgaataca
acattcttgaacttcatggccgtgcaggatgacacagccaaggtctggaccgaggagctg
ttcaagctggctatgaacatcctggctcagaacgcctcccggaacacctttctgagaaaa
gcatacaccaagctgaagctgcaggtgaaccaggatggacggatcccagtgaagaacatc
ctgaagatgttctcagcagataagaagcgcgtcgagactgcgctggaatcctgtggcctc
aatttcaaccggagtgagtccatccggcccgacgagttctccttggaaatcttcgagcgg
ttcctgaataagctgtgtctgcggccagacattgacaagatcctgctggagataggcgcc
aagggcaagccatacctgacgctggagcagctcatggacttcatcaaccagaagcaacgg
gacccgaggctcaacgaagtgctgtacccacccctgcggccctcccaggcccggctgctc
attgagaagtatgagcccaaccagcagttcctggaacgagaccagatgtccatggagggc
ttcagccgctacctggggggtgaggagaatggaatcctgcccttggaggccctggatctg
agcgcagacatgacccagccgctaagcgcctacttcatcaactcctcacacaacacctat
ctcacaggtgagtgagccaccctcgggcagctggagcggtggcatnnnnnactgctctgg
ggctgccgctgcgtggagctggacgtgtggaaagggcggcccccggaggaggagcccttt
atcacccacggcttcaccatgaccaccgaggtgccgctgcgagacgtgctcgaggccatt
gcggaaaccgccttcaagacctcgccctaccctgtcatcctctccttcgagaaccacgtg
gactcggcaaagcagcaggccaagatggccgagtactgtcgttcgatcttcggggacgcg
ctgctcatcgacccactggacaagtacccgctggccccaggcgtccccctgcccagcccc
caggacctgatgggccgcatcctggtgaagaacaagaagcgacaccagcccagcactggt
gtccccaacagctccattcgcaagcggccgctggagcagagcaactcggccctgagcgag
agctctgccgccaccgagccctcctcacctcagctcgggtcccccagctctgacagctgc
ctgggcctgagcaatggggaagagctgggccttgagaagcccagcctggagcctcggaag
tctctgggcgaggaggggctacagcggggccctgatgctcttggatctgccgaccgtgag
gatgaggaggaagacgaggaagaggaggaacaggcagatcccaaaaagccgacctcagat
gaggtcagtcccgcgggcgggaagaggcagacgcagcgtgttttaattccccaagcgttt
gctgaacacctactgtgtgccagacacagcactgtgtactggcccccagagaggaacaaa
tgcttcgagatgtcatccttcgtggaaaccaaggccatggagcaactgaccaagagcccc
atggagtttgtggaatacaataaacaacagctcagccgcatctaccccaagggcacccgc
gtggactcctccaattatatgccccagctcttctggaacgtgggctgccagcttgtggcc
ctcaactttcagaccctggatgtggcgatgcagctgaacgcgggtgtgtttgagtacaac
gggcgcagcggctacctgctcaagcccgagttcatgcggcggccggacaagtccttcgac
cccttcaccgaagtcatcgtggacggcatcgtggccaatgccttgcgggtcaaggtgatc
tcggggcagttcctgtccgacaggaaggtgggcatctacgtggaggtggacatgtttggc
ctccccgttgacacacggcgcaagtaccgcactcggacgtctcaggggaactcgttcaat
cctgtgtgggatgaggaaccctttgacttccccaaggtggtgctccccacgctggcttcg
ctgcgcatcgcggcctttgaggaaggcggcaagtttgtggggcatcggattctgcccgtc
tctgccatccgttcagggtaccactacatttgcctgcggaatgaggccaaccagccgctc
tgcctgccggccctgctcatatacaccgaagcctccgactatattcctgatgaccaccag
gactacgcagaggccctgatcaaccccatcaagcatgtcagcctgatggaccagagggcc
aagcagttggccgccctcatcggggagagcgaggctcaggttggcccagaaacctgccag
gagactccatctcagcagccggtgaccccaaaccccacacccagcacactggacatctcc
ccgcgccggcccccgggcgagcacgtatttccagcaaccggtgcccacacaggctcccgt
cattcggatggaactgatgggcctcgttgttggcataacagacaccgccctcccagcccg
agtccctgtgacaacctgagtgtcacccagaggggttcttcctgcagaggcggggaggac
gagaaggcggaggaggaagaggtgaagcggtatcgagagttccagaagagacaggtgcag
agtctgctggagctgcgggaggcccaggcggatacagaggccgagcggaggctggagcat
ctgcgacaggctcagcagaggctcagggagatcgtcctggatgctcacgcgacccagttc
aagcggctgaaggagacgaacgagaggtgcaatggtcacgcccctgggagcggcgggcac
ctgtctggcgccgactcagagagccaagaggagaatacgaagctctga

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (7)   
   Pfam (7)   
All databases (14)   

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