KEGG   Panthera uncia (snow leopard): 125936809
Entry
125936809         CDS       T08832                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
puc  Panthera uncia (snow leopard)
Pathway
puc00562  Inositol phosphate metabolism
puc01100  Metabolic pathways
puc04015  Rap1 signaling pathway
puc04020  Calcium signaling pathway
puc04022  cGMP-PKG signaling pathway
puc04062  Chemokine signaling pathway
puc04070  Phosphatidylinositol signaling system
puc04071  Sphingolipid signaling pathway
puc04072  Phospholipase D signaling pathway
puc04081  Hormone signaling
puc04082  Neuroactive ligand signaling
puc04261  Adrenergic signaling in cardiomyocytes
puc04270  Vascular smooth muscle contraction
puc04310  Wnt signaling pathway
puc04371  Apelin signaling pathway
puc04540  Gap junction
puc04611  Platelet activation
puc04613  Neutrophil extracellular trap formation
puc04621  NOD-like receptor signaling pathway
puc04713  Circadian entrainment
puc04720  Long-term potentiation
puc04723  Retrograde endocannabinoid signaling
puc04724  Glutamatergic synapse
puc04725  Cholinergic synapse
puc04726  Serotonergic synapse
puc04728  Dopaminergic synapse
puc04730  Long-term depression
puc04742  Taste transduction
puc04750  Inflammatory mediator regulation of TRP channels
puc04911  Insulin secretion
puc04912  GnRH signaling pathway
puc04915  Estrogen signaling pathway
puc04916  Melanogenesis
puc04918  Thyroid hormone synthesis
puc04919  Thyroid hormone signaling pathway
puc04921  Oxytocin signaling pathway
puc04922  Glucagon signaling pathway
puc04924  Renin secretion
puc04925  Aldosterone synthesis and secretion
puc04926  Relaxin signaling pathway
puc04927  Cortisol synthesis and secretion
puc04928  Parathyroid hormone synthesis, secretion and action
puc04929  GnRH secretion
puc04933  AGE-RAGE signaling pathway in diabetic complications
puc04934  Cushing syndrome
puc04935  Growth hormone synthesis, secretion and action
puc04961  Endocrine and other factor-regulated calcium reabsorption
puc04970  Salivary secretion
puc04971  Gastric acid secretion
puc04972  Pancreatic secretion
puc04973  Carbohydrate digestion and absorption
puc05010  Alzheimer disease
puc05016  Huntington disease
puc05017  Spinocerebellar ataxia
puc05022  Pathways of neurodegeneration - multiple diseases
puc05142  Chagas disease
puc05143  African trypanosomiasis
puc05146  Amoebiasis
puc05163  Human cytomegalovirus infection
puc05200  Pathways in cancer
puc05415  Diabetic cardiomyopathy
puc05417  Lipid and atherosclerosis
Module
puc_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:puc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    125936809
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    125936809
   04310 Wnt signaling pathway
    125936809
   04371 Apelin signaling pathway
    125936809
   04020 Calcium signaling pathway
    125936809
   04070 Phosphatidylinositol signaling system
    125936809
   04072 Phospholipase D signaling pathway
    125936809
   04071 Sphingolipid signaling pathway
    125936809
   04022 cGMP-PKG signaling pathway
    125936809
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    125936809
   04081 Hormone signaling
    125936809
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    125936809
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    125936809
   04613 Neutrophil extracellular trap formation
    125936809
   04621 NOD-like receptor signaling pathway
    125936809
   04062 Chemokine signaling pathway
    125936809
  09152 Endocrine system
   04911 Insulin secretion
    125936809
   04922 Glucagon signaling pathway
    125936809
   04929 GnRH secretion
    125936809
   04912 GnRH signaling pathway
    125936809
   04915 Estrogen signaling pathway
    125936809
   04921 Oxytocin signaling pathway
    125936809
   04926 Relaxin signaling pathway
    125936809
   04935 Growth hormone synthesis, secretion and action
    125936809
   04918 Thyroid hormone synthesis
    125936809
   04919 Thyroid hormone signaling pathway
    125936809
   04928 Parathyroid hormone synthesis, secretion and action
    125936809
   04916 Melanogenesis
    125936809
   04924 Renin secretion
    125936809
   04925 Aldosterone synthesis and secretion
    125936809
   04927 Cortisol synthesis and secretion
    125936809
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    125936809
   04270 Vascular smooth muscle contraction
    125936809
  09154 Digestive system
   04970 Salivary secretion
    125936809
   04971 Gastric acid secretion
    125936809
   04972 Pancreatic secretion
    125936809
   04973 Carbohydrate digestion and absorption
    125936809
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    125936809
  09156 Nervous system
   04724 Glutamatergic synapse
    125936809
   04725 Cholinergic synapse
    125936809
   04728 Dopaminergic synapse
    125936809
   04726 Serotonergic synapse
    125936809
   04720 Long-term potentiation
    125936809
   04730 Long-term depression
    125936809
   04723 Retrograde endocannabinoid signaling
    125936809
  09157 Sensory system
   04742 Taste transduction
    125936809
   04750 Inflammatory mediator regulation of TRP channels
    125936809
  09159 Environmental adaptation
   04713 Circadian entrainment
    125936809
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125936809
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    125936809
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    125936809
   05142 Chagas disease
    125936809
   05143 African trypanosomiasis
    125936809
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125936809
   05016 Huntington disease
    125936809
   05017 Spinocerebellar ataxia
    125936809
   05022 Pathways of neurodegeneration - multiple diseases
    125936809
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125936809
   05415 Diabetic cardiomyopathy
    125936809
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    125936809
   04934 Cushing syndrome
    125936809
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:puc04131]
    125936809
Enzymes [BR:puc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     125936809
Membrane trafficking [BR:puc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    125936809
 Endocytosis
  Macropinocytosis
   Phospholipase C
    125936809
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 125936809
NCBI-ProteinID: XP_049507083
Position
A3
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSIRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIESADQEEEAHPEYKFGSELSADDLGHKEAVANSVKKASD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEVGSRDGPQTSNSSV
KLQNAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcaaaaggaagttccttcctttttgcaagaagga
gccgtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggagaagtgaaggcaaggaaggacaagttcta
gaatgctccctcatcaacagtattcgattgggagccaccccaaaggatcccaaaatcctg
gctgctcttgaagctgttggaaagtcagagaatgatctggaagggcgaatagtttgtgtc
tgcagtggcacagatctggtgaacatcagtttcacatacatggtggctgaaaatccggaa
gtaactaagcaatgggtagaaggactgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacctgcctcaaaaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaatcgag
cctgcagcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcgaaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttgttc
ccattttatgatgctaaaagggcaatgcagatcatcgagatgtatgagcctgatgaagat
ttgaagaaaaaaggcctcatatcaagcgatgggttttgcagatatctgatgtcagatgaa
aatgcccctgtcttcctggatcgtttagaactttaccaagaaatggaccatcctctggcc
cactacttcatcagttcttcccataacacctatctcactggccgacagtttggtggaaag
tcttccgtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaagaccaggaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcgtttgtcacatcc
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccactcgaaccaggcaggcccttaccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataagcggctgaaacctgaggtcgaaaaaaaacagcttgaagctttgaaaagcatg
atggaagctggagaatctgctgccccggttaacatcttagaggatgataatgaagaagaa
atagagagtgctgaccaagaggaggaagctcaccctgaatacaaatttggaagtgaactt
tctgctgatgacttgggtcacaaggaggctgttgcaaatagtgtcaagaaggcttcagat
gaccttgaacatgaaatcaacaaaaagggcctggttactgtagaagatgaacaggcatgg
atggcatcttataaatatgtaggtgctaccactaatatccatccatatttgtctacaatg
atcaactatgcacagcccgtaaaatttcaaggtttccatgtggctgaagagcgcaatatt
cattataacatgtcttcttttaatgagtccgttggtctaggctacttgaagacacacgcg
attgaatttgtgaattacaacaaacggcaaatgagccgcatttaccccaagggaggccgg
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcg
ctcaactatcagaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcatgcgggtaccttctcaaaccagacttcatgagacggcccgatcgaacatttgat
cccttctctgaaactcctgtcgacggggttattgcagccacttgctcagtgcaggtcata
tcaggtcagtttttatcagataagaaaattggtacatatgtagaagtggatatgtatggt
ttacccactgacaccatacgtaaggaattccgaactcgcatggtgatgaacaatggactc
aatccagtttacaatgaagaatcatttgtgtttcggaaggtgatcctccctgacctggca
gtcttgagaatagctgtgtatgacgacaacaataggctgataggccagaggattcttccg
ctggatggcctccaagcaggttatcgacacatttctcttcgaaatgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagtgat
acttctaagaatgacaagaaaggaaaggccaacactgccaaagcaaacgtgaccccgcag
agcagctctgagctcagaccaaccaccacggcggccctggggtctggagtggaagccaag
aaaggtattgaacttatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagctaaattctttaaagaagaaacatgctaag
gagcacagcaccatgcagaagctgcattgcacacaagttgacaaaattgtggcacagtat
gacaaagagaagtcgacgcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagatagtggcccagcacacaaaggaatggtcagaaatgatt
aacacccacagtgctgaggaacaagaaatccgggacctgcacctcagccagcagtgcgag
ctcctgagaaagctactgatcaacgcccacgagcagcaaacccagcagctaaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggagagtcagg
gagttaaatagcagcaacaccaaaaagtttctggaagaaagaaagagactcgccatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctggagttcctagag
aaacagaatgagcagctattgaaatcctgccatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaagttggaagccgagatggaccgcagaccagcaacagtagtgtg
aaactccagaacgcaaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (5)   
   RefSeq(pep) (5)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
Protein domain (9)   
   Pfam (9)   
All databases (21)   

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