KEGG   Pteropus vampyrus (large flying fox): 105298737
Entry
105298737         CDS       T07815                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pvp  Pteropus vampyrus (large flying fox)
Pathway
pvp00562  Inositol phosphate metabolism
pvp01100  Metabolic pathways
pvp04015  Rap1 signaling pathway
pvp04020  Calcium signaling pathway
pvp04022  cGMP-PKG signaling pathway
pvp04062  Chemokine signaling pathway
pvp04070  Phosphatidylinositol signaling system
pvp04071  Sphingolipid signaling pathway
pvp04072  Phospholipase D signaling pathway
pvp04081  Hormone signaling
pvp04082  Neuroactive ligand signaling
pvp04261  Adrenergic signaling in cardiomyocytes
pvp04270  Vascular smooth muscle contraction
pvp04310  Wnt signaling pathway
pvp04371  Apelin signaling pathway
pvp04540  Gap junction
pvp04611  Platelet activation
pvp04613  Neutrophil extracellular trap formation
pvp04621  NOD-like receptor signaling pathway
pvp04713  Circadian entrainment
pvp04720  Long-term potentiation
pvp04723  Retrograde endocannabinoid signaling
pvp04724  Glutamatergic synapse
pvp04725  Cholinergic synapse
pvp04726  Serotonergic synapse
pvp04728  Dopaminergic synapse
pvp04730  Long-term depression
pvp04742  Taste transduction
pvp04750  Inflammatory mediator regulation of TRP channels
pvp04911  Insulin secretion
pvp04912  GnRH signaling pathway
pvp04915  Estrogen signaling pathway
pvp04916  Melanogenesis
pvp04918  Thyroid hormone synthesis
pvp04919  Thyroid hormone signaling pathway
pvp04921  Oxytocin signaling pathway
pvp04922  Glucagon signaling pathway
pvp04924  Renin secretion
pvp04925  Aldosterone synthesis and secretion
pvp04926  Relaxin signaling pathway
pvp04927  Cortisol synthesis and secretion
pvp04928  Parathyroid hormone synthesis, secretion and action
pvp04929  GnRH secretion
pvp04933  AGE-RAGE signaling pathway in diabetic complications
pvp04934  Cushing syndrome
pvp04935  Growth hormone synthesis, secretion and action
pvp04961  Endocrine and other factor-regulated calcium reabsorption
pvp04970  Salivary secretion
pvp04971  Gastric acid secretion
pvp04972  Pancreatic secretion
pvp04973  Carbohydrate digestion and absorption
pvp05010  Alzheimer disease
pvp05016  Huntington disease
pvp05017  Spinocerebellar ataxia
pvp05022  Pathways of neurodegeneration - multiple diseases
pvp05142  Chagas disease
pvp05143  African trypanosomiasis
pvp05146  Amoebiasis
pvp05163  Human cytomegalovirus infection
pvp05200  Pathways in cancer
pvp05415  Diabetic cardiomyopathy
pvp05417  Lipid and atherosclerosis
Module
pvp_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pvp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    105298737 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    105298737 (PLCB4)
   04310 Wnt signaling pathway
    105298737 (PLCB4)
   04371 Apelin signaling pathway
    105298737 (PLCB4)
   04020 Calcium signaling pathway
    105298737 (PLCB4)
   04070 Phosphatidylinositol signaling system
    105298737 (PLCB4)
   04072 Phospholipase D signaling pathway
    105298737 (PLCB4)
   04071 Sphingolipid signaling pathway
    105298737 (PLCB4)
   04022 cGMP-PKG signaling pathway
    105298737 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    105298737 (PLCB4)
   04081 Hormone signaling
    105298737 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    105298737 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105298737 (PLCB4)
   04613 Neutrophil extracellular trap formation
    105298737 (PLCB4)
   04621 NOD-like receptor signaling pathway
    105298737 (PLCB4)
   04062 Chemokine signaling pathway
    105298737 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    105298737 (PLCB4)
   04922 Glucagon signaling pathway
    105298737 (PLCB4)
   04929 GnRH secretion
    105298737 (PLCB4)
   04912 GnRH signaling pathway
    105298737 (PLCB4)
   04915 Estrogen signaling pathway
    105298737 (PLCB4)
   04921 Oxytocin signaling pathway
    105298737 (PLCB4)
   04926 Relaxin signaling pathway
    105298737 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    105298737 (PLCB4)
   04918 Thyroid hormone synthesis
    105298737 (PLCB4)
   04919 Thyroid hormone signaling pathway
    105298737 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    105298737 (PLCB4)
   04916 Melanogenesis
    105298737 (PLCB4)
   04924 Renin secretion
    105298737 (PLCB4)
   04925 Aldosterone synthesis and secretion
    105298737 (PLCB4)
   04927 Cortisol synthesis and secretion
    105298737 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    105298737 (PLCB4)
   04270 Vascular smooth muscle contraction
    105298737 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    105298737 (PLCB4)
   04971 Gastric acid secretion
    105298737 (PLCB4)
   04972 Pancreatic secretion
    105298737 (PLCB4)
   04973 Carbohydrate digestion and absorption
    105298737 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    105298737 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    105298737 (PLCB4)
   04725 Cholinergic synapse
    105298737 (PLCB4)
   04728 Dopaminergic synapse
    105298737 (PLCB4)
   04726 Serotonergic synapse
    105298737 (PLCB4)
   04720 Long-term potentiation
    105298737 (PLCB4)
   04730 Long-term depression
    105298737 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    105298737 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    105298737 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    105298737 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    105298737 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105298737 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    105298737 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105298737 (PLCB4)
   05142 Chagas disease
    105298737 (PLCB4)
   05143 African trypanosomiasis
    105298737 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105298737 (PLCB4)
   05016 Huntington disease
    105298737 (PLCB4)
   05017 Spinocerebellar ataxia
    105298737 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    105298737 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105298737 (PLCB4)
   05415 Diabetic cardiomyopathy
    105298737 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    105298737 (PLCB4)
   04934 Cushing syndrome
    105298737 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pvp04131]
    105298737 (PLCB4)
Enzymes [BR:pvp01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     105298737 (PLCB4)
Membrane trafficking [BR:pvp04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    105298737 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    105298737 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 105298737
NCBI-ProteinID: XP_011368439
UniProt: A0A6P3QSY8
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAIFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGADLVNISFTYMVAENPE
VTKQWVDGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGVISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGRSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEQKQLEALKSM
MEAGESAAPVNILEDDNEEEVENAEQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLITVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALASGMEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKTLEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSM
KLQNVN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggcgaaaccttatgaatttaactggcaaaaggaagttccttcctttttgcaagaagga
gcaatttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggaaaagtgaaggcaaggaaggacaagtgcta
gaatgctccctcatcaacagtgttcggttgggagccacaccaaaggatcccaaaatcctg
gctgctcttgaagctgttggaaaatccgaaaatgatctggaagggcggatagtttgtgtc
tgcagtggtgcagatctggtgaacatcagtttcacttacatggtggctgagaatccagaa
gtaactaagcaatgggtagacggcctgagatcaatcatacacaacttcagggccaacaac
gtcagtccaatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cctgcagcatttacttatgaaaagttctatgaactgacacaaaaaatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattc
ccattttatgatgctaaaagggcaatgcagatcattgagatgtatgagcctgatgaagac
ttaaagaaaaaaggcgtcatatcaagtgacggattttgcagatatctgatgtcagatgaa
aatgcccccgtctttctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagctcttcccacaacacctatctcactggccgacaatttggtgggagg
tcttcggtggaaatgtacagacaggttctcctggccgggtgcagatgtgtcgaacttgac
tgttgggatggaaaaggtgaagaccaagaaccgataataactcatggaaaagcaatgtgt
acagatatcctttttaaagatgttattcaggccatcaaggaaacagcatttgtcacatct
gaatatccagtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggcccttgccatcccccaatgacctcaaaagaaaaatactcata
aaaaataaacggctgaaacctgaagttgaacaaaaacagcttgaagctttgaaaagcatg
atggaagctggagaatctgctgccccagttaacatcttagaggatgataatgaagaagaa
gtagaaaatgctgagcaagaggaagaagctcaccctgaatacaaatttggaaatgaactt
tctgcagatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcttctgat
gaccttgaacatgaaaacaacaaaaagggcctgattactgtagaagatgagcaggcgtgg
atggcatcttataaatacgtaggtgctaccactaatatccatccatatttgtccacaatg
atcaactatgcacagcctgtaaagtttcaaggtttccatgtggctgaagaacgcaatatt
cattataacatgtcttcttttaatgagtcagtcggtctaggctacttgaagacacacgcg
attgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttca
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgaatataat
ggatcatgcgggtaccttctcaaaccggatttcatgaggcggcctgatcgaacgtttgat
cccttctctgaaactcctgttgacggtgttattgcagccacttgctcagtgcaggtcata
tcaggtcagttcttatcagataagaaaattggcacatatgtagaagtggatatgtatggg
ttgcccaccgacactatacgtaaggaatttcgaactcgcatggtgatgaacaatggactc
aatccagtttacaatgaagaatcatttgtatttcggaaggtaatcctccctgacctggca
gtcttgagaatagcagtgtatgatgacaacaacaagctgattggccagaggattcttcca
ctggatggccttcaggcaggctatcgacacatttctcttcgaaatgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatacgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaagtttctttcaattacggaaaagagg
gcggaccaaatgagagctatgggcattgaaaccagtgacatagctgatgtgcccagtgac
acttctaagaatgacaagaaaggaaaggccaacactgccaaagcaaatgtgaccccacag
agcagctctgagctcagaccaaccaccacagccgccctggcgtctggcatggaagccaaa
aaaggtatcgaacttatccctcaagtgaggatagaagatttaaagcaaatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagctaaattctttaaagaagaagcatgcaaag
gagcacagtaccatgcagaagttacattgcacacaagttgacaaaattgtggcacaatat
gacaaagagaagtcgactcatgagaaaaccctagagaaggcaatgaagaagaagggggga
agtaattgccttgaaatgaaaaaagaaacagaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagattgtggcacagcacacaaaggaatggtcagaaatgatc
aacacccacagtgctgaggagcaagaaatccgagacctgcacctcagccagcagtgtgag
ctgctgaaaaagctcctgatcaacgcccacgagcagcaaacccagcagctgaaattgtcc
cacgacagagaaagcaaggaaatgagagcacaccaagctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggcgagttagg
gagttaaacagcagcaacactaagaagtttctggaagaaagaaagagacttgcaatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctagaattcctagag
aaacagaatgaacagcttttgaaatcctgtcatgcagtgtcccaaactcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatg
aaactccaaaacgtaaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (9)   
   Pfam (9)   
All databases (18)   

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