KEGG   Rhinolophus ferrumequinum (greater horseshoe bat): 117025871
Entry
117025871         CDS       T07722                                 
Symbol
IRS1
Name
(RefSeq) insulin receptor substrate 1
  KO
K16172  insulin receptor substrate 1
Organism
rfq  Rhinolophus ferrumequinum (greater horseshoe bat)
Pathway
rfq04022  cGMP-PKG signaling pathway
rfq04068  FoxO signaling pathway
rfq04081  Hormone signaling
rfq04140  Autophagy - animal
rfq04150  mTOR signaling pathway
rfq04151  PI3K-Akt signaling pathway
rfq04152  AMPK signaling pathway
rfq04211  Longevity regulating pathway
rfq04213  Longevity regulating pathway - multiple species
rfq04722  Neurotrophin signaling pathway
rfq04910  Insulin signaling pathway
rfq04920  Adipocytokine signaling pathway
rfq04923  Regulation of lipolysis in adipocytes
rfq04930  Type II diabetes mellitus
rfq04931  Insulin resistance
rfq04932  Non-alcoholic fatty liver disease
rfq04935  Growth hormone synthesis, secretion and action
rfq04960  Aldosterone-regulated sodium reabsorption
rfq05010  Alzheimer disease
rfq05206  MicroRNAs in cancer
rfq05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:rfq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    117025871 (IRS1)
   04022 cGMP-PKG signaling pathway
    117025871 (IRS1)
   04151 PI3K-Akt signaling pathway
    117025871 (IRS1)
   04152 AMPK signaling pathway
    117025871 (IRS1)
   04150 mTOR signaling pathway
    117025871 (IRS1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    117025871 (IRS1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    117025871 (IRS1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    117025871 (IRS1)
   04923 Regulation of lipolysis in adipocytes
    117025871 (IRS1)
   04920 Adipocytokine signaling pathway
    117025871 (IRS1)
   04935 Growth hormone synthesis, secretion and action
    117025871 (IRS1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    117025871 (IRS1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    117025871 (IRS1)
  09149 Aging
   04211 Longevity regulating pathway
    117025871 (IRS1)
   04213 Longevity regulating pathway - multiple species
    117025871 (IRS1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    117025871 (IRS1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    117025871 (IRS1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    117025871 (IRS1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    117025871 (IRS1)
   04932 Non-alcoholic fatty liver disease
    117025871 (IRS1)
   04931 Insulin resistance
    117025871 (IRS1)
SSDB
Motif
Pfam: IRS PH PH_11
Other DBs
NCBI-GeneID: 117025871
NCBI-ProteinID: XP_032968095
Ensembl: ENSRFEG00010018222
UniProt: A0A671FP93
Position
8:10324561..10378915
AA seq 1238 aa
MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGASALGVGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLTAPN
GHYILPRGGNGHRYITGAGLGTSPALAGDETASAADLDNRFRKRTHSAGTSPTISHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTQSYPEEGLEMHPLERRGGHSR
PDTSTLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGSCSPDIGGGPSSSSAAPSGSTYGKLWTNGVGGHHSHILPHPKLPVESGGSK
LLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELEETA
RHQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGYCGARPEPSLPHHLHHQVLQPHLPR
KVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQPALLHPPEPKSPGEYVNIEFGS
DQPGYLSGPMASHSSPSVRCPSQLQPAPREEETGTEEYMNMDLGPGRRATWQESPGVQAG
RGGPAPPGTAGVCRPTRAVPSSRGDYMTMQMGCPRQSYVDTSPVAPVSYADIRTGIVEEA
SLPGATAAAPSSSSAASASPTTPQGTGELVARSSLLGGAQGPGGMSAFTRVNLSPSCNQS
AKVIRADPQGCRRRHSSETFSSTPSATRAGNTVPFGVGAAMGGSSGGSSSTEDVKRHSSA
SFENVWLRPGELGGAPKEPGQVCGAAGGLENGLNYIDLDLVKDFKQRPQERPPQLQPPPP
PPPHQPLGSGESSSTSHSNEDLSAYASISFQKQPEDLQ
NT seq 3717 nt   +upstreamnt  +downstreamnt
atggcgagtcctccggagaccgacggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc
ccggcgcgcctcgagtattacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgttcgatccccctggagagctgcttcaacatcaacaagcgggcggactccaagaac
aagcacctggtagccctctacactcgggacgagcactttgccatcgcggcagacagcgaa
gcagagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac
cacgacggggcctcggcccttggcgtgggaggcggcgggggcagctgcagcggcagttct
ggccttggggaggctggggaggatttgagctacggggatgtgcccccaggacccgcgttc
aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaatctgatt
ggcatctaccgcctctgcctgaccagcaagaccatcagctttgtgaagctgaactcagag
gcagcggctgtggtactgcagctgatgaacatccggcgctgtggccactcggagaacttc
ttcttcatcgaagtgggccgttccgcagtgacgggacccggagagttctggatgcaggtg
gatgactcggtggtggcccagaacatgcacgagacaatcctggaggccatgcgggccatg
agcgatgagttccgccctcgcagcaagagccagtcctcttccaactgttccaaccccatc
agtgtccccctgcgcaggcaccatcttaacaaccccccacccagccaggtggggctgacc
cgccgctcacgcaccgagagcatcactgccacttctccagctagcatggtgggcgggaag
cagggctccttccgtgtccgtgcctccagcgacggtgaaggcaccatgtcccgcccggct
tcggtggacggcagtcctgtgagtcctagtaccaacaggacccacgcccatcggcatcgg
ggcagctcccggctgcaccccccactcaaccacagccgctccattcctatgccttcttcg
cgctgctcaccttcagccactagccctgtcagtctgtcatctagcagcaccagtggccac
ggctccacctctgactgtctcttccctcggagatctagtgcttctgtgtctggttccccc
agcgatggcggtttcatctcttccgatgagtatggttccagtccctgcgatttccgaagt
tccttccgcagtgtcaccccggattccctgggccacaccccaccggcccgcggagaggag
gagctgagcaactacatctgcatgggaggcaaggggtcctccaccctcaccgctcccaat
ggtcactacattttgcctcggggtggcaatggccaccgctacatcacaggagctggcttg
ggtaccagcccagccctggctggggatgaaacagccagtgctgcagatctggataatcgg
ttccgaaagcggactcactctgctggcacctcccccaccatttcccaccagaagaccccc
tcccagtcctccgtggcttccattgaggaatatacagagatgatgcctgcctacccacca
ggaggtggcagtggaggccgactgcccggctaccggcactctgccttcgtgcccacccag
tcctaccctgaggagggtctggaaatgcaccccttggagcgtcgtggaggccacagtcgc
ccagatacctccaccctccacacggatgatggctacatgcccatgtccccaggggtggct
ccagtgcccggcagccgaaaaggcagtggggactacatgcccatgagccccaagagtgtg
tctgccccacagcagatcatcaaccccatcagacgccatccccagagagtggaccccaat
ggctacatgatgatgtccccaagcggcagctgctcccctgacattggcggtgggcccagc
agcagcagtgctgccccttctgggagtacttatgggaagctatggacaaatggggtcggg
ggccaccactctcacatcctgccacaccccaaactacccgtggagagcggtggtagcaag
ctcttgtcctgtacaggtgactacatgaacatgtcgccagtgggggactccaataccagc
agcccctccgactgctactacggccccgaggacccccagcacaagccagttctctcctac
tactcattgccaaggtcctttaagcacacgcagcgccccggggagctggaggagactgcc
cggcaccagcacctccgcctttcctccagctctggtcgccttctctatgctgcagcagca
gaagattcctcttcctccaccagcagcgacagcctgggcgggggatactgtggggcgagg
cccgagcccagcctcccgcatcatctccaccatcaggtcctgcagcctcatctgcctcga
aaggtggacacagctgcacagaccaacagccgcctggctcggcccacaaggttgtccctg
ggggacccgaaggccagcaccttacctcgggcccgagagcagcagcagcagcagccagcc
ctgctgcaccctccggagcccaagagcccaggggaatatgtgaatatcgaatttgggagt
gatcagccgggctacttgtctggcccaatggcatcccacagctcaccttctgtcaggtgt
ccgtcccagctccagccagctcccagagaggaagagactggcacggaagagtacatgaac
atggacctggggccaggccggagggccacctggcaagagagccctggggtccaggctggc
agggggggccctgcacctccggggactgctggcgtgtgcaggcctacccgggcagtgcct
agcagccgtggtgactacatgaccatgcagatgggttgtccccgtcagagctatgtggac
acctctccagttgcccctgtcagctatgctgacattcggacgggcattgtggaggaggcg
agccttcctggggccacagcggctgctccgtcctcatcctcagcagcctctgcttccccc
accacacctcaaggaacaggggagctggtagcccgctcttccctgctggggggcgcacag
ggacctgggggcatgagcgccttcaccagggtgaacctcagccccagctgcaaccagagt
gccaaagtgatccgtgcagacccgcaagggtgccggaggaggcatagctccgagaccttc
tcttccacaccgagtgccacccgggcgggcaacacagtgcccttcggagtgggagctgca
atggggggcagcagtggtggcagcagcagcacggaggatgtgaaacgccacagctctgct
tcctttgagaacgtgtggctgaggcctggggagctcgggggagcccccaaggagccaggg
caagtgtgtggggctgctgggggcttggagaacggtctcaactacatagatctggatttg
gtcaaggacttcaaacagcgccctcaggagcgcccccctcaactgcagccgcccccgccc
ccgcctcctcatcagcctctgggcagcggtgagagcagctccaccagccattccaatgag
gatttaagcgcctatgccagcatcagtttccagaagcagccagaggatctccagtag

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (3)   
   Pfam (3)   
All databases (9)   

Download RDF
DBGET integrated database retrieval system