KEGG   PATHWAY: rn00984
Entry
rn00984                     Pathway                                

Name
Steroid degradation
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
rn00984  Steroid degradation
rn00984

Other DBs
GO: 0006707
Reaction
R01459  Cholesterol:oxygen oxidoreductase
R01834  3-Oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase
R01836  testosterone:NAD+ 17-oxidoreductase
R01838  testosterone:NADP+ 17-oxidoreductase
R04597  3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)
R09819  3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FMNH2:oxygen oxidoreductase
R09860  androsta-1,4-diene-3,17-dione,[reduced ferredoxin]:oxygen oxidoreductase (9alpha-hydroxylating)
R09883  4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase ( (2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming)
R09884  androstenedione:acceptor Delta1-oxidoreductase
R09885   
R09919   
R09920  cholesterol:NAD+ 3-oxidoreductase
R09955  5-androstene-3,17-dione delta5-delta4-isomerase
R09956  epiandrosterone:NAD+ oxidoreductase
R09957  dehydroepiandrosterone:NAD+ oxidoreductase
R10769  3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate:CoA ligase (AMP-forming)
R11357  cholest-4-en-3-one,[reduced ferredoxin]:oxygen oxidoreductase [(25S)-3-oxocholest-4-en-26-oate forming]
R11361  cholest-4-en-3-one,reduced-2Fe-2S]-ferredoxin:oxygen oxidoreductase [(25R)-3-oxocholest-4-en-26-oate forming]
Compound
C00187  Cholesterol
C00280  Androstenedione
C00535  Testosterone
C00599  Cholest-4-en-3-one
C00674  5alpha-Androstane-3,17-dione
C01227  Dehydroepiandrosterone
C04793  3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
C04844  3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate
C07635  Epiandrosterone
C11354  2-Hydroxy-cis-hex-2,4-dienoate
C14909  9alpha-Hydroxyandrosta-1,4-diene-3,17-dione
C19944  3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
C20144  Androsta-1,4-diene-3,17-dione
C20199  3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate
C20252  5-Androstene-3,17-dione
C20838  3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
C20839  (25R)-3-Oxocholest-4-en-26-oate
C21076  Delta4-Dafachronic acid
Reference
  Authors
Ouellet H, Johnston JB, de Montellano PR
  Title
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
  Journal
Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009
Reference
  Authors
Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD
  Title
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
  Journal
Proc Natl Acad Sci U S A 104:1947-52 (2007)
DOI:10.1073/pnas.0605728104
Reference
  Authors
Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS
  Title
Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism.
  Journal
J Biol Chem 286:43668-78 (2011)
DOI:10.1074/jbc.M111.313643
Reference
  Authors
Driscoll MD, McLean KJ, Levy C, Mast N, Pikuleva IA, Lafite P, Rigby SE, Leys D, Munro AW
  Title
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
  Journal
J Biol Chem 285:38270-82 (2010)
DOI:10.1074/jbc.M110.164293
Reference
  Authors
Johnston JB, Ouellet H, Ortiz de Montellano PR
  Title
Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.
  Journal
J Biol Chem 285:36352-60 (2010)
DOI:10.1074/jbc.M110.161117
Reference
  Authors
Yang X, Dubnau E, Smith I, Sampson NS
  Title
Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.
  Journal
Biochemistry 46:9058-67 (2007)
DOI:10.1021/bi700688x
Reference
  Authors
Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD
  Title
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.
  Journal
J Biol Chem 285:434-43 (2010)
DOI:10.1074/jbc.M109.058081
Reference
  Authors
Kreit J, Sampson NS
  Title
Cholesterol oxidase: physiological functions.
  Journal
FEBS J 276:6844-56 (2009)
DOI:10.1111/j.1742-4658.2009.07378.x
Reference
  Authors
Horinouchi M, Hayashi T, Kudo T
  Title
Steroid degradation in Comamonas testosteroni.
  Journal
J Steroid Biochem Mol Biol 129:4-14 (2012)
DOI:10.1016/j.jsbmb.2010.10.008
Reference
  Authors
Horinouchi M, Kurita T, Hayashi T, Kudo T
  Title
Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot.
  Journal
J Steroid Biochem Mol Biol 122:253-63 (2010)
DOI:10.1016/j.jsbmb.2010.06.002
Related
pathway
rn00100  Steroid biosynthesis
rn00140  Steroid hormone biosynthesis
rn00622  Xylene degradation
KO pathway
ko00984   

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