KEGG   PATHWAY: rn00998
Entry
rn00998                     Pathway                                

Name
Biosynthesis of various secondary metabolites - part 2
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
rn00998  Biosynthesis of various secondary metabolites - part 2
rn00998

Module
M00787  Bacilysin biosynthesis, prephenate => bacilysin [PATH:rn00998]
M00848  Aurachin biosynthesis, anthranilate => aurachin A [PATH:rn00998]
M00877  Kanosamine biosynthesis, glucose 6-phosphate => kanosamine [PATH:rn00998]
M00889  Puromycin biosynthesis, ATP => puromycin [PATH:rn00998]
M00891  Ditryptophenaline biosynthesis, tryptophan + phenylalanine => ditryptophenaline [PATH:rn00998]
M00901  Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline [PATH:rn00998]
M00902  Podophyllotoxin biosynthesis, coniferyl alcohol => podophyllotoxin [PATH:rn00998]
M00903  Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin [PATH:rn00998]
Reaction
R00661  phosphoenolpyruvate 2,3-phosphonomutase
R00982  Anthranilate:CoA ligase (AMP-forming)
R04053  3-phosphonopyruvate carboxy-lyase
R05668   
R05669   
R05670   
R05671   
R05672   
R05673   
R05674   
R05675   
R05676   
R05677   
R05772  feruloyl-CoA hydro-lyase/vanillin-lyase (acetyl-CoA-forming)
R05773  feruloyl-CoA hydro-lyase/vanillin-lyase (acetyl-CoA-forming)
R08861   
R08863  (S)-2-hydroxypropylphosphonate,NADH:oxygen epoxidase
R09090   
R09478  2-hydroxyethylphosphonate:NAD+ oxidoreductase
R10129  (-)-secoisolariciresinol:NAD+ oxidoreductase
R10225  (+)-lariciresinol:NADP+ oxidoreductase
R10226  (-)-secoisolariciresinol:NADP+ oxidoreductase
R10227  (-)-lariciresinol:NADP+ oxidoreductase
R10228  (+)-secoisolariciresinol:NADPH+ oxidoreductase
R10519  D-glucose-6-phosphate:NAD+ oxidoreductase
R10547  kanosamine-6-phosphate phosphohydrolase
R10698  kanosamine-6-phosphate:2-oxoglutarate aminotransferase
R10917  L-dihydroanticapsin:NAD+ oxidoreductase
R10934  prephenate carboxy-lyase (3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate-forming)
R11064  L-alanine:L-anticapsin ligase (ADP-forming)
R11065  3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase
R11066   
R11067   
R11068   
R11149  aurachin B:NAD+ 3-oxidoreductase
R11210  (-)-yatein,2-oxoglutarate:oxygen oxidoreductase (ring-forming)
R11211  (-)-bursehernin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5'-hydroxylating)
R11222  (-)-matairesinol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (methylenedioxy-bridge-forming)
R11230  S-adenosyl-L-methionine:(-)-pluviatolide 4-O-methyltransferase
R11382  aurachin C:NADH:oxygen oxidoreductase (4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide-forming)
R11383  aurachin C:NADPH:oxygen oxidoreductase (4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide-forming)
R11545  S-adenosyl-L-methionine:(-)-5'-demethylyatein 5'-O-methyltransferase
R12049   
R12050   
R12051  aurachin-D,NADPH:oxygen oxidoreductase (N-hydroxylating)
R12052  aurachin-B,NADPH:oxygen oxidoreductase (2',3'-epoxidizing)
R12053  aurachin-B,NADH:oxygen oxidoreductase (2',3'-epoxidizing)
R12054   
R12126   
R12127   
R12145   
R12413   
R12414  S-adenosyl-L-methionine:cyclo(L-Trp-L-Phe) N-methyltransferase
R12415   
R12417   
R12418   
R12419   
R12420   
R12421   
R12497  S-adenosyl-L-methionine:cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} C-methyltransferase
R12498   
R12499   
R12622  L-alanine:vanillin aminotransferase
R12626  (6E)-8-methylnon-6-enoyl-CoA:vanillylamine 8-methylnon-6-enoyltranferase
R12628   
Compound
C00002  ATP
C00041  L-Alanine
C00074  Phosphoenolpyruvate
C00078  L-Tryptophan
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00092  D-Glucose 6-phosphate
C00108  Anthranilate
C00251  Chorismate
C00254  Prephenate
C00279  D-Erythrose 4-phosphate
C00406  Feruloyl-CoA
C00423  trans-Cinnamate
C00590  Coniferyl alcohol
C00630  2-Methylpropanoyl-CoA
C00755  4-Hydroxy-3-methoxy-benzaldehyde
C00811  4-Coumarate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01610  Puromycin
C02247  Anthraniloyl-CoA
C02798  3-Phosphonopyruvate
C03167  Phosphonoacetaldehyde
C05345  beta-D-Fructose 6-phosphate
C05366  (+)-Pinoresinol
C06451  2-Hydroxyethylphosphonate
C06452  (S)-2-Hydroxypropylphosphonate
C06454  Fosfomycin
C06866  Capsaicin
C07024  3'-Keto-3'-deoxy-ATP
C07025  3'-Keto-3'-deoxy-AMP
C07026  3'-Amino-3'-deoxy-AMP
C07027  N6,N6,O-Tridemethylpuromycin-5'-phosphate
C07028  N-Acetyl-N6,N6,O-tridemethylpuromycin-5'-phosphate
C07029  N-Acetyl-N6,O-didemethylpuromycin-5'-phosphate
C07030  N-Acetyl-O-demethylpuromycin-5'-phosphate
C07031  N-Acetyl-O-demethylpuromycin
C07032  N-Acetylpuromycin
C07303  4-Hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA
C10556  Deoxypodophyllotoxin
C10557  Dihydroanhydropodorhizol
C10641  Aurachin D
C10646  Lariciresinol
C10682  Matairesinol
C10874  Podophyllotoxin
C12212  Kanosamine
C12213  Kanosamine 6-phosphate
C16666  Vanillylamine
C18167  Secoisolariciresinol
C18202  8-Methyl-6-nonenoic acid
C20454  (-)-Lariciresinol
C20455  (-)-Pinoresinol
C20456  (+)-Secoisolariciresinol
C20668  3-Dehydro-D-glucose 6-phosphate
C20940  L-Dihydroanticapsin
C20941  L-Anticapsin
C20942  Bacilysin
C20953  3-[(4R)-4-Hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate
C21085  3-[(1E,4R)-4-Hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate
C21086  (3E)-3-[(1R,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]heptan-2-ylidene]-2-oxopropanoate
C21087  3-[(1R,2S,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate
C21140  Aurachin B
C21141  4-Hydroxy-2-methyl-3-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide
C21183  Bursehernin
C21184  (-)-5'-Demethylyatein
C21191  Pluviatolide
C21330  Aurachin C
C21873  2-Methylquinolin-4-ol
C21874  Aurachin B epoxide
C21875  Aurachin A
C22142  Cyclo(L-Trp-L-Phe)
C22143  N-Methyl-cyclo(L-Trp-L-Phe)
C22144  (-)-Ditryptophenaline
C22145  Fumiquinazoline F
C22146  Fumiquinazoline F-indoline-2',3'-diol
C22147  Fumiquinazoline A
C22148  Fumiquinazoline C
C22149  Fumiquinazoline D
C22216  Cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate}
C22217  Cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate}
C22289  (6E)-8-Methylnon-6-enoyl-CoA
Reference
  Authors
Vetter ND, Langill DM, Anjum S, Boisvert-Martel J, Jagdhane RC, Omene E, Zheng H, van Straaten KE, Asiamah I, Krol ES, Sanders DA, Palmer DR
  Title
A previously unrecognized kanosamine biosynthesis pathway in Bacillus subtilis.
  Journal
J Am Chem Soc 135:5970-3 (2013)
DOI:10.1021/ja4010255
Reference
  Authors
Saruwatari T, Yagishita F, Mino T, Noguchi H, Hotta K, Watanabe K
  Title
Cytochrome P450 as dimerization catalyst in diketopiperazine alkaloid biosynthesis.
  Journal
Chembiochem 15:656-9 (2014)
DOI:10.1002/cbic.201300751
Reference
  Authors
Lim FY, Ames B, Walsh CT, Keller NP
  Title
Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus.
  Journal
Cell Microbiol 16:1267-83 (2014)
DOI:10.1111/cmi.12284
Reference
  Authors
Sandmann A, Dickschat J, Jenke-Kodama H, Kunze B, Dittmann E, Muller R
  Title
A Type II polyketide synthase from the gram-negative Bacterium Stigmatella aurantiaca is involved in Aurachin alkaloid biosynthesis.
  Journal
Angew Chem Int Ed Engl 46:2712-6 (2007)
DOI:10.1002/anie.200603513
Reference
  Authors
Ozcengiz G, Ogulur I
  Title
Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic.
  Journal
N Biotechnol 32:612-9 (2015)
DOI:10.1016/j.nbt.2015.01.006
Reference
PMID:8576156
  Authors
Tercero JA, Espinosa JC, Lacalle RA, Jimenez A.
  Title
The biosynthetic pathway of the aminonucleoside antibiotic puromycin, as deduced from the molecular analysis of the pur cluster of Streptomyces alboniger.
  Journal
J Biol Chem 271:1579-90 (1996)
DOI:10.1074/jbc.271.3.1579
Reference
  Authors
Mazourek M, Pujar A, Borovsky Y, Paran I, Mueller L, Jahn MM
  Title
A dynamic interface for capsaicinoid systems biology.
  Journal
Plant Physiol 150:1806-21 (2009)
DOI:10.1104/pp.109.136549
Reference
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
Related
pathway
rn00010  Glycolysis / Gluconeogenesis
rn00030  Pentose phosphate pathway
rn00280  Valine, leucine and isoleucine degradation
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00440  Phosphonate and phosphinate metabolism
rn00940  Phenylpropanoid biosynthesis
KO pathway
ko00998   

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