KEGG   PATHWAY: rno00531
Entry
rno00531                    Pathway                                

Name
Glycosaminoglycan degradation - Rattus norvegicus (rat)
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
rno00531  Glycosaminoglycan degradation
rno00531

Module
rno_M00076  Dermatan sulfate degradation [PATH:rno00531]
rno_M00077  Chondroitin sulfate degradation [PATH:rno00531]
rno_M00079  Keratan sulfate degradation [PATH:rno00531]
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
367166  Hyal1; hyaluronidase-1 precursor [KO:K01197] [EC:3.2.1.35]
64468  Hyal2; hyaluronidase-2 precursor [KO:K01197] [EC:3.2.1.35]
404783  Hyal4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
300993  Hyal3; hyaluronidase-3 precursor [KO:K01197] [EC:3.2.1.35]
500051  Hyal6; hyaluronoglucosaminidase 6 precursor [KO:K01197] [EC:3.2.1.35]
117037  Spam1; hyaluronidase PH-20 precursor [KO:K01197] [EC:3.2.1.35]
500052  Hyal5; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
24434  Gusb; beta-glucuronidase precursor [KO:K01195] [EC:3.2.1.31]
363513  Ids; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
360904  Idua; alpha-L-iduronidase precursor [KO:K01217] [EC:3.2.1.76]
25227  Arsb; arylsulfatase B precursor [KO:K01135] [EC:3.1.6.12]
64537  Hpse; heparanase precursor [KO:K07964] [EC:3.2.1.166]
368128  Hpse2; inactive heparanase-2 precursor [KO:K07965] [EC:3.2.1.-]
688293  Sgsh; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
360630  Naglu; alpha-N-acetylglucosaminidase isoform X1 [KO:K01205] [EC:3.2.1.50]
292073  Galns; N-acetylgalactosamine-6-sulfatase precursor [KO:K01132] [EC:3.1.6.4]
316033  Glb1; beta-galactosidase precursor [KO:K12309] [EC:3.2.1.23]
299825  Gns; N-acetylglucosamine-6-sulfatase precursor [KO:K01137] [EC:3.1.6.14]
294673  Hexb; beta-hexosaminidase subunit beta precursor [KO:K12373] [EC:3.2.1.52]
300757  Hexa; beta-hexosaminidase subunit alpha precursor [KO:K12373] [EC:3.2.1.52]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00634  Chondroitin 4-sulfate
C00925  Heparan sulfate
G00526   
G00711   
G00872  DWA-2
G01391   
G01945   
G01977   
G02632   
G09660   
G10008   
G10505  Hyaluronic acid
G12336   
G13034   
G13035   
G13036   
G13037   
G13038   
G13039   
G13040   
G13041   
G13042   
G13043   
G13073   
G13074   
Reference
PMID:27570
  Authors
Greiling H, Stuhlsatz HW, Cantz M, Gehler J
  Title
Increased urinary excretion of keratan sulfate in fucosidosis.
  Journal
J Clin Chem Clin Biochem 16:329-34 (1978)
DOI:10.1515/cclm.1978.16.6.329
Reference
PMID:3161730
  Authors
Fuchs W, Beck M, Kresse H
  Title
Intralysosomal formation and metabolic fate of N-acetylglucosamine 6-sulfate from keratan sulfate.
  Journal
Eur J Biochem 151:551-6 (1985)
DOI:10.1111/j.1432-1033.1985.tb09138.x
Related
pathway
rno00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
rno00533  Glycosaminoglycan biosynthesis - keratan sulfate
rno00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
KO pathway
ko00531   

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