KEGG   Rattus norvegicus (rat): 252857
Entry
252857            CDS       T01003                                 

Gene name
Rapgef4
Definition
(RefSeq) rap guanine nucleotide exchange factor 4
  KO
K04351  Rap guanine nucleotide exchange factor 4
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04015  Rap1 signaling pathway
rno04024  cAMP signaling pathway
rno04072  Phospholipase D signaling pathway
rno04261  Adrenergic signaling in cardiomyocytes
rno04670  Leukocyte transendothelial migration
rno04911  Insulin secretion
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    252857 (Rapgef4)
   04072 Phospholipase D signaling pathway
    252857 (Rapgef4)
   04024 cAMP signaling pathway
    252857 (Rapgef4)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    252857 (Rapgef4)
  09152 Endocrine system
   04911 Insulin secretion
    252857 (Rapgef4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    252857 (Rapgef4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    252857 (Rapgef4)
Membrane trafficking [BR:rno04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   Rab associated proteins
    252857 (Rapgef4)
SSDB
Motif
Pfam: RasGEF cNMP_binding DEP RasGEF_N
Other DBs
NCBI-GeneID: 252857
NCBI-ProteinID: NP_001094112
RGD: 621886
Ensembl: ENSRNOG00000001516
Position
3
AA seq 1011 aa
MVAAHAAHSPSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFERFHPNLLRQICLCSY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRENSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEHEDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTADDLEIIYDELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA
FLEEFYVSVSDDARMMVAFKEQLAELEKTVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK
VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM
TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
NT seq 3036 nt   +upstreamnt  +downstreamnt
atggttgctgcgcacgctgcacactctccgtcctcggccgagtggatcgcctgcctggat
aaaaggccgttggagcgatctagtgaagatgtggacataattttcacgcggctgaaagga
gttaaagcttttgagagatttcacccaaacctccttcgtcagatttgtttatgcagttac
tatgagaacctggagaaaggaatcacactgtttcgacaaggggacattggaaccaactgg
tatgctgtcctagctgggtctttggatgttaaagtgtctgagaccagcagtcaccaggat
gcggtgaccatctgtaccctgggaattgggacagcctttggagagtccattctcgacaac
acacctcgtcatgcaaccattgttaccagagagaacagtgagctcctccgtatcgagcag
gaagactttaaggcactatgggagaaataccgacagtatatggccggacttctggctcct
ccctatggtgttatggaaacgggctctaacaatgacaggattccggacaaggagaataca
cctctcattgaacctcacgttcctctccgccctgctcacaccattaccaaggtcccttca
gagaagatcctcagagctggaaaaattttgcgaattgccattctctctcgagcaccccac
atgataagagacagaaaataccacctaaagacatacagacaatgctgtgttgggactgag
ctggtagactggatgatacagcagacgtcctgtgttcactcccggactcaagctgttggc
atgtggcaagtcttgctggaagatggcgtcctcaaccacgtggaccaggagcgccatttc
caagataaatatttattttatcgatttctggatgacgagcatgaggatgcccctttgcct
actgaggaggagaagaaggagtgcgatgaagagctccaggacaccatgctgctgctgtca
caaatgggccctgacgcccacatgagaatgatcctgcgaaaaccacctggccagaggact
gcagatgacctagagattatctacgacgaactccttcatattaaagccttatcccatctt
tctaccacagtgaaacgggagttagcaggtgttctcatttttgagtctcacgccaaagga
ggaactgtgttgtttaaccagggggaagaaggtacctcctggtacatcattctgaaagga
tccgtgaatgtagtcatttatggcaagggtgtggtctgcaccctgcatgagggagatgac
tttggcaagttagctctggtgaacgatgctccgagagctgcatccattgttcttcgggaa
gataattgtcacttcctaagagttgacaaggaagacttcaatcggattctgagggacgtt
gaggcgaatacagtcagacttaaagaacatgaccaagatgtcttggtactggagaaggtc
ccagcagggaacagagcttctaatcaaggaaactcacagcctcagcaaaagtatactgtg
atgtcaggaacacctgaaaagattttagagcattttctagaaacaatacgccttgagcca
tctttgaatgaagcaacagattcagttttaaatgacttcgttatgatgcactgtgttttt
atgccaaacacccagctttgccccgccctcgtggcccattaccacgcacagccttctcaa
ggtacagaacaggagagaatggattacgccctcaacaacaagaggcgggtcatccgcctg
gttctgcaatgggcagccatgtatggtgatcttctccaagaagacgacgtggccatggct
ttcctggaggagttctatgtgtctgtatcagatgatgcacggatgatggtcgccttcaag
gagcagctggctgagctggagaagactgtcaaacagatctcagaagacgcaaaagctcca
cagaagaagcacaaggtgcttttgcagcagtttaatacaggtgacgagagggcccagaag
cgtcagccgattcgtggctctgatgaggttttgttcaaggtctactgcattgaccacacc
tataccaccatccgagtgcctgtagccgcctcggtgaaggaagtcatcagtgcagtagca
gacaaacttggctctggggaaggcctgatcattgtcaagatgaactctggaggagaaaag
gtggtgctcaaacctaatgatgtttcagtatttacgacgctcaccattaatggacgcctg
tttgcctgcccgcgagagcaattcgactcactgactcccttgccagaacaggagggcccg
accactgggacagtggggacgtttgaactgatgagctcgaaagacttggcgtaccagatg
acaacgtatgactgggaactcttcaactgtgtgcacgagctggagctaatctaccacaca
tttggaaggcataattttaaaaagaccacagcaaacttggatttgttcctgaggagattt
aatgaaattcagttttgggttgtcactgagatctgcctttgttcccagctcagcaaacgt
gttcagcttttgaaaaaatttatcaagatagcggctcactgcaaggagtacaaaaacctg
aattccttcttcgccatcgtcatggggctcagtaacgtggctgtgagccgcctggcatta
acatgggagaaactgccgagcaagtttaagaagttctatgcggagtttgagagcttaatg
gatccttccagaaatcacagggcgtacaggctgacagcagctaaactggagccccccctc
atccctttcatgcccttgcttattaaagatatgacatttactcatgaggggaacaagaca
ttcattgacaatctagtaaactttgaaaaaatgcgcatgattgcaaatactgccagaacg
gtgcgctactacaggagccagccattcaatccggatgctgctcaagctaataagaaccat
caggatgtccggagttatgtacggcaattaaatgtgattgacaaccagagaactttatca
cagatgtcacacagattagagcctcgcaggccatag

KEGG   Rattus norvegicus (rat): 59326
Entry
59326             CDS       T01003                                 

Gene name
Rapgef3
Definition
(RefSeq) rap guanine nucleotide exchange factor 3
  KO
K08014  Rap guanine nucleotide exchange factor 3
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04015  Rap1 signaling pathway
rno04024  cAMP signaling pathway
rno04072  Phospholipase D signaling pathway
rno04261  Adrenergic signaling in cardiomyocytes
rno04670  Leukocyte transendothelial migration
rno04720  Long-term potentiation
rno04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    59326 (Rapgef3)
   04072 Phospholipase D signaling pathway
    59326 (Rapgef3)
   04024 cAMP signaling pathway
    59326 (Rapgef3)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    59326 (Rapgef3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    59326 (Rapgef3)
  09156 Nervous system
   04726 Serotonergic synapse
    59326 (Rapgef3)
   04720 Long-term potentiation
    59326 (Rapgef3)
SSDB
Motif
Pfam: RasGEF cNMP_binding DEP RasGEF_N
Other DBs
NCBI-GeneID: 59326
NCBI-ProteinID: NP_067722
RGD: 621869
Ensembl: ENSRNOG00000059961
UniProt: Q9Z1C8 Q3B7C8
Position
7
AA seq 884 aa
MVLKRMHRPRCCSYQLVFEHRRPSCIQGLRWTPLTNSEGSLDFRVSLEQATTEHVHKAGK
LLYRHLLATYPTLIRDRKYHLRLHRQCCSGRELVDGILALGLGVHSRSQAVGICQVLLDE
GALCHVKHDWTFQDRDAQFYRFPGPEPQPAGTHDVEEELVEAMALLSQRGPDALLTVALR
KSPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS
WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDF
NRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE
AMRPDSSAHDPTETFLSDFLLTHSVFMPCTQLFAALLHHFHVEPSEPAGGSEQERSTYIC
NKRQQILRLVSRWVALYSPMLRSDPVATSFLQKLSDLVSRDTRLSNLLREQYPERRRHHR
LENGCGNVSPQTKARNAPVWFPNHEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVT
ASVREVMAALAHEDHWTKGQVLVKVNSAGDVVGLQPDARGVATSLGLNERIFVVDPQEVH
ELTPHPEQLGPTLGSSEMLDLVSAKDLAGQLTEHDWNLFNRIHQVELIHYVLGPQHLRDV
TTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMF
GLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLL
KDMTFIHEGNHTLVENLINFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQA
SRISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
NT seq 2655 nt   +upstreamnt  +downstreamnt
atggtgctgaagagaatgcaccgtccccggtgctgctcttaccagctagtgttcgagcac
cggcgcccaagctgcatccagggacttcgctggacgccacttaccaacagtgagggctcc
ctggacttcagagtgagcctggagcaggccaccacagagcatgtgcacaaggccgggaag
ctcctgtaccgtcatctcttggcaacgtaccctaccctcatccgagacagaaaataccat
ctgcgactacatcggcagtgctgctctggccgggagctagtggatgggatcttggctctg
ggtcttggggtccactcacggagccaagctgtgggcatctgccaggtgttgctggatgag
ggtgccctttgccatgtaaaacatgactggaccttccaggaccgagacgcccaattctac
agattccctggaccggagccccagcctgcaggaactcatgacgtggaagaggagcttgtt
gaggcaatggccctactctcccagcgagggcctgatgccctactcactgttgcactccgg
aagtccccgggtcagcgtacagatgaagagctggacctcatcttcgaggagctgctacat
atcaaggcggtggctcacctttctaactcggtgaaacgggaactagctgctgttctgctc
tttgaaccacacagcaaggcaggaactgtgttgttcagccagggggacaagggtacctca
tggtacattatctggaagggatctgtcaatgtggtgacccatggcaaggggctggtgacc
acgttgcacgagggagatgactttggacagctggctctggtgaacgacgcacctcgagca
gccaccatcatccttcgagaaaataactgtcactttctgcgtgtggacaagcaggacttc
aaccgcatcatcaaggatgtggaagcaaaaaccatgagactggaagaacacggcaaagtg
gtgttagttttggagagaacctctcagggtgctggcccttcccgccctccgaccccaggc
aggaaccgatatacggtaatgtctggcaccccagagaaaatcctagaactcctgttggag
gctatgagaccggattccagtgctcatgacccaacagagacattcctcagtgacttcctg
ctgacgcacagtgtcttcatgccctgcacacagctctttgccgccctcctgcaccacttc
cacgtggagccatcagagcctgccgggggcagcgagcaggaacgcagcacctacatctgc
aacaagaggcagcagattctgcgtctggtcagccggtgggtggccctctacagccccatg
ctccgctcagatcccgtggccaccagcttcctccagaaactctcagacctggtgagcaga
gatacccgacttagcaacttgctgagggaacagtatccggagagacggcgacaccacagg
ttggagaatggctgtgggaatgtatctcctcagaccaaggcccggaatgcacctgtttgg
tttcctaaccatgaggaacccctcccaagcagcgctggggccatccgagtcggggacaaa
gtcccctatgatatctgcagacccgaccactcggtgctgaccctgcacctgccggtgaca
gcctccgtgagggaagtgatggcagctttggcccatgaggaccactggaccaaggggcag
gtgctggtaaaggtcaattctgccggtgatgtcgttggcttgcagccagatgcccgcggt
gtggccacatccctggggctcaatgagcggatctttgttgtcgacccacaggaagtgcac
gagctgaccccacaccctgagcagctggggcccactctgggttcttctgagatgctggac
ctagtgagtgccaaggacctggcaggccagctcacagagcatgactggaacctcttcaac
aggatccaccaggtggagctgatccactatgtactgggcccccagcacctgcgggacgtc
accactgcaaacctggagcgcttcatgcgacgcttcaacgagctgcagtactgggtggcc
accgaactctgtctctgcccggttcctggcccccgggctcagctactccggaagttcatc
aagctggcagcccacctcaaggagcagaagaatctcaactctttctttgcggtcatgttt
ggcctcagcaactcggccatcagccgcctggcccacacctgggagcgtctgccccataaa
gtacggaagctgtactcggccctggaaaggttgctggacccttcctggaaccaccgagtg
taccgattggctctcaccaagctctctcctcctgtcatccctttcatgcccctgctactc
aaagacatgaccttcatccatgaagggaaccacacactggtagaaaacctcatcaacttt
gagaagatgcgaatgatggccagagccgtgcggatgctccaccactgccgaagccacagc
accgcgcctctatcaccactcagaagccgggtttcccacatccacgaggacagccaggca
tcaagaatctccacatgttccgagcagtccctgagcacccggagtccagccagcacctgg
gcttatgtccagcagctgaaggtcattgacaaccagcgggaactgtcccgcctctcccgg
gaactggaaccatga

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