LOCUS NC_001357 7857 bp DNA circular VRL 13-AUG-2018
DEFINITION Human papillomavirus - 18, complete genome.
ACCESSION NC_001357
VERSION NC_001357.1
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq; E1 gene; E2 gene; E5 gene; E6 gene; E7 gene; L1 gene; L2
gene.
SOURCE Alphapapillomavirus 7
ORGANISM Alphapapillomavirus 7
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota;
Papovaviricetes; Zurhausenvirales; Papillomaviridae;
Firstpapillomavirinae; Alphapapillomavirus.
REFERENCE 1
AUTHORS Cole,S.T. and Danos,O.
TITLE Nucleotide sequence and comparative analysis of the human
papillomavirus type 18 genome. Phylogeny of papillomaviruses and
repeated structure of the E6 and E7 gene products
JOURNAL J. Mol. Biol. 193 (4), 599-608 (1987)
PUBMED 3039146
REFERENCE 2 (bases 1 to 7857)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (01-AUG-2000) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from X05015.
Data kindly reviewed (14-AUG-1987) by Danos O.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..7857
/organism="Alphapapillomavirus 7"
/mol_type="genomic DNA"
/db_xref="taxon:337042"
gene 105..581
/gene="E6"
/locus_tag="HpV18gp1"
/db_xref="GeneID:1489088"
CDS 105..581
/gene="E6"
/locus_tag="HpV18gp1"
/codon_start=1
/product="E6 protein"
/protein_id="NP_040310.1"
/db_xref="GOA:P06463"
/db_xref="InterPro:IPR001334"
/db_xref="UniProtKB/Swiss-Prot:P06463"
/db_xref="GeneID:1489088"
/translation="MARFEDPTRRPYKLPDLCTELNTSLQDIEITCVYCKTVLELTEV
FEFAFKDLFVVYRDSIPHAACHKCIDFYSRIRELRHYSDSVYGDTLEKLTNTGLYNLL
IRCLRCQKPLNPAEKLRHLNEKRRFHNIAGHYRGQCHSCCNRARQERLQRRRETQV"
misc_feature 144..527
/gene="E6"
/locus_tag="HpV18gp1"
/note="Early Protein (E6); Region: E6; cl27673"
/db_xref="CDD:332494"
gene 590..907
/gene="E7"
/locus_tag="HpV18gp2"
/db_xref="GeneID:1489089"
CDS 590..907
/gene="E7"
/locus_tag="HpV18gp2"
/codon_start=1
/product="E7 protein"
/protein_id="NP_040311.1"
/db_xref="GOA:P06788"
/db_xref="UniProtKB/Swiss-Prot:P06788"
/db_xref="GeneID:1489089"
/translation="MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGV
NHQHLPARRAEPQRHTMLCMCCKCEARIELVVESSADDLRAFQQLFLNTLSFVCPWCA
SQQ"
misc_feature 590..901
/gene="E7"
/locus_tag="HpV18gp2"
/note="E7 protein, Early protein; Region: E7; cl02891"
/db_xref="CDD:295537"
gene 914..2887
/gene="E1"
/locus_tag="HpV18gp3"
/db_xref="GeneID:1489084"
CDS 914..2887
/gene="E1"
/locus_tag="HpV18gp3"
/note="E1; The Papillomaviriuses are icosahedral dsDNA
viruses that encode 7 early proteins, E1 to E7, and 2 late
structural proteins L1 and L2. Host infection by members
of the papillomaviruses gives rise to warts and cancer in
some instances. The E1 helicase protein is an
ATP-dependent DNA helicase that facilitates the
inititiation of viral DNA replication through its
interactions with the viral E2 protein. The E1-E2 complex
binds to the viral origin of replication where E1 acts to
unwind the DNA and E2 acts as a transcriptional
activator."
/codon_start=1
/product="E1"
/protein_id="NP_040312.1"
/db_xref="GOA:P06789"
/db_xref="InterPro:IPR001177"
/db_xref="UniProtKB/Swiss-Prot:P06789"
/db_xref="GeneID:1489084"
/translation="MADPEGTDGEGTGCNGWFYVQAIVDKKTGDVISDDEDENATDTG
SDMVDFIDTQGTFCEQAELETAQALFHAQEVHNDAQVLHVLKRKFAGGSTENSPLGER
LEVDTELSPRLQEISLNSGQKKAKRRLFTISDSGYGCSEVEATQIQVTTNGEHGGNVC
SGGSTEAIDNGGTEGNNSSVDGTSDNSNIENVNPQCTIAQLKDLLKVNNKQGAMLAVF
KDTYGLSFTDLVRNFKSDKTTCTDWVTAIFGVNPTIAEGFKTLIQPFILYAHIQCLDC
KWGVLILALLRYKCGKSRLTVAKGLSTLLHVPETCMLIQPPKLRSSVAALYWYRTGIS
NISEVMGDTPEWIQRLTIIQHGIDDSNFDLSEMVQWAFDNELTDESDMAFEYALLADS
NSNAAAFLKSNCQAKYLKDCATMCKHYRRAQKRQMNMSQWIRFRCSKIDEGGDWRPIV
QFLRYQQIEFITFLGALKSFLKGTPKKNCLVFCGPANTGKSYFGMSFIHFIQGAVISF
VNSTSHFWLEPLTDTKVAMLDDATTTCWTYFDTYMRNALDGNPISIDRKHKPLIQLKC
PPILLTTNIHPAKDNRWPYLESRITVFEFPNAFPFDKNGNPVYEINDKNWKCFFERTW
SRLDLHEEEEDADTEGNPFGTFKLRAGQNHRPL"
misc_feature 914..2884
/gene="E1"
/locus_tag="HpV18gp3"
/note="E1; Provisional; Region: PHA02774"
/db_xref="CDD:222927"
misc_feature 914..1336
/gene="E1"
/locus_tag="HpV18gp3"
/note="E1 Protein, N terminal domain; Region: PPV_E1_N;
pfam00524"
/db_xref="CDD:278925"
misc_feature 1562..2857
/gene="E1"
/locus_tag="HpV18gp3"
/note="Parvovirus non-structural protein NS1; Region:
Parvo_NS1; cl24009"
/db_xref="CDD:305166"
gene 2817..3914
/gene="E2"
/locus_tag="HpV18gp4"
/db_xref="GeneID:1489085"
CDS 2817..3914
/gene="E2"
/locus_tag="HpV18gp4"
/codon_start=1
/product="E2 protein"
/protein_id="NP_040313.1"
/db_xref="GOA:P06790"
/db_xref="UniProtKB/Swiss-Prot:P06790"
/db_xref="GeneID:1489085"
/translation="MQTPKETLSERLSCVQDKIIDHYENDSKDIDSQIQYWQLIRWEN
AIFFAAREHGIQTLNHQVVPAYNISKSKAHKAIELQMALQGLAQSRYKTEDWTLQDTC
EELWNTEPTHCFKKGGQTVQVYFDGNKDNCMTYVAWDSVYYMTDAGTWDKTATCVSHR
GLYYVKEGYNTFYIEFKSECEKYGNTGTWEVHFGNNVIDCNDSMCSTSDDTVSATQLV
KQLQHTPSPYSSTVSVGTAKTYGQTSAATRPGHCGLAEKQHCGPVNPLLGAATPTGNN
KRRKLCSGNTTPIIHLKGDRNSLKCLRYRLRKHSDHYRDISSTWHWTGAGNEKTGILT
VTYHSETQRTKFLNTVAIPDSVQILVGYMTM"
misc_feature 2832..3416
/gene="E2"
/locus_tag="HpV18gp4"
/note="E2 (early) protein, N terminal; Region: PPV_E2_N;
pfam00508"
/db_xref="CDD:278909"
misc_feature 3678..3905
/gene="E2"
/locus_tag="HpV18gp4"
/note="E2 (early) protein, C terminal; Region: PPV_E2_C;
pfam00511"
/db_xref="CDD:278912"
gene 3418..3684
/gene="E4"
/locus_tag="HpV18gp5"
/db_xref="GeneID:1489086"
CDS 3418..3684
/gene="E4"
/locus_tag="HpV18gp5"
/codon_start=1
/product="E4 protein"
/protein_id="NP_040314.1"
/db_xref="InterPro:IPR003861"
/db_xref="UniProtKB/Swiss-Prot:P06791"
/db_xref="GeneID:1489086"
/translation="MTLCAVPVTTRYPLLSLLNSYSTPPHRIPAPCPWAPQRPTARRR
LLHDLDTVDSRRSSIVDLSTHFSVQLHLQATTKDGNSVVVTLRL"
misc_feature 3424..3681
/gene="E4"
/locus_tag="HpV18gp5"
/note="E4 protein; Region: Pap_E4; pfam02711"
/db_xref="CDD:367150"
gene 3936..4157
/gene="E5"
/locus_tag="HpV18gp6"
/db_xref="GeneID:1489087"
CDS 3936..4157
/gene="E5"
/locus_tag="HpV18gp6"
/codon_start=1
/product="E5 protein"
/protein_id="NP_040315.1"
/db_xref="InterPro:IPR004270"
/db_xref="UniProtKB/Swiss-Prot:P06792"
/db_xref="GeneID:1489087"
/translation="MLSLIFLFCFCVCMYVCCHVPLLPSVCMCAYAWVLVFVYIVVIT
SPATAFTVYVFCFLLPMLLLHIHAILSLQ"
misc_feature 3939..4154
/gene="E5"
/locus_tag="HpV18gp6"
/note="Papillomavirus E5; Region: Papilloma_E5; pfam03025"
/db_xref="CDD:145918"
gene 4244..5632
/gene="L2"
/locus_tag="HpV18gp7"
/db_xref="GeneID:1489091"
CDS 4244..5632
/gene="L2"
/locus_tag="HpV18gp7"
/codon_start=1
/product="L2 protein"
/protein_id="NP_040316.1"
/db_xref="GOA:P06793"
/db_xref="InterPro:IPR000784"
/db_xref="UniProtKB/Swiss-Prot:P06793"
/db_xref="GeneID:1489091"
/translation="MVSHRAARRKRASVTDLYKTCKQSGTCPPDVVPKVEGTTLADKI
LQWSSLGIFLGGLGIGTGSGTGGRTGYIPLGGRSNTVVDVGPTRPPVVIEPVGPTDPS
IVTLIEDSSVVTSGAPRPTFTGTSGFDITSAGTTTPAVLDITPSSTSVSISTTNFTNP
AFSDPSIIEVPQTGEVAGNVFVGTPTSGTHGYEEIPLQTFASSGTGEEPISSTPLPTV
RRVAGPRLYSRAYQQVSVANPEFLTRPSSLITYDNPAFEPVDTTLTFDPRSDVPDSDF
MDIIRLHRPALTSRRGTVRFSRLGQRATMFTRSGTQIGARVHFYHDISPIAPSPEYIE
LQPLVSATEDNDLFDIYADDMDPAVPVPSRSTTSFAFFKYSPTISSASSYSNVTVPLT
SSWDVPVYTGPDITLPSTTSVWPIVSPTAPASTQYIGIHGTHYYLWPLYYFIPKKRKR
VPYFFADGFVAA"
misc_feature 4244..>5320
/gene="L2"
/locus_tag="HpV18gp7"
/note="major capsid L1 protein; Provisional; Region:
PHA02777"
/db_xref="CDD:165142"
misc_feature 4262..5593
/gene="L2"
/locus_tag="HpV18gp7"
/note="Late Protein L2; Region: Late_protein_L2;
pfam00513"
/db_xref="CDD:278914"
gene 5430..7136
/gene="L1"
/locus_tag="HpV18gp8"
/db_xref="GeneID:1489090"
CDS 5430..7136
/gene="L1"
/locus_tag="HpV18gp8"
/note="major capsid L1 protein; Two structural proteins
are involved in papillomavirus capsid formation, a major
(L1) and a minor (L2) protein; L1 forms the pentameric
assembly unit of the viral shell while L2 mediates several
facets of viral entry including endosomal escape after
uncoating"
/codon_start=1
/product="major capsid L1 protein"
/protein_id="NP_040317.1"
/db_xref="GOA:P06794"
/db_xref="InterPro:IPR002210"
/db_xref="InterPro:IPR008975"
/db_xref="UniProtKB/Swiss-Prot:P06794"
/db_xref="GeneID:1489090"
/translation="MCLYTRVLILHYHLLPLYGPLYHPRPLPLHSILVYMVHIIICGH
YIILFLRNVNVFPIFLQMALWRPSDNTVYLPPPSVARVVNTDDYVTPTSIFYHAGSSR
LLTVGNPYFRVPAGGGNKQDIPKVSAYQYRVFRVQLPDPNKFGLPDTSIYNPETQRLV
WACAGVEIGRGQPLGVGLSGHPFYNKLDDTESSHAATSNVSEDVRDNVSVDYKQTQLC
ILGCAPAIGEHWAKGTACKSRPLSQGDCPPLELKNTVLEDGDMVDTGYGAMDFSTLQD
TKCEVPLDICQSICKYPDYLQMSADPYGDSMFFCLRREQLFARHFWNRAGTMGDTVPQ
SLYIKGTGMPASPGSCVYSPSPSGSIVTSDSQLFNKPYWLHKAQGHNNGVCWHNQLFV
TVVDTTPSTNLTICASTQSPVPGQYDATKFKQYSRHVEEYDLQFIFQLCTITLTADVM
SYIHSMNSSILEDWNFGVPPPPTTSLVDTYRFVQSVAITCQKDAAPAENKDPYDKLKF
WNVDLKEKFSLDLDQYPLGRKFLVQAGLRRKPTIGPRKRSAPSATTSSKPAKRVRVRA
RK"
misc_feature 5613..7124
/gene="L1"
/locus_tag="HpV18gp8"
/note="major capsid L1 protein; Provisional; Region:
PHA02778"
/db_xref="CDD:222928"
ORIGIN
1 attaatactt ttaacaattg tagtatataa aaaagggagt aaccgaaaac ggtcgggacc
61 gaaaacggtg tatataaaag atgtgagaaa cacaccacaa tactatggcg cgctttgagg
121 atccaacacg gcgaccctac aagctacctg atctgtgcac ggaactgaac acttcactgc
181 aagacataga aataacctgt gtatattgca agacagtatt ggaacttaca gaggtatttg
241 aatttgcatt taaagattta tttgtggtgt atagagacag tataccccat gctgcatgcc
301 ataaatgtat agatttttat tctagaatta gagaattaag acattattca gactctgtgt
361 atggagacac attggaaaaa ctaactaaca ctgggttata caatttatta ataaggtgcc
421 tgcggtgcca gaaaccgttg aatccagcag aaaaacttag acaccttaat gaaaaacgac
481 gatttcacaa catagctggg cactatagag gccagtgcca ttcgtgctgc aaccgagcac
541 gacaggaacg actccaacga cgcagagaaa cacaagtata atattaagta tgcatggacc
601 taaggcaaca ttgcaagaca ttgtattgca tttagagccc caaaatgaaa ttccggttga
661 ccttctatgt cacgagcaat taagcgactc agaggaagaa aacgatgaaa tagatggagt
721 taatcatcaa catttaccag cccgacgagc cgaaccacaa cgtcacacaa tgttgtgtat
781 gtgttgtaag tgtgaagcca gaattgagct agtagtagaa agctcagcag acgaccttcg
841 agcattccag cagctgtttc tgaacaccct gtcctttgtg tgtccgtggt gtgcatccca
901 gcagtaagca acaatggctg atccagaagg tacagacggg gagggcacgg gttgtaacgg
961 ctggttttat gtacaagcta ttgtagacaa aaaaacagga gatgtaatat cagatgacga
1021 ggacgaaaat gcaacagaca cagggtcgga tatggtagat tttattgata cacaaggaac
1081 attttgtgaa caggcagagc tagagacagc acaggcattg ttccatgcgc aggaggtcca
1141 caatgatgca caagtgttgc atgttttaaa acgaaagttt gcaggaggca gcacagaaaa
1201 cagtccatta ggggagcggc tggaggtgga tacagagtta agtccacggt tacaagaaat
1261 atctttaaat agtgggcaga aaaaggcaaa aaggcggctg tttacaatat cagatagtgg
1321 ctatggctgt tctgaagtgg aagcaacaca gattcaggta actacaaatg gcgaacatgg
1381 cggcaatgta tgtagtggcg gcagtacgga ggctatagac aacgggggca cagagggcaa
1441 caacagcagt gtagacggta caagtgacaa tagcaatata gaaaatgtaa atccacaatg
1501 taccatagca caattaaaag acttgttaaa agtaaacaat aaacaaggag ctatgttagc
1561 agtatttaaa gacacatatg ggctatcatt tacagattta gttagaaatt ttaaaagtga
1621 taaaaccacg tgtacagatt gggttacagc tatatttgga gtaaacccaa caatagcaga
1681 aggatttaaa acactaatac agccatttat attatatgcc catattcaat gtctagactg
1741 taaatgggga gtattaatat tagccctgtt gcgttacaaa tgtggtaaga gtagactaac
1801 agttgctaaa ggtttaagta cgttgttaca cgtacctgaa acttgtatgt taattcaacc
1861 accaaaattg cgaagtagtg ttgcagcact atattggtat agaacaggaa tatcaaatat
1921 tagtgaagta atgggagaca cacctgagtg gatacaaaga cttactatta tacaacatgg
1981 aatagatgat agcaattttg atttgtcaga aatggtacaa tgggcatttg ataatgagct
2041 gacagatgaa agcgatatgg catttgaata tgccttatta gcagacagca acagcaatgc
2101 agctgccttt ttaaaaagca attgccaagc taaatattta aaagattgtg ccacaatgtg
2161 caaacattat aggcgagccc aaaaacgaca aatgaatatg tcacagtgga tacgatttag
2221 atgttcaaaa atagatgaag ggggagattg gagaccaata gtgcaattcc tgcgatacca
2281 acaaatagag tttataacat ttttaggagc cttaaaatca tttttaaaag gaacccccaa
2341 aaaaaattgt ttagtatttt gtggaccagc aaatacagga aaatcatatt ttggaatgag
2401 ttttatacac tttatacaag gagcagtaat atcatttgtg aattccacta gtcatttttg
2461 gttggaaccg ttaacagata ctaaggtggc catgttagat gatgcaacga ccacgtgttg
2521 gacatacttt gatacctata tgagaaatgc gttagatggc aatccaataa gtattgatag
2581 aaagcacaaa ccattaatac aactaaaatg tcctccaata ctactaacca caaatataca
2641 tccagcaaag gataatagat ggccatattt agaaagtaga ataacagtat ttgaatttcc
2701 aaatgcattt ccatttgata aaaatggcaa tccagtatat gaaataaatg acaaaaattg
2761 gaaatgtttt tttgaaagga catggtccag attagatttg cacgaggaag aggaagatgc
2821 agacaccgaa ggaaaccctt tcggaacgtt taagttgcgt gcaggacaaa atcatagacc
2881 actatgaaaa tgacagtaaa gacatagaca gccaaataca gtattggcaa ctaatacgtt
2941 gggaaaatgc aatattcttt gcagcaaggg aacatggcat acagacatta aaccaccagg
3001 tggtgccagc ctataacatt tcaaaaagta aagcacataa agctattgaa ctgcaaatgg
3061 ccctacaagg ccttgcacaa agtcgataca aaaccgagga ttggacactg caagacacat
3121 gcgaggaact atggaataca gaacctactc actgctttaa aaaaggtggc caaacagtac
3181 aagtatattt tgatggcaac aaagacaatt gtatgaccta tgtagcatgg gacagtgtgt
3241 attatatgac tgatgcagga acatgggaca aaaccgctac ctgtgtaagt cacaggggat
3301 tgtattatgt aaaggaaggg tacaacacgt tttatataga atttaaaagt gaatgtgaaa
3361 aatatgggaa cacaggtacg tgggaagtac attttgggaa taatgtaatt gattgtaatg
3421 actctatgtg cagtaccagt gacgacacgg tatccgctac tcagcttgtt aaacagctac
3481 agcacacccc ctcaccgtat tccagcaccg tgtccgtggg caccgcaaag acctacggcc
3541 agacgtcggc tgctacacga cctggacact gtggactcgc ggagaagcag cattgtggac
3601 ctgtcaaccc acttctcggt gcagctacac ctacaggcaa caacaaaaga cggaaactct
3661 gtagtggtaa cactacgcct ataatacatt taaaaggtga cagaaacagt ttaaaatgtt
3721 tacggtacag attgcgaaaa catagcgacc actatagaga tatatcatcc acctggcatt
3781 ggacaggtgc aggcaatgaa aaaacaggaa tactgactgt aacataccat agtgaaacac
3841 aaagaacaaa atttttaaat actgttgcaa ttccagatag tgtacaaata ttggtgggat
3901 acatgacaat gtaatacata tgctgtagta ccaatatgtt atcacttatt tttttatttt
3961 gcttttgtgt atgcatgtat gtgtgctgcc atgtcccgct tttgccatct gtctgtatgt
4021 gtgcgtatgc atgggtattg gtatttgtgt atattgtggt aataacgtcc cctgccacag
4081 cattcacagt atatgtattt tgttttttat tgcccatgtt actattgcat atacatgcta
4141 tattgtcttt acagtaattg tataggttgt tttatacagt gtattgtaca ttgtatattt
4201 tgttttatac cttttatgct ttttgtattt ttgtaataaa agtatggtat cccaccgtgc
4261 cgcacgacgc aaacgggctt cggtaactga cttatataaa acatgtaaac aatctggtac
4321 atgtccacct gatgttgttc ctaaggtgga gggcaccacg ttagcagata aaatattgca
4381 atggtcaagc cttggtatat ttttgggtgg acttggcata ggtactggca gtggtacagg
4441 gggtcgtaca gggtacattc cattgggtgg gcgttccaat acagtggtgg atgttggtcc
4501 tacacgtccc ccagtggtta ttgaacctgt gggccccaca gacccatcta ttgttacatt
4561 aatagaggac tccagtgtgg ttacatcagg tgcacctagg cctacgttta ctggcacgtc
4621 tgggtttgat ataacatctg cgggtacaac tacacctgcg gttttggata tcacaccttc
4681 gtctacctct gtgtctattt ccacaaccaa ttttaccaat cctgcatttt ctgatccgtc
4741 cattattgaa gttccacaaa ctggggaggt ggcaggtaat gtatttgttg gtacccctac
4801 atctggaaca catgggtatg aggaaatacc tttacaaaca tttgcttctt ctggtacggg
4861 ggaggaaccc attagtagta ccccattgcc tactgtgcgg cgtgtagcag gtccccgcct
4921 ttacagtagg gcctaccaac aagtgtcagt ggctaaccct gagtttctta cacgtccatc
4981 ctctttaatt acatatgaca acccggcctt tgagcctgtg gacactacat taacatttga
5041 tcctcgtagt gatgttcctg attcagattt tatggatatt atccgtctac ataggcctgc
5101 tttaacatcc aggcgtggga ctgttcgctt tagtagatta ggtcaacggg caactatgtt
5161 tacccgcagc ggtacacaaa taggtgctag ggttcacttt tatcatgata taagtcctat
5221 tgcaccttcc ccagaatata ttgaactgca gcctttagta tctgccacgg aggacaatga
5281 cttgtttgat atatatgcag atgacatgga ccctgcagtg cctgtaccat cgcgttctac
5341 tacctccttt gcatttttta aatattcgcc cactatatct tctgcctctt cctatagtaa
5401 tgtaacggtc cctttaacct cctcttggga tgtgcctgta tacacgggtc ctgatattac
5461 attaccatct actacctctg tatggcccat tgtatcaccc acggcccctg cctctacaca
5521 gtatattggt atacatggta cacattatta tttgtggcca ttatattatt ttattcctaa
5581 gaaacgtaaa cgtgttccct atttttttgc agatggcttt gtggcggcct agtgacaata
5641 ccgtatatct tccacctcct tctgtggcaa gagttgtaaa taccgatgat tatgtgactc
5701 ccacaagcat attttatcat gctggcagct ctagattatt aactgttggt aatccatatt
5761 ttagggttcc tgcaggtggt ggcaataagc aggatattcc taaggtttct gcataccaat
5821 atagagtatt tagggtgcag ttacctgacc caaataaatt tggtttacct gatactagta
5881 tttataatcc tgaaacacaa cgtttagtgt gggcctgtgc tggagtggaa attggccgtg
5941 gtcagccttt aggtgttggc cttagtgggc atccatttta taataaatta gatgacactg
6001 aaagttccca tgccgccacg tctaatgttt ctgaggacgt tagggacaat gtgtctgtag
6061 attataagca gacacagtta tgtattttgg gctgtgcccc tgctattggg gaacactggg
6121 ctaaaggcac tgcttgtaaa tcgcgtcctt tatcacaggg cgattgcccc cctttagaac
6181 ttaaaaacac agttttggaa gatggtgata tggtagatac tggatatggt gccatggact
6241 ttagtacatt gcaagatact aaatgtgagg taccattgga tatttgtcag tctatttgta
6301 aatatcctga ttatttacaa atgtctgcag atccttatgg ggattccatg tttttttgct
6361 tacggcgtga gcagcttttt gctaggcatt tttggaatag agcaggtact atgggtgaca
6421 ctgtgcctca atccttatat attaaaggca caggtatgcc tgcttcacct ggcagctgtg
6481 tgtattctcc ctctccaagt ggctctattg ttacctctga ctcccagttg tttaataaac
6541 catattggtt acataaggca cagggtcata acaatggtgt ttgctggcat aatcaattat
6601 ttgttactgt ggtagatacc actcccagta ccaatttaac aatatgtgct tctacacagt
6661 ctcctgtacc tgggcaatat gatgctacca aatttaagca gtatagcaga catgttgagg
6721 aatatgattt gcagtttatt tttcagttgt gtactattac tttaactgca gatgttatgt
6781 cctatattca tagtatgaat agcagtattt tagaggattg gaactttggt gttccccccc
6841 ccccaactac tagtttggtg gatacatatc gttttgtaca atctgttgct attacctgtc
6901 aaaaggatgc tgcaccggct gaaaataagg atccctatga taagttaaag ttttggaatg
6961 tggatttaaa ggaaaagttt tctttagact tagatcaata tccccttgga cgtaaatttt
7021 tggttcaggc tggattgcgt cgcaagccca ccataggccc tcgcaaacgt tctgctccat
7081 ctgccactac gtcttctaaa cctgccaagc gtgtgcgtgt acgtgccagg aagtaatatg
7141 tgtgtgtgta tatatatata catctattgt tgtgtttgta tgtcctgtgt ttgtgtttgt
7201 tgtatgattg cattgtatgg tatgtatggt tgttgttgta tgttgtatgt tactatattt
7261 gttggtatgt ggcattaaat aaaatatgtt ttgtggttct gtgtgttatg tggttgcgcc
7321 ctagtgagta acaactgtat ttgtgtttgt ggtatgggtg ttgcttgttg ggctatatat
7381 tgtcctgtat ttcaagttat aaaactgcac accttacagc atccatttta tcctacaatc
7441 ctccattttg ctgtgcaacc gatttcggtt gcctttggct tatgtctgtg gttttctgca
7501 caatacagta cgctggcact attgcaaact ttaatctttt gggcactgct cctacatatt
7561 ttgaacaatt ggcgcgcctc tttggcgcat ataaggcgca cctggtatta gtcattttcc
7621 tgtccaggtg cgctacaaca attgcttgca taactatatc cactccctaa gtaataaaac
7681 tgcttttagg cacatatttt agtttgtttt tacttaagct aattgcatac ttggcttgta
7741 caactacttt catgtccaac attctgtcta cccttaacat gaactataat atgactaagc
7801 tgtgcataca tagtttatgc aaccgaaata ggttgggcag cacatactat acttttc
//
