LOCUS       NP_001116336             537 aa            linear   VRT 27-JUN-2020
DEFINITION  suppressor of cytokine signaling 9 [Takifugu rubripes].
ACCESSION   NP_001116336
VERSION     NP_001116336.1
DBSOURCE    REFSEQ: accession NM_001122864.1
KEYWORDS    RefSeq.
SOURCE      Takifugu rubripes (Fugu rubripes)
  ORGANISM  Takifugu rubripes
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Neoteleostei;
            Acanthomorphata; Eupercaria; Tetraodontiformes; Tetradontoidea;
            Tetraodontidae; Takifugu.
REFERENCE   1  (residues 1 to 537)
  AUTHORS   Jin HJ, Shao JZ, Xiang LX, Wang H and Sun LL.
  TITLE     Global identification and comparative analysis of SOCS genes in
            fish: insights into the molecular evolution of SOCS family
  JOURNAL   Mol. Immunol. 45 (5), 1258-1268 (2008)
   PUBMED   18029016
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF195752.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF195752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02369524, SAMN02369525
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Takifugu rubripes"
                     /db_xref="taxon:31033"
                     /chromosome="11"
                     /map="11"
     Protein         1..537
                     /product="suppressor of cytokine signaling 9"
                     /calculated_mol_wt=59537
     Region          <111..150
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          377..477
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(395,413,434,436)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198173"
     Site            order(435,465)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198173"
     Region          488..537
                     /region_name="SOCS"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; cl02533"
                     /db_xref="CDD:470605"
     Site            order(488..492,498,505,511)
                     /site_type="active"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     CDS             1..537
                     /gene="socs9"
                     /coded_by="NM_001122864.1:263..1876"
                     /db_xref="GeneID:100144312"
ORIGIN      
        1 mslpketgnr devpdrgarp kvrqsrseer rdagrgrkss rgkkkgsasn aaaaerpvsd
       61 gfeygellgd lhtrdqssss plkenwrgfd aatslpgpeq vtsrlglgpf sssmepsaps
      121 eresrgsnsn rtlrqkiqda mgqcfpikth aaaaaatpqa lapsaasasa ssrrkihlse
      181 lmlddcpfpa gselaqkwyl ikqhtapitq ppvldspagp stpvsslpta vddvddrlre
      241 rrrisieqgv epppnaeiht fevtaqinpl ykhgpklahg mnelagpdaa plpqqqelll
      301 qrqqqhqlll qrcldtldev vasasfhacs ansdaqpdae laasgtppgv dplqaehlkp
      361 qhgyrvhtqi dyihclvpdl lqisslpyyw gvmdryeaet llegkpegtf llrdsaqedy
      421 lfsvsfrryg rslharieqw nhnfsfdvhd psvfhaptvt gllehykdpn scmffeplls
      481 npihrkqpfq lqhicravis srttydginv lpipnvlkkh lkeyhykqrv rvrrmda
//