LOCUS NP_008933 407 aa linear PRI 20-NOV-2025
DEFINITION proteasomal ubiquitin receptor ADRM1 isoform 1 [Homo sapiens].
ACCESSION NP_008933
VERSION NP_008933.2
DBSOURCE REFSEQ: accession NM_007002.4
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 407)
AUTHORS Schaffer,L.V., Hu,M., Qian,G., Moon,K.M., Pal,A., Soni,N.,
Latham,A.P., Pontano Vaites,L., Tsai,D., Mattson,N.M., Licon,K.,
Bachelder,R., Cesnik,A., Gaur,I., Le,T., Leineweber,W., Palar,A.,
Pulido,E., Qin,Y., Zhao,X., Churas,C., Lenkiewicz,J., Chen,J.,
Ono,K., Pratt,D., Zage,P., Echeverria,I., Sali,A., Harper,J.W.,
Gygi,S.P., Foster,L.J., Huttlin,E.L., Lundberg,E. and Ideker,T.
TITLE Multimodal cell maps as a foundation for structural and functional
genomics
JOURNAL Nature 642 (8066), 222-231 (2025)
PUBMED 40205054
REMARK Erratum:[Nature. 2025 Oct;646(8086):E16. doi:
10.1038/s41586-025-09648-x. PMID: 41039152]
REFERENCE 2 (residues 1 to 407)
AUTHORS Shao,Z., Wang,Y., He,Y., Zhang,C., Zhao,Y., Zhang,M., Li,Q. and
Wang,J.
TITLE The high expression of ADRM1 in hepatocellular carcinoma is closely
related to tumor immune infiltration and is regulated by
miR-891a-5p
JOURNAL Sci Rep 14 (1), 14002 (2024)
PUBMED 38890391
REMARK GeneRIF: The high expression of ADRM1 in hepatocellular carcinoma
is closely related to tumor immune infiltration and is regulated by
miR-891a-5p.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 407)
AUTHORS Osei-Amponsa,V., Chandravanshi,M., Lu,X., Magidson,V., Das,S.,
Andresson,T., Dyba,M., Sabbasani,V.R., Swenson,R.E., Fromont,C.,
Shrestha,B., Zhao,Y., Clapp,M.E., Chari,R. and Walters,K.J.
TITLE hRpn13 shapes the proteome and transcriptome through epigenetic
factors HDAC8, PADI4, and transcription factor NF-kappaB p50
JOURNAL Mol Cell 84 (3), 522-537 (2024)
PUBMED 38151017
REMARK GeneRIF: hRpn13 shapes the proteome and transcriptome through
epigenetic factors HDAC8, PADI4, and transcription factor NF-kappaB
p50.
REFERENCE 4 (residues 1 to 407)
AUTHORS Zhu,D. and Zhong,Q.
TITLE Potential of adhesion-regulating molecule 1 (ADRM1) as a biomarker
for patients with renal clear-cell carcinoma or papillary-cell
carcinoma
JOURNAL Asian J Surg 46 (10), 4666-4668 (2023)
PUBMED 37268471
REMARK GeneRIF: Potential of adhesion-regulating molecule 1 (ADRM1) as a
biomarker for patients with renal clear-cell carcinoma or
papillary-cell carcinoma.
REFERENCE 5 (residues 1 to 407)
AUTHORS Xiao,J., Xie,Y., Duan,Q., Liu,T., Ye,R., Duan,X., Le,Z., Deng,N.
and Liu,F.
TITLE LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1
Transcription to Facilitate the Pathological Progression of
Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell
Models
JOURNAL Int Heart J 64 (4), 750-758 (2023)
PUBMED 37518356
REMARK GeneRIF: LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1
Transcription to Facilitate the Pathological Progression of
Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell
Models.
REFERENCE 6 (residues 1 to 407)
AUTHORS Jorgensen,J.P., Lauridsen,A.M., Kristensen,P., Dissing,K.,
Johnsen,A.H., Hendil,K.B. and Hartmann-Petersen,R.
TITLE Adrm1, a putative cell adhesion regulating protein, is a novel
proteasome-associated factor
JOURNAL J Mol Biol 360 (5), 1043-1052 (2006)
PUBMED 16815440
REMARK GeneRIF: Adrm1 has a specialised role in proteasome function.
Identified Adrm1 as a novel component of the regulatory ATPase
complex of the 26 S proteasome
REFERENCE 7 (residues 1 to 407)
AUTHORS Lamerant,N. and Kieda,C.
TITLE Adhesion properties of adhesion-regulating molecule 1 protein on
endothelial cells
JOURNAL FEBS J 272 (8), 1833-1844 (2005)
PUBMED 15819879
REMARK GeneRIF: ARM-1 is a cytosolic protein associated with the plasma
membrane. However, no cell surface expression of the protein was
observed. These results suggest an indirect role of ARM-1 in
adhesion rather than a direct role as an adhesion molecule
itself.[ARM-1]
REFERENCE 8 (residues 1 to 407)
AUTHORS Cascio,P., Call,M., Petre,B.M., Walz,T. and Goldberg,A.L.
TITLE Properties of the hybrid form of the 26S proteasome containing both
19S and PA28 complexes
JOURNAL EMBO J 21 (11), 2636-2645 (2002)
PUBMED 12032076
REFERENCE 9 (residues 1 to 407)
AUTHORS Simins,A.B., Weighardt,H., Weidner,K.M., Weidle,U.H. and
Holzmann,B.
TITLE Functional cloning of ARM-1, an adhesion-regulating molecule
upregulated in metastatic tumor cells
JOURNAL Clin Exp Metastasis 17 (8), 641-648 (1999)
PUBMED 10919708
REFERENCE 10 (residues 1 to 407)
AUTHORS Shimada,S., Ogawa,M., Takahashi,M., Schlom,J. and Greiner,J.W.
TITLE Molecular cloning and characterization of the complementary DNA of
an M(r) 110,000 antigen expressed by human gastric carcinoma cells
and upregulated by gamma-interferon
JOURNAL Cancer Res 54 (14), 3831-3836 (1994)
PUBMED 8033103
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL354836.13.
This sequence is a reference standard in the RefSeqGene project.
On Feb 13, 2003 this sequence version replaced NP_008933.1.
Summary: This gene encodes a member of the adhesion regulating
molecule 1 protein family. The encoded protein is a component of
the proteasome where it acts as a ubiquitin receptor and recruits
the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase
L5. Increased levels of the encoded protein are associated with
increased cell adhesion, which is likely an indirect effect of this
intracellular protein. Dysregulation of this gene has been
implicated in carcinogenesis. Alternative splicing results in
multiple transcript variants. [provided by RefSeq, Jul 2013].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longer isoform (1). Variants 1 and 2
encode the same isoform.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC093021.1, SRR3476690.381698.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000253003.7/ ENSP00000253003.2
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..407
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="20"
/map="20q13.33"
Protein 1..407
/product="proteasomal ubiquitin receptor ADRM1 isoform 1"
/note="110 kDa cell membrane glycoprotein; M(r) 110,000
surface antigen; proteasomal ubiquitin receptor ADRM1;
rpn13 homolog; proteasome regulatory particle non-ATPase
13; proteasome ubiquitin receptor; adhesion regulating
molecule 1"
/calculated_mol_wt=42022
Site 2
/site_type="acetylation"
/note="N-acetylthreonine.
/evidence=ECO:0007744|PubMed:19413330,
ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378;
propagated from UniProtKB/Swiss-Prot (Q16186.2)"
Site 15
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (Q16186.2)"
Region 24..128
/region_name="PH_Rpn13"
/note="Pleckstrin homology-like domain of Regulatory
Particle Non-ATPase 13; cd13314"
/db_xref="CDD:270124"
Site order(53..54,56,73..80,98..100,103)
/site_type="other"
/note="ubiquitin binding site [polypeptide binding]"
/db_xref="CDD:270124"
Site 127
/site_type="phosphorylation"
/note="Phosphotyrosine.
/evidence=ECO:0007744|PubMed:24275569; propagated from
UniProtKB/Swiss-Prot (Q16186.2)"
Site 140
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:24275569; propagated from
UniProtKB/Swiss-Prot (Q16186.2)"
Region 194..259
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q16186.2)"
Site 211
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:18669648; propagated from
UniProtKB/Swiss-Prot (Q16186.2)"
Site 217
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:16964243,
ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163;
propagated from UniProtKB/Swiss-Prot (Q16186.2)"
Region 253..407
/region_name="Interaction with UCHL5.
/evidence=ECO:0000269|PubMed:20471946"
/note="propagated from UniProtKB/Swiss-Prot (Q16186.2)"
Region 274..381
/region_name="RPN13_C"
/note="UCH-binding domain; pfam16550"
/db_xref="CDD:465170"
Region 379..407
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q16186.2)"
Site 405
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9JMB5; propagated from
UniProtKB/Swiss-Prot (Q16186.2)"
CDS 1..407
/gene="ADRM1"
/gene_synonym="ARM-1; ARM1; GP110; PSMD16"
/coded_by="NM_007002.4:55..1278"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS13496.1"
/db_xref="GeneID:11047"
/db_xref="HGNC:HGNC:15759"
/db_xref="MIM:610650"
ORIGIN
1 mttsgalfps lvpgsrgasn kylvefragk mslkgttvtp dkrkglvyiq qtddslihfc
61 wkdrtsgnve ddliifpddc efkrvpqcps grvyvlkfka gskrlffwmq epktdqdeeh
121 crkvneylnn ppmpgalgas gssghelsal ggegglqsll gnmshsqlmq ligpaglggl
181 gglgaltgpg lasllgssgp pgsssssssr sqsaavtpss ttsstratpa psapaaasat
241 spspapssgn gastaasptq piqlsdlqsi latmnvpagp aggqqvdlas vltpeimapi
301 lanadvqerl lpylpsgesl pqtadeiqnt ltspqfqqal gmfsaalasg qlgplmcqfg
361 lpaeaveaan kgdveafaka mqnnakpeqk egdtkdkkde eedmsld
//
