LOCUS       WP_004078661              86 aa            linear   BCT 02-MAR-2025
DEFINITION  type II toxin-antitoxin system HicB family antitoxin [Methanoplanus
            limicola].
ACCESSION   WP_004078661
VERSION     WP_004078661.1
KEYWORDS    RefSeq.
SOURCE      Methanoplanus limicola
  ORGANISM  Methanoplanus limicola
            Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
            Methanomicrobia; Methanomicrobiales; Methanomicrobiaceae;
            Methanoplanus.
REFERENCE   1  (residues 1 to 86)
  AUTHORS   Winter,A.J., Williams,C., Isupov,M.N., Crocker,H., Gromova,M.,
            Marsh,P., Wilkinson,O.J., Dillingham,M.S., Harmer,N.J.,
            Titball,R.W. and Crump,M.P.
  TITLE     The molecular basis of protein toxin HicA-dependent binding of the
            protein antitoxin HicB to DNA
  JOURNAL   J Biol Chem 293 (50), 19429-19440 (2018)
   PUBMED   30337369
REFERENCE   2  (residues 1 to 86)
  AUTHORS   Hall,A.M., Gollan,B. and Helaine,S.
  TITLE     Toxin-antitoxin systems: reversible toxicity
  JOURNAL   Curr Opin Microbiol 36, 102-110 (2017)
   PUBMED   28279904
REFERENCE   3  (residues 1 to 86)
  AUTHORS   Bibi-Triki,S., Li de la Sierra-Gallay,I., Lazar,N., Leroy,A., Van
            Tilbeurgh,H., Sebbane,F. and Pradel,E.
  TITLE     Functional and structural analysis of HicA3-HicB3, a novel
            toxin-antitoxin system of Yersinia pestis
  JOURNAL   J Bacteriol 196 (21), 3712-3723 (2014)
   PUBMED   25112480
REFERENCE   4  (residues 1 to 86)
  AUTHORS   Makarova,K.S., Grishin,N.V. and Koonin,E.V.
  TITLE     The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin
            system in archaea and bacteria
  JOURNAL   Bioinformatics 22 (21), 2581-2584 (2006)
   PUBMED   16895922
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10003996
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..86
                     /organism="Methanoplanus limicola"
                     /db_xref="taxon:2315"
     Protein         1..86
                     /product="type II toxin-antitoxin system HicB family
                     antitoxin"
                     /GO_component="GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /calculated_mol_wt=9517
     Region          14..73
                     /region_name="HicB"
                     /note="Antitoxin component HicB of the HicAB
                     toxin-antitoxin system [Defense mechanisms]; COG1598"
                     /db_xref="CDD:441206"
ORIGIN      
        1 miieyiqaal skanyeiied depyygevpg lagvwatgkt leecrnnlae vidgwivirl
       61 rkglsippid gykieefsrm ntgvtv
//