LOCUS       WP_120189242             709 aa            linear   BCT 15-JUL-2025
DEFINITION  HD family phosphohydrolase [Ammoniphilus oxalaticus].
ACCESSION   WP_120189242
VERSION     WP_120189242.1
KEYWORDS    RefSeq.
SOURCE      Ammoniphilus oxalaticus
  ORGANISM  Ammoniphilus oxalaticus
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales;
            Paenibacillaceae; Aneurinibacillus group; Ammoniphilus.
REFERENCE   1  (residues 1 to 709)
  AUTHORS   Huynh,T.N., Luo,S., Pensinger,D., Sauer,J.D., Tong,L. and
            Woodward,J.J.
  TITLE     An HD-domain phosphodiesterase mediates cooperative hydrolysis of
            c-di-AMP to affect bacterial growth and virulence
  JOURNAL   Proc Natl Acad Sci U S A 112 (7), E747-E756 (2015)
   PUBMED   25583510
REFERENCE   2  (residues 1 to 709)
  AUTHORS   Aravind,L. and Koonin,E.V.
  TITLE     The HD domain defines a new superfamily of metal-dependent
            phosphohydrolases
  JOURNAL   Trends Biochem Sci 23 (12), 469-472 (1998)
   PUBMED   9868367
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11445215
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..709
                     /organism="Ammoniphilus oxalaticus"
                     /db_xref="taxon:66863"
     Protein         1..709
                     /product="HD family phosphohydrolase"
                     /EC_number="3.1.4.59"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0106409 - cyclic-di-AMP phosphodiesterase
                     activity [Evidence IEA]"
                     /calculated_mol_wt=79649
     Region          17..707
                     /region_name="PgpH"
                     /note="Cyclic di-AMP-specific phosphodiesterase PgpH, HD
                     superfamily [Signal transduction mechanisms]; COG1480"
                     /db_xref="CDD:441089"
ORIGIN      
        1 mkkrllqsvq ripnnwktsr amrallfvll aiaiyfllle hvipktydlq rnmisdvlvt
       61 apmevedtes tkklqgdaik avspiytmde riianqlkvl dqifrdvtdv klkreeesal
      121 tnsseqqqdk eklkelvpyn fsdetyqtll kqtpeslatm kaisrnivss imlegfrsge
      181 evkvkdrvte qlttselesr mvqaireval atvvpnivfd eqateqakdr varsvkpvii
      241 hkgeilvgeg eyitdeiyrk lgvagllthn pnyypyigla lfvslavvff hlyiskgale
      301 irvnntqllm fiviillnlv vlktvslgkd leysfigfla pvafgsmliv lfidyhlalf
      361 agglfsicas lmfnssseyl fnygygfval aacvtgaycl hnrtkrrnil laglfvvftn
      421 iisvtsiyml fysvkwaelf qlygfaitsg llasiltigf vpflessfgi lssmkliels
      481 spnqpllrrl lmetpgtyhh simvanlsea aaeaigangl larvgayyhd vgkmkrpqff
      541 ienqmggenp hdkqaptlsr tiilshtedg vkllqeynlp kpiqdiaaqh hgtsllrffy
      601 hkatqeatrp iseeefrypg pkpqfkeaai vgicdsveaa vrslakpspe qienlvrkiv
      661 kdrlddrqls ecdltflele qitqsicetl kgifhtriey paeaevkha
//