LOCUS WP_149425701 965 aa linear BCT 01-APR-2025
DEFINITION bifunctional diguanylate cyclase/phosphodiesterase [Oryzomicrobium
terrae].
ACCESSION WP_149425701
VERSION WP_149425701.1
KEYWORDS RefSeq.
SOURCE Oryzomicrobium terrae
ORGANISM Oryzomicrobium terrae
Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
Rhodocyclales; Rhodocyclaceae; Oryzomicrobium.
REFERENCE 1 (residues 1 to 965)
AUTHORS Upadhyay,A.A., Fleetwood,A.D., Adebali,O., Finn,R.D. and
Zhulin,I.B.
TITLE Cache Domains That are Homologous to, but Different from PAS
Domains Comprise the Largest Superfamily of Extracellular Sensors
in Prokaryotes
JOURNAL PLoS Comput Biol 12 (4), e1004862 (2016)
PUBMED 27049771
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 965)
AUTHORS Romling,U. and Amikam,D.
TITLE Cyclic di-GMP as a second messenger
JOURNAL Curr Opin Microbiol 9 (2), 218-228 (2006)
PUBMED 16530465
REFERENCE 3 (residues 1 to 965)
AUTHORS Simm,R., Fetherston,J.D., Kader,A., Romling,U. and Perry,R.D.
TITLE Phenotypic convergence mediated by GGDEF-domain-containing proteins
JOURNAL J Bacteriol 187 (19), 6816-6823 (2005)
PUBMED 16166544
REMARK Erratum:[J Bacteriol. 2006 Mar;188(5):2024]
REFERENCE 4 (residues 1 to 965)
AUTHORS Romling,U., Gomelsky,M. and Galperin,M.Y.
TITLE C-di-GMP: the dawning of a novel bacterial signalling system
JOURNAL Mol Microbiol 57 (3), 629-639 (2005)
PUBMED 16045609
REFERENCE 5 (residues 1 to 965)
AUTHORS Chan,C., Paul,R., Samoray,D., Amiot,N.C., Giese,B., Jenal,U. and
Schirmer,T.
TITLE Structural basis of activity and allosteric control of diguanylate
cyclase
JOURNAL Proc Natl Acad Sci U S A 101 (49), 17084-17089 (2004)
PUBMED 15569936
REFERENCE 6 (residues 1 to 965)
AUTHORS Simm,R., Morr,M., Kader,A., Nimtz,M. and Romling,U.
TITLE GGDEF and EAL domains inversely regulate cyclic di-GMP levels and
transition from sessility to motility
JOURNAL Mol Microbiol 53 (4), 1123-1134 (2004)
PUBMED 15306016
REFERENCE 7 (residues 1 to 965)
AUTHORS D'Argenio,D.A. and Miller,S.I.
TITLE Cyclic di-GMP as a bacterial second messenger
JOURNAL Microbiology (Reading) 150 (Pt 8), 2497-2502 (2004)
PUBMED 15289546
REFERENCE 8 (residues 1 to 965)
AUTHORS Jenal,U.
TITLE Cyclic di-guanosine-monophosphate comes of age: a novel secondary
messenger involved in modulating cell surface structures in
bacteria?
JOURNAL Curr Opin Microbiol 7 (2), 185-191 (2004)
PUBMED 15063857
REFERENCE 9 (residues 1 to 965)
AUTHORS Zhulin,I.B., Nikolskaya,A.N. and Galperin,M.Y.
TITLE Common extracellular sensory domains in transmembrane receptors for
diverse signal transduction pathways in bacteria and archaea
JOURNAL J Bacteriol 185 (1), 285-294 (2003)
PUBMED 12486065
REFERENCE 10 (residues 1 to 965)
AUTHORS Galperin,M.Y., Nikolskaya,A.N. and Koonin,E.V.
TITLE Novel domains of the prokaryotic two-component signal transduction
systems
JOURNAL FEMS Microbiol Lett 203 (1), 11-21 (2001)
PUBMED 11557134
REMARK Erratum:[FEMS Microbiol Lett 2001 Oct 16;204(1):213-4]
REFERENCE 11 (residues 1 to 965)
AUTHORS Pei,J. and Grishin,N.V.
TITLE GGDEF domain is homologous to adenylyl cyclase
JOURNAL Proteins 42 (2), 210-216 (2001)
PUBMED 11119645
REFERENCE 12 (residues 1 to 965)
AUTHORS Anantharaman,V. and Aravind,L.
TITLE Cache - a signaling domain common to animal Ca(2+)-channel subunits
and a class of prokaryotic chemotaxis receptors
JOURNAL Trends Biochem Sci 25 (11), 535-537 (2000)
PUBMED 11084361
REFERENCE 13 (residues 1 to 965)
AUTHORS Hurley,J.H.
TITLE The adenylyl and guanylyl cyclase superfamily
JOURNAL Curr Opin Struct Biol 8 (6), 770-777 (1998)
PUBMED 9914257
COMMENT REFSEQ: This record represents a single, non-redundant, protein
sequence which may be annotated on many different RefSeq genomes
from the same, or different, species.
##Evidence-For-Name-Assignment-START##
Evidence Category :: Conserved Domain (CDD)
Evidence Accession :: Domain architecture ID 20590127
Evidence Source :: NCBI SPARCLE
##Evidence-For-Name-Assignment-END##
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..965
/organism="Oryzomicrobium terrae"
/db_xref="taxon:1735038"
Protein 1..965
/product="bifunctional diguanylate
cyclase/phosphodiesterase"
/EC_number="2.7.7.65"
/EC_number="3.1.4.52"
/GO_function="GO:0005525 - GTP binding [Evidence IEA]"
/GO_function="GO:0046872 - metal ion binding [Evidence
IEA]"
/GO_function="GO:0052621 - diguanylate cyclase activity
[Evidence IEA]"
/GO_function="GO:0071111 - cyclic-guanylate-specific
phosphodiesterase activity [Evidence IEA]"
/GO_process="GO:0007165 - signal transduction [Evidence
IEA]"
/calculated_mol_wt=105409
Region 39..334
/region_name="dCache_2"
/note="Cache domain; pfam08269"
/db_xref="CDD:462414"
Region 324..958
/region_name="COG5001"
/note="Cyclic di-GMP metabolism protein, combines GGDEF
and EAL domains with a 6TM membrane domain [Signal
transduction mechanisms]"
/db_xref="CDD:444025"
ORIGIN
1 msppffsrnl khlplagmlv ivltlcvglg gyftwqyart frdnlnqlhq atqaqhqaql
61 ktqadaartd lnhtralaea rlrlrlqqev eegvsiaaal yqqaqqrdsa atrrliadal
121 rpvrffagrg yffiysedgq ailapgeptt eghsvagvhd dtgqsilasl rqavanpega
181 gfvtyrwhap gerelrhkis yvrrfapygw ligagdfvda vememqqeal arlrtfpvlk
241 ngellvmsrs grlllaqglp aleglasqdm pspelqaata qlrdaaangg gfvshawvkp
301 gtqveedgpp ppltphlayv tppdawgwsl vsgieqsvid aaeteqradl egqlarqgsa
361 ivlvllvtvt vtmlfaifya rwletllrry rqdsiehtea leanaqdlrl aarvfesgne
421 alivtdhtna ivavnaaftq itgysaaevl ghnprllssg yhdaefyrqm wesitttgtw
481 sgeiwnrrkd gslypewlhi stlfdehgqa thrvaafsdv serkaaearv rylseydsvt
541 slpnrlllee rtneamiaar rnhsgltlci ldldrfktin dslghgvgnr vlhtvgerlv
601 eaagenatvs rlggdefavi fpgtaeeaca aaaatslmns lsqplvvdgh ilaincsvgv
661 alfpgdggdf dtllrnadsa vnhaketgrn rmqfyreemn aralerlsle qalrraleaq
721 eltlfyqgqf dlatgrllga eallrwqhpe lglvppdrfi piaedtglil sigrwvlvea
781 crraaswqrp gqapvtvavn isarqfhhgd lvaevehala qsglpaaqle levtesvlmg
841 giqpvidtld qlkamgvrla lddfgtgyss laylkrfpld vlkvdrsfir alpqdqddaa
901 ivaailgmag hlglatvaeg vedeaqrahl laqgcqvaqg ylfarplpae efearlgeat
961 ltpas
//
