LOCUS       XP_004315341             440 aa            linear   MAM 07-MAY-2025
DEFINITION  suppressor of cytokine signaling 4 [Tursiops truncatus].
ACCESSION   XP_004315341
VERSION     XP_004315341.1
DBLINK      BioProject: PRJNA625792
DBSOURCE    REFSEQ: accession XM_004315293.4
KEYWORDS    RefSeq.
SOURCE      Tursiops truncatus (common bottlenose dolphin)
  ORGANISM  Tursiops truncatus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha;
            Cetacea; Odontoceti; Delphinidae; Tursiops.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_047035.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_011762595.2-RS_2025_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/30/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Tursiops truncatus"
                     /isolate="mTurTru1"
                     /db_xref="taxon:9739"
                     /chromosome="2"
                     /sex="male"
                     /tissue_type="spleen"
                     /geo_loc_name="USA: Baltimore, Maryland"
                     /lat_lon="39.2851 N 76.6083 W"
                     /collection_date="11-Nov-2018"
                     /collected_by="Leigh Clayton, Jill Arnold, Winston Timp,
                     Norah Hilger"
     Protein         1..440
                     /product="suppressor of cytokine signaling 4"
                     /calculated_mol_wt=50128
     Region          58..111
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          275..375
                     /region_name="SH2_SOCS4"
                     /note="Src homology 2 (SH2) domain found in suppressor of
                     cytokine signaling (SOCS) proteins; cd10385"
                     /db_xref="CDD:198248"
     Site            order(283,285)
                     /site_type="other"
                     /note="Elongin-C binding interface [polypeptide binding]"
                     /db_xref="CDD:198248"
     Site            order(293,311,313,321,334)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198248"
     Site            order(344,346,364)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198248"
     Region          384..439
                     /region_name="SOCS_SOCS4"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS4-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. The general
                     function of the SOCS box is the...; cd03738"
                     /db_xref="CDD:239707"
     Site            order(385..390,396,403,409,414)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239707"
     CDS             1..440
                     /gene="SOCS4"
                     /coded_by="XM_004315293.4:303..1625"
                     /db_xref="GeneID:101317925"
ORIGIN      
        1 maensesnsk nvdvrpktsr srsadrkdgy vwsgkklsws kksescsdae tvsaiektev
       61 plrsqerkhs cssieldldh scghrflgrs lkqklqdavg qcfpikncss rhssglpskr
      121 kihiselmld kcpfpprsdl afrwhfikrh tapispksde wvstdlsqte lrdgqlkqrr
      181 nmeevncfsh tsvqpcvitn ndssgrggpg tgsimnlasn nsiedsdmds ddeiitlcts
      241 srkrnkpkwe ideetlqlet ppkyhtqidy vhclvpdllq innnpcywgv mdkyaaeall
      301 egkpegtfll rdsaqedylf svsfrrysrs lharieqwnh nfsfdahdpc vfhspditgl
      361 lehykdpsac mffepllstp lirtfpfplq hicrtvicnc ttydgidalp ipssmklylk
      421 eyhykskvrv lridapeqqc
//