LOCUS       XP_006250941            1088 aa            linear   ROD 22-FEB-2024
DEFINITION  platelet-derived growth factor receptor alpha isoform X2 [Rattus
            norvegicus].
ACCESSION   XP_006250941
VERSION     XP_006250941.1
DBLINK      BioProject: PRJNA1074393
DBSOURCE    REFSEQ: accession XM_006250879.5
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_086032) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_036323735.1-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/09/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1088
                     /organism="Rattus norvegicus"
                     /strain="BN/NHsdMcwi"
                     /bio_material="RGD 61498"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /sex="male"
                     /tissue_type="kidney, spleen, liver"
                     /geo_loc_name="USA: Wisconsin, Milwaukee"
                     /lat_lon="43.05 N 88.04 W"
                     /collected_by="Rebecca Schilling, Melinda Dwinell"
     Protein         1..1088
                     /product="platelet-derived growth factor receptor alpha
                     isoform X2"
                     /calculated_mol_wt=122569
     Region          27..99
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          211..309
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          230..234
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          243..247
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          272..276
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          286..291
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          301..304
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          312..412
                     /region_name="Ig4_PDGFR"
                     /note="Fourth immunoglobulin (Ig)-like domain of
                     platelet-derived growth factor receptor (PDGFR); cd05859"
                     /db_xref="CDD:409445"
     Region          554..955
                     /region_name="PTKc_PDGFR_alpha"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Platelet Derived Growth Factor Receptor alpha; cd05105"
                     /db_xref="CDD:173653"
     Site            order(598..599,601..604,606,624,626,674,676,680,817,
                     821..822,824,835,853..857,866,901)
                     /site_type="active"
                     /db_xref="CDD:173653"
     Site            order(598..599,601..604,606,624,626,674,676,680,821..822,
                     824,835)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173653"
     Site            order(817,821,853..857,866,901)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173653"
     Site            834..859
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173653"
     CDS             1..1088
                     /gene="Pdgfra"
                     /gene_synonym="APDGFR; PDGFACE"
                     /coded_by="XM_006250879.5:660..3926"
                     /db_xref="GeneID:25267"
                     /db_xref="RGD:3284"
ORIGIN      
        1 mgtsqaflvl sclltgpsli vcqlllpsil pnenekivpl sssfslrcfg esevswqhpm
       61 seeedpnvei rteennsslf vtvlevvnas aahtgwytcy ynhtqteese iegrhiyiyv
      121 pdpdmafvpl gmtdslvive eddsaiipcr ttdpdtevtl hnngrlvpas ydsrqgfngt
      181 fsvgpyicea tvrgrtfkts efnvyalkat selnlemdtr qtvykageti vvtcavfnne
      241 vvdlqwtypg evrnkgitml eeiklpsikl vytltvpkat vkdsgdyeca arqatkevke
      301 mktvtisvhe kgfvqirptf ghletvnlhq vrefvvevqa yptpriswlk dnltlienlt
      361 eittdvqrsq etryqsklkl irakeedsgh ytiivqnddd mksytfelst lvpasilelv
      421 ddhhgsgggq tvrctaegtp lpniewmick dikkcnndts wtvlasnvsn iitefhqrgr
      481 stvegrvsfa kveetiavrc lakndlgign relklvaptl rseltvaaav lvllvivivs
      541 livlvviwkq kpryeirwrv iesispdghe yiyvdpmqlp ydsrwefprd glvlgrilgs
      601 gafgkvvegt ayglsrsqpv mkvavkmlkp tarssekqal mselkimthl gphlnivnll
      661 gactksgpiy iiteycfygd lvnylhknrd sfmsrhpekp kkdldifgln padestrsyv
      721 ilsfenngdy vdmkqadttq yvpmlerkev skysdiqrsl ydrpasykkk smldseaknl
      781 lsdddseglt lldllsftyq vargmeflas kncvhrdlaa rnvllaqgki vkicdfglar
      841 dimhdsnyvs kgstflpvkw mapesifdnl yttlsdvwsy gvllweifsl ggtpypgmmv
      901 dstfynkiks gyrmakpdha tsevyeimvq cwnsepekrp sfyhlseive nllpgqykks
      961 yekihldflk sdhpavarmr vdsdnayigv tykneedklk eweggldeqr lsadsgyiip
     1021 lpdidpvpee edlgkrnrhs sqtseesaie tgsssstfik redetiedid mmddigidss
     1081 dlvedsfl
//