LOCUS       XP_007108794             536 aa            linear   MAM 10-JAN-2025
DEFINITION  suppressor of cytokine signaling 5 [Physeter macrocephalus].
ACCESSION   XP_007108794
VERSION     XP_007108794.1
DBLINK      BioProject: PRJNA434122
DBSOURCE    REFSEQ: accession XM_007108732.3
KEYWORDS    RefSeq.
SOURCE      Physeter macrocephalus (sperm whale)
  ORGANISM  Physeter macrocephalus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha;
            Cetacea; Odontoceti; Physeteridae; Physeter.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_041225.1) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_002837175.3-RS_2025_01
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 01/08/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Physeter macrocephalus"
                     /isolate="SW-GA"
                     /db_xref="taxon:9755"
                     /chromosome="12"
                     /sex="female"
                     /tissue_type="muscle"
                     /dev_stage="adult"
     Protein         1..536
                     /product="suppressor of cytokine signaling 5"
                     /calculated_mol_wt=61083
     Region          145..193
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          370..470
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(388,406,427,429)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198173"
     Site            order(428,458)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198173"
     Region          479..534
                     /region_name="SOCS_SOCS5"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS5-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. SOCS5
                     inhibits Th2 differentiation by inhibiting...; cd03739"
                     /db_xref="CDD:239708"
     Site            order(480..485,491,498,504,509)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239708"
     CDS             1..536
                     /gene="SOCS5"
                     /coded_by="XM_007108732.3:900..2510"
                     /db_xref="GeneID:102991485"
ORIGIN      
        1 mdkvgkmwnn fkyrcqnlfs heggsrsenv dmnsnrclsv ndknisigds apqqqssplr
       61 envalqlgls psknssrrnq ncateipqiv eisiekdnds cvtpgtrlar rdsysrhapw
      121 ggkkkhscst ktqssldtdk kfgrtrsglq rrerrygvss vhdmdsvssr avgsrslrqr
      181 lqdtvglcfp mrtynkqskp lfsnkrkihl selmlekcpf pagsdlaqkw hlikqhtapv
      241 sphstffdtf dpslvstede edrlrerrrl sieegvdppp naqihtfeat aqvnplyklg
      301 pklapgmtei ngdssaipqa ncdseedttt lclqsrrqkq rqvsgdshah vsrqgawkvh
      361 tqidyihclv pdllqitgnp cywgvmdrye aeallegkpe gtfllrdsaq edylfsvsfr
      421 rynrslhari eqwnhnfsfd ahdpcvfhss tvtgllehyk dpsscmffep lltislnrtf
      481 pfslqyicra vicrcttydg idglplpsml qdflkeyhyk qkvrvrwler epvkak
//