LOCUS       XP_012509329             536 aa            linear   PRI 01-JUN-2015
DEFINITION  PREDICTED: suppressor of cytokine signaling 5 [Propithecus
            coquereli].
ACCESSION   XP_012509329
VERSION     XP_012509329.1
DBLINK      BioProject: PRJNA281642
DBSOURCE    REFSEQ: accession XM_012653875.1
KEYWORDS    RefSeq.
SOURCE      Propithecus coquereli (Coquerel's sifaka)
  ORGANISM  Propithecus coquereli
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
            Lemuriformes; Indriidae; Propithecus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_012150063.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Propithecus coquereli Annotation
                                           Release 100
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 6.3
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Propithecus coquereli"
                     /isolate="6110/MARCELLA"
                     /db_xref="taxon:379532"
                     /chromosome="Unknown"
                     /sex="female"
                     /tissue_type="kidney"
     Protein         1..536
                     /product="suppressor of cytokine signaling 5"
                     /calculated_mol_wt=61143
     Region          145..193
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          370..470
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(388,406,427,429)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198173"
     Site            order(428,458)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198173"
     Region          479..534
                     /region_name="SOCS_SOCS5"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS5-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. SOCS5
                     inhibits Th2 differentiation by inhibiting...; cd03739"
                     /db_xref="CDD:239708"
     Site            order(480..485,491,498,504,509)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239708"
     CDS             1..536
                     /gene="SOCS5"
                     /coded_by="XM_012653875.1:277..1887"
                     /db_xref="GeneID:105818014"
ORIGIN      
        1 mdkvgkmwnn fkyrcqnlfs heggsrgesv dmnsnrclsv keknisivds apqqqssplr
       61 envalqlgls psknssrrnq ncateipqiv eisiekdnes cvtpgtrlar rdsysrhapw
      121 ggkkkhscst ktqssldtdk kfgrtrsglq rrerrygvss vhdmdsvssr tvgsrslrqr
      181 lqdtvglcfp mrtynkqskp lfsnkrkihl selmlekcpf pagsdlaqkw hlikqhtapv
      241 sphstffdtf dpslvstede edrlrerrrl sieegvdppp naqihtfeat aqvnplyklg
      301 pklapgmtei sgdssaipqt ncdseedttt lclqsrrqkq rqvsgdshah vsrqgawkvh
      361 tqidyihclv pdllqitgnp cywgvmdrye aeallegkpe gtfllrdsaq edylfsvsfr
      421 rynrslhari eqwnhnfsfd ahdpcvfhss tvtgllehyk dpsscmffep lltislnrtf
      481 pfslqyicra vicrcttydg idglplpsml qdflkeyhyk qkvrvrwler epvkak
//