LOCUS       XP_012613480             440 aa            linear   PRI 01-DEC-2025
DEFINITION  suppressor of cytokine signaling 4 [Microcebus murinus].
ACCESSION   XP_012613480
VERSION     XP_012613480.2
DBLINK      BioProject: PRJNA1284384
DBSOURCE    REFSEQ: accession XM_012758026.2
KEYWORDS    RefSeq.
SOURCE      Microcebus murinus (gray mouse lemur)
  ORGANISM  Microcebus murinus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
            Lemuriformes; Cheirogaleidae; Microcebus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_134109) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Aug 6, 2025 this sequence version replaced XP_012613480.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_040939455.1-RS_2025_12
            Annotation Pipeline         :: NCBI Eukaryotic Genome Annotation
                                           Pipeline (EGAP)
            Annotation Software Version :: 10.5
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Microcebus murinus"
                     /isolate="Inina"
                     /db_xref="taxon:30608"
                     /chromosome="6"
                     /sex="female"
                     /cell_type="Fibroblast"
                     /tissue_type="ear"
                     /geo_loc_name="USA: California, Stanford University"
                     /collection_date="2021-07-30"
                     /collected_by="Stephen Chang"
     Protein         1..440
                     /product="suppressor of cytokine signaling 4"
                     /calculated_mol_wt=50389
     Region          58..111
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          275..375
                     /region_name="SH2_SOCS4"
                     /note="Src homology 2 (SH2) domain found in suppressor of
                     cytokine signaling (SOCS) proteins; cd10385"
                     /db_xref="CDD:198248"
     Site            order(283,285)
                     /site_type="other"
                     /note="Elongin-C binding interface [polypeptide binding]"
                     /db_xref="CDD:198248"
     Site            order(293,311,313,321,334)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198248"
     Site            order(344,346,364)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198248"
     Region          384..439
                     /region_name="SOCS"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; cl02533"
                     /db_xref="CDD:470605"
     Site            order(385..390,396,403,409)
                     /site_type="active"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     CDS             1..440
                     /gene="SOCS4"
                     /coded_by="XM_012758026.2:442..1764"
                     /db_xref="GeneID:105867701"
ORIGIN      
        1 maennennsk nvdvrpktnr srsadrrdgy vwsgkklsws kksescsdae tvntiekteg
       61 slrsqerkhs cssieldldh scghrflgrs lkqklqdavg qcfpikncss rhssglpskr
      121 kihiselmld kcpfpprsdl afrwhfikrh tapinpksde wvstdlsqse lrdgqlkqrr
      181 nmeedincfs htsvqpcvit tnnascrgpm pgsvmnlvsn nsiedsdmds ddeiitlcts
      241 srkrnkpkwe lddeilqlet ppkyhtqidy vhclvpdllq innnpcywgv mdkyaaeall
      301 egkpegtfll rdsaqedylf svsfrrysrs lharieqwnh nfsfdahdpc vfhspditgl
      361 lehykdpsac mffepllstp lirtfpfslq hicrtvicnc ttydgidalp ipssmklylk
      421 eyhykskvrv lridaaeqqc
//