LOCUS       XP_014009618             561 aa            linear   VRT 24-APR-2026
DEFINITION  suppressor of cytokine signaling 5b [Salmo salar].
ACCESSION   XP_014009618
VERSION     XP_014009618.1
DBLINK      BioProject: PRJNA1432933
DBSOURCE    REFSEQ: accession XM_014154143.3
KEYWORDS    RefSeq.
SOURCE      Salmo salar (Atlantic salmon)
  ORGANISM  Salmo salar
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
            Salmoniformes; Salmonidae; Salmoninae; Salmo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_138308) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_965601325.1-RS_2026_04
            Annotation Pipeline         :: NCBI Eukaryotic Genome Annotation
                                           Pipeline (EGAP)
            Annotation Software Version :: 10.5
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/06/2026
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..561
                     /organism="Salmo salar"
                     /db_xref="taxon:8030"
                     /chromosome="ssa18"
                     /geo_loc_name="Norway:Vestland, Fortun"
                     /collection_date="2021-12-07"
     Protein         1..561
                     /product="suppressor of cytokine signaling 5b"
                     /calculated_mol_wt=61760
     Region          156..199
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          394..494
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(412,430,451,453)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198173"
     Site            order(452,482)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198173"
     Region          504..559
                     /region_name="SOCS"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; cl02533"
                     /db_xref="CDD:470605"
     Site            order(504..509,515,522,528)
                     /site_type="active"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239708"
     CDS             1..561
                     /gene="socs5b"
                     /coded_by="XM_014154143.3:587..2272"
                     /db_xref="GeneID:106576765"
ORIGIN      
        1 mekvgkmwsn lrsrcqtlfh sdgagpsten svvevdgmhc vvdlerggns geaqasrass
       61 lsrsllplpm vtggrrhncv sdipqiveit idskdhedar ggrggvpvar rdsysrhapw
      121 ggkkkhscst ktqssmdtdr rsgrargaag rrerrygvss iqemgdsgsg gcslsarslr
      181 qrlsdtvglc lplprrrsrs sktptiskrk ihltelmlet cpfpqgsdla nkwhlikqht
      241 apvsphssta lldafdtahp spedeeerlr errrlsieeg vdpppnaqih tlealaqgss
      301 lyklgpkmap giaeasgear gavaccsggg vsvqvlggat aqladcdsee dsttlclqal
      361 rpkqrhasgd gnlsrnqpgp wkvhtqidyi hclvpdllqi talpcywgvm dryeaealld
      421 grpegtfllr dsaqedylfs vsfrrynrsl harieqwnhn fsfdahdpcv fhsstvtgll
      481 ehykdpsacm ffeplltapl hrafpfglqh laraaicprt tydgigglpl ppalqdflke
      541 yhykqkvrvr wlerepplki k
//