LOCUS       XP_017718224             536 aa            linear   PRI 22-MAY-2026
DEFINITION  suppressor of cytokine signaling 5 isoform X1 [Rhinopithecus
            bieti].
ACCESSION   XP_017718224
VERSION     XP_017718224.1
DBLINK      BioProject: PRJNA339282
DBSOURCE    REFSEQ: accession XM_017862735.1
KEYWORDS    RefSeq.
SOURCE      Rhinopithecus bieti (black snub-nosed monkey)
  ORGANISM  Rhinopithecus bieti
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Colobinae; Rhinopithecus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_016824934.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_001698545.2-RS_2026_05
            Annotation Pipeline         :: NCBI Eukaryotic Genome Annotation
                                           Pipeline (EGAP)
            Annotation Software Version :: 10.5
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 05/20/2026
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Rhinopithecus bieti"
                     /isolate="Rb0"
                     /db_xref="taxon:61621"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="blood"
     Protein         1..536
                     /product="suppressor of cytokine signaling 5 isoform X1"
                     /calculated_mol_wt=61129
     Region          145..195
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          370..470
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(388,406,427,429)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198173"
     Site            order(428,458)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198173"
     Region          479..534
                     /region_name="SOCS_SOCS5"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS5-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. SOCS5
                     inhibits Th2 differentiation by inhibiting...; cd03739"
                     /db_xref="CDD:239708"
     Site            order(480..485,491,498,504,509)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239708"
     CDS             1..536
                     /gene="SOCS5"
                     /coded_by="XM_017862735.1:92..1702"
                     /db_xref="GeneID:108522507"
ORIGIN      
        1 mdkvgkmwnn fkyrcqnlfg heggsrsenv dmnsnrclsv reknisigds tpqqqssplr
       61 envalqlgls psknssrrnq ncateipqiv eisiekdnds cvtpgtrlar rdsysrhapw
      121 ggkkkhscst ktqssldadk kfgrtrsglq rrerrygvss vhdmdsvssr tvgsrslrqr
      181 lqdtvglcfp mrtyskqskp lfsnkrkihl selmlekcpf pagsdlaqkw hlikqhtapv
      241 sphstffdtf dpslvstede edrlrerrrl sieegvdppp naqihtfeat aqvnplyklg
      301 pklapgmtei sgdssaipqa ncdseedttt lclqsrrqkq rqisgdshth vsrqgawkvh
      361 tqidyihclv pdllqitgnp cywgvmdrye aeallegkpe gtfllrdsaq edylfsvsfr
      421 rynrslhari eqwnhnfsfd ahdpcvfhss tvtgllehyk dpsscmffep lltislnrtf
      481 pfslqyicra vicrcttydg idglplpsml qdflkeyhyk qkvrvrwler epvkak
//