LOCUS       XP_023591201             537 aa            linear   MAM 29-JAN-2024
DEFINITION  suppressor of cytokine signaling 5 [Trichechus manatus
            latirostris].
ACCESSION   XP_023591201
VERSION     XP_023591201.1
DBLINK      BioProject: PRJNA189960
DBSOURCE    REFSEQ: accession XM_023735433.1
KEYWORDS    RefSeq.
SOURCE      Trichechus manatus latirostris (Florida manatee)
  ORGANISM  Trichechus manatus latirostris
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_004443941.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000243295.1-RS_2024_01
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 01/26/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Trichechus manatus latirostris"
                     /isolate="Lorelei"
                     /sub_species="latirostris"
                     /db_xref="taxon:127582"
                     /chromosome="Unknown"
                     /sex="female"
     Protein         1..537
                     /product="suppressor of cytokine signaling 5"
                     /calculated_mol_wt=61068
     Region          146..196
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          371..471
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(389,407,428,430)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198173"
     Site            order(429,459)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198173"
     Region          480..535
                     /region_name="SOCS_SOCS5"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS5-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. SOCS5
                     inhibits Th2 differentiation by inhibiting...; cd03739"
                     /db_xref="CDD:239708"
     Site            order(481..486,492,499,505,510)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239708"
     CDS             1..537
                     /gene="SOCS5"
                     /coded_by="XM_023735433.1:41..1654"
                     /db_xref="GeneID:101348056"
ORIGIN      
        1 mdkvgkmwnn fkyrcqnlfs heggsrsenv gmnssrclsv kerntsigdp apqqqssplr
       61 envalhlgls ssknssrrsq ncaaeipqiv eisiekendp cvttpgtrla rrdsysrhap
      121 wggkkkhscs tktqssldte kkfgrtrsgl qrrerrygvs svhdmdsvss rtvgsrslrq
      181 rlqdtvglcf pmrtyskqsk plfsnkrkih lselmlekcp fpagsdlaqk whlikqhtap
      241 vsphstffdt fdpslvsted eedrlrerrr lsieegvdpp pnaqihtfea taqvnplykl
      301 gpklapgmte isgdssavpq ascdseedtt tlclqsrrqk qrqvsgdsha hvsrqgawkv
      361 htqidyihcl vpdllqitgn pcywgvmdry eaeallegkp egtfllrdsa qedylfsvsf
      421 rrynrslhar ieqwnhnfsf dahdpcvfhs stvtgllehy kdpsscmffe plltislnrt
      481 fpfslqyicr avicrcttyd gidglplpsm lqdflkeyhy kqkvrvrwle repvkak
//