LOCUS       XP_027409966             440 aa            linear   MAM 25-DEC-2018
DEFINITION  suppressor of cytokine signaling 4 [Bos indicus x Bos taurus].
ACCESSION   XP_027409966
VERSION     XP_027409966.1
DBLINK      BioProject: PRJNA508959
DBSOURCE    REFSEQ: accession XM_027554165.1
KEYWORDS    RefSeq.
SOURCE      Bos indicus x Bos taurus (hybrid cattle)
  ORGANISM  Bos indicus x Bos taurus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_040085.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Bos indicus x Bos taurus Annotation
                                           Release 100
            Annotation Version          :: 100
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.1
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Bos indicus x Bos taurus"
                     /db_xref="taxon:30522"
                     /chromosome="10"
                     /sex="male"
                     /tissue_type="lung"
                     /dev_stage="fetus"
                     /collected_by="Stefan Hiendleder"
                     /breed="Angus x Brahman F1 hybrid"
     Protein         1..440
                     /product="suppressor of cytokine signaling 4"
                     /calculated_mol_wt=50087
     Region          58..111
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          275..375
                     /region_name="SH2_SOCS4"
                     /note="Src homology 2 (SH2) domain found in suppressor of
                     cytokine signaling (SOCS) proteins; cd10385"
                     /db_xref="CDD:198248"
     Site            order(283,285)
                     /site_type="other"
                     /note="Elongin-C binding interface [polypeptide binding]"
                     /db_xref="CDD:198248"
     Site            order(293,311,313,321,334)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198248"
     Site            order(344,346,364)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198248"
     Region          384..439
                     /region_name="SOCS_SOCS4"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS4-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. The general
                     function of the SOCS box is the...; cd03738"
                     /db_xref="CDD:239707"
     Site            order(385..390,396,403,409,414)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239707"
     CDS             1..440
                     /gene="SOCS4"
                     /coded_by="XM_027554165.1:434..1756"
                     /db_xref="GeneID:113900408"
ORIGIN      
        1 maensesnsk nvdvrpktsr srsadrkdgy vwsgkklsws kksescsdae tvsaiektev
       61 plrsqerkhs cssieldldh scghrflgrs lkqklqdavg qcfpikncss rhssglpskr
      121 kihiselmld kcpfpprsdl afrwhfikrh tapispksde wvstdlsqse lrdgqlkqrr
      181 nmeevscfsh tsvqpcvits nnssgrggpg tdsivnlasn nsiedsdmds ddeiitlcts
      241 srkrnkpkwe ideeilqlet ppkyhtqidy vhclvpdllq innnpcywgv mdkyaaeall
      301 egkpegtfll rdsaqedylf svsfrrysrs lharieqwnh nfsfdahdpc vfhspditgl
      361 lehykdpsac mffepllstp lirtfpfslq hicrtvicnc ttydgidalp ipssmklylk
      421 eyhykskvrv lridapeqqc
//